| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.56524919 |
| The oxytocin receptor ( OTR ) also binds AVP with high affinity but exhibits a different pharmacological profile to the 5 ( 1a ) R . 0.56524919^^^ |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| These data show that oxytocin and AVP have different effects on testosterone production by Leydig cells in vitro and support the hypothesis that oxytocin acts in the testis through a specific oxytocin receptor . . ^^^ |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| It is concluded that AVP probably does not mediate biological activity through the oxytocin receptor in non pregnant ewes . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| Amino acid sequence identity with the rat liver V1a AVP receptor , the human and rat V 2 AVP receptors , and the human oxytocin receptor was 72 , 36 , 37 , and 45 % , respectively . ^^^ |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| AVP , the V1b receptor agonist [ deamino 1 , D 3 ( pyridyl ) Ala 2 , Arg 8 ] vasopressin , the V 2 receptor agonist 1 desamino 8 D arginine vasopressin , oxytocin , and the selective oxytocin receptor agonist [ Thr 4 , Gly 7 ] oxytocin ( TG OXT ) , each at 10 nM , significantly increased [ Ca2+ ] 1 ( 69 . 52 + / 10 . 25 , 27 . 0 + / 11 . 7 , 24 . 33 + / 5 . 83 , 14 . 75 + / 2 . 81 , and 14 . 57 + / 3 . 50 nM . min , respectively ) . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| In this paper , we present evidence that AVP , a full agonist of the vasopressin receptors , acts as a partial agonist on the oxytocin receptor . ^^^ We also found that AVP becomes a full agonist when two aromatic residues of the oxytocin receptor are replaced by the residues present at equivalent positions in the vasopressin receptor subtypes . ^^^ Our results indicate that these two residues modulate the response of the oxytocin receptor to the partial agonist AVP . . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| The selective oxytocin receptor antagonist desGlyNH2d ( CH 2 ) 5 [ Tyr ( Me ) Thr 4 ] OVT ( 10 ( 7 ) M ) does not inhibit AVP stimulated cAMP production but eliminates IP 3 production in response to AVP or the V 2 receptor agonist VDAVP . ^^^ These studies demonstrate that AVP or a V 2 receptor agonist stimulate PI hydrolysis in cultured RIMCT cells via occupancy of the oxytocin receptor . . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| Neither the V 1 receptor antagonist d ( CH 2 ) 5 [ Tyr ( Me ) 2 ] AVP nor the oxytocin receptor antagonist desGly ( NH 2 ) 9d ( CH 2 ) 5 [ Tyr ( Me ) 2Thr4 ] OVT possessed anti convulsive activity . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| The affinity and specificity of an antagonist of oxytocin , [ 1 D ( CH 2 ) 5 , Tyr ( ME ) 2 , Thr 4 , Tyr NH 2 ( 9 ) ] ornithine vasotocin ( OTA ) , to oxytocin receptors ( OTR ) in bovine gestational endometrium was determined in displacement experiments with oxytocin ( OT ) and vasopressin ( AVP ) analogues and compared to myometrial OTR . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| When the PCR products were cloned , the sequences were identical to those of the real type ( V 2 ) AVP receptor and oxytocin receptor transcripts . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| To determine exactly which subtypes of OT / AVP receptors are expressed in the rat uterus near parturition , we carried out absolute quantitations of the neurohypophysial hormone receptor ( OT R and the vasopressin receptors V1a R , V1b R and V 2 R ) mRNAs with an assay based on reverse transcription polymerase chain reaction ( RT PCR ) using in vitro transcribed mutated cRNAs as internal standards . ^^^ Therefore , the heterogeneity of OT and AVP receptors in the rat uterus can only be assigned to the presence of OT R and V1a R neurohypophysial hormone receptor subtypes , whereas V1b R and V 2 R can not be invoked . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| However , treatment with the oxytocin receptor antagonist des Gly NH 2 d ( CH 2 ) 5 [ Tyr ( Me ) 2Thr4 ] OVT interfered with the ability to establish this kind of olfactory memory although the vasopressin V 1 receptor antagonist d ( CH 2 ) 5Tyr ( Me ) AVP ( 100 ng / 5 microl each ) via the same route did not . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| Vasopressin ( AVP ) and oxytocin ( OT ) are cyclic nonapeptides whose actions are mediated by activation of specific G protein coupled receptors ( GPCRs ) currently classified into V 1 vascular ( V1R ) , V 2 renal ( V2R ) and V 3 pituitary ( V3R ) AVP receptors and OT receptors ( OTR ) . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| By detailed binding studies on a second series of chimeric V2 / OT receptors with AVP , OT and the two hybrid hormone derivatives arginine vasotocin and oxypressin it was further demonstrated that the first two extracellular domains of the OTR are involved in binding to the C terminal tripeptide of OT . ^^^ Moreover , the third extracellular domain of the OTR is able to contact the cyclic part of OT and the fourth outer domain does not interact with the two variable amino acid residues of AVP and OT . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to determine the specificity and concentration of oxytocin ( OT ) and arginine vasopressin ( AVP ) binding sites in non pregnant ( NP ) human and rhesus monkey endometrium , myometrium and fibromyomas , and to determine the cellular localization of OT receptor ( OTR ) . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| This inhibition by AVP was reversed by V 1 but not by oxytocin receptor antagonist . ^^^ |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| These results indicate that AVP and oxytocin induce cAMP accumulation from a common ATP pool in IMCD cells , and that separate vasopressin V 2 and oxytocin receptor systems are involved , perhaps coupled to a common adenylate cyclase system . . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| In contrast , the V 2 receptor agonist , dDAVP , and the specific oxytocin receptor agonist , [ Thr 4 , Gly 7 ] oxytocin , did not affect AVP binding . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| On the contrary , in uterine preparations , binding of [ 3H ] d ( CH 2 ) 5Tyr ( Me ) AVP was more effectively displaced by oxytocin and the oxytocin receptor selective antagonist , L 371257 , ( 1 [ 1 [ 4 [ N Acetyl 4 piperidinyl ) oxy ] 2 methoxybenzoyl ] piperidin 4 yl ] 4H 3 , 1 benzoxazin 2 ( 1H ) one ) , than vasopressin and SR 49059 , suggesting that binding may be due to cross reaction with the oxytocin receptors . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| These highly potent V 2 agonists , which are devoid of vasopressor activity , are promising leads for improving drugs for treating diabetes insipidus , enuresis and coagulation disorders . ( 2 ) Diaminopropionic acid and diaminobutyric acid substitution at position 5 in oxytocin and in V1a antagonists yielded , respectively , the first specific antagonist for the oxytocin receptor , desGly NH 2 , d ( CH 2 ) 5 [ D Trp 2 , Thr 4 , Dap 5 ] OVT and the first specific antagonist for the vasopressin V1a receptor , d ( CH 2 ) 5 [ Tyr ( Me ) 2 , Dab 5 ] AVP . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| A majority ( > 90 % ) of neurons responded to bath applied AVP ( 10 nM to 3 microM ) and ( Phe ( 2 ) , Orn ( 8 ) ) vasotocin , a 5 ( 1 ) receptor agonist , but not 5 ( 2 ) or oxytocin receptor agonists . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| Second , OTR mRNA was detected by RT PCR analysis whereas transcripts for AVP 5 ( 1a ) , 5 ( 1b ) or 5 ( 2 ) receptors ( 5 ( 1a ) R , 5 ( 1b ) R and 5 ( 2 ) R respectively ) were not detected . ^^^ Third , the presence of functional OTRs was evidenced by showing that agonist substances having a high affinity for the human OTR , namely OT , AVP and [ Thr ( 4 ) Gly ( 7 ) ] OT , increased the rate of myoblasts fusion and myotubes formation in the cultures , whereas F 180 , a 5 ( 1a ) R selective agonist , and dDAVP , a 5 ( 2 ) R agonist had no significant effect on the fusion process . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| Their main activities include the urine concentration ( via stimulation of AVP V 2 receptors , V2R , in the kidneys ) , blood pressure regulation ( via stimulation of vascular V1a AVP receptors , V1aR ) , ACTH control ( via stimulation of V1b receptors , V1bR , in the pituitary ) and labor and lactation control ( via stimulation of OT receptors , OTR , in the uterus and nipples , respectively ) . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| Vasopressin ( AVP ) and oxytocin ( OT ) are cyclic nonapeptides whose actions are mediated by the stimulation of specific G protein coupled receptors ( GPCRs ) currently classified into 5 ( 1 ) vascular ( 5 ( 1 ) R ) , 5 ( 2 ) renal ( 5 ( 2 ) R ) and 5 ( 3 ) pituitary ( 5 ( 3 ) R ) AVP receptors and OT receptors ( OTR ) . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| In this paper we propose the interactions responsible for OT binding and selectivity to OTR versus vasopressin ( [ F 3 , R 8 ] OT , AVP ) receptors : V1aR and V2R , all three belonging to the Class A G protein coupled receptors ( GPCRs ) . ^^^ |
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| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| In this study , the interactions responsible for AVP binding to vasopressin V1a and V 2 receptors versus the closely related oxytocin ( [ I 3 , L 8 ] AVP , OT ) receptor ( OTR ) have been investigated . ^^^ |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01185 and P30559 |
Pubmed |
SVM Score :0.0 |
| NA |
|