| Interacting proteins: P30304 and P00533 |
Pubmed |
SVM Score :0.75552889 |
| We have shown here that Cdc25A interacts with epidermal growth factor receptor ( EGFR ) both physically and functionally in Hep3B human hepatoma cells . 0.75552889^^^ |
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| Interacting proteins: P30304 and P00533 |
Pubmed |
SVM Score :0.0 |
| In addition , using an in vitro model of ovarian cancer , we demonstrated that malignant transformation of ROSE cells resulted in alteration of downstream effectors of the EGFR pathway , as exemplified by aberrant expression of p66Shc , c Jun , c Myc , c Fos , Lot 1 , p21Cip / Waf , and cdc25A . ^^^ |
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| Interacting proteins: P30304 and P00533 |
Pubmed |
SVM Score :0.0 |
| An EGFR dephosphorylation assay suggested that Cdc25A interacts with the EGFR , with inhibition by NSC 95397 resulting in activation of the receptor . ^^^ In summary , cell cycle and GJC are connected via Cdc25A and the EGFR ERK pathway . . ^^^ |
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| Interacting proteins: P30304 and P00533 |
Pubmed |
SVM Score :0.0 |
| Cdc25A and ERK interaction : EGFR independent ERK activation by a protein phosphatase Cdc25A inhibitor , compound 5 . ^^^ We previously found that 2 ( 2 mercaptoethanol ) 3 methyl 1 , 4 napthoquinone or Compound 5 ( Cpd 5 ) , is a Cdc25A protein phosphatase inhibitor and causes prolonged , strong ERK phosphorylation which is triggered by epidermal growth factor receptor ( EGFR ) activation . ^^^ We now report that Cpd 5 can directly cause ERK phosphorylation by inhibiting Cdc25A activity independently of the EGFR pathway . ^^^ In EGFR devoid NR 6 fibroblasts and MEK ( ERK kinase ) mutated MCF 7 cells , Cpd 5 treatment also resulted in ERK phosphorylation , providing support for the idea that Cpd 5 can directly act on ERK phosphorylation by inhibiting Cdc25A activity . ^^^ These data suggest that phospho ERK is likely another Cdc25A substrate , and Cpd 5 caused ERK phosphorylation is probably regulated by both EGFR dependent and EGFR independent pathways . . ^^^ |
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| Interacting proteins: P30304 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|