| Interacting proteins: O75052 and P29475 |
Pubmed |
SVM Score :0.89877206 |
| CAPON competes with PSD 95 for interaction with nNOS , and overexpression of CAPON results in a loss of PSD95 / nNOS complexes in transfected cells . 0.89877206^^^ |
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| Interacting proteins: O75052 and P29475 |
Pubmed |
SVM Score :0.96742996 |
| CONCLUSION : Based on the known interactions between CAPON , neuronal nitric oxide synthase ( nNOS ) , and proteins associated with the N methyl D aspartate receptor ( NMDAR ) complex , overexpression of either CAPON isoform would be expected to disrupt the association between nNOS and the NMDAR , leading to changes consistent with the NMDAR hypofunctioning hypothesis of schizophrenia . 0.96742996^^^ |
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| Interacting proteins: O75052 and P29475 |
Pubmed |
SVM Score :0.0 |
| Additionally , NMR studies further show that the Asp 10 Val COOH peptide and a C terminal peptide from a novel cytosolic protein named CAPON bind to the same pocket of the nNOS PDZ domain . . ^^^ |
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| Interacting proteins: O75052 and P29475 |
Pubmed |
SVM Score :0.0 |
| In addition , PSD 95 binds with neuronal nitric oxide synthase ( nNOS ) , which is competitively inhibited by carboxy terminal PDZ ligand of nNOS ( CAPON ) and , thereby , nNOS activity is thought to be regulated by PSD 95 and CAPON . ^^^ We investigated the changes in mRNA for PSD 95 , CAPON and nNOS in the facial motor nucleus of adult rats following axotomy , by in situ hybridization , in combination with the time course of muscle reinnervation , by retrograde tracing and nNOS protein expression , by examining nicotinamide adenine nucleotide phosphate diaphorase ( NADPH d ) activity . ^^^ It was also found that mRNA and protein expression of nNOS started to increase in the axotomized facial motoneurons just prior to the recovery of mRNA expression of PSD 95 and CAPON . ^^^ |
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| Interacting proteins: O75052 and P29475 |
Pubmed |
SVM Score :0.0 |
| The dyc 1 gene encodes a novel protein sharing similarities with the mammalian neural nitric oxide synthase ( nNOS ) binding protein CAPON , and is expressed in the muscles of the worm . ^^^ |
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| Interacting proteins: O75052 and P29475 |
Pubmed |
SVM Score :0.0 |
| Here we identify a selective interaction of the nNOS adaptor protein CAPON with Dexras 1 , a brain enriched member of the Ras family of small monomeric G proteins . ^^^ We also find that nNOS , CAPON , and Dexras 1 form a ternary complex that enhances the ability of nNOS to activate Dexras 1 . ^^^ |
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| Interacting proteins: O75052 and P29475 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the nNOS adapter protein , CAPON , interacts with synapsins 1 , 2 , and 3 through an N terminal phosphotyrosine binding domain interaction , which leads to a ternary complex comprising nNOS , CAPON , and synapsin 1 . ^^^ |
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| Interacting proteins: O75052 and P29475 |
Pubmed |
SVM Score :0.0 |
| Neural nitric oxide synthase ( nNOS ) , synapsin 1 , and nNOS adapter protein ( CAPON ) constitute a ternary complex necessary for specific NO and synapsin functions at a presynaptic level . ^^^ |
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| Interacting proteins: O75052 and P29475 |
Pubmed |
SVM Score :0.0 |
| The identification of CAPON transcripts and protein in mammalian muscle and responses to L arginine suggest CAPON may have a functional role in stabilizing neuronal NOS in skeletal muscle in the cytoskeletal complex associated with dystrophin / utrophin , with possible applications to therapy for human muscular dystrophy . . ^^^ In neurons , the adaptor protein , carboxy terminal PDZ ligand of nNOS ( CAPON ) , regulates the distribution of neuronal nitric oxide synthase ( nNOS ) , which produces the key signaling molecule nitric oxide ( NO ) . ^^^ CAPON expression in skeletal muscle is regulated by position , repair , NOS activity , and dystrophy . ^^^ Expression of CAPON RNA increased in diaphragm muscle of normal and mdx mice after treatment with L arginine , the NOS substrate . ^^^ |
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| Interacting proteins: O75052 and P29475 |
Pubmed |
SVM Score :0.0 |
| It binds to neuronal nitric oxide synthase ( nNOS ) via the adaptor protein CAPON , eliciting S nitrosylation and activation of Dexras 1 . ^^^ |
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| Interacting proteins: O75052 and P29475 |
Pubmed |
SVM Score :0.0 |
| A common genetic variant in the NOS 1 regulator NOS1AP modulates cardiac repolarization . ^^^ |
|
| Interacting proteins: O75052 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75052 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75052 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
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