| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| However , a fundamental difference was found ; unlike NTR 1 , NTR 2 recognizes , with high affinity , levocabastine , a histamine H 1 receptor antagonist previously shown to compete with NT for low affinity binding sites in brain . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Interestingly , despite its high KD ( 620 nM ) at the cloned NTR 1 , NT 27 1 ( the iodinated form of NT 27 ) exerted a potent hypothermic effect even at a very low dose ( 0 . 6 nmol ) . ^^^ Equally intriguing , was that NT 24 , a sterioisomer of NT 27 , with a much higher affinity ( KD=0 . 5 nM ) at NTR 1 , did not selectively induce hypothermia in mice , but did selectively induce hypothermia in rats . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Recent pharmacological evidence obtained with NT agonists and antagonists suggests that these effects are mediated by a receptor distinct from the initially cloned high affinity NT receptor ( NTR 1 ) . ^^^ These data confirm that NTR 1 is involved in the NT elicited turning behavior and demonstrate that the NTR 2 mediates NT induced analgesia . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Intraperitoneal injection of an unmodified antisense peptide nucleic acid ( PNA ) complementary to mRNA of the rat neurotensin ( NT ) receptor ( NTR 1 ) was demonstrated by a gel shift assay to be present in brain , thus indicating that the PNA had in fact crossed the blood brain barrier . ^^^ Additionally , the sense NTR 1 PNA , targeted to DNA , microinjected directly into the brain specifically reduced mRNA levels by 50 % and caused a loss of response to NT . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Here , we present radioligand binding data for some novel hexapeptide analogs of NT ( 8 13 ) at the molecularly cloned rat and human neurotensin receptors ( NTR 1 ) , along with behavioral and physiological effects of several of these peptides after intraperitoneal ( i . p . ) administration in rats . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| In the present study , we investigated whether this is due to NT receptor 1 ( NTR 1 ) mRNA up regulation and whether NTR 1 mRNA could also be used as a specific diagnostic marker and treatment target in pancreatic cancer . ^^^ Furthermore , consecutive tissue sections were analyzed for NTR 1 mRNA expression and NT binding . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The neurotensin ( NT ) receptor , subtype 1 ( NTR 1 ) , is a 7 transmembrane spanning receptor , forming 3 extracellular and 3 intracellular loops . ^^^ Previously , we showed that the third outer loop ( E 3 ) is the binding site for NT and its analogs , several of which bind with higher affinity to rat NTR 1 ( rNTR 1 ) than to human NTR 1 ( hNTR 1 ) . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| We recently showed that the 2 structurally different receptors NTR 1 and NTR 3 were coexpressed in several human cancer cells on which NT exerts proliferative effects . ^^^ The NTR 1 NTR3 complex is then internalized on NT stimulation . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Photoaffinity labeling of the NT receptor NTR 1 was enhanced in CCB treated cells . ^^^ These results suggest that CCBs exert two effects : 1 ) they inhibit NT induced IP formation , perhaps by preventing Ca2+ influx dependent activation of PLCdelta ; and 2 ) they enhance NTR 1 affinity by an unexplained Ca2+ independent mechanism . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Earlier work indicated that these effects , which involved the G protein coupled NT receptor NTR 1 , were indirect and required cellular metabolism or architecture . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Two G protein coupled neurotensin ( NT ) receptors , termed NTR 1 and NTR 2 , have been identified so far . ^^^ The unique pharmacological profile of the hNTR 2 is discussed in the light of its sequence similarity with the NTR 1 and the known binding site topology of NT and SR 48692 in the NTR1 . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Mice deficient in the neurotensin ( NT ) 1 receptor ( NTR 1 ) were developed to characterize the NT receptor subtypes that mediate various in vivo responses to NT . ^^^ In contrast , NT 2 had no effect in NTR 1 null mice , whereas the hypomotility effect of clonidine was intact . ^^^ These data indicate that NTR 1 mediates several of the central and peripheral effects of NT . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Binding to NT 1 receptors ( NTR 1 ) was saturable and specific . ^^^ After interacting with NTR 1 , ( 99m ) Tc ( CO ) ( 3 ) NT 8 was rapidly internalized , with more than 90 % internalized after 30 min . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : The purpose of the study was to investigate whether cultured human keratocytes express the neurotensin receptors ( NTR 1 , NTR 2 , and NTR 3 ) , to determine the presence of neurotensin ( NT ) in keratocytes , and to assess the influence of NT on these cells . ^^^ NT , NTR 1 , NTR 2 , and NTR 3 mRNA were detected in human keratocytes by means of reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ CONCLUSIONS : These results indicate that cultured human keratocytes express NTR 1 and NTR 3 and that NT may exert physiological effects on cornea such as regulation of keratocyte proliferation and apoptosis . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Neurotensin ( NT ) regulates a variety of biological processes primarily through interaction with neurotensin receptor 1 ( NTR 1 ) , a heterotrimeric G protein coupled receptor ( GPCR ) . ^^^ Here , we report that activation of NTR 1 by NT inhibits Akt activity as determined by the dephosphorylation of Akt at both Ser 473 and Thr 308 in AV 12 cells constitutively expressing human NTR 1 ( NTR1 / AV12 ) . ^^^ This effect of NT was completely blocked by the specific NTR 1 antagonist , ( S ) ( + ) [ 1 ( 7 chloro 4 quinolinyl ) 5 ( 2 , 6 dimethoxyphenyl ) pyrazol 3 yl ) carbonylamino ] cyclohexylacetic acid ( SR 48527 ) , but unaffected by the less active enantiomer ( ( R ) ( ) [ 1 ( 7 chloro 4 quinolinyl ) 5 ( 2 , 6 dimethoxyphenyl ) pyrazol 3 yl ) carbonylamino ] cyclohexylacetic acid ( SR 49711 ) ) , indicating the stereospecificity of NTR 1 in the negative regulation of Akt . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Here , androgen independent PC 3 cells , which express high levels of the type 1 NT receptor ( NTR 1 ) , are used to examine the involvement of epidermal growth factor receptor ( EGFR ) , mitogen activated protein kinases ( ERK , SAPK / JNK and p 38 ) , PI 3 kinase and PKC in the mitogenic effect of NT . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Expression of the neuropeptide neurotensin ( NT ) and its high affinity receptor ( NTR 1 ) is increased during the course of Clostridium difficile toxin A induced acute colitis , and NTR 1 antagonism attenuates the severity of toxin A induced inflammation . ^^^ Here we used NCM 460 cells , which normally express low levels of NTR 1 , and NCM 460 cells stably transfected with NTR 1 to identify the upstream signaling molecules involved in NT NTR 1 mediated MAP kinase activation . ^^^ This is the first report demonstrating that NT binding to NTR 1 transactivates the EGFR and that this response is linked to NT mediated proinflammatory signaling . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The selective NTR 1 receptor antagonist SR 48692 reversibly blocked the effects of NT on both action potentials and spontaneous synaptic currents . ^^^ Our results suggest that NTR 1 receptors can modulate post synaptic responses in neurons of the subpostremal NTS by increasing cell excitability as a result of blockade of a potassium conductance . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| We also show that microinjection of NT or the NTR 1 selective agonist PD 149163 in the RVM both produce dose dependent antinociception in the tail flick test that is blocked by the NTR 1 selective antagonist SR 48692 . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The first area concerns the functional activation of the high affinity NT receptor , NTR 1 , including the delineation of the NT binding pocket and receptor domains involved in functional coupling to intracellular signaling pathways . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Abundance of transcripts that encode NT and NT receptors 1 , 2 , and 3 ( NTR 1 , NTR 2 , and NTR 3 ) in total hypothalamic RNA was the quantitative trait measured . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| LOX blockers dramatically enhanced 125I neurotensin binding to NT receptor NTR 1 in PC 3 cells , whereas they inhibited NT induced inositol phosphate formation . ^^^ Also supporting the involvement of arachidonic acid metabolism in NTR 1 regulation was the finding that inhibitors of PLA 2 and DAG lipase enhanced NT binding . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| RT PCR analysis revealed the expression of NT receptor type ( NTR ) 3 mRNA but not NTR 1 and NTR 2 mRNAs in the human adrenal tissue . ^^^ CONCLUSION : Our results indicate that NT 1 11 may act as an endocrine factor to inhibit cortisol secretion through activation of a receptor distinct from the classical NTR 1 , NTR 2 , and NTR3 . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Because neurotensin ( NT ) and its high affinity receptor ( NTR 1 ) modulate immune responses , chloride secretion , and epithelial cell proliferation , we sought to investigate their role in the repair process that follows the development of mucosal injuries during a persistent inflammation . ^^^ Colonic NT and NTR 1 , mRNA , and protein significantly increased only after dextran sodium sulfate ( DSS ) induced inflammatory damage developed . ^^^ Colitis induced body weight loss , colonic myeloperoxidase activity , and histological damage were significantly enhanced by SR 48642 administration , a nonpeptide NTR 1 antagonist , whereas continuous NT infusion ameliorated colitis outcome . ^^^ To evaluate the NT and NTR 1 role in tissue healing , mucosal inflammatory injury was established administering 3 % DSS for 5 days . ^^^ After DSS discontinuation , mice rapidly gained weight , ulcers were healed , and colonic NT , NTR 1 , and cyclooxygenase ( COX ) 2 mRNA levels were upregulated , whereas SR 48642 treatment caused a further body weight loss , ulcer enlargement , and a blunted colonic COX 2 mRNA upregulation . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| To date , three different types of NT receptor ( NTR ) , NTR 1 , NTR 2 and NTR 3 , have been identified only in mammalian species . ^^^ Mammalian NTR 1 but not NTR 2 responds to NT , whereas both bfNTR 1 and bfNTR 4 show a high sensitivity to NT . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| To gain insight into the subcellular substrate for these effects , we compared by electron microscopy the distribution of immunoreactive high affinity NT receptor proteins ( NTRH ) with that of high affinity 125I NT binding sites in this region of rat brain . ^^^ The distributions of immunoreactive NTRH and 125I NT binding sites along somatodendritic plasma membranes were highly correlated and homogeneous , suggesting that membrane targeted NTRH proteins were functional and predominantly extrasynaptic . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The peptides neurotensin ( NT ) and neuromedin N exert effects on neurons by means of a high affinity NT receptor ( NTRH ) belonging to the superfamily of G protein coupled receptors . ^^^ Our results identify many novel sites of NTRH mRNA expression in adult brain and provide a basis for investigating involvement of NT and related peptides in regulating the activity of these diverse cells , whose phenotypes remain largely undetermined . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to determine whether human colon cancers ( HCC ) ( 1 ) express the mRNA for NT / neuromedin N ( N ) , ( 2 ) produce NT peptide , and ( 3 ) express the mRNA for a functional NT receptor ( NTR ) . ^^^ Neurotensin peptide content , NTR expression , and intracellular Ca++ ( [ Ca++ ] 1 ) mobilization in response to NT were evaluated in three HCC cell lines ( LoVo , HT 29 , HCT 116 ) . ^^^ These findings demonstrate the presence of NT / N mRNA and NT peptide and the presence of a functional NTR in certain HCC . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| However , the 3 ' terminal non translated region ( NTR ) of TuMV Jap RNA is significantly shorter ( 212 nts ) than the 3 ' NTR of TuMV Can RNA ( 668 nts ) , but of equal length as the 3 ' NTR of the TuMV Chi isolate which also measures 212 nts . ^^^ Irrespective of the origin of this extra sequence in the reported TuMV Can sequence , which may have been introduced by a genuine RNA recombination event , it is concluded that the standard TuMV genome has a CP gene of 864 nts and an conserved 3 ' NTR of approximately 212 nucleotides in length . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Although most of the regions found here to express NTRL mRNA were previously reported to be devoid of mRNA encoding the high affinity NT receptor ( NTRH ) , a few areas ( e . g . , the anterior olfactory nucleus , medial septum , diagonal band of Broca , reticular thalamic nucleus , suprachiasmatic hypothalamic nucleus , and pontine nucleus ) were enriched in both receptor subtypes , suggesting a possible coexpression of these receptors by the same cells . ^^^ In cerebral cortex , the developmental increase in NTRL expression was correlated over time with the decrease in NTRH expression previously documented in the rat , suggesting a progressive takeover of the latter by the former for transduction of the effects of NT in this structure . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| In the hypothalamic cultures , 125I NT bound to a single class of binding sites , presenting a selectivity similar to that observed for the high affinity NTR previously described in the adult rat brain . ^^^ However , a combined treatment with both agents led to a 40 % decrease in 125I NT binding , corresponding to a reduced number of binding sites , and to a 68 % decrease in the amount of NTR mRNA . ^^^ Moreover , the decreases in 125I NT binding and NTR mRNA induced by this treatment were abolished in the presence of an anti NT antibody or SR 48692 , a non peptidic antagonist of NTR , suggesting that the down regulation of NTR observed after dex plus fsk treatment was mediated by the release of endogenous NT . ^^^ Agonist induced down regulation of the NTR in this system was confirmed by the application of an exogenous NT analogue , JMV 449 . ^^^ The present findings indicate that , in hypothalamic cultures , dex and fsk indirectly down regulate NTR expression via the release of endogenous NT . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| First , we showed that NTR stimulation by NT induced the activation of the mitogen activated protein kinases ( MAPKs ) in time and dose dependent manners . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Rat neurotensin ( NT ) receptor ( NTR ) cDNA was subcloned into the pRC CMV expression vector and transfected into 293 cells , and cellular clones that stably expressed the NTR were isolated and characterized . [ 3H ] NT binding to membranes prepared from the NTR cDNA transfected cells displayed specificity and saturability , with an apparent Kd of 1 . 25 nM and a Bmax of 43 . 4 pmol / mg of protein ( approximately 3 . 5 10 10 ( 6 ) binding sites / cell ) . ^^^ NT stimulated an increase in [ 3H ] inositol phosphate levels in the NTR expressing cells up to 2500 % of basal levels . ^^^ Although NTR occupancy has been shown to stimulate cGMP formation in several brain preparations and cell lines , NT was unable to mediate cGMP synthesis in the NTR expressing 293 cells . ^^^ Because it was possible that the production of nitric oxide is required as the mediator of NT induced cGMP synthesis , we subcloned NOS cDNA into the pCEP 4 expression vector and transiently expressed it in the NTR cells . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| On the other hand , DAergic cells of the periventricular nucleus of the hypothalamus and dorsal aspect of the arcuate nucleus , revealed by TH in situ hybridization , did not exhibit NTR mRNA even though dense NT binding sites have been previously described in this nuclei . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Competitive inhibition studies indicated that both p 30 and p 39 bound with greater affinity to sites in the 5 ' half of the NTR ( a probe representing nt 1 to 354 ) than to the more 3 ' site ( nt 634 to 744 ) . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| This new NT receptor ( NTR ) type is 39 % homologous to , but pharmacologically distinct from , the only other NTR cloned to date from the rat brain and the human HT 29 cell line . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The influence of a bowel trophic neurotensin ( NT ) treatment ( 13 days , 300 micrograms / kg / every 12 hrs . ) on neurotensin like immunopositive structures ( neurons , fibres and epithelial N cells ) and the neurotensin receptors ( NTr ) in the residual bowel after resection ( 90 % small bowel or 75 % colon ) in the rat was studied using histochemical methods . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Genetic correlations were found between high affinity neurotensin receptor ( NTR ( H ) ) densities and NT immunoreactivity ( NT ir ) levels in specific brain regions and sensitivity to hypnotic and hypothermic effects of ethanol in LSXSS recombinant inbred strains of mice . ^^^ Simple sequence length polymorphisms were used to identify quantitative trait loci ( QTL ) influencing hypnotic and hypothermic sensitivity to ethanol , NTR ( H ) and low affinity neurotensin receptor densities and NT ir levels in LSXSS recombinant inbred strains . ^^^ Common QTL for NTR ( H ) receptor densities , NT ir levels and these ethanol actions were identified . ^^^ Two common QTL for NT ir levels , but not NTR ( H ) or low affinity neurotensin receptor receptors , and ethanol induced hypothermia were observed on chromosomes 4 ( 43 cM ) and 6 ( 41 cM ) . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| By studying the effect of the concentration and time of NT agonist exposure , two separate regulatory mechanisms were detected for the neurotensin receptor ( NTR ) gene in human colonic adenocarcinoma cells ( HT 29 ) . ^^^ The incubation of cells for 6 h with the NT agonist , JMV 449 , resulted in an increase of 270 % in NTR mRNA levels . ^^^ In addition , the transcriptional activation of the NTR gene was dependent on NT receptor complex internalization and de novo protein synthesis . ^^^ NT agonist appears to regulate the synthesis of NTR mRNA . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| In order to identify charged amino acid residues of the cloned rat brain neurotensin ( NT ) receptor ( NTR ) that are critical for NT binding , we performed site directed mutagenesis on the cDNA encoding this protein , followed by transient expression into mammalian COS 7 cells and in Xenopus laevis oocytes . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Representative species of the Mollicutes possess a thioredoxin reductase system ( NTS ) composed of a low molecular mass thioredoxin ( TRX ) and NADPH binding thioredoxin reductase ( NTR ) . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Using a human cell line , ODM 2 , derived from the nonpigmented ciliary epithelium , we demonstrate that ( 1 ) NT expression is highly activated by nerve growth factor , glucocorticoid , and activators of adenylate cyclase ; ( 2 ) NTr expression is up regulated by selective ligand activated beta 2 adrenergic receptor ; and ( 3 ) PC 1 and PC 2 expression are up regulated via distinct signaling transduction pathways . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Therefore , this study promotes a better understanding of the localization of NTR synthesis in relationship with the various physiological effects of NT . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| In this study we have shown that in the human neuroblastoma cell line CHP 212 , an NT agonist , JMV 449 , induced high affinity neurotensin receptor ( NTR ) gene activation . 125I NT binding of cells challenged with JMV 449 rapidly decreased then reappeared and subsequently stabilized at 50 % of the control values after 48 h of agonist exposure . ^^^ In the murine neuroblastoma cell line , N1E 115 , NT did not stimulate NTR gene activation but induced NTR mRNA destabilization after long term agonist exposure . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The 5 ' nontranslated region ( NTR ) of hepatitis C virus ( HCV ) consists of 341 nucleotides ( nt ) . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Although the majority of the available evidence is indirect , the availability of several NT receptor ( NTR ) antagonists have now made possible the direct examination of the involvement of the NT system in the mechanism of action of APDs . ^^^ Although effects of selective NTR antagonists in normal volunteers or schizophrenic patients have not been studied , and nonpeptidergic NTR agonists have not yet been identified , these cumulative results provide the groundwork for the use of NT ergic compounds in the treatment of schizophrenia . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| In the absence of Na+ , 125I Neurotensin ( 125I NT ) binding to the Neurotensin receptor ( NTR ) produces a stable noncovalent 125I NT NTR complex whose dissociation rate is extremely low even after the addition of 1 microM NT , 100 microM SR 48692 ( antagonist ) , 100 microM GPPNHP or 100 mM NaCl . ^^^ GTPgamma35S binding to membranes in the presence of 30 mM NaCl suggests that Na+ inhibition of 125I NT binding is due to the uncoupling of NTR associated G protein ( s ) . ^^^ In Step 1 , interaction between NT and NTR produces a transient complex , which attains a stable state in the absence of NaCl via step 2 , thereby altering the native NTR conformation . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| However , because malignant cell migration within the prostate occurs predominantly by direct extension around prostatic nerves , the presence and possible upregulation of NTs from autocrine / paracrine sources and NTR expression within prostate epithelial tumor cells may be important in metastasis . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The low affinity neurotrophin ( NT ) receptor , p 75 ( NTR ) , has complex biologic functions . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| However , the termini of the genome ( the first 60 nt of the 5 ' NTR and the entire 3 ' NTR ) were highly similar in all five isolates . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| This indicates that despite the results with the recently cloned levocabastine sensitive NT receptors ( NTR ) in the rat ( NTR 2 ) and mouse ( NTRL ) , levocabastine by itself does not mediate either hypothermia or antinociception at NT receptors . ^^^ Therefore , these data may suggest the presence of yet unidentified NTR subtypes responsible for NT mediated hypothermia and antinociception . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Both the NT receptor p 75 ( NTR ) and the NGF tyrosine kinase receptor trkA were found to be expressed in the ovaries of infantile normal mice and mice carrying a null mutation of the NGF gene . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The 5 ' NTR of BRAV RNA 1 is 66 nt long and 78 % identical with RNA 2 5 ' NTR only over the first 57 nucleotides . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The strains of echovirus 19 ( EV 19 ) and echovirus 11 ( EV 11 ) , isolated from infants with similar clinical symptoms of acute enterovirus uveitis ( EU ) in Russia ( Siberia ) in 1980 1989 , were investigated phylogenetically ( nucleotide sequence of a 300 nt fragment in 5 ' NTR and VP 4 junction ) and serologically . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| METHODS : Expression of nerve growth factor ( NGF ) ; neurotrophins ( NT ) 3 and NT 4 ; brain derived neurotrophic factor ( BDNF ) ; tyrosine kinase transducing receptors TrkA , TrkB , and TrkC ; and a pan NT low affinity receptor ( p 75 ( NTR ) ) was examined by immunostaining in the normal human corneolimbus , HLE grown on intact epithelially denuded AM , and stratified HLE , after subcutaneous implantation in NIH bg nu xid BR mice . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| This study was conducted to determine whether neurotrophic factor receptors ( tyrosine kinase receptors trkA , trkB , and trkC ; low affinity neurotrophin [ NT ] receptor p 75 [ p 75 ( NTR ) ] ; glial cell line derived neurotrophic factor receptor alpha 1 [ GFR alpha 1 ] and GFR alpha 2 ; and Ret ) are involved in the formation of ERMs after PDR . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Neurotensin ( NT ) , a gastrointestinal ( GI ) hormone , binds its receptor ( NTR ) to stimulate proliferation of normal and neoplastic GI tissues ; the molecular mechanisms remain largely undefined . ^^^ The purposes of this study were : ( 1 ) to identify whether the MAPKs ( ERK1 / 2 and JNK ) are activated by NT and ( 2 ) to determine the effect of NT on downstream transcription factors using the human pancreatic adenocarcinoma cell line , MIA PaCa 2 , which possesses high affinity NTR . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Previously , the authors have shown that NT , an important GI hormone , stimulates the proliferation of an NT receptor ( NTR ) positive pancreatic cancer . ^^^ In addition , NTR expression , [ Ca2+ ] 1 mobilization , and growth in response to NT was determined in L3 . 6 , a metastatic pancreatic cancer cell line . ^^^ Expression of NTR , functionally coupled to the Ca2+ signaling pathway , was identified in L3 . 6 cells ; treatment with NT ( 10 micromol / L ) stimulated proliferation of these cells . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| We showed earlier that a transition mutation U234C , located within the completely conserved 5 nucleotide ( nt ) tract 5 ' CGUUA ( nt 232 236 ) in the 5 ' non translated region ( NTR ) of the coxsackievirus B 3 ( CVB 3 ) genome , attenuated CVB 3 cardiovirulence in mice . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| In comparison with that of K 7 , P 6 had only 6 nucleotides ( nt ) mutations , P 12 had 7 mutational changes , in addition to 6 same mutations with P 6 , there appeared a new mutation in 5 ' NTR at nucleotide position 591 resulting in a nucleotide exchange from A to G . ^^^ P 18 had 10 nt mutations , among the 10 mutations , 7 mutational changes were same as with P 12 , three new mutational changes appeared in the genome , one in 5 ' NTR , one in 3C coding region , one in 3D coding region , at P 22 there appeared 18 nucleotide changes in the genome , on the basis of P 18 , there occurred additional 8 nucleotide mutations , two in 5 ' NTR , three in 2C , one in 3A , one in 3C and one in 3D . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The various members of the Trk tyrosine kinase family and p 75 neurotrophin receptor ( p 75 ( NTR ) ) have been identified as signaling receptors for the structurally related members of the neurotrophins ( NT ) family . ^^^ These cells express aberrant levels of functional p 75 ( NTR ) and TrkC , the putative high affinity receptor for the neurotrophin NT 3 . ^^^ It is similar to the one reported to relate with p 75 ( NTR ) and TrkA receptors and stimulated by the prototypic NT , nerve growth factor . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The 3 ' terminal nucleotide ( nt ) sequence of 1669 nt of the viral RNA genome has been determined , which covered the coding region of the C terminal part of the large nuclear inclusion protein ( NIb , RNA polymerase ) , capsid protein ( CP ) gene and the 3 ' nontranslated region ( NTR ) . ^^^ The CP gene consisted of 909 nt ( including the stop codon ) encoding 302 amino acid residues , and the 3 ' NTR was 241 nt in length excluding the polyadenylated tract . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Native neurotensin ( NT ) is a tridecapeptide that binds to NTR and induces tumor growth . ^^^ In vivo biodistribution of a representative ( 111 ) In DTPA NT peptide analogue in SCID mice bearing NTR positive human adenocarcinoma ( HT 29 ) xenograft shows that the compound was primarily retained in tumor tissue ( 2 . 2 % ID / g ) and the kidneys ( 4 . 8 % ID / g ) at 4 h postinjection . ^^^ Coinjection of cold NT and the radiolabeled NT peptide analogue inhibited the tumor but not the kidney uptake , demonstrating that retention of the radiolabeled compound in tumor tissue was mediated by NTR specific uptake while it accumulates in the kidneys by a nonspecific mechanism . ^^^ These findings show that the new NT peptide analogues are robust and can deliver imaging agents to NTR positive tumors such as pancreatic cancer . . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The 273 nucleotide ( nt ) 3 ' NTR is highly conserved ( approximately 95 % ) among the sequenced CTV isolates in contrast to the highly diverse 5 ' NTR sequences . ^^^ The 3 ' replication signals were mapped to the 3 ' 234 nts within the NTR . ^^^ Deletions into the 3 ' NTR , up to 66 nts from the 5 ' direction and 11 nts from the 3 ' direction , deleting or disrupting putative SL 1 , SL 2 and SL 3 , or SL 10 , resulted in continued replication , suggesting that these sequences are not essential for basal level replication , but are required for efficient replication . ^^^ |
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| Interacting proteins: P30989 and P30990 |
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SVM Score :0.0 |
| It was shown that efficient transcription termination was signalled by a 33 nt sequence within the 5 ' non translated region ( NTR ) of the S segment . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Such effects are mediated by the NT receptors Ntsr 1 , Ntsr 2 and Ntsr 3 , although the involvement of each receptor in specific NT functions remains unknown . ^^^ In addition , histochemical analyses of both Ntsr 1 and Ntsr 2 mRNAs were performed in the mouse brain regions involved in NT related nociception . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The NADPH / NADP thioredoxin ( Trx ) reductase ( NTR ) / Trx system ( NTS ) is a redox system that plays a posttranslational regulatory role by reducing protein targets involved in crucial cellular processes in microorganisms and animals . ^^^ To determine whether NTS was operational during germination of legume seeds and which Trx h isoforms could be implicated , Trx h isoforms expression was monitored in germinating pea ( Pisum sativum cv Baccara ) seeds , together with the amount of NTR and NADPH . ^^^ The presence of NTR and NADPH in seeds suggests that NTS could be functional during germination . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| METHODS : RT PCR was performed on RNA isolated from male rat lacrimal gland , using oligonucleotides specific to each NT and NTr . ^^^ The presence of NT and NTr protein , was determined by Western blot analysis of lacrimal gland homogenate or membranes . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The p 75 neurotrophin receptor ( p 75 ( NTR ) ) , a common receptor for members of the neurotrophins ( NT ) family , was previously identified as a molecular determinant of brain metastasis . ^^^ Finally , we observed an increased survival of sorted p 75 ( NTR L ) cells , dependent upon treatment of NT members whose functional receptors are present on these cells . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| Myelin inhibitors activate a p 75 ( NTR ) dependent signaling cascade in neurons that not only inhibits axonal growth but also prevents neurotrophins ( NT ) from stimulating growth . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NTR and had mutation at nt 3 , 889 ( aa 1 052 Val ) in 2B region , these mutations and insertion are molecular basis for cell adaptation ; mutation at nt 4 , 185 ( aa 1 152 Lys ) in 2C region should be attenuated marker ; deletion in 3A region ( nt 5 , 020 5 , 025 ) that caused two amino acids deletion is virus fast growth basis . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| The p 75 receptor ( p 75 ( NTR ) ) binds growth promoting neurotrophins ( NTs ) as well as the common receptor for growth inhibiting myelin derived proteins ( the Nogo receptor ) and so is well situated to gauge the balance of positive and negative influences on axonal plasticity . ^^^ These in vivo results illustrate the interactions of p 75 ( NTR ) with NTs , with their respective tropomyosin related kinase receptors and with inhibitory myelin derived molecules . ^^^ |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30989 and P30990 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| On the other hand , DAergic cells of the periventricular nucleus of the hypothalamus and dorsal aspect of the arcuate nucleus , revealed by TH in situ hybridization , did not exhibit NTR mRNA even though dense NT binding sites have been previously described in this nuclei . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Competitive inhibition studies indicated that both p 30 and p 39 bound with greater affinity to sites in the 5 ' half of the NTR ( a probe representing nt 1 to 354 ) than to the more 3 ' site ( nt 634 to 744 ) . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| However , a fundamental difference was found ; unlike NTR 1 , NTR 2 recognizes , with high affinity , levocabastine , a histamine H 1 receptor antagonist previously shown to compete with NT for low affinity binding sites in brain . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| This new NT receptor ( NTR ) type is 39 % homologous to , but pharmacologically distinct from , the only other NTR cloned to date from the rat brain and the human HT 29 cell line . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to determine whether human colon cancers ( HCC ) ( 1 ) express the mRNA for NT / neuromedin N ( N ) , ( 2 ) produce NT peptide , and ( 3 ) express the mRNA for a functional NT receptor ( NTR ) . ^^^ Neurotensin peptide content , NTR expression , and intracellular Ca++ ( [ Ca++ ] 1 ) mobilization in response to NT were evaluated in three HCC cell lines ( LoVo , HT 29 , HCT 116 ) . ^^^ These findings demonstrate the presence of NT / N mRNA and NT peptide and the presence of a functional NTR in certain HCC . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Rat neurotensin ( NT ) receptor ( NTR ) cDNA was subcloned into the pRC CMV expression vector and transfected into 293 cells , and cellular clones that stably expressed the NTR were isolated and characterized . [ 3H ] NT binding to membranes prepared from the NTR cDNA transfected cells displayed specificity and saturability , with an apparent Kd of 1 . 25 nM and a Bmax of 43 . 4 pmol / mg of protein ( approximately 3 . 5 10 10 ( 6 ) binding sites / cell ) . ^^^ NT stimulated an increase in [ 3H ] inositol phosphate levels in the NTR expressing cells up to 2500 % of basal levels . ^^^ Although NTR occupancy has been shown to stimulate cGMP formation in several brain preparations and cell lines , NT was unable to mediate cGMP synthesis in the NTR expressing 293 cells . ^^^ Because it was possible that the production of nitric oxide is required as the mediator of NT induced cGMP synthesis , we subcloned NOS cDNA into the pCEP 4 expression vector and transiently expressed it in the NTR cells . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| In the hypothalamic cultures , 125I NT bound to a single class of binding sites , presenting a selectivity similar to that observed for the high affinity NTR previously described in the adult rat brain . ^^^ However , a combined treatment with both agents led to a 40 % decrease in 125I NT binding , corresponding to a reduced number of binding sites , and to a 68 % decrease in the amount of NTR mRNA . ^^^ Moreover , the decreases in 125I NT binding and NTR mRNA induced by this treatment were abolished in the presence of an anti NT antibody or SR 48692 , a non peptidic antagonist of NTR , suggesting that the down regulation of NTR observed after dex plus fsk treatment was mediated by the release of endogenous NT . ^^^ Agonist induced down regulation of the NTR in this system was confirmed by the application of an exogenous NT analogue , JMV 449 . ^^^ The present findings indicate that , in hypothalamic cultures , dex and fsk indirectly down regulate NTR expression via the release of endogenous NT . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| First , we showed that NTR stimulation by NT induced the activation of the mitogen activated protein kinases ( MAPKs ) in time and dose dependent manners . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The influence of a bowel trophic neurotensin ( NT ) treatment ( 13 days , 300 micrograms / kg / every 12 hrs . ) on neurotensin like immunopositive structures ( neurons , fibres and epithelial N cells ) and the neurotensin receptors ( NTr ) in the residual bowel after resection ( 90 % small bowel or 75 % colon ) in the rat was studied using histochemical methods . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Genetic correlations were found between high affinity neurotensin receptor ( NTR ( H ) ) densities and NT immunoreactivity ( NT ir ) levels in specific brain regions and sensitivity to hypnotic and hypothermic effects of ethanol in LSXSS recombinant inbred strains of mice . ^^^ Simple sequence length polymorphisms were used to identify quantitative trait loci ( QTL ) influencing hypnotic and hypothermic sensitivity to ethanol , NTR ( H ) and low affinity neurotensin receptor densities and NT ir levels in LSXSS recombinant inbred strains . ^^^ Common QTL for NTR ( H ) receptor densities , NT ir levels and these ethanol actions were identified . ^^^ Two common QTL for NT ir levels , but not NTR ( H ) or low affinity neurotensin receptor receptors , and ethanol induced hypothermia were observed on chromosomes 4 ( 43 cM ) and 6 ( 41 cM ) . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| By studying the effect of the concentration and time of NT agonist exposure , two separate regulatory mechanisms were detected for the neurotensin receptor ( NTR ) gene in human colonic adenocarcinoma cells ( HT 29 ) . ^^^ The incubation of cells for 6 h with the NT agonist , JMV 449 , resulted in an increase of 270 % in NTR mRNA levels . ^^^ In addition , the transcriptional activation of the NTR gene was dependent on NT receptor complex internalization and de novo protein synthesis . ^^^ NT agonist appears to regulate the synthesis of NTR mRNA . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Using a human cell line , ODM 2 , derived from the nonpigmented ciliary epithelium , we demonstrate that ( 1 ) NT expression is highly activated by nerve growth factor , glucocorticoid , and activators of adenylate cyclase ; ( 2 ) NTr expression is up regulated by selective ligand activated beta 2 adrenergic receptor ; and ( 3 ) PC 1 and PC 2 expression are up regulated via distinct signaling transduction pathways . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Therefore , this study promotes a better understanding of the localization of NTR synthesis in relationship with the various physiological effects of NT . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| This indicates that despite the results with the recently cloned levocabastine sensitive NT receptors ( NTR ) in the rat ( NTR 2 ) and mouse ( NTRL ) , levocabastine by itself does not mediate either hypothermia or antinociception at NT receptors . ^^^ Therefore , these data may suggest the presence of yet unidentified NTR subtypes responsible for NT mediated hypothermia and antinociception . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Although most of the regions found here to express NTRL mRNA were previously reported to be devoid of mRNA encoding the high affinity NT receptor ( NTRH ) , a few areas ( e . g . , the anterior olfactory nucleus , medial septum , diagonal band of Broca , reticular thalamic nucleus , suprachiasmatic hypothalamic nucleus , and pontine nucleus ) were enriched in both receptor subtypes , suggesting a possible coexpression of these receptors by the same cells . ^^^ In cerebral cortex , the developmental increase in NTRL expression was correlated over time with the decrease in NTRH expression previously documented in the rat , suggesting a progressive takeover of the latter by the former for transduction of the effects of NT in this structure . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Interestingly , despite its high KD ( 620 nM ) at the cloned NTR 1 , NT 27 1 ( the iodinated form of NT 27 ) exerted a potent hypothermic effect even at a very low dose ( 0 . 6 nmol ) . ^^^ Equally intriguing , was that NT 24 , a sterioisomer of NT 27 , with a much higher affinity ( KD=0 . 5 nM ) at NTR 1 , did not selectively induce hypothermia in mice , but did selectively induce hypothermia in rats . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| In this study we have shown that in the human neuroblastoma cell line CHP 212 , an NT agonist , JMV 449 , induced high affinity neurotensin receptor ( NTR ) gene activation . 125I NT binding of cells challenged with JMV 449 rapidly decreased then reappeared and subsequently stabilized at 50 % of the control values after 48 h of agonist exposure . ^^^ In the murine neuroblastoma cell line , N1E 115 , NT did not stimulate NTR gene activation but induced NTR mRNA destabilization after long term agonist exposure . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| In order to identify charged amino acid residues of the cloned rat brain neurotensin ( NT ) receptor ( NTR ) that are critical for NT binding , we performed site directed mutagenesis on the cDNA encoding this protein , followed by transient expression into mammalian COS 7 cells and in Xenopus laevis oocytes . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Although the majority of the available evidence is indirect , the availability of several NT receptor ( NTR ) antagonists have now made possible the direct examination of the involvement of the NT system in the mechanism of action of APDs . ^^^ Although effects of selective NTR antagonists in normal volunteers or schizophrenic patients have not been studied , and nonpeptidergic NTR agonists have not yet been identified , these cumulative results provide the groundwork for the use of NT ergic compounds in the treatment of schizophrenia . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| To gain insight into the subcellular substrate for these effects , we compared by electron microscopy the distribution of immunoreactive high affinity NT receptor proteins ( NTRH ) with that of high affinity 125I NT binding sites in this region of rat brain . ^^^ The distributions of immunoreactive NTRH and 125I NT binding sites along somatodendritic plasma membranes were highly correlated and homogeneous , suggesting that membrane targeted NTRH proteins were functional and predominantly extrasynaptic . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The 5 ' nontranslated region ( NTR ) of hepatitis C virus ( HCV ) consists of 341 nucleotides ( nt ) . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The peptides neurotensin ( NT ) and neuromedin N exert effects on neurons by means of a high affinity NT receptor ( NTRH ) belonging to the superfamily of G protein coupled receptors . ^^^ Our results identify many novel sites of NTRH mRNA expression in adult brain and provide a basis for investigating involvement of NT and related peptides in regulating the activity of these diverse cells , whose phenotypes remain largely undetermined . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Recent pharmacological evidence obtained with NT agonists and antagonists suggests that these effects are mediated by a receptor distinct from the initially cloned high affinity NT receptor ( NTR 1 ) . ^^^ These data confirm that NTR 1 is involved in the NT elicited turning behavior and demonstrate that the NTR 2 mediates NT induced analgesia . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Intraperitoneal injection of an unmodified antisense peptide nucleic acid ( PNA ) complementary to mRNA of the rat neurotensin ( NT ) receptor ( NTR 1 ) was demonstrated by a gel shift assay to be present in brain , thus indicating that the PNA had in fact crossed the blood brain barrier . ^^^ Additionally , the sense NTR 1 PNA , targeted to DNA , microinjected directly into the brain specifically reduced mRNA levels by 50 % and caused a loss of response to NT . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Here , we present radioligand binding data for some novel hexapeptide analogs of NT ( 8 13 ) at the molecularly cloned rat and human neurotensin receptors ( NTR 1 ) , along with behavioral and physiological effects of several of these peptides after intraperitoneal ( i . p . ) administration in rats . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The neurotensin ( NT ) receptor , subtype 1 ( NTR 1 ) , is a 7 transmembrane spanning receptor , forming 3 extracellular and 3 intracellular loops . ^^^ Previously , we showed that the third outer loop ( E 3 ) is the binding site for NT and its analogs , several of which bind with higher affinity to rat NTR 1 ( rNTR 1 ) than to human NTR 1 ( hNTR 1 ) . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| In the absence of Na+ , 125I Neurotensin ( 125I NT ) binding to the Neurotensin receptor ( NTR ) produces a stable noncovalent 125I NT NTR complex whose dissociation rate is extremely low even after the addition of 1 microM NT , 100 microM SR 48692 ( antagonist ) , 100 microM GPPNHP or 100 mM NaCl . ^^^ GTPgamma35S binding to membranes in the presence of 30 mM NaCl suggests that Na+ inhibition of 125I NT binding is due to the uncoupling of NTR associated G protein ( s ) . ^^^ In Step 1 , interaction between NT and NTR produces a transient complex , which attains a stable state in the absence of NaCl via step 2 , thereby altering the native NTR conformation . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The low affinity neurotrophin ( NT ) receptor , p 75 ( NTR ) , has complex biologic functions . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| However , the termini of the genome ( the first 60 nt of the 5 ' NTR and the entire 3 ' NTR ) were highly similar in all five isolates . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| In the present study , we investigated whether this is due to NT receptor 1 ( NTR 1 ) mRNA up regulation and whether NTR 1 mRNA could also be used as a specific diagnostic marker and treatment target in pancreatic cancer . ^^^ Furthermore , consecutive tissue sections were analyzed for NTR 1 mRNA expression and NT binding . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Neurotensin ( NT ) , a gastrointestinal ( GI ) hormone , binds its receptor ( NTR ) to stimulate proliferation of normal and neoplastic GI tissues ; the molecular mechanisms remain largely undefined . ^^^ The purposes of this study were : ( 1 ) to identify whether the MAPKs ( ERK1 / 2 and JNK ) are activated by NT and ( 2 ) to determine the effect of NT on downstream transcription factors using the human pancreatic adenocarcinoma cell line , MIA PaCa 2 , which possesses high affinity NTR . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Previously , the authors have shown that NT , an important GI hormone , stimulates the proliferation of an NT receptor ( NTR ) positive pancreatic cancer . ^^^ In addition , NTR expression , [ Ca2+ ] 1 mobilization , and growth in response to NT was determined in L3 . 6 , a metastatic pancreatic cancer cell line . ^^^ Expression of NTR , functionally coupled to the Ca2+ signaling pathway , was identified in L3 . 6 cells ; treatment with NT ( 10 micromol / L ) stimulated proliferation of these cells . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| We showed earlier that a transition mutation U234C , located within the completely conserved 5 nucleotide ( nt ) tract 5 ' CGUUA ( nt 232 236 ) in the 5 ' non translated region ( NTR ) of the coxsackievirus B 3 ( CVB 3 ) genome , attenuated CVB 3 cardiovirulence in mice . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Two G protein coupled neurotensin ( NT ) receptors , termed NTR 1 and NTR 2 , have been identified so far . ^^^ The unique pharmacological profile of the hNTR 2 is discussed in the light of its sequence similarity with the NTR 1 and the known binding site topology of NT and SR 48692 in the NTR1 . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Mice deficient in the neurotensin ( NT ) 1 receptor ( NTR 1 ) were developed to characterize the NT receptor subtypes that mediate various in vivo responses to NT . ^^^ In contrast , NT 2 had no effect in NTR 1 null mice , whereas the hypomotility effect of clonidine was intact . ^^^ These data indicate that NTR 1 mediates several of the central and peripheral effects of NT . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The strains of echovirus 19 ( EV 19 ) and echovirus 11 ( EV 11 ) , isolated from infants with similar clinical symptoms of acute enterovirus uveitis ( EU ) in Russia ( Siberia ) in 1980 1989 , were investigated phylogenetically ( nucleotide sequence of a 300 nt fragment in 5 ' NTR and VP 4 junction ) and serologically . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Binding to NT 1 receptors ( NTR 1 ) was saturable and specific . ^^^ After interacting with NTR 1 , ( 99m ) Tc ( CO ) ( 3 ) NT 8 was rapidly internalized , with more than 90 % internalized after 30 min . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| METHODS : Expression of nerve growth factor ( NGF ) ; neurotrophins ( NT ) 3 and NT 4 ; brain derived neurotrophic factor ( BDNF ) ; tyrosine kinase transducing receptors TrkA , TrkB , and TrkC ; and a pan NT low affinity receptor ( p 75 ( NTR ) ) was examined by immunostaining in the normal human corneolimbus , HLE grown on intact epithelially denuded AM , and stratified HLE , after subcutaneous implantation in NIH bg nu xid BR mice . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| This study was conducted to determine whether neurotrophic factor receptors ( tyrosine kinase receptors trkA , trkB , and trkC ; low affinity neurotrophin [ NT ] receptor p 75 [ p 75 ( NTR ) ] ; glial cell line derived neurotrophic factor receptor alpha 1 [ GFR alpha 1 ] and GFR alpha 2 ; and Ret ) are involved in the formation of ERMs after PDR . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Both the NT receptor p 75 ( NTR ) and the NGF tyrosine kinase receptor trkA were found to be expressed in the ovaries of infantile normal mice and mice carrying a null mutation of the NGF gene . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The 5 ' NTR of BRAV RNA 1 is 66 nt long and 78 % identical with RNA 2 5 ' NTR only over the first 57 nucleotides . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The 273 nucleotide ( nt ) 3 ' NTR is highly conserved ( approximately 95 % ) among the sequenced CTV isolates in contrast to the highly diverse 5 ' NTR sequences . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| We recently showed that the 2 structurally different receptors NTR 1 and NTR 3 were coexpressed in several human cancer cells on which NT exerts proliferative effects . ^^^ The NTR 1 NTR3 complex is then internalized on NT stimulation . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| In comparison with that of K 7 , P 6 had only 6 nucleotides ( nt ) mutations , P 12 had 7 mutational changes , in addition to 6 same mutations with P 6 , there appeared a new mutation in 5 ' NTR at nucleotide position 591 resulting in a nucleotide exchange from A to G . ^^^ P 18 had 10 nt mutations , among the 10 mutations , 7 mutational changes were same as with P 12 , three new mutational changes appeared in the genome , one in 5 ' NTR , one in 3C coding region , one in 3D coding region , at P 22 there appeared 18 nucleotide changes in the genome , on the basis of P 18 , there occurred additional 8 nucleotide mutations , two in 5 ' NTR , three in 2C , one in 3A , one in 3C and one in 3D . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The various members of the Trk tyrosine kinase family and p 75 neurotrophin receptor ( p 75 ( NTR ) ) have been identified as signaling receptors for the structurally related members of the neurotrophins ( NT ) family . ^^^ These cells express aberrant levels of functional p 75 ( NTR ) and TrkC , the putative high affinity receptor for the neurotrophin NT 3 . ^^^ It is similar to the one reported to relate with p 75 ( NTR ) and TrkA receptors and stimulated by the prototypic NT , nerve growth factor . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The 3 ' terminal nucleotide ( nt ) sequence of 1669 nt of the viral RNA genome has been determined , which covered the coding region of the C terminal part of the large nuclear inclusion protein ( NIb , RNA polymerase ) , capsid protein ( CP ) gene and the 3 ' nontranslated region ( NTR ) . ^^^ The CP gene consisted of 909 nt ( including the stop codon ) encoding 302 amino acid residues , and the 3 ' NTR was 241 nt in length excluding the polyadenylated tract . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : The purpose of the study was to investigate whether cultured human keratocytes express the neurotensin receptors ( NTR 1 , NTR 2 , and NTR 3 ) , to determine the presence of neurotensin ( NT ) in keratocytes , and to assess the influence of NT on these cells . ^^^ NT , NTR 1 , NTR 2 , and NTR 3 mRNA were detected in human keratocytes by means of reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ CONCLUSIONS : These results indicate that cultured human keratocytes express NTR 1 and NTR 3 and that NT may exert physiological effects on cornea such as regulation of keratocyte proliferation and apoptosis . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Such effects are mediated by the NT receptors Ntsr 1 , Ntsr 2 and Ntsr 3 , although the involvement of each receptor in specific NT functions remains unknown . ^^^ In addition , histochemical analyses of both Ntsr 1 and Ntsr 2 mRNAs were performed in the mouse brain regions involved in NT related nociception . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Native neurotensin ( NT ) is a tridecapeptide that binds to NTR and induces tumor growth . ^^^ In vivo biodistribution of a representative ( 111 ) In DTPA NT peptide analogue in SCID mice bearing NTR positive human adenocarcinoma ( HT 29 ) xenograft shows that the compound was primarily retained in tumor tissue ( 2 . 2 % ID / g ) and the kidneys ( 4 . 8 % ID / g ) at 4 h postinjection . ^^^ Coinjection of cold NT and the radiolabeled NT peptide analogue inhibited the tumor but not the kidney uptake , demonstrating that retention of the radiolabeled compound in tumor tissue was mediated by NTR specific uptake while it accumulates in the kidneys by a nonspecific mechanism . ^^^ These findings show that the new NT peptide analogues are robust and can deliver imaging agents to NTR positive tumors such as pancreatic cancer . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| METHODS : RT PCR was performed on RNA isolated from male rat lacrimal gland , using oligonucleotides specific to each NT and NTr . ^^^ The presence of NT and NTr protein , was determined by Western blot analysis of lacrimal gland homogenate or membranes . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Photoaffinity labeling of the NT receptor NTR 1 was enhanced in CCB treated cells . ^^^ These results suggest that CCBs exert two effects : 1 ) they inhibit NT induced IP formation , perhaps by preventing Ca2+ influx dependent activation of PLCdelta ; and 2 ) they enhance NTR 1 affinity by an unexplained Ca2+ independent mechanism . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The p 75 neurotrophin receptor ( p 75 ( NTR ) ) , a common receptor for members of the neurotrophins ( NT ) family , was previously identified as a molecular determinant of brain metastasis . ^^^ Finally , we observed an increased survival of sorted p 75 ( NTR L ) cells , dependent upon treatment of NT members whose functional receptors are present on these cells . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Earlier work indicated that these effects , which involved the G protein coupled NT receptor NTR 1 , were indirect and required cellular metabolism or architecture . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Neurotensin ( NT ) regulates a variety of biological processes primarily through interaction with neurotensin receptor 1 ( NTR 1 ) , a heterotrimeric G protein coupled receptor ( GPCR ) . ^^^ Here , we report that activation of NTR 1 by NT inhibits Akt activity as determined by the dephosphorylation of Akt at both Ser 473 and Thr 308 in AV 12 cells constitutively expressing human NTR 1 ( NTR1 / AV12 ) . ^^^ This effect of NT was completely blocked by the specific NTR 1 antagonist , ( S ) ( + ) [ 1 ( 7 chloro 4 quinolinyl ) 5 ( 2 , 6 dimethoxyphenyl ) pyrazol 3 yl ) carbonylamino ] cyclohexylacetic acid ( SR 48527 ) , but unaffected by the less active enantiomer ( ( R ) ( ) [ 1 ( 7 chloro 4 quinolinyl ) 5 ( 2 , 6 dimethoxyphenyl ) pyrazol 3 yl ) carbonylamino ] cyclohexylacetic acid ( SR 49711 ) ) , indicating the stereospecificity of NTR 1 in the negative regulation of Akt . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Here , androgen independent PC 3 cells , which express high levels of the type 1 NT receptor ( NTR 1 ) , are used to examine the involvement of epidermal growth factor receptor ( EGFR ) , mitogen activated protein kinases ( ERK , SAPK / JNK and p 38 ) , PI 3 kinase and PKC in the mitogenic effect of NT . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Expression of the neuropeptide neurotensin ( NT ) and its high affinity receptor ( NTR 1 ) is increased during the course of Clostridium difficile toxin A induced acute colitis , and NTR 1 antagonism attenuates the severity of toxin A induced inflammation . ^^^ Here we used NCM 460 cells , which normally express low levels of NTR 1 , and NCM 460 cells stably transfected with NTR 1 to identify the upstream signaling molecules involved in NT NTR 1 mediated MAP kinase activation . ^^^ This is the first report demonstrating that NT binding to NTR 1 transactivates the EGFR and that this response is linked to NT mediated proinflammatory signaling . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Myelin inhibitors activate a p 75 ( NTR ) dependent signaling cascade in neurons that not only inhibits axonal growth but also prevents neurotrophins ( NT ) from stimulating growth . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NTR and had mutation at nt 3 , 889 ( aa 1 052 Val ) in 2B region , these mutations and insertion are molecular basis for cell adaptation ; mutation at nt 4 , 185 ( aa 1 152 Lys ) in 2C region should be attenuated marker ; deletion in 3A region ( nt 5 , 020 5 , 025 ) that caused two amino acids deletion is virus fast growth basis . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The selective NTR 1 receptor antagonist SR 48692 reversibly blocked the effects of NT on both action potentials and spontaneous synaptic currents . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| We also show that microinjection of NT or the NTR 1 selective agonist PD 149163 in the RVM both produce dose dependent antinociception in the tail flick test that is blocked by the NTR 1 selective antagonist SR 48692 . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Because neurotensin ( NT ) and its high affinity receptor ( NTR 1 ) modulate immune responses , chloride secretion , and epithelial cell proliferation , we sought to investigate their role in the repair process that follows the development of mucosal injuries during a persistent inflammation . ^^^ Colonic NT and NTR 1 , mRNA , and protein significantly increased only after dextran sodium sulfate ( DSS ) induced inflammatory damage developed . ^^^ Colitis induced body weight loss , colonic myeloperoxidase activity , and histological damage were significantly enhanced by SR 48642 administration , a nonpeptide NTR 1 antagonist , whereas continuous NT infusion ameliorated colitis outcome . ^^^ To evaluate the NT and NTR 1 role in tissue healing , mucosal inflammatory injury was established administering 3 % DSS for 5 days . ^^^ After DSS discontinuation , mice rapidly gained weight , ulcers were healed , and colonic NT , NTR 1 , and cyclooxygenase ( COX ) 2 mRNA levels were upregulated , whereas SR 48642 treatment caused a further body weight loss , ulcer enlargement , and a blunted colonic COX 2 mRNA upregulation . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| To date , three different types of NT receptor ( NTR ) , NTR 1 , NTR 2 and NTR 3 , have been identified only in mammalian species . ^^^ Mammalian NTR 1 but not NTR 2 responds to NT , whereas both bfNTR 1 and bfNTR 4 show a high sensitivity to NT . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The first area concerns the functional activation of the high affinity NT receptor , NTR 1 , including the delineation of the NT binding pocket and receptor domains involved in functional coupling to intracellular signaling pathways . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Abundance of transcripts that encode NT and NT receptors 1 , 2 , and 3 ( NTR 1 , NTR 2 , and NTR 3 ) in total hypothalamic RNA was the quantitative trait measured . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| It was shown that efficient transcription termination was signalled by a 33 nt sequence within the 5 ' non translated region ( NTR ) of the S segment . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| LOX blockers dramatically enhanced 125I neurotensin binding to NT receptor NTR 1 in PC 3 cells , whereas they inhibited NT induced inositol phosphate formation . ^^^ Also supporting the involvement of arachidonic acid metabolism in NTR 1 regulation was the finding that inhibitors of PLA 2 and DAG lipase enhanced NT binding . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| RT PCR analysis revealed the expression of NT receptor type ( NTR ) 3 mRNA but not NTR 1 and NTR 2 mRNAs in the human adrenal tissue . ^^^ However , the pharmacological profile of the adrenal NT 1 11 receptor was different from that of NTR 3 , indicating that this receptor type is not involved in the action of NT 1 11 on corticosteroidogenesis . ^^^ CONCLUSION : Our results indicate that NT 1 11 may act as an endocrine factor to inhibit cortisol secretion through activation of a receptor distinct from the classical NTR 1 , NTR 2 , and NTR3 . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The p 75 receptor ( p 75 ( NTR ) ) binds growth promoting neurotrophins ( NTs ) as well as the common receptor for growth inhibiting myelin derived proteins ( the Nogo receptor ) and so is well situated to gauge the balance of positive and negative influences on axonal plasticity . ^^^ These in vivo results illustrate the interactions of p 75 ( NTR ) with NTs , with their respective tropomyosin related kinase receptors and with inhibitory myelin derived molecules . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| However , the 3 ' terminal non translated region ( NTR ) of TuMV Jap RNA is significantly shorter ( 212 nts ) than the 3 ' NTR of TuMV Can RNA ( 668 nts ) , but of equal length as the 3 ' NTR of the TuMV Chi isolate which also measures 212 nts . ^^^ Irrespective of the origin of this extra sequence in the reported TuMV Can sequence , which may have been introduced by a genuine RNA recombination event , it is concluded that the standard TuMV genome has a CP gene of 864 nts and an conserved 3 ' NTR of approximately 212 nucleotides in length . . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| Representative species of the Mollicutes possess a thioredoxin reductase system ( NTS ) composed of a low molecular mass thioredoxin ( TRX ) and NADPH binding thioredoxin reductase ( NTR ) . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| However , because malignant cell migration within the prostate occurs predominantly by direct extension around prostatic nerves , the presence and possible upregulation of NTs from autocrine / paracrine sources and NTR expression within prostate epithelial tumor cells may be important in metastasis . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| The NADPH / NADP thioredoxin ( Trx ) reductase ( NTR ) / Trx system ( NTS ) is a redox system that plays a posttranslational regulatory role by reducing protein targets involved in crucial cellular processes in microorganisms and animals . ^^^ To determine whether NTS was operational during germination of legume seeds and which Trx h isoforms could be implicated , Trx h isoforms expression was monitored in germinating pea ( Pisum sativum cv Baccara ) seeds , together with the amount of NTR and NADPH . ^^^ The presence of NTR and NADPH in seeds suggests that NTS could be functional during germination . ^^^ |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30990 and P30989 |
Pubmed |
SVM Score :0.0 |
| NA |
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