| Interacting proteins: P30307 and Q16512 |
Pubmed |
SVM Score :0.0 |
| PKN delays mitotic timing by inhibition of Cdc25C : possible involvement of PKN in the regulation of cell division . ^^^ The Cdc25C activity for the dephosphorylation of Tyr 15 in Cdc 2 was suppressed by pretreatment with the active form of PKN . ^^^ Furthermore , PKN efficiently phosphorylated Cdc25C in vitro , indicating that PKN directly inhibits Cdc25C activity by phosphorylation . ^^^ These results suggest that PKN plays a significant role in the control of mitotic timing by inhibition of Cdc25C . . ^^^ |
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| Interacting proteins: P30307 and Q16512 |
Pubmed |
SVM Score :0.0 |
| We show here that in response to arsenite exposure , PKN 1 kinase activity was stimulated , which was associated with increased binding of PKN 1 to Cdc25C and delayed mitotic entry . ^^^ Further experiments indicate that PKN 1 directly phosphorylated serine 216 ( Ser 216 ) in Cdc25C , which then facilitated association between Cdc25C and 14 3 3 . ^^^ Together , our results suggest that PKN 1 mediates arsenite induced delay of the G ( 2 ) / M transition by binding to and phoshorylating Cdc25C . . ^^^ |
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