| The highest levels of Cdc25A and Cdc25C expression and their subcellular localization during meiotic prophase coincide with that of cyclin A 1 , and when overexpressed in HeLa cells , cyclin A 1 coimmunoprecipitates with Cdc25A . ^^^ Furthermore , the protein kinase complexes consisting of cyclin A 1 and either Cdc 2 or Cdk 2 phosphorylate both Cdc25A and Cdc25C in vitro . ^^^ |