| Interacting proteins: Q07687 and P28360 |
Pubmed |
SVM Score :0.0 |
| Finally , we show that the expression patterns of representative Msx and Dlx genes ( Msx 1 , Msx 2 , Dlx 2 , and Dlx 5 ) overlap in mouse embryogenesis during limb bud and craniofacial development , consistent with the potential for their protein products to interact in vivo . ^^^ |
|
| Interacting proteins: Q07687 and P28360 |
Pubmed |
SVM Score :0.0 |
| Candidate genes for clefting , including TGFA , BCL 3 , DLX 2 , MSX 1 , and TGFB 3 , were screened for LD with either CL / P or CPO in a predominantly Caucasian population , with both case control and nuclear family based approaches . ^^^ In addition , a mutation search in the genes DLX 2 , MSX 1 , and TGFB 3 was performed in 69 CPO patients and in a subset of the CL / P patients . ^^^ |
|
| Interacting proteins: Q07687 and P28360 |
Pubmed |
SVM Score :0.0 |
| Although the maintenance of molar mesenchymal Dlx 2 expression at the bud stage is Msx 1 dependent , both the maintenance of Dlx 1 expression and the initial activation of mesenchymal Dlx 1 and Dlx 2 expression during the lamina stage are not . ^^^ Moreover , in contrast to the tooth bud stage arrest observed in Msx 1 mutants , Msx 1 , Msx 2 double mutants exhibit an earlier phenotype closely resembling the lamina stage arrest observed in Dlx 1 , Dlx 2 double mutants . ^^^ Indeed , as predicted by such a model , BMP 4 and FGF 8 , epithelial signals that induce differential Msx 1 and Msx 2 expression in dental mesenchyme , also differentially induce Dlx 1 and Dlx 2 expression , and do so in an Msx 1 independent manner . ^^^ These results integrate Dlx 1 , Dlx 2 and Fgf 3 and Fgf 8 into the odontogenic regulatory hierarchy along with Msx 1 , Msx 2 and Bmp 4 , and provide a basis for interpreting tooth induction in terms of transcription factors which , individually , are necessary but not sufficient for the expression of downstream signals and therefore must act in specific combinations . . ^^^ |
|
| Interacting proteins: Q07687 and P28360 |
Pubmed |
SVM Score :0.0 |
| Biomineralization , life time of odontogenic cells and differential expression of the two homeobox genes MSX 1 and DLX 2 in transgenic mice . ^^^ More specifically , Msx 1 , Msx 2 , and Dlx 2 homeobox genes contribute to the initial patterning of the dentition . ^^^ Transgenic mice produced with LacZ reporter constructs for Dlx 2 and Msx 1 were used to detect different components of the gene expression patterns with the sensitive beta galactosidase histoenzymology . ^^^ |
|
| Interacting proteins: Q07687 and P28360 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of a Bmp 4 transgene driven by the mouse Msx1promoter in the dental mesenchyme restored the expression of Lef 1 and Dlx 2 but neither Fgf 3 nor syndecan 1 in the Msx 1 mutant molar tooth germ . ^^^ |
|
| Interacting proteins: Q07687 and P28360 |
Pubmed |
SVM Score :0.0 |
| Expression of homeobox gene Msx 1 , Msx 2 and Dlx 2 during murine mandibular first molar development ] . ^^^ OBJECTIVE : To observe the expression of homeobox gene Msx 1 , Msx 2 and Dlx 2 during murine mandibular first molar development . ^^^ Msx 1 , Msx 2 and Dlx 2 RNA probes were synthesized by in vitro transcription and labeled with digoxigenin . ^^^ Msx 1 , Msx 2 and Dlx 2 mRNA expression was observed after in situ hybridization . ^^^ CONCLUSIONS : Msx 1 , Msx 2 and Dlx 2 are expressed in various patterns during murine mandibular first molar development , suggesting they possibly play a role in the interaction between the epithelium and mesenchyme during the molar development . . ^^^ |
|
| Interacting proteins: Q07687 and P28360 |
Pubmed |
SVM Score :0.0 |
| Transcripts encoding a set of homeobox proteins involved in craniofacial development , such as Pax 9 , Msx 1 , Cbfa 1 , Dlx 2 and 5 were also expressed albeit at a different level . ^^^ |
|
| Interacting proteins: Q07687 and P28360 |
Pubmed |
SVM Score :0.0 |
| NA |
|