| Interacting proteins: P28335 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28335 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28335 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28335 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28335 and P50148 |
Pubmed |
SVM Score :0.0 |
| Using fibroblast cell lines derived from wild type and Galphaq / Galpha11 deficient mice , we show that agonist dependent activation of the endogenous receptors for thrombin or lysophosphatidic acid and of the heterologously expressed bradykinin B 2 , vasopressin V1A , endothelin ETA , and serotonin 5 HT2C receptors induced stress fiber formation in either the presence or absence of Galphaq / Galpha11 . ^^^ |
|
| Interacting proteins: P28335 and P50148 |
Pubmed |
SVM Score :0.0 |
| While high affinity agonist binding to the 5 HT2C receptor was increased to a greater extent by Galphaq than by Galphai 2 , the high affinity agonist binding to the 5 HT1A receptor was preferentially enhanced by Galphai 2 coexpression . ^^^ When the two 5 HT receptors were expressed in cells also expressing G proteins , both 5 HT2C and 5 HT1A receptors appear to activate Galphai 2 in preference to Galphaq . ^^^ In contrast , in situ reconstitution data show that 5 HT2C receptors robustly activate Galphaq and marginally activate Galphao or Galphai , whereas 5 HT1A receptors only marginally activate Galphaq and robustly activate Galphao and Galphai . ^^^ |
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