| For 11 of these same genes ( FPGS , DHFR , GGH , NME 1 , NME 2 , RRM 2 , UMPH 2 , UNG , UMPS , TP 53 , and TK 1 ) , a significant proportion of the patients showed an over expression of the particular gene in tumor tissue with a tumor to nonmalignant ( T / N ) ratio > 1 . 2 , whereas one gene ( DPYD ) showed the converse with a large number of patients showing a lower expression in the tumor tissue ( T / N < 0 . 8 ) . ^^^ |