| Interacting proteins: P10600 and P29279 |
Pubmed |
SVM Score :0.0 |
| CTGF expression increased greater than 150 fold when stimulated with TGF beta 1 ( p < 0 . 002 ) and greater than 100 fold when stimulated by TGF beta 2 or TGF beta 3 compared with normal fibroblasts ( p < 0 . 02 and p < 0 . 002 , respectively ) . ^^^ CTGF expression was greatest after TGF beta 1 stimulation in hypertrophic scar fibroblasts compared with TGF beta 2 ( p < 0 . 04 ) and TGF beta 3 ( p < 0 . 02 ) . ^^^ Keloid fibroblast CTGF expression also increased greater than 100 fold after stimulation with TGF beta 1 ( p = 0 . 16 ) and greater than 75 fold after addition of TGF beta 2 and TGF beta 3 ( p = 0 . 06 and p = 0 . 22 , respectively ) . ^^^ |
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| Interacting proteins: P10600 and P29279 |
Pubmed |
SVM Score :0.0 |
| We tested this hypothesis in paired leiomyoma and myometrium by evaluating the expression of TGF beta1 / TGF beta 3 and CCN 2 , the other members of the CCN family , CCN 3 and CCN 4 , as well as fibulin 1C and S100A4 , calcium binding proteins that interact with CCNs . ^^^ |
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| Interacting proteins: P10600 and P29279 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To evaluate the clinical features and the expression of transforming growth factor beta 3 ( TGF beta 3 ) and connective tissue growth factor ( CTGF ) in myometrium and uterine leiomyomas after preoperative treatment with gonadotropin releasing hormone analogs ( GnRH a ) and tibolone . ^^^ Immunohistochemical expression of TGF beta 3 and CTGF in myometrium and myoma samples was evaluated semiquantitatively . ^^^ In untreated cases , TGF beta 3 and CTGF smooth muscle cell immunoexpression was lower in myometrium than in leiomyomas . ^^^ CONCLUSION : This study focuses on the effects of GnRH a and tibolone on TGF beta 3 and CTGF expression in myometrium and myomas and supports the hypothesis of a pathogenetic role of these growth factors in uterine fibromatosis . . ^^^ |
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| Interacting proteins: P10600 and P29279 |
Pubmed |
SVM Score :0.0 |
| TGF beta 3 induced more than 70 fold , 50 fold , and 20 fold increases in CTGF expression in E 17 , E 19 , and adult fibroblasts , respectively ( p < 0 . 01 for each ) . ^^^ |
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| Interacting proteins: P10600 and P29279 |
Pubmed |
SVM Score :0.0 |
| Fibrosis related gene expression featured upregulation of connective tissue growth factor and transforming growth factor beta 3 . ^^^ |
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| Interacting proteins: P10600 and P29279 |
Pubmed |
SVM Score :0.0 |
| To elucidate the role of CTGF in fibrovascular proliferative retinopathy , we investigated the regulation of CTGF gene expression in a cell line of retinal vascular endothelial cells ( RVEC ) stimulated with fetal calf serum ( FCS ) and angiogenic growth factors , including vascular endothelial growth factor ( VEGF ) , basic fibroblast growth factor ( bFGF ) , platelet derived growth factor BB ( PDGF BB ) , endothelial growth factor ( EGF ) , transforming growth factor beta 1 and beta 3 ( TGF beta 1 , TGF beta 3 ) , and insulin like growth factor 1 ( IGF 1 ) . ^^^ RESULTS : FCS , TGF beta 1 , TGF beta 3 , bFGF , and EGF induced an upregulation of CTGF gene expression in RVEC in a time dependent manner . ^^^ |
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| Interacting proteins: P10600 and P29279 |
Pubmed |
SVM Score :0.0 |
| These included strong upregulation of interferon responsive genes such as interferon response factor 7 ( IRF 7 ) and myxovirus resistance protein R 1 , plus upregulation of exodus 2 beta chemokine , RDC 1 alpha chemokine receptor , and transforming growth factor beta 3 , together with strong downregulation of cell adhesion factors alpha ( 4 ) integrin and fibronectin plus downregulation of bone morphogenesis protein 4 , matrix metalloproteinase 2 , endothelial plasminogen activator inhibitor 1 , connective tissue growth factor , and interleukin 8 . ^^^ |
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| Interacting proteins: P10600 and P29279 |
Pubmed |
SVM Score :0.0 |
| STUDY DESIGN : Collagen content and the expression of transforming growth factor beta and its isoforms transforming growth factor beta 1 and transforming growth factor beta 3 , connective tissue growth factor , basic fibroblast growth factor , vascular endothelial growth factor , platelet derived growth factor , and tumor necrosis factor alpha in myometrium of lower uterine segment were assessed in 19 otherwise healthy term patients with one previous cesarean delivery who were not in labor . ^^^ RESULTS : In the case of uterine dehiscence , the scarred lower uterine segment showed a higher collagen content , a reduction of pan transforming growth factor beta expression because of a marked decrease or absence of transforming growth factor beta 3 , a reduction of connective tissue growth factor , an increase in basic fibroblast growth factor and a slight enhancement in vascular endothelial growth factor , platelet derived growth factor , and tumor necrosis factor alpha expression . ^^^ |
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| Interacting proteins: P10600 and P29279 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P29279 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P29279 |
Pubmed |
SVM Score :0.0 |
| NA |
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