| Interacting proteins: P29475 and Q15700 |
Pubmed |
SVM Score :0.0 |
| Two nNOS interacting proteins were identified : the postsynaptic density proteins PSD 93 and PSD 95 . ^^^ PSD 93 , like PSD 95 , binds to nNOS and to the NMDA receptor 2B . ^^^ We also demonstrate that the PDZ domain at the N terminus of nNOS is required , but it is not sufficient for interaction with PSD 93 / 95 . ^^^ Given that PSD 93 and PSD 95 each contain multiple potential binding sites for nNOS and the NMDA receptor , complexes involving oligomers of PSD 93 / 95 may help account for the functional as well as the physical coupling of nNOS to NMDA receptors . . ^^^ |
|
| Interacting proteins: P29475 and Q15700 |
Pubmed |
SVM Score :0.0 |
| In brain , nNOS is anchored to synaptic membranes by specific postsynaptic density proteins ( PSD ) 95 and PSD 93 . ^^^ Using different sized immunogold particles , a portion of nNOS in the macula densa colocalized with PSD 93 adjacent to cytoplasmic vesicles and the basolateral membrane . ^^^ |
|
| Interacting proteins: P29475 and Q15700 |
Pubmed |
SVM Score :0.0 |
| Neuronal nitric oxide synthase ( nNOS ) has a PSD 95 / Dlg / ZO 1 ( PDZ ) domain that can interact with multiple proteins . nNOS has been known to interact with PSD 95 and a related protein , PSD 93 , in brain and with alpha 1 syntrophin in skeletal muscle in mammals . ^^^ |
|
| Interacting proteins: P29475 and Q15700 |
Pubmed |
SVM Score :0.0 |
| One of these proteins , PSD 93 , co localizes with a subpopulation of nNOS in the macula densa . ^^^ |
|
| Interacting proteins: P29475 and Q15700 |
Pubmed |
SVM Score :0.0 |
| We investigated whether deletion of PSD 93 would dissociate the NMDAR from nNOS and be neuroprotective . ^^^ In the absence of PSD 93 , PSD 95 still interacted with NR2B and nNOS . ^^^ |
|
| Interacting proteins: P29475 and Q15700 |
Pubmed |
SVM Score :0.0 |
| PSD 93 , a molecular adaptive protein , binds to and clusters the N methyl D aspartate ( NMDA ) receptor and assembles a specific set of signaling proteins ( for example neuronal nitric oxide synthase , nNOS ) around the NMDA receptor at synapses in the central nervous system . ^^^ |
|