| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| Several naturally occurring SREs containing Ets motifs at different locations to that in the human c fos SRE allow SAP 1 and Elk 1 recruitment in vitro . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| Some members of the Ets family , Ets 1 and Ets 2 , cooperate in transcription with the AP 1 transcription factor , the product of the proto oncogene families , fos and jun , while others , Elk 1 and SAP 1 , form ternary complexes with the serum response factor ( SRF ) . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| SAP 1 , SAP 2 , and ELK 1 form a related subgroup of ETS domain proteins that can form ternary complexes with the transcription factor SRF at the c fos serum response element ( SRE ) . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| Net has sequence similarity in three regions with the ets factors Elk 1 and SAP 1 , which have been implicated in the serum response of the fos promoter . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| The appearance and decay of hyperphosphorylated TCF / Elk 1 containing complexes after stimulation coincide with the activation of mitogen activated protein kinase ( MAPK ) and the induction and repression of c fos and egr 1 , whereas modified TCF / SAP 1 containing complexes decay more slowly . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| Characterization of SAP 1 , a protein recruited by serum response factor to the c fos serum response element . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| Transcriptional activation domains of elk 1 , delta elk 1 and SAP 1 proteins . elk 1 , an ets related gene codes for a sequence specific DNA binding transcriptional activator which in association with serum response factor ( SRF ) forms a ternary complex at the c fos serum response element ( SRE ) . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| Characterization of SAP 1 , a protein recruited by serum response factor to the c fos serum response element . ^^^ We used a yeast genetic screen to isolate cDNAs that encode a protein , SRF accessory protein 1 ( SAP 1 ) , that is recruited to the c fos serum response element ( SRE ) as part of a ternary complex that includes serum response factor ( SRF ) . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| Although all the proteins contain sequences required for ternary complex formation with SRF , only Elk 1 and SAP 1 appear to interact with the c fos SRE efficiently in vivo . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| We have analysed the expression of the genes encoding transcription factors involved in c fos transcriptional regulation , i . e . the serum response factor ( SRF ) and the ETS related proteins ELK 1 and SAP 1 , in a variety of human cell lines . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| Increased SRE binding may reflect a compensation for a decreased binding of other transcription proteins to the c fos promoter , alteration in the phosphorylation status of SRF , or a change in the ternary complex factors Elk 1 or SAP 1 . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| The transcription factors Elk 1 and SAP 1 bind together with serum response factor to the serum response element present in the c fos promoter and mediate increased gene expression . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| Structures of SAP 1 bound to DNA targets from the E 74 and c fos promoters : insights into DNA sequence discrimination by Ets proteins . ^^^ SAP 1 is a member of the Ets transcription factors and cooperates with SRF protein to activate transcription of the c fos protooncogene . ^^^ The crystal structures of the conserved ETS domain of SAP 1 bound to DNA sequences from the E 74 and c fos promoters reveal that a set of conserved residues contact a GGA core DNA sequence . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| SAP 1 and Elk 1 are members of a large group of eukaryotic transcription factors that contain a conserved ETS DNA binding domain and that cooperate with the serum response factor ( SRF ) to activate transcription of the c fos protooncogene . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| Crystal structure of a ternary SAP 1 / SRF / c fos SRE DNA complex . ^^^ The c fos promoter contains a serum response element ( SRE ) that mediates ternary complex formation with the Ets proteins SAP 1 or Elk 1 and the MADS box protein , serum response factor ( SRF ) . ^^^ Here , we report the crystal structure of a ternary SAP 1 / SRF / c fos SRE DNA complex containing the minimal DNA binding domains of each protein . ^^^ |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28324 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|