| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.63978876 |
| Interactions between nNOS and caveolin 3 , therefore , appear to be direct and to involve two distinct caveolin scaffolding / inhibitory domains . 0.63978876^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.65813985 |
| Potential regulatory interactions between caveolin 3 and NOS 1 may nevertheless exist in those fibers where both molecules are colocalized . 0.65813985^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.60181361 |
| The association of NOS 2 with caveolin 3 might have implications for the regulation of contraction of , and / or glucose uptake by , slow twitch muscle fibres . . 0.60181361^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| Western immunoblotting confirmed the identity of these proteins as well as the absence of neuronal NOS , inducible NOS , caveolin 2 , and caveolin 3 . ^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| Additionally , the inactivation of eNOS and nNOS by the scaffolding domain of caveolin 3 suggests that eNOS in cardiac myocytes and nNOS in skeletal muscle are likely subject to negative regulation by this muscle specific caveolin isoform . . ^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| Using immunohistochemistry , we investigated the localization of constitutive neuronal ( nNOS ) and endothelial ( eNOS ) enzyme isoforms along with caveolin 1 ( CAV 1 ) and caveolin 3 ( CAV 3 ) throughout the systemic vasculature and peripheral tissues of the hamster . ^^^ In endothelial cells , eNOS and CAV 1 were present throughout the vasculature , whereas nNOS and CAV 3 were absent except in capillaries , which reacted for nNOS . ^^^ In smooth muscle cells , nNOS and CAV 1 were also expressed systemically , whereas eNOS was absent ; CAV 3 was present in the arterial but not the venous vasculature . ^^^ Both nNOS and CAV 3 were located at the sarcolemma of skeletal muscle fibers , which were devoid of eNOS and CAV 1 . ^^^ These immunolabeling patterns suggest functional interactions between eNOS and CAV 1 throughout the endothelium , regional differences in the modulation of nNOS by caveolin isoforms in vascular smooth muscle , and modulation of nNOS by CAV 3 in skeletal muscle . . ^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| Caveolin 3 , a strong inhibitor of all NOS isoforms , is expressed in sarcolemmal caveolae microdomains and binds to cNOS in vivo : endothelial nitric oxide synthase ( eNOS ) in cardiac myocytes and neuronal nitric oxide synthase ( nNOS ) in skeletal myocytes . ^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| Diseased hearts had a significant increase in nNOS mRNA and protein expression , and activity associated with the translocation of nNOS to the sarcolemma through interactions with caveolin 3 . ^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| Using catalytic histochemistry and immunohistochemistry on rat skeletal muscle NOS 1 was colocalized in the costameres together with dystrophin , beta dystroglycan , alpha , beta and gamma sarcoglycan , beta 1 integrin , vinculin , paxillin and caveolin 3 . ^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| Both NF kappaB and NOS activities were essential for IGF 2 induced terminal differentiation ( myotube formation and expression of skeletal muscle proteins : myosin heavy chain , GLUT 4 , and caveolin 3 ) , which was totally blocked by NF kappaB or NOS inhibitors in rat and human myoblasts . ^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| Neither the expression nor the interaction of caveolin 1 and caveolin 3 with NOS enzymes was found to be altered in muscle of diabetic rats . ^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| The association between caveolin 3 and NOS 3 at the sarcolemma and T tubules was unchanged in HF compared with control myocytes . ^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| We examined the effects of chronic hypoxia on NOS gene and protein expression and on NOS protein association with caveolin 3 . ^^^ Immunoblots of NOS 3 immunoprecipitates showed that chronic hypoxia increases NOS 3 protein by 2 . 0 + / 0 . 4 fold and decreases the amount of caveolin 3 that can be coprecipitated with NOS 3 by 5 . 5 + / 0 . 9 fold . ^^^ These data suggest that a decrease in caveolin 3 plays a role in the mechanisms by which chronic hypoxia increases NOS 3 activity in the myocardium . . ^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| Using an experimental model of myocardial infarction ( MI ) in senescent rats , we demonstrated a significant increase in cardiac NOS 1 expression and activity in MI , coupled with the translocation of this enzyme to the sarcolemma through interactions with caveolin 3 . ^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| In addition , we demonstrate that the activity of nitric oxide synthase ( NOS ) is down regulated by high levels of caveolin 3 in the heart . ^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry demonstrated that NOS 1 was co localized with integral ( beta dystroglycan , alpha sarcoglycan ) and peripheral ( caveolin 3 , dystrophin ) members of the enlarged dystrophin complex in the irregular costameres but not with non sarcolemmal organized proteins ( myosin heavy chain , alpha actinin , desmin and sarcoplasmic reticulum located Ca2+ dependent ATPase 1 ) . ^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| This was associated with translocation of NOS 1 from the ryanodine receptor to the sarcolemma through interactions with caveolin 3 in HF hearts . ^^^ |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29475 and P56539 |
Pubmed |
SVM Score :0.0 |
| NA |
|