| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.69625995 |
| Endogenous CCN 2 directly binds fibronectin and the fibronectin receptors integrins alpha 4 beta1 and alpha 5 and syndecan 4 . 0.69625995^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis revealed that 3 cDNAs encoded previously unidentified genes ( C 1 , C 5 , C 7 ) , while 3 encoded known genes : connective tissue growth factor ( CTGF ; A 1 ) , fibronectin ( A 8 ) and the mitochondrial genome ( B 1 ) . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| On day 70 , the ECM composition was expanded by increased deposition of fibronectin , whereas connective tissue growth factor , fibroblast growth factor ( FGF ) 1 , and FGF 2 mRNA expression levels were elevated in addition to TGF beta 1 . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| These included strong upregulation of interferon responsive genes such as interferon response factor 7 ( IRF 7 ) and myxovirus resistance protein R 1 , plus upregulation of exodus 2 beta chemokine , RDC 1 alpha chemokine receptor , and transforming growth factor beta 3 , together with strong downregulation of cell adhesion factors alpha ( 4 ) integrin and fibronectin plus downregulation of bone morphogenesis protein 4 , matrix metalloproteinase 2 , endothelial plasminogen activator inhibitor 1 , connective tissue growth factor , and interleukin 8 . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Connective tissue growth factor / IGF binding protein related protein 2 is a mediator in the induction of fibronectin by advanced glycosylation end products in human dermal fibroblasts . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to determine whether aminoguanidine ( AG ) , an inhibitor of advanced glycation , prevents expression of the profibrotic cytokine , connective tissue growth factor ( CTGF ) , as well as accumulation of the previously reported CTGF dependent matrix protein , fibronectin , in a model of experimental diabetic nephropathy . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| TGF beta induces its downstream mediator connective tissue growth factor ( CTGF ) , which stimulates fibronectin matrix synthesis , a process that requires the presence of alpha5beta1 integrin . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Incubation of murine mesangial cells with TGF beta ( 50 200 pM ) increased cell associated collagen type 4 and fibronectin , soluble collagen type 4 , thrombospondin , and connective tissue growth factor ( CTGF ) . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression of proliferative cell nuclear antigen ( PCNA ) , epithelial cell growth factor ( EGF ) , alpha smooth muscle actin ( alpha SMA ) , fibronectin ( FN ) , collagen type 3 and 4 , transforming growth factor beta 1 ( TGF beta 1 ) and connective tissue growth factor in renal biopsy samples of patients with MD ATN ( 4 patients ) and A ATN ( 5 patients ) were compared with immunohistochemical SP method . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| This review discusses the current state of knowledge concerning interactions among the profibrotic proteins transforming growth factor beta ( TGF beta ) , connective tissue growth factor ( CTGF , CCN 2 ) , and ED A fibronectin ( ED A FN ) and the antifibrotic proteins tumor necrosis factor alpha ( TNF alpha ) and gamma interferon ( IFN gamma ) . . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| TGF beta , connective tissue growth factor ( CTGF ) , collagen type 4 , and fibronectin mRNA were upregulated in the disease control group , and anti factor 5 neutralizing antibody injection suppressed these mRNA expressions in glomeruli . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Interestingly , cardiac myocytes plated on FN showed elevated expression of the fibrosis promoting peptides connective tissue growth factor ( CTGF ) , WNT 1 inducible signaling pathway protein 2 ( WISP 2 ) , and secreted acidic cysteine rich glycoprotein ( SPARC ) . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| At various time points , corneas were processed for histology and stained for nuclei ; F actin ; ED A fibronectin ; alpha smooth muscle actin ; TGF beta 1 , beta 2 , and beta receptor 2 ; and connective tissue growth factor ( CTGF ) . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Altered local gene expression of humoral factors ( eg , transforming growth factor b , connective tissue growth factor , and platelet derived growth factor ) can lead to increased production of ECM components ( eg , fibronectin and collagen 4 ) or decreased degradation through matrix metalloproteinases ( eg , MMP 1 , MMP 2 ) . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the effect of quercetin on the expression of connective tissue growth factor ( CTGF ) and fibronectin ( FN ) in hepatic stellate cells ( HSCs ) stimulated with transforming growth factor ( TGF ) beta 1 . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Treatment with SB 431542 prevented TGFbeta induced stimulation of collagen , fibronectin , plasminogen activator inhibitor 1 , and connective tissue growth factor gene expression , TGFbeta autoinduction , and myofibroblast transdifferentiation , and it could reverse stimulation even when added to the cultures after TGFbeta . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To study whether glaucomatous extracellular matrix ( ECM ) modifications in the lamina cribrosa might be induced by TGF beta 2 , the effect of TGF beta 2 on the expression of collagen types 1 ( Col 1 alpha 1 ) , 3 ( Col 3 alpha 1 ) , and 4 ( Col 4 alpha 2 ) ; fibronectin ( FN ) ; tissue transglutaminase ( TGM 2 ) ; connective tissue growth factor ( CTGF ) ; and thrombospondin ( TSP 1 ) in cultured human optic nerve head ( ONH ) astrocytes was investigated . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Genes for E cadherin , collagen type 1 alpha 2 ( COL1A2 ) , insulin like growth factor binding protein 2 ( IGFBP 2 ) , connective tissue growth factor ( CTGF ) and fibronectin 1 exhibited aberrant methylation in several hepatoma cell lines . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Immunoreactive TGF beta 1 , connective tissue growth factor , HGF receptor , c Met , and fibronectin all increased in remnant ( 2 . 85 + / 0 . 51 , 3 . 83 + / 0 . 55 , 2 . 56 + / 0 . 31 , and 2 . 80 + / 0 . 39 fold sham respectively , n = 4 8 , p < 0 . 05 ) , and SC 58236 blunted the increases ( to 1 . 45 + / 0 . 34 , 1 . 85 + / 0 . 13 , 1 . 75 + / 0 . 30 , and 1 . 60 + / 0 . 32 fold sham ) . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Matrix metalloproteinase 2 decreased the amount of connective tissue growth factor and vascular endothelial growth factor , but not fibronectin deposited in the extracellular matrix . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined fibronectin and collagen production and signal transduction pathways after stimulation with TGF beta and connective tissue growth factor . ^^^ In both asthmatic and nonasthmatic airway smooth muscle cells , TGF beta and connective tissue growth factor led to the production of fibronectin and collagen 1 . ^^^ TGF beta induction of fibronectin and collagen was in part mediated by an autocrine action of connective tissue growth factor . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| The expression levels of transforming growth factor beta 1 ( TGF beta 1 ) , connective tissue growth factor ( CTGF ) , fibronectin ( FN ) and plasminogen activator inhibitor 1 ( PAI 1 ) were detected by real time quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) at the end of the experiment . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| RESULTS : High glucose stimulated a striking increase in BRPC gremlin mRNA levels in parallel with increases in mRNA for the growth factors vascular endothelial growth factor ( VEGF ) , transforming growth factor beta ( TGFbeta ) , and connective tissue growth factor ( CTGF ) and changes in other genes including fibronectin and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Whole cell connective tissue growth factor ( CTGF ) and fibronectin expression were determined by Western blot analysis . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Role of connective tissue growth factor in fibronectin synthesis in cultured human prostate stromal cells . ^^^ OBJECTIVES : To clarify the correlation of connective tissue growth factor ( CTGF ) expression and fibronectin ( FN ) synthesis after transforming growth factor beta 1 ( TGF beta 1 ) stimulation in human prostate stromal cells . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Expression of alphaB crystallin , fibronectin ( FN ) , plasminogen activator inhibitor ( PAI ) 1 , thrombospondin ( TSP ) 1 , and connective tissue growth factor ( CTGF ) mRNA and protein in medium perfused and TGF beta 2 perfused anterior segments was examined by Northern and Western blot analyses . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| In WT mice , subcutaneous ( s . c . ) AngII ( 1 . 1 mg / kg / day for 2 wk ) significantly increased NADPH oxidase activity , interstitial fibrosis ( 11 . 5+ / 1 . 0 % vs . 7 . 2+ / 0 . 7 % ; P < 0 . 05 ) , expression of fibronectin , procollagen 1 , and connective tissue growth factor mRNA , MMP 2 activity , and NF kB activation . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : We examined the effect of corticosteroids , long acting beta ( 2 ) agonists , and a phosphodiesterase 4 ( PDE 4 ) inhibitor on ASM released connective tissue growth factor ( CTGF ) , collagen 1 , fibronectin , versican , and IL 6 . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Finally , induction of TGFbeta induced fibroblast adhesion to fibronectin and type 1 collagen was significantly diminished in ccn 2 / fibroblasts . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| As assessed by RT PCR or Western blotting , CCN 2 ( 3 ) stimulated production of fibronectin and pro collagen type 4 ( alpha 5 ) , both of which are downstream components of HSC mediated fibrogenesis and which are constituents of high density matrix in fibrotic lesions . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| In NRK fibroblasts , both TGF beta and CTGF significantly increased the transcripts encoding alpha 1 type 1 collagen , alpha 5 integrin , and fibronectin . ^^^ Stimulation of type 1 collagen and fibronectin protein synthesis by TGF beta and CTGF was confirmed by pulse labeling of cells with [ 35S ] methionine . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Expression of transforming growth factor beta 1 ( TGF beta 1 ) , the only known inducer of CTGF so far , as well as of the CTGF target genes collagen 1 alpha 1 , fibronectin and integrin alpha 5 revealed a strong correlation with the expression of CTGF . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Exposure of MC to recombinant human CTGF significantly increased fibronectin and collagen type 1 production . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Interestingly , increased expression of this mitogen was accompanied by elevated levels of the extracellular matrix molecule fibronectin , which is a known target of CTGF action . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Since members of the CTGF family regulate the expression of specific genes , such as collagen and fibronectin , we propose that CTGF may play a previously unreported role in normal skeletal modeling / remodeling . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| CTGF stimulated a two to threefold increase in proalpha 1 ( 1 ) collagen and fibronectin synthesis by both dermal and lung fibroblasts in culture and promoted significant matrix remodeling of fibroblast populated three dimensional collagen lattices . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Recombinant human CTGF augments the production of fibronectin and type 4 collagen by mesangial cells and the effects of high glucose on mesangial cell CTGF expression and matrix production are attenuated , in part , by anti TGF beta antibody . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Upregulation of CTGF coincided with an increase in fibronectin , collagen type 1 and plasminogen activator inhibitor 1 production . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Compared with fibroblast adhesion to fibronectin , laminin , or type 1 collagen , cell adhesion to Cyr 61 or CTGF induces 1 ) more extensive and prolonged formation of filopodia and lamellipodia , concomitant with formation of integrin alpha ( 6 ) beta ( 1 ) containing focal complexes localized at leading edges of pseudopods ; 2 ) activation of intracellular signaling molecules including focal adhesion kinase , paxillin , and Rac with similar rapid kinetics ; 3 ) sustained activation of p42 / p44 MAPKs lasting for at least 9 h ; and 4 ) prolonged gene expression changes including up regulation of MMP 1 ( collagenase 1 ) and MMP 3 ( stromelysin 1 ) mRNAs and proteins sustained for at least 24 h . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| In addition , overexpression of CTGF also promotes VSMC to express more extracellular matrix protein collagen 1 and fibronectin . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| In addition , fibronectin expression was upregulated by both CTGF and TGFbeta , as measured by dot blot analysis . ^^^ Moreover , anti CTGF significantly reduced TGFbeta induced increase in fibronectin . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| CTGF induces collagen type 1 and fibronectin , and the deposition of such molecules leads to fibrotic disease in many tissues . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Transient transfection of a transformed human mesangial cell line with a CTGF V 5 epitope fusion protein markedly increased fibronectin and plasminogen activator inhibitor 1 synthesis in cultures maintained in normal glucose ( 4 mM ) conditions ; a CTGF antisense construct reduced the elevated synthesis of these proteins in high glucose ( 30 mM ) cultures . ^^^ Culture of primary human mesangial cells for 14 days in high glucose , or in low glucose supplemented with recombinant CTGF or transforming growth factor beta 1 , markedly increased CTGF mRNA levels and fibronectin synthesis . ^^^ However , whilst co culture with a CTGF antisense oligonucleotide reduced the CTGF mRNA pool by greater than 90 % in high glucose , it only partially reduced fibronectin mRNA levels and synthesis . ^^^ A chick anti CTGF neutralizing antibody had a similar effect on fibronectin synthesis . ^^^ Thus both CTGF and CTGF independent pathways mediate increased fibronectin synthesis in high glucose . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| To explore the implication of CTGF in renal fibrosis , we investigated gene expression of CTGF , fibronectin , and alpha 1 ( 1 ) collagen in an obstructive nephropathy model in rats . ^^^ After unilateral ureteral obstruction , TGF beta 1 and CTGF messenger RNA ( mRNA ) expression in the obstructed kidney was coordinately upregulated from the early stage of interstitial fibrosis , followed by marked induction of fibronectin and alpha 1 ( 1 ) collagen mRNA expression . ^^^ In cultured normal rat kidney fibroblast ( NRK 49F ) cells , CTGF antisense ODN transfection significantly attenuated TGF beta 1 induced fibronectin and alpha 1 ( 1 ) collagen mRNA expression compared with control reverse ODNs . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| The addition of CTGF to primary mesangial cells induced fibronectin production , cell migration , and cytoskeletal rearrangement . ^^^ The inhibition of CTGF induced p42 / 44 MAPK or phosphatidylinositol 3 kinase ( PI3K ) / protein kinase B pathway activities abrogated the induction of fibronectin expression . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Dexamethasone decreased GM CSF induced TbetaR 1 , TbetaR 2 , TbetaR 3 , pSmad 2 , CTGF , collagen 1 , and fibronectin . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Incubation with a CTGF antisense oligonucleotide decreased CTGF and fibronectin upregulation caused by Ang 2 . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| At various time points , corneas were processed for histology and stained for nuclei , f actin , ED A fibronectin , alpha smooth muscle actin , TGF beta 1 , TGF beta 2 , TGF beta receptor 2 , and CTGF . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| At day 7 , AngII infused rats presented overexpression of CTGF in glomeruli , tubuli , and renal arteries , as well as tubular injury and elevated fibronectin deposition . ^^^ Only treatment with an AT ( 1 ) receptor antagonist , but not an AT ( 2 ) , diminished CTGF and fibronectin overexpression and ameliorated tubular damage . ^^^ In cultured renal cells ( mesangial and tubular epithelial cells ) AngII , via AT ( 1 ) , increased CTGF mRNA and protein production , and a CTGF antisense oligonucleotide decreased AngII induced fibronectin synthesis . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| METHODS : Northern blot analysis for CTGF , TGF beta , and fibronectin expression was performed in the glomeruli of STZ induced diabetic rats from 3 days to 12 weeks after the induction of diabetes , together with histological examination . ^^^ RESULTS : Glomerular expression of CTGF and TGF beta 1 mRNA was coordinately upregulated as early as day 3 , followed by fibronectin induction and mesangial matrix accumulation . ^^^ Chronic aspirin treatment in diabetic rats significantly attenuated mesangial expansion , and effectively suppressed CTGF induction , as well as inhibiting the upregulation of TGF beta 1 and fibronectin expression . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| BNP opposed TGF beta regulated genes related to fibrosis ( collagen 1 , fibronectin , CTGF , PAI 1 , and TIMP 3 ) , myofibroblast conversion ( alpha smooth muscle actin 2 and nonmuscle myosin heavy chain ) , proliferation ( PDGFA , IGF 1 , FGF 18 , and IGFBP 10 ) , and inflammation ( COX 2 , IL 6 , TNFalpha induced protein 6 , and TNF superfamily , member 4 ) . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Ribozyme markedly decreased expression of fibronectin , p27kip1 , and CTGF mRNAs in injured vessel , whereas a mismatch ribozyme had no effect on these mRNAs . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Moreover , TGF beta 1 , its receptor TGF beta receptor 1 , and extracellular matrix molecules ( collagen type 1 and fibronectin ) were co localized with CTGF mRNA positive crescents . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| To further elucidate the role of CTGF in renal tubular transdifferentiation and extracellular matrix ( ECM ) metabolism , we examined the time course of CTGF , alpha smooth muscle actin ( alpha SMA ) , fibronectin and plasminogen activator inhibitor 1 ( PAI 1 ) gene expression upon the stimulation of TGF beta 1 ( 5 microg / L ) in cultured human proximal tubular epithelial cell line ( HKC ) , and further investigated the effects of endogenous CTGF blockade . ^^^ On reverse transcriptional polymerase chain reaction ( RT PCR ) analysis , TGF beta 1 upregulated CTGF gene expression , preceding that of alpha SMA , fibronectin and PAI 1 . ^^^ The alpha SMA , fibronectin and PAI 1 mRNA expression induced by TGF beta 1 were significantly inhibited by CTGF antisense oligodeoxynucleotide ( ODN ) transfection . ^^^ With prolonged incubation time , CTGF antisense ODN also inhibited intracellular alpha SMA and PAI 1 protein synthesis , lowered the level of fibronectin and PAI 1 protein secreted into the media , as confirmed by indirect immuno fluorescence , flow cytometry , enzyme linked immunosorbent assay ( ELISA ) and Western blot methods respectively . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| It was shown previously that the blockade of CTGF by antisense oligonucleotide ( ODN ) inhibits TGF beta induced production of fibronectin and type 1 collagen in cultured renal fibroblasts . ^^^ At day 7 after UUO , the gene expression of CTGF , fibronectin , fibronectin ED A , and alpha 1 ( 1 ) collagen in untreated or control ODN treated obstructed kidneys was prominently upregulated . ^^^ CTGF antisense ODN treatment , by contrast , markedly attenuated the induction of CTGF , fibronectin , fibronectin ED A , and alpha 1 ( 1 ) collagen genes , whereas TGF beta gene upregulation was not affected . ^^^ The antisense treatment also reduced interstitial deposition of CTGF , fibronectin ED A , and type 1 collagen and the interstitial fibrotic areas . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| METHODS : L6E9 myoblast cell line was transfected with human endoglin , and collagen , fibronectin and CTGF production was assessed by Western blot and by proline incorporation to collagen proteins . ^^^ Upon endoglin transfection , endoglin expressing cells displayed a decreased CTGF expression and decreased collagen and fibronectin accumulation respect to mock transfectants . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that CTGF alone has no influence on myofibroblast transformation and fibronectin secretion in kidney interstitial fibroblasts , whereas incubation of CTGF in combination with TGFbeta 1 enhanced TGFbeta 1 responses , including myofibroblast activation , de novo expression of alpha SMA , and extracellular accumulation of fibronectin . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| We present the novel finding that the intracellular pathogen Trypanosoma cruzi elicits immediate and sustained repression of basal CTGF expression in dermal fibroblasts , followed by down regulation of the extracellular matrix proteins , fibronectin , and collagen 1 alpha 1 . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| CTGF ( 20 ng / ml ) induced fibronectin and collagen 4 secretion in primary cultures of human proximal tubule cells ( PTC ) and cortical fibroblasts ( CF ) compared with control values ( P < 0 . 005 in all cases ) . ^^^ TGF beta ( 1 ) induced a greater increase in fibronectin and collagen 4 secretion in both PTC ( P < 0 . 01 ) and CF ( P < 0 . 01 ) compared with that observed with CTGF alone . ^^^ The combination of TGF beta ( 1 ) and CTGF was additive in their effects on both PTC and CF fibronectin and collagen 4 secretion . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Direct exposure of rat mesangial cells to AGEs in vitro significantly induced increases in fibronectin and Col 4 production , which could be completely prevented by pretreatment with anti CTGF antibody . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| The CTGF positive astrocytes coexpressed the activation associated intermediate filaments nestin , vimentin ( > 80 % ) , and mesenchymal scar component fibronectin ( 50 % ) . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| TGF beta , CTGF , and fibronectin mRNA were upregulated in the disease control group , and TJ 114 suppressed these mRNA expressions in glomeruli . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Transient transfection with Smad 7 , which interferes with receptor mediated activation of Smad 2 , diminished Ang 2 induced CTGF promoter activation , gene and protein expression , and fibronectin and type 1 procollagen overexpression , showing that Smad activation is involved in Ang 2 induced fibrosis . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| The blockade of CTGF by a CTGF antisense oligonucleotide decreased FN and type 1 collagen expression in ET 1 treated cells , showing that CTGF participates in ET 1 induced ECM accumulation . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Our studies further demonstrate that in the CTGF gene silenced cells , CTGF partially mediates TGF beta ( 1 ) induced fibronectin and collagen 4 secretion . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| TGF beta 1 was also shown to stimulate the secretion of FN in cultured supernatant and the CTGF mRNA expression of NRK52E cells . ^^^ There was no statistically significant difference between HGF treated groups and control group in the result of alpha SMA immunostaining and the level of FN , except that CTGF mRNA expression was slightly increased in the HGF treated groups . ^^^ The addition of HGF inhibited the TGF beta 1 induced TEMT , the secretion of FN , and the CTGF expression of NRK52E cells , there was a significant correlation between the expression of CTGF and the expression of alpha SMA . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Mechanical strengthening of FSPCs was accompanied by increased type 1 collagen and fibronectin matrix accumulation and distribution , and significantly increased gene expression for type 1 collagen , TGFbeta 1 , and CTGF . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| We also examined the roles of THBS 1 and CTGF in mediating high glucose and glycated albumin induced synthesis of the matrix protein , fibronectin , by mesangial cells . ^^^ However , increased fibronectin synthesis in both conditions required CTGF . ^^^ In contrast to THBS 1 , CTGF is required for mesangial synthesis of fibronectin stimulated by high glucose or glycated albumin , and is thus a potential therapeutic target . . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| CTGF is selectively induced by transforming growth factor beta and des Arg kallidin in lung fibroblasts and increases steady state mRNA levels of alpha type 1 collagen , 5alpha integrin and fibronectin in fibroblasts . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Long term DEX treatment resulted in fibronectin deposition in the kidneys of C57B6 but not SJL mice , and this effect was inhibited by co administration of CTGF anti sense oligodeoxynucleotides . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| CTGF significantly induced cell hypertrophy , increased fibronectin , and collagen 4 secretion in PTCs and CFs . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| Quantitative comparative RT / PCR and real time PCR were used to evaluate the expression of collagen 3 and 4 , fibronectin , tenascin , MMP 2 , CTGF , E cadherin and cadherin 11 genes , as well as those of the Smad signalling pathway . ^^^ |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29279 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|