| Interacting proteins: P23760 and P28360 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23760 and P28360 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23760 and P28360 |
Pubmed |
SVM Score :0.0 |
| Somites that label for Msx 1 ( nlacZ ) transgene expression in the forelimb region partially overlap with those that contribute Pax 3 expressing cells to the forelimb . ^^^ We show that most cells migrating into the wing field express the Msx 1 ( nlacZ ) transgene , together with Pax 3 . ^^^ |
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| Interacting proteins: P23760 and P28360 |
Pubmed |
SVM Score :0.0 |
| Similarly , we show that the homeodomain transcription factor Msx 1 , which like Pax 3 is an early marker of the lateral neural plate , is induced by posterior nonaxial mesoderm and blocked by dominant negative XWnt 8 . ^^^ Together these data support a model in which patterning of the lateral neural plate by Wnt mediated signals is an early event that establishes a posteriolateral domain , marked by Pax 3 and Msx 1 expression , from which Rohon Beard cells and neural crest will subsequently arise . . ^^^ |
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| Interacting proteins: P23760 and P28360 |
Pubmed |
SVM Score :0.0 |
| Msx 1 antagonizes the myogenic activity of Pax 3 in migrating limb muscle precursors . ^^^ Here we show that in chicken embryos , expression of the Msx 1 homeobox gene overlaps with Pax 3 in migrating limb muscle precursors , which are committed myoblasts that do not express myogenic differentiation genes such as MyoD . ^^^ Conversely , ectopic expression of Pax 3 activates MyoD expression , while co ectopic expression of Msx 1 and Pax 3 neutralizes their effects on MyoD . ^^^ Moreover , we find that Msx 1 represses and Pax 3 activates MyoD regulatory elements in cell culture , while in combination , Msx 1 and Pax 3 oppose each other ' s trancriptional actions on MyoD . ^^^ Finally , we show that the Msx 1 protein interacts with Pax 3 in vitro , thereby inhibiting DNA binding by Pax 3 . ^^^ |
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| Interacting proteins: P23760 and P28360 |
Pubmed |
SVM Score :0.0 |
| By analysing Msx 1 ( nlacZ ) expression in a Splotch mutant , we observed that migration of these cells does not depend on Pax 3 , in contrast to other migratory populations such as limb muscle progenitor cells and neural crest cells . ^^^ |
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| Interacting proteins: P23760 and P28360 |
Pubmed |
SVM Score :0.0 |
| We analyzed the spatiotemporal pattern of expression of 15 transcription factors ( Six 1 , Six 4 , Eya 1 , Sox 3 , Sox 2 , Pax 6 , Pax 3 , Pax 2 , Pax 8 , Dlx 3 , Msx 1 , FoxI1c , Tbx 2 , Tbx 3 , Xiro 1 ) during placode development in Xenopus laevis from neural plate to late tail bud stages . ^^^ |
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| Interacting proteins: P23760 and P28360 |
Pubmed |
SVM Score :0.0 |
| Interfering with beta catenin and LEF / TCF inhibits G1 / S transition , neural crest delamination and transcription of various BMP dependent genes , which include Cad6B , Pax 3 and Msx 1 , but not that of Slug , Sox 9 or FoxD 3 . ^^^ |
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| Interacting proteins: P23760 and P28360 |
Pubmed |
SVM Score :0.0 |
| Msx 1 and Pax 3 cooperate to mediate FGF 8 and WNT signals during Xenopus neural crest induction . ^^^ To understand how these signals are integrated , we have analyzed the role of the transcription factors Msx 1 and Pax 3 . ^^^ Using a combination of overexpression and morpholino mediated knockdown strategies in Xenopus , we show that Msx 1 and Pax 3 are both required for neural crest formation , display overlapping but nonidentical activities , and that Pax 3 acts downstream of Msx 1 . ^^^ Msx 1 induces Pax 3 and ZicR 1 cell autonomously , in turn , Pax 3 combined with ZicR 1 activates Slug in a WNT dependent manner . ^^^ Upstream of this , WNTs initiate Slug induction through Pax 3 activity , whereas FGF 8 induces neural crest through both Msx 1 and Pax 3 activities . ^^^ |
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| Interacting proteins: P23760 and P28360 |
Pubmed |
SVM Score :0.0 |
| The results show that Wnt signaling up regulates in a distinct temporal pattern the expression of several genes normally expressed in the dorsal neural tube ( slug , Pax 3 , Msx 1 , FoxD 3 , cadherin 6B ) at `` premigratory ' ' stages . ^^^ While slug is maintained in early migrating crest cells , Pax 3 , FoxD 3 , Msx 1 and cadherin 6B all are down regulated by the start of migration . ^^^ |
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