| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| In this study , a respiration deficient Chinese hamster cell line with a defect in succinate dehydrogenase activity is shown to result from a single base change in a codon in the coding sequence for the membrane anchor protein CII 3 ( also referred to as QPs 1 ) . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| A . 85 , 5809 5813 ) as a probe , we isolated a different species of cDNA ( SDH 3 ) from the same cDNA library from which SDH 2 was obtained . ^^^ In vitro transcription / translation experiment demonstrated that SDH 3 encoded a polypeptide of 35 kDa , a size in agreement with that of the subunit of the purified protein , whereas SDH 2 , despite having a size larger than SDH 3 , produced a peptide of much smaller size that reacted with anti serine dehydratase IgG . ^^^ Also , SDH 2 has a 5 ' noncoding sequence different from that of SDH 3 . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| These complex 2 genes , sdh 2 , sdh 3 , and sdh 4 , are homologs , respectively , of Escherichia coli sdhB , sdhC , and sdhD . ^^^ Amino acid sequence similarities indicate that sdh 2 , sdh 3 , and sdh 4 were originally encoded in the protomitochondrial genome and have subsequently been transferred to the nuclear genome in most eukaryotes . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The mature cybL and cybS contain 140 and 103 amino acids , respectively , and show little similarity to the amino acid sequences of the subunits from other species in contrast to the highly conserved features of the flavoprotein ( Fp ) subunit and iron sulfur protein ( Ip ) subunit . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Complex 2 is comprised of two hydrophilic proteins , flavoprotein ( Fp ) and iron sulfur protein ( Ip ) , and two transmembrane proteins ( CybL and CybS ) , as well as prosthetic groups required for electron transfer from succinate to ubiquinone . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The binding of these antibodies to SMP was greatly increased when succinate dehydrogenase was removed from SMP by alkaline treatment , indicating that QPs 1 is a transmembranous protein and that some of its specific epitopes are covered by succinate dehydrogenase . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The succinate dehydrogenase ( SDH ) of Saccharomyces cerevisiae is composed of four nonidentical subunits encoded by the nuclear genes SDH 1 , SDH 2 , SDH 3 , and SDH 4 . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| SDH is encoded by the SDH 1 , SDH 2 , SDH 3 , and SDH 4 genes . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The Saccharomyces cerevisiae succinate ubiquinone reductase or succinate dehydrogenase ( SDH ) is a tetramer of non equivalent subunits encoded by the SDH 1 , SDH 2 , SDH 3 , and SDH 4 genes . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Here we report frequent transfer of two respiratory genes , sdh 3 and sdh 4 ( encoding subunits 3 and 4 of succinate dehydrogenase ) , and we also show that these genes are present and expressed in the mitochondria of diverse angiosperms . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Mitochondrial respiratory complex 2 contains four subunits : a flavoprotein ( SDHI ) , an iron sulphur subunit ( SDH 2 ) and two membrane anchor subunits ( SDH 3 and SDH 4 ) . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Succinate dehydrogenase ( SDH ) of Saccharomyces cerevisiae consists of four subunits encoded by the SDH 1 , SDH 2 , SDH 3 , and SDH 4 genes . ^^^ Succinate dehydrogenase ( SDH ) of Saccharomyces cerevisiae consists of four subunits encoded by the SDH 1 , SDH 2 , SDH 3 , and SDH 4 genes . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The decay of the polycistronic Bacillus subtilis sdh mRNA was analysed using probes specific for each of the component cistrons , sdhC , sdhA and sdhB . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| FrdC was found to be homologous with the cytochrome b ( SdhC ) of the Bacillus subtilis succinate dehydrogenase , but not with the hydrophobic subunits of the fumarate reductase or succinate dehydrogenase of Escherichia coli . . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The B . subtilis DNA insert in pKIM 2 could transform B . subtilis sdhA ( cytochrome b 558 ) , sdhB ( flavoprotein ) , and sdhC ( iron sulfur protein ) mutants to the wild type . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Translation of the two succinate dehydrogenase genes from the sdhCAB polycistronic transcript does not seem to be coupled to translation of sdhC . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The nucleotide sequence of a 3614 base pair segment of DNA containing the sdhA gene , encoding the flavoprotein subunit of succinate dehydrogenase of Escherichia coli , and two genes sdhC and sdhD , encoding small hydrophobic subunits , has been determined . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| It is separated by a 15 base pair intergenic region from the preceding flavoprotein gene ( sdhA ) and is the distal gene of an operon that also includes genes ( sdhC and D ) encoding two hydrophobic subunits , sdhCDAB . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Mutations in sdhA affect cytochrome b 558 , mutations in sdhB affect Fp , and mutations in sdhC affect Ip . . ^^^ The designation citF will be omitted , and the citF locus will be divided into three genes : sdhA , sdhB , and sdhC . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Two subunits of the succinate dehydrogenase complex ( sdhB and sdhC ) , usually found on nuclear genomes , are also located on the mtDNA of C . crispus . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Computer assisted structural analysis of the predicted product of the previously described open reading frame ( ORF ) YKL 4 located on the left arm of chromosome 11 of Saccharomyces cerevisiae revealed a high degree of similarity ( > 50 % ) to bovine cytochrome b 560 , the sdhC polypeptide of the Escherichia coli succinate dehydrogenase ( SDH ) complex and the protein specified by ORF 137 located on the chloroplast DNA of Marchantia polymorpha . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Two genes , sdhB and sdhC , that encode subunits of the succinate dehydrogenase , were identified by similarity . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The isolated reductase is resolved into a reconstitutively active , two subunit succinate dehydrogenase and a two subunit membrane anchoring protein fraction ( the SdhC SdhD fraction ) by alkaline ( pH 10 . 2 ) treatment of the reductase in the presence of 1 M urea , followed by DEAE Sepharose CL 6B column chromatography under anaerobic conditions . ^^^ Isolated succinate dehydrogenase and the SdhC SdhD fraction alone show no succinate ubiquinone reductase activity . ^^^ However , when a given amount of the SdhC SdhD fraction is mixed with varying amounts of succinate dehydrogenase or vice versa succinate ubiquinone reductase activity increases as the amount of succinate dehydrogenase or the SdhC SdhD fraction added increases . ^^^ Maximum reconstitution is obtained when the weight ratio of succinate dehydrogenase to the SdhC SdhD fraction reaches 5 . 26 . ^^^ This ratio is slightly higher than the calculated value of 3 . 37 , obtained by assuming 1 mol of succinate dehydrogenase reacts with 1 mol of SdhC and SdhD . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The sdh operon of Sulfolobus acidocaldarius DSM 639 is composed of four genes coding for the 63 . 1 kDa flavoprotein ( SdhA ) , the 36 . 5 kDa iron sulfur protein ( SdhB ) , and the 32 . 1 kDa SdhC and 14 . 1 kDa SdhD subunits . ^^^ The S . acidocaldarius SdhA and SdhB subunits show characteristic sequence similarities to the succinate dehydrogenases and fumarate reductases of other organisms , while the SdhC and SdhD subunits , thought to form the membrane anchoring domain , lack typical transmembrane alpha helical regions present in all other succinate : quinone reductases ( SQRs ) and quinol : ifumarate reductases ( QFRs ) so far examined . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Two of the subunits ( SDHC and SDHD ) are hydrophobic and anchor the two more hydrophilic ( flavin and iron sulfur ) subunits ( SDHA and SDHB ) to the cytoplasmic membrane . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Their respective genes in mammals are SDHA , SDHB , SDHC and SDHD ) in order of decreasing molecular weights of the peptides . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The gene products of two components of succinate dehydrogenase , SDHC and SDHD , anchor the gene products of two other components , SDHA and SDHB , which form the catalytic core , to the inner mitochondrial membrane . ^^^ Although mutations in SDHC and in SDHD may cause hereditary paraganglioma , germline SDHA mutations are associated with juvenile encephalopathy , and the phenotypic consequences of SDHB mutations have not been defined . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Linkage and radiation hybrid mapping of the porcine gene for subunit C of succinate dehydrogenase complex ( SDHC ) to chromosome 4 . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Mitochondrial complex 2 ( succinate : ubiquinone oxidoreductase ) is the smallest complex in the respiratory chain and is composed of four subunits encoded by nuclear genes SDHA , SDHB , SDHC , and SDHD . ^^^ SDHA and SDHB encode the flavoprotein and iron sulfur proteins , respectively , and SDHC and SDHD encode the two hydrophobic membrane spanning subunits . ^^^ While mutations in SDHA display a phenotype resembling other mitochondrial and Krebs cycle gene defects , those in SDHB , SDHC and SDHD cause hereditary paraganglioma . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| It now appears that mutations in SDHB , SDHC , and SDHD , which encode subunits of mitochondrial complex 2 ( succinate dehydrogenase ; succinate ubiquinone oxidoreductase ) , are responsible for the majority of familial paragangliomas and also for a significant fraction of non familial tumours . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Complex 2 ( succinate ubiquinone oxidoreductase ) is the smallest complex in the respiratory chain and contains four nuclear encoded subunits SdhA , SdhB , SdhC , and SdhD . ^^^ Enzyme depletion and mutations in SDHA compromise TCA activity and energy production , whereas mutations in SDHB , SDHC , and SDHD induce paraganglioma . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Germline mutations in three of the succinate dehydrogenase ( SDH , mitochondrial complex 2 ) subunits ( SDHD , SDHB and SDHC ) cause susceptibility to head and neck paragangliomas , and may be found in approximately 20 % of unselected patients . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The SDHD , SDHC , and SDHB genes code for subunits of succinate dehydrogenase , which forms part of the mitochondrial respiratory chain . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Because of inactivating mutations in the succinate dehydrogenase subunit B ( SDHB ) , C ( SDHC ) , or D ( SDHD ) gene , the paraganglia undergo a chronic hypoxic stimulus leading to proliferation of the paraganglionic cells . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| PGL tumors are caused by germline inactivating heterozygous mutations in the SDHB , SDHC and SDHD genes , which encode three of the four subunits of succinate dehydrogenase ( SDH ; succinate : ubiquinone oxidoreductase ; mitochondrial complex 2 ) . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Hereditary paraganglioma syndrome has recently been shown to be caused by germline heterozygous mutations in three ( SDHB , SDHC , and SDHD ) of the four genes that encode mitochondrial succinate dehydrogenase . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Germline mutations in succinate dehydrogenase subunits B , C and D ( SDHB , SDHC and SDHD ) , genes encoding subunits of mitochondrial complex 2 , cause hereditary paragangliomas and phaeochromocytomas . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Analysis of a subclone containing the resistance gene revealed the presence of the sdhC gene , which encodes the cytochrome b 560 subunit of the succinate dehydrogenase ( SDH ) complex ( Complex 2 ) in the mitochondrial membrane . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : Germline mutations in succinate dehydrogenase ( SDH ) B , SDHC and SDHD , encoding three of the four subunits of mitochondrial complex 2 , have been implicated in the tumourigenesis of familial paragangliomas and phaeochromocytomas . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Mutations in the genes encoding the three other succinate dehydrogenase subunits ( SDHB , SDHC and SDHD ) have been identified in patients affected by familial or ' apparently sporadic ' paraganglioma and / or pheochromocytoma , an autosomal inherited cancer susceptibility syndrome . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| SDHC and SDHD anchor the catalytic subunits SDHA and B of mitochondrial complex 2 in the inner mitochondrial membrane . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The enzyme contained two heme B molecules and three polypeptides with apparent molecular masses of 67 , 29 and 23 kDa , which corresponded to SdhA ( flavoprotein ) , SdhB ( iron sulfur protein ) , and SdhC ( membrane anchor protein ) , respectively . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Germline mutations of the genes for succinate dehydrogenase subunits D , B , or C ( SDHD , SDHB , SDHC ) have been identified in some kindreds with familial paraganglioma . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| In the case of pheochromocytoma and paraganglioma , the demonstration that three genes encoding three succinate dehydrogenase subunits ( SDHD , SDHB , SDHC ) , belonging to the complex 2 of the respiratory chain in the mitochondria , are involved in the genetics of familial and especially in apparently sporadic phaeochromocytomas have dramatically modified our practice . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The recent discoveries on genes encoding three succinate dehydrogenase subunits ( SDHD , SDHB et SDHC ) will allow a genetic detection of asymptomatic case and will define the procedures for their management , coordinated by a national network PGL . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The SDHA , SDHB , SDHC and SDHD genes encode the subunits of succinate dehydrogenase ( succinate : ubiquinone oxidoreductase ) , a component of both the Krebs cycle and the mitochondrial respiratory chain . ^^^ SDHA , a flavoprotein and SDHB , an iron sulfur protein together constitute the catalytic domain , while SDHC and SDHD encode membrane anchors that allow the complex to participate in the respiratory chain as complex 2 . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Germline mutations of the three succinate dehydrogenase subunits SDHB , SDHC and SDHD have recently been associated with familial pheochromocytoma and paraganglioma . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Since the discovery 5 years ago that the D subunit of succinate dehydrogenase ( SDHD ) can behave as a classic tumour suppressor , other nuclear encoded mitochondrial proteins ( SDHB , SDHC and fumarate hydratase ) have been implicated in tumour susceptibility . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The neoplasms , respectively , did not show germline SDHA , SDHB , SDHC , and SDHD , and KIT mutations associated with familial paraganglioma and familial GIST . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Germline mutations of the SDHD , SDHB and SDHC genes , encoding three of the four subunits of succinate dehydrogenase , are a major cause of hereditary paraganglioma and pheochromocytoma , and demonstrate that these genes are classic tumor suppressors . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| The complete nucleotide sequences of four subunits ( SdhA , SdhB , SdhC and SdhD ) of succinate ubiquinone oxidoreductase ( SQR ) were cloned by polymerase chain reaction ( PCR ) amplification . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Assignment of the subunit C of succinate dehydrogenase complex ( SDHC ) gene to bovine chromosome 2 with somatic and radiation hybrid panel mapping . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| Finally , isolated familial syndromes of endocrine tumors have been described : isolated familial hyperparathyroidism type 2 ( HRPT 2 ) , associated with alterations in a gene coding for an original protein , parafibromin , or isolated familial syndromes of pheochromocytomas and paragangliomas ( PRG ) associated with mutations in the genes SDHB , SDHC or SDHD , which encode succinate dehydrogenase subunits . ^^^ |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99643 and P31040 |
Pubmed |
SVM Score :0.0 |
| NA |
|