| Interacting proteins: P11309 and P30304 |
Pubmed |
SVM Score :0.9865554 |
| We found that Pim 1 physically interacts with Cdc25A both in vitro and in vivo and phosphorylates Cdc25A . 0.9865554^^^ |
|
| Interacting proteins: P11309 and P30304 |
Pubmed |
SVM Score :0.0 |
| Recently , Pim 1 has been shown to enhance the activities of p 100 , c Myb and cdc25a , and in part this might explain reported effects on mitogenesis . ^^^ |
|
| Interacting proteins: P11309 and P30304 |
Pubmed |
SVM Score :0.0 |
| While overexpression of Pim 1 positively affects cell cycle progression in selected CD 4 ( ) CD 8 ( ) double negative precursors , it did not affect expression of components of the cell cycle machinery , with the exception of the G ( 1 ) specific phosphatase Cdc25A upon antigen receptor stimulation . ^^^ |
|
| Interacting proteins: P11309 and P30304 |
Pubmed |
SVM Score :0.0 |
| The target proteins phosphorylated by Pim 1 , including p 100 , Cdc25A , PAP 1 and heterochromatin protein 1 , have been identified . ^^^ |
|
| Interacting proteins: P11309 and P30304 |
Pubmed |
SVM Score :0.0 |
| The proto oncogene Pim 1 encodes a serine threonine kinase which is a downstream effector of cytokine signaling and can enhance cell cycle progression by altering the activity of several cell cycle regulators among them the G 1 specific inhibitor p 21 ( Waf ) , the phosphatase Cdc25A and the kinase C TAK 1 . ^^^ |
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