| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.92913412 |
| Horse leukocyte elastase inhibitor rapidly forms stable , equimolar complexes with both human leukocyte elastase and cathepsin G , porcine pancreatic elastase , and bovine alpha chymotrypsin . 0.92913412^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Partial amino acid sequencing of the purified B 43 showed that this protein was homologous to glia derived nexin / protease nexin 1 ( GDN / PN 1 ) , plasminogen activator inhibitor 2 , leukocyte elastase inhibitor ( LEI ) and placental thrombin inhibitor ( PTI ) among the serpins . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Protein sequencing of random peptides demonstrated that this enzyme is derived from a ubiquitous serpin , the leukocyte elastase inhibitor ( LEI ) , by an acidic dependent posttranslational modification or by digestion with elastase . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Leukocyte elastase inhibitor ( LEI ) is a cytosolic component of lung macrophages and blood leukocytes that inhibits neutrophil elastase . ^^^ Leukocyte elastase inhibitor ( LEI ) is a cytosolic component of lung macrophages and blood leukocytes that inhibits neutrophil elastase . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| L DNase 2 derives from LEI ( Leukocyte Elastase Inhibitor ) by a post translational modification carried out by elastase in apoptosis induced in vitro . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| The ovalbumin family of serine protease inhibitors ( serpins ) provides a unique tool to test this assumption , since individual members can be secreted ( ovalbumin ) , cytosolic ( leukocyte elastase inhibitor , LEI ) , or targeted to both compartments ( plasminogen activator inhibitor 2 , PAI 2 ) . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| At different time intervals after transplantation , apoptosis was assessed by diamino 2 phenylindol staining and annexin 5 binding on flat mount corneas , and by terminal transferase dUTP nick end labeling ( TUNEL ) , caspase 3 dependent and leukocyte elastase inhibitor ( LEI ) / LDNase 2 caspase independent pathways on sections . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Pull down assay also showed that leukocyte elastase inhibitor ( LEI ) and Ku 70 binding protein were bound to the E 7 oncoprotein . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Overexpression of leukocyte elastase inhibitor ( LEI ) and translocation of cathepsin D to the cytosol accompanied by upregulation of other defined proteins resulted in Bax independent AIF translocation from mitochondria into the nucleus and apoptosis . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| This elastolytic activity was completely abolished by a specific human leukocyte elastase inhibitor . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Equine leukocyte elastase inhibitor . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| In the present study , we examined the effects of tissue plasminogen activator ( t PA , 1 mg / kg over 20 minutes ) given intravenously with either saline or a leukocyte elastase inhibitor ( ICI 200 , 880 , 5 mg / kg ) in dogs with electrically induced coronary artery thrombosis . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Both proteolysis and generation of chemotactic activity were inhibited by a specific leukocyte elastase inhibitor and by more general proteinase inhibitors . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| In addition , the inhibitor recovered from the acid induced dissociation of the leukocyte elastase inhibitor complexes , exhibits a substantially higher specific activity than does the native molecule . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| The kcat / Km value derived from this experiment was 9 10 10 ( 4 ) M 1 s 1 , a value much lower than the rate constant for the leukocyte elastase inhibitor association ( kass , 1 . 7 10 10 ( 7 ) M 1 s 1 ) . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| These results suggested that the lavage fluids from group 1 contained significant amounts of undefined leukocyte elastase inhibitor ( s ) . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Leukocyte elastase inhibitor complexes in porcine blood , 2 . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Calla bulbs contained a 33 , 000 dalton polymorphonuclear leukocyte elastase inhibitor and a 4 , 000 dalton cathepsin G inhibitor . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Phenylmethylsulfonyl fluoride ( PMSF ) and the leukocyte elastase inhibitor , methoxy succinate alanine alanine valine chloromethyl ketone ( MeO ) each inhibited cleavage of C3b by 90 % and C3bi by 60 % . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Studies on a leukocyte elastase inhibitor present in the culture medium of inflamed synovial tissue . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Placement of an isostere of valine at P 1 and a 1 ( phenyl mercaptotetrazole at P ' 1 resulted in the most active human leukocyte elastase inhibitor within this series of compounds ( Ki 3 . 0 10 10 ( 7 ) M ) . . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| The new gene encodes a 397 amino acid protein , designated bomapin , with a calculated molecular mass of 45 kDa and 48 % amino acid identity with plasminogen activator inhibitor 2 , human leukocyte elastase inhibitor , and cytoplasmic antiproteinase . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Isolation and characterization of guamerin , a new human leukocyte elastase inhibitor from Hirudo nipponia . ^^^ A new human leukocyte elastase inhibitor was extracted and purified from a Korean native leech Hirudo nipponia . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| A specific leukocyte elastase inhibitor abrogated the increased detachment but catalase had no effect . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| A novel human leukocyte elastase inhibitor , FR 901277 was discovered in the fermentation broth of Streptomyces resistomycificus No . 7622 . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Amino acid sequence comparisons suggest that its reactive center is located at Arg 341 and Cys 342 , that it lacks a classical N terminal signal sequence , and that it has the highest degree of similarity to intracellular serine proteinase inhibitors ( serpins ) , such as the human monocyte / neutrophil elastase inhibitor and the equine leukocyte elastase inhibitor . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Effect of a synthetic leukocyte elastase inhibitor on thrombin induced pulmonary edema in the rat . ^^^ The effect of a synthetic leukocyte elastase inhibitor on thrombin induced pulmonary edema was studied in rats . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| It exhibits close to 50 % homology with several recently cloned protease inhibitors such as the leukocyte elastase inhibitor , the placental thrombin inhibitor and the squamous cell carcinoma antigen . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| A novel human leukocyte elastase inhibitor from duck egg white . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Expression of human leukocyte elastase inhibitor , elafin , otherwise known as skin derived antileukoproteinase inhibitor ( SKALP ) , was investigated in normal and abnormal oral tissues using a specific anti SKALP rabbit antiserum . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Studies with specific peptidyl inhibitors of human leukocyte elastase and cathepsin G , major serine proteinases of PMNs , demonstrated some inhibition with the cathepsin G inhibitor , while the human leukocyte elastase inhibitor almost completely abolished fibronectin proteolysis . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Secretory leukocyte proteinase inhibitor is a major leukocyte elastase inhibitor in human neutrophils . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| We have now studied the specificity of binding and endocytosis by VLDLR and alpha2MR / LRP among a variety of serine proteinase / serpin complexes , including various combinations of the serine proteinases urokinase type and tissue type plasminogen activators , plasmin , thrombin , human leukocyte elastase , cathepsin G , and plasma kallikrein with the serpins PAI 1 , horse leukocyte elastase inhibitor , protein C inhibitor , C 1 inhibitor , alpha 2 antiplasmin , alpha 1 proteinase inhibitor , alpha 1 antichymotrypsin , protease nexin 1 , heparin cofactor 2 , and antithrombin 3 . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| This protein , which has at least a 31 % sequence identity to human leukocyte elastase inhibitor and stimulates [ 3H ] thymidine incorporation into the DNA of human TILs , may be found in the cytosol of many tumor cells . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| A leukocyte elastase inhibitor reduces thrombin induced pulmonary oedema in the rat : mechanisms of action . ^^^ The effect of a selective leukocyte elastase inhibitor , ICI 200 , 355 , on thrombin induced pulmonary oedema was studied in rats . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| In contrast , the acid L DNase 2 ( derived from Leukocyte Elastase Inhibitor by post translational modification ) , recently identified in our laboratory , is mainly active in the apoptotic pathway induced by long term culture . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| In contrast , PTEN overexpression upregulated protein phosphatase 2A1B , ubiquitin protease ( unph ) , secreted phosphoprotein 1 , leukocyte elastase inhibitor , nuclear factor kappaB , cyclic adenosine monophosphate response element binding protein , DNA ligase 1 , heat shock protein 90 , and some EST genes . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| The leukocyte elastase inhibitor homologue and 2 unknowns induced significant proliferation by lymph node cells recovered from mice vaccinated with irradiated cercariae . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Neither inhibition of alveolar neutrophil influx using a leukocyte elastase inhibitor ( EPI hNE 4 ) nor inhibition of gelatinase activities by recombinant adenovirus for the human tissue inhibitor of matrix metalloproteinase 1 gene transfer decreased lung edema in HCl induced injury . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Blockade of SDF 1 and CXCR 4 proteolysis by the specific leukocyte elastase inhibitor , N methoxysuccinyl alanine alanine proline valine chloromethyl ketone , identified elastase as the major enzyme among leukocyte secreted proteinases that accounts for inactivation of both SDF 1 and CXCR 4 . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Via a proteomics approach three major impurities were identified : leukocyte elastase inhibitor , protein C inhibitor , and zinc alpha ( 2 ) glycoprotein . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Structure and sequence of human M / NEI ( monocyte / neutrophil elastase inhibitor ) , an Ov serpin family gene . ^^^ Human monocyte / neutrophil Elastase Inhibitor ( M / NEI ) is a proteinase inhibitor that regulates the activity of the neutrophil proteases : elastase , cathepsin G and proteinase 3 . ^^^ A 14 nucleotide upstream motif including the atypical TATA box TATAAGAG otherwise occurs only twice in GenBank , in the genes encoding neutrophil elastase and proteinase 3 , target proteases inhibited by M / NEI . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| The purified recombinant protein was shown to inhibit human neutrophil elastase by the formation of a stable equimolar complex , as had been shown for M / NEI isolated from monocyte derived cell lines . rM / NEI was remarkably stable in aqueous buffers from pH 6 to pH 8 , but not in buffers below pH 6 . rM / NEI activity was stable when subjected to freeze thaw cycles and low temperature storage in Tris or phosphate buffers . rM / NEI could also be lyophilized without significant loss of activity . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Those at 6p25 include proteinase inhibitor 6 ( PI 6 ; gene symbol PI 6 ) , proteinase inhibitor 9 ( PI 9 ; gene symbol PI 9 ) and monocyte neutrophil elastase inhibitor ( M / NEI ; gene symbol ELANH 2 ) . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Human monocyte / neutrophil elastase inhibitor ( M / NEI ) is a fast acting stoichiometric inhibitor of neutrophil elastase ( NE ) , cathepsin G , and proteinase 3 . ^^^ Recombinant M / NEI ( rM / NEI ) was evaluated with a rat model of NE induced lung damage . rM / NEI was found to protect against pulmonary injury caused by instilled human NE or by a preparation from airway secretions ( sputum ) of cystic fibrosis patients ( CF sol ) . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Characterization and chromosomal localization of ELANH 2 , the gene encoding human monocyte / neutrophil elastase inhibitor . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| We also show that the related serpins , PI 6 , monocyte neutrophil elastase inhibitor ( MNEI ) , PI 8 , plasminogen activator inhibitor 2 ( PAI 2 ) , and the viral serpin CrmA exhibit similar nucleocytoplasmic distributions . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| MNEI ( monocyte / neutrophil elastase inhibitor ) is a 42 kDa serpin superfamily protein characterized initially as a fast acting inhibitor of neutrophil elastase . ^^^ Reaction of MNEI with neutrophil proteinase 3 , an elastase like protease , and porcine pancreatic elastase demonstrated rapid inhibition rate constants > 10 ( 7 ) M ( 1 ) s ( 1 ) , similar to that observed for neutrophil elastase . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Characterization of four murine homologs of the human ov serpin monocyte neutrophil elastase inhibitor MNEI ( SERPINB 1 ) . ^^^ The human ov serpin monocyte neutrophil elastase inhibitor ( MNEI ) is encoded by a single gene SERPINB 1 . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Human monocyte / neutrophil elastase inhibitor ( MNEI ) , a 42 kDa serpin protein , is an effective inhibitor of neutrophil elastase , cathepsin G , and proteinase 3 , related proteases released from inflammatory neutrophils . ^^^ In vitro studies showed that MNEI causes dose dependent inhibition of the activity of rat neutrophil elastase . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| In the terminally differentiated cells , nuclear chromatin accumulates a nucleocytoplasmic serpin , monocyte and neutrophil elastase inhibitor ( MNEI ) . ^^^ |
|
| Interacting proteins: P30740 and P08246 |
Pubmed |
SVM Score :0.0 |
| Analysis of the HMM complex by coimmunoprecipitation showed that these complexes were formed between SERPINB 1 and NE or cat G . ^^^ Thus SERPINB 1 upregulation in new BPD may be protective by contributing to the regulation of neutrophil proteases NE and cat G . . ^^^ SERPINB 1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia . ^^^ |
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