| Interacting proteins: P61812 and P29279 |
Pubmed |
SVM Score :0.0 |
| Expression of mRNAs for TGF beta 1 , TGF beta 2 , TGF beta receptor type 2 , and connective tissue growth factor ( CTGF ) was significantly greater in anterior polar type than in nuclear type cataracts . ^^^ |
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| Interacting proteins: P61812 and P29279 |
Pubmed |
SVM Score :0.0 |
| Among these genes , we found down regulation of 11 genes ( MMP 9 , protease M , uPAR , VEGF , neuropilin , TSP , BPGF , LPA , TGF beta 2 , TSP 1 , PAR 2 ) and up regulation of two genes ( connective tissue growth factor , connective tissue activation peptide ) , which are related to angiogenesis , tumor cell invasion and metastasis . ^^^ |
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| Interacting proteins: P61812 and P29279 |
Pubmed |
SVM Score :0.0 |
| At various time points , corneas were processed for histology and stained for nuclei , f actin , ED A fibronectin , alpha smooth muscle actin , TGF beta 1 , TGF beta 2 , TGF beta receptor 2 , and CTGF . ^^^ TGF beta 1 , TGF beta 2 , TGF beta receptor 2 , and CTGF were expressed in the band from day 2 . ^^^ |
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| Interacting proteins: P61812 and P29279 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To study whether glaucomatous extracellular matrix ( ECM ) modifications in the lamina cribrosa might be induced by TGF beta 2 , the effect of TGF beta 2 on the expression of collagen types 1 ( Col 1 alpha 1 ) , 3 ( Col 3 alpha 1 ) , and 4 ( Col 4 alpha 2 ) ; fibronectin ( FN ) ; tissue transglutaminase ( TGM 2 ) ; connective tissue growth factor ( CTGF ) ; and thrombospondin ( TSP 1 ) in cultured human optic nerve head ( ONH ) astrocytes was investigated . ^^^ The effect of CTGF silencing on the TGF beta 2 modulated expression of these genes was investigated by transfection of CTGF small interfering ( si ) RNA before TGF beta 2 treatment . ^^^ RESULTS : TGF beta 2 treatment upregulated the expression of Col 1 alpha 1 , Col 4 alpha 2 , FN , CTGF , TGM 2 , and TSP 1 mRNA and protein in cultured astrocytes . ^^^ Transfection of 10 nM CTGF siRNA inhibited the TGF beta 2 induced upregulation of CTGF , Col 4 alpha 2 , Col 1 alpha 1 , TGM 2 , and FN , whereas TSP 1 expression was not reduced . ^^^ CONCLUSIONS : TGF beta 2 is capable of inducing the expression of ECM and basement membrane components in cultured ONH astrocytes via CTGF and upregulated TSP 1 , a protein naturally involved in the activation of latent TGF beta . ^^^ |
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| Interacting proteins: P61812 and P29279 |
Pubmed |
SVM Score :0.0 |
| CTGF expression increased greater than 150 fold when stimulated with TGF beta 1 ( p < 0 . 002 ) and greater than 100 fold when stimulated by TGF beta 2 or TGF beta 3 compared with normal fibroblasts ( p < 0 . 02 and p < 0 . 002 , respectively ) . ^^^ CTGF expression was greatest after TGF beta 1 stimulation in hypertrophic scar fibroblasts compared with TGF beta 2 ( p < 0 . 04 ) and TGF beta 3 ( p < 0 . 02 ) . ^^^ Keloid fibroblast CTGF expression also increased greater than 100 fold after stimulation with TGF beta 1 ( p = 0 . 16 ) and greater than 75 fold after addition of TGF beta 2 and TGF beta 3 ( p = 0 . 06 and p = 0 . 22 , respectively ) . ^^^ |
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| Interacting proteins: P61812 and P29279 |
Pubmed |
SVM Score :0.0 |
| Expression of alphaB crystallin , fibronectin ( FN ) , plasminogen activator inhibitor ( PAI ) 1 , thrombospondin ( TSP ) 1 , and connective tissue growth factor ( CTGF ) mRNA and protein in medium perfused and TGF beta 2 perfused anterior segments was examined by Northern and Western blot analyses . ^^^ |
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| Interacting proteins: P61812 and P29279 |
Pubmed |
SVM Score :0.0 |
| However , when skin cells are exposed to transforming growth factor beta ( TGF beta ) , CTGF is induced in fibroblasts but not in epithelial cells . ^^^ |
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| Interacting proteins: P61812 and P29279 |
Pubmed |
SVM Score :0.0 |
| Here , we show that in fibroblasts , activation of the Ras / MEK / ERK pathway is required for the SMAD mediated induction of CTGF by TGFbeta 2 . ^^^ |
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| Interacting proteins: P61812 and P29279 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P61812 and P29279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61812 and P29279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61812 and P29279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61812 and P29279 |
Pubmed |
SVM Score :0.0 |
| NA |
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