Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In contrast , DV 7028 had no affinity for 5 HT1A , 5 HT1B and 5 HT1D receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
No significant binding ( Ki greater than 10 mumol / l ) of DAU 6285 to serotonergic 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , and 5 HT 2 receptors as well as to adrenergic alpha 1 , alpha 2 , dopaminergic D 1 , D 2 or muscarinic M 1 M3 receptor subtypes was found . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effect of metergoline ( 1 mg . kg 1 ) , a substance with a very high affinity for the 5 HT1D receptor as well as for the 5 HT1A , 5 HT1B , 5 HT1C and 5 HT 2 receptors , was studied on the responses to 5 HT and sumatriptan . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effects of the following serotoninergic drugs were tested : the 5 HT1A receptor agonist 8 OH DPAT , the 5 HT1B receptor agonist trifluoromethyl phenylpiperazine ( TFMPP ) , CGS 12066 B and RU 24969 , the 5 HT1A / 1B antagonist ( + / ) pindolol , the 5 HT2 / 1C receptor antagonist ritanserin , the 5 HT2 / 1C receptor agonist DL 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane ( DOI ) , the 5 HT 3 receptor antagonist BRL 43694 , the unselective 5 HT receptor antagonist methiothepin , and carbidopa + L 5 hydroxytryptophan ( L 5 HTP ) to achieve a general , unselective stimulation of multiple 5 HT receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT 2 receptor displayed a genomic organization quite different from the 5 HT1A , 5 HT1B and 5 HT1D receptor subtypes . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The results of these and other published studies suggest roles for 5 hydroxytryptamine 1B ( 5 HT1B ) , 5 HT1C , and , possibly , sigma receptors in the mediation of the TFMPP stimulus and indicate a lack of involvement of 5 HT1A , 5 HT 2 , dopaminergic , and adrenergic mechanisms in this behavior . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The role of 5 HT1A and 5 HT1B receptors in spinal nociceptive transmission and in the modulation of NMDA induced behaviour . ^^^ The effects on nociception of intrathecal ( i . th . ) administration of selective 5 HT1A and 5 HT1B agonists were studied in rats . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Recently , we reported on a series of arylpiperazines 4 which exhibit high affinity for the serotonin 5 HT 1A and 5 HT 1B binding sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The anticonflict effect of m CPP ( 0 . 25 mg / kg ) was antagonized by the non selective 5 HT antagonist metergoline ( 1 4 mg / kg ) and by the beta adrenoceptor blocker SDZ 21009 ( 2 and 4 mg / kg ) with affinity for 5 HT1A and 5 HT1B receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Long term mCPP treatment led to a 36 % increase in [ 3H ] 8 hydroxy 2 ( di n propylamino ) tetralin ( [ 3H ] 8 OH DPAT ) binding to 5 HT1a receptors in hippocampus and a 74 % decrease in [ 3H ] ketanserin binding to 5 HT 2 receptors in cortex , while ( ) [ 125I ] iodocyanopindolol ( [ 125I ] CYP ) binding to 5 HT1b receptors in hypothalamus and striatum was unchanged . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These properties were shared by the benzodiazepine anxiolytic chlordiazepoxide but not by the specific 5 HT 2 antagonists ketanserin and altanserin , nor by the 5 HT1A and 5 HT1B antagonists cyanopindolol and pindolol . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In radioligand binding studies anpirtoline displayed submicromolar affinity for 5 HT1A , 5 HT1B and 5 HT 3 receptor recognition sites ( Ki = 151 , 28 and 30 nM , respectively ) and more modest affinity for 5 HT 2 receptor recognition sites ( Ki = 1 . 48 microM ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In the first study , rats were pretreated with saline , a 5 HT1A receptor agonist ( 8 hydroxy 2 ( di n propylamino ) tetralin , 1 . 0 mg / kg ) , a 5 HT1B receptor agonist [ 5 methoyx 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridinyl ) 1H indole butane dioate ( RU 24969 ) , 2 . 5 mg / kg ] or a 5 HT1C / 5 HT 2 receptor agonist ( 2 , 5 dimethoxy 4 iodoamphetamine , 1 . 0 mg / kg ) twice daily for 3 days . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
On the other hand , the non selective 5 HT antagonist metergoline ( 0 . 5 4 mg / kg ) , the 5 HT1A antagonist NAN 190 ( 0 . 5 2 mg / kg ) , the beta adrenoceptor blockers with high affinity for 5 HT1A and 5 HT1B receptors : pindolol and SDZ 21009 ( 2 8 mg / kg ) and the agonist / antagonist of 5 HT1A receptors ipsapirone ( 2 . 5 and 5 mg / kg ) did not affect the 8 OH DPAT induced hypoactivity . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Pretreatment with spiperone ( 5 HT1A / 5 HT2 / D2 antagonist ) , propranolol or CGP361A ( beta adrenoceptor antagonists that also have binding affinities for 5 HT1A and 5 HT1B sites ) and MDL 72222 ( 5 HT 3 antagonist ) did not attenuate DOI induced suppression of food intake . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
On the other hand , the 5 HT1A , 5 HT1B and beta adrenoceptor antagonists pindolol ( 2 mg / kg ) and cyanopindolol ( 2 mg / kg ) , the 5 HT1A receptor agonist / antagonist ipsapirone ( 10 and 35 mg / kg ) and haloperidol ( 0 . 25 and 0 . 5 mg / kg ) showed a tendency towards enhancing the TFMPP or m CPP induced hyperthermia . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The voltammetric DOPAC signal in the Locus coeruleus , used as a measure of NE neuronal activity , was increased after systemic application of the 5 HT1B agonist CGS 12066B , the 5 HT 2 antagonist ritanserin , and , to a lesser extent , by ipsapirone , a 5 HT1A agonist . ^^^ The findings suggest that the NE neuronal system of the Locus coeruleus is stimulated by 5 HT1A and 5 HT1B receptor activation and inhibited by 5 HT 2 receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The results indicate that sertraline and citalopram given repeatedly decrease the responsiveness of 5 HT1A ( presynaptic ) and 5 HT 2 receptors but increase the responsiveness of 5 HT1B receptors to respective agonists . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The non selective 5 HT 1 like and 5 HT 2 receptor antagonist , methiothepin ( 2 . 0 mg / kg , i . p . ) and the beta adrenoceptor antagonist propranolol ( 16 . 0 mg / kg , s . c . ) , which is a putative antagonist at 5 HT1A and 5 HT1B receptor subtypes , significantly potentiated the arousal effect of RU 24969 . ^^^ The putative 5 HT1A and 5 HT1B receptor antagonist , cyanopinolol ( 4 . 0 mg / kg , s . c . ) , mixed 5 HT1A receptor agonist / antagonist MDL 72832 ( 1 . 0 mg / kg , s . c . ) and the alpha 1 adrenoceptor antagonist prazosin ( 2 . 0 mg / kg ) did not affect the vigilance , altered by RU 24969 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
To explore whether the inhibitory actions of endogenous serotonin on rat male sexual behavior were mediated via the stimulation of the 5 hydroxytryptamine1A ( 5 HT1A ) or 5 HT1B receptor subtypes , two series of studies were undertaken . ^^^ In the second series , a possible synergistic effect of a subthreshold dose of 5 HTP ( 12 . 5 mg / kg ) with low doses of the selective 5 HT1B agonist 1 ( m trifluoro methylphenyl ) piperazine ( TFMPP , 0 . 125 mg / kg ) or the selective 5 HT1A agonist 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT , 0 . 0625 mg / kg ) was investigated . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The ability of 5 HT1A and 5 HT1B agonists to alter a spinal animal ' s nociceptive threshold was examined using two analgesiometric tests . ^^^ Similar to the effects noted with 5 HT1A agonists , administration of 5 HT1B agonists RU 24969 , mCPP and TFMPP resulted in a hyperalgesic response with an overall percent maximal increase of 43 + / 6 % for the ventroflexion reflex , 51 + / 6 % for the dorsiflexion reflex and 38 + / 9 % for the lateral flexion reflex . ^^^ In the tail flick analgesiometric test , administration of the 5 HT1A agonists 8 OH DPAT and ipsapirone and the 5 HT1B agonists RU 24969 and mCPP resulted in a significant dose dependent increase in tail flick latencies when compared to predrug baseline values , indicating a decrease in nociceptive sensitivity to noxious thermal stimuli . ^^^ No differences in magnitude of the effect of the two receptor subtypes were found , indicating that stimulation of either 5 HT1A or 5 HT1B receptors was equipotent in producing the antinociceptive tail flick response . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The laminar distribution and density of other high affinity 3H 5 HT binding sites present in rat spinal cord , 5 HT1A , 5 HT1B and 5 HT1C , was also determined . ^^^ A similar spatial pattern of receptor density was observed for 5 HT1A , 5 HT1B and 5 HT1C receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
RU 24969 ( 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydropyridin 4 yl ) 1H indole ) , at doses of 5 . 6 10 mg / kg , and eltoprazine ( 5 . 6 mg / kg ) , both mixed 5 HT1A / B agonists , substituted completely for 8 OH DPAT , whereas 3 . 0 10 mg / kg of the 5 HT1B / C agonist TFMPP ( 1 ( m trifluromethylphenyl ) piperazine ) and 0 . 1 3 . 0 of the 5 HT 3 antagonist MDL 72222 ( 3 tropanyl 3 , 5 dichlorobenzoate ) yielded only saline appropriate responses . ^^^ Substitution for 8 OH DPAT by eltoprazine and RU 24969 , which does not occur in rats , provides in vivo support for the suggestion that the absence of a 5 HT1B receptor in the pigeon allows more complete expression of 5 HT1A mediated effects . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The present study was aimed at characterizing this receptor with respect to the currently recognized 5 HT 1 receptor subtypes ( 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D ) . ^^^ The concentration response curve for 5 carboxamidotryptamine ( 5 CT , a 5 HT 1 like receptor agonist ) was unaffected by propranolol ( 10 microM ) , which is reported to have affinity for 5 HT1A , 5 HT1B and 5 HT1C recognition sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In contrast , pretreatment with various doses of metergoline ( 5 HT1 / 5 HT 2 antagonist ) , propranolol ( beta adrenoceptor antagonist that also has binding affinity for 5 HT1A , 5 HT1B and 5 HT1C sites ) , mesulergine and mianserin ( 5 HT1C / 5 HT 2 antagonists ) attenuated m CPP induced increases in plasma prolactin . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The facilitory effect in infant and young rats was counteracted by methiothepine but not by ritanserin , suggesting that it is mediated through 5 HT1A or 5 HT1B receptor subtypes . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Brain 5 HT1A and 5 HT1B receptors are important targets for drug induced modulation of 5 HT function in vivo . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Functional interaction between 5 HT1B and 5 HT1A or 5 HT 2 receptors in mice . ^^^ The present results suggest that a functional interaction exists between 5 HT1B and 5 HT1A or 5 HT 2 receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
We performed acute dose response and time course behavioral studies in 1 day old rats with the putative selective agonists 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) ( 5 HT1A ) , 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydropyridin 4 yl ) 1H indole ( RU 24969 ) ( 5 HT1B ) , and ( + ) 1 ( 2 , 5 dimethoxy 4 iodo phenyl aminopropane ) 2 ( DOI ) ( 5 HT2 / 1C ) . ^^^ These studies suggest that functional and differential activity of 5 HT1A , 5 HT1B , and 5 HT2 / 1C receptors occurs much earlier in the rat than previously appreciated . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Furthermore , SR 46349B displayed moderate affinity for the 5 HT1C receptor and had no affinity for the other 5 HT 1 subclass ( 5 HT1A , 5 HT1B or 5 HT1D ) , dopamine ( D 1 or D 2 ) , `` alpha ' ' adrenergic ( alpha 1 or alpha 2 ) , sodium and calcium channel and histamine ( H 1 ) receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Rats were treated by intraperitoneal injection for four weeks with either RU 24969 , a 5 HT1B and 5 HT1A agonist or imipramine , a 5 HT uptake inhibitor . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
However , when 1 [ 1H Indol 4 yloxy ] 3 [ isopropylamino ] 2 propanol ( pindolol ) , a drug that acts at both beta adrenergic receptors and at 5 HT1A and 5 HT1B receptors , was coadministered with quipazine there was a reversal of the quipazine effect on aggression only in TP dominant rats . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These data suggest that the 5 HT induced increase in intragastric pressure in the spinal and bilaterally vagotomized rat is mediated by an atypical 5 HT 1 like receptor , which , based on the low agonist potency of 5 carboxamidotryptamine and RU 24969 and the resistance to blockade by metergoline , does not seem to correspond to either the 5 HT1A , 5 HT1B , 5 HT1C or the 5 HT1D receptor subtypes . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The eltoprazine stimulus generalized to the structurally related experimental drug fluprazine , the mixed 5 HT1a / 1b agonist 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydropyridinyl ) 1H indole , ( RU 24969 ) , the 5 HT1b / 1c agonist 1 [ 3 ( trifluoromethyl ) phenyl ] piperazine , ( TFMPP ) , the 5 HT1a agonist 8 hydroxy 2 ( di n propylamino ) tetralin HB , ( 8 OH DPAT ) , and the beta adrenergic / 5 HT 1 antagonists ( + / ) pindolol and ( + / ) propranolol . ^^^ The eltoprazine cue partially generalized to the cues of the 5 HT1a agonists flesinoxan and buspirone , ( m CPP ) , the 5 HT1b / 1c agonist 1 , 3 chlorophenyl piperazine dihydrochloride and the 5 HT1c / 2 antagonist mesulergine , and did not generalize to the 5 HT2 / 1c agonist DOI . ^^^ The present data show that eltoprazine can serve as a discriminative stimulus in rats and suggest that specifically 5 HT 1 ( i . e . , 5 HT1a and 5 HT1b ) receptors are involved in the stimulus properties of eltoprazine . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Selective agonists exist for the 5 HT1A , 5 HT1B and 5 HT 3 receptors and selective antagonists for the 5 HT 2 and 5 HT 3 receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The amplitude of the GABAB synaptic potential was reduced by the 5 HT1B receptor agonists 1 [ 3 ( trifluoromethyl ) phenyl ] piperazine ( 300 nM ) and 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo [ 1 , 2 a ] quinoxaline ( 1 microM ) , but not by the 5 HT1A agonist N , N dipropyl 5 carboxamidotryptamine ( 1 microM ) or the 5 HT 2 agonist ( + / ) 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 amino propane ( 10 microM ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Autoradiographic analyses of the effects of adrenalectomy and corticosterone on 5 HT1A and 5 HT1B receptors in the dorsal hippocampus and cortex of the rat . ^^^ Quantitative autoradiography was used to evaluate the effects of adrenalectomy ( ADX ) and corticosterone ( CORT ) on binding at 5 HT1A and 5 HT1B receptors in the dorsal hippocampus and cortex of the rat . ^^^ It is suggested that decreases in binding at 5 HT1A and 5 HT1B / 1D receptors resulting from chronic exposure to high levels of CORT may also occur in animals that fail to adapt to chronic severe stress . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Concentration response relationships for 8 hydroxy 2 ( di n propylamino ) tetralin ( 5 HT1A agonist ) ( 0 . 3 100 microM ) , CGS 12066B maleate ( 5 HT1B agonist ) ( 0 . 01 30 microM ) , alpha methylserotonin maleate ( 5 HT 2 agonist ) ( 0 . 01 30 microM ) , 1 ( m chlorophenyl ) biguanide ( 5 HT 3 agonist ) ( 0 . 1 100 microM ) and serotonin ( 0 . 1 300 microM ) were studied in vitro using 2 mm segments of bovine proximal left anterior descending coronary artery . ^^^ Contractions induced by 8 hydroxy 2 ( di n propylamino ) tetralin or alpha methylserotonin maleate were attenuated by pretreatment with S ( ) propranolol ( 2 . 6 microM ) , a relatively selective 5 HT1A and 5 HT1B receptor antagonist , and ketanserin ( 0 . 3 microM ) , a selective 5 HT 2 receptor antagonist , respectively . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Stimulation of 5 HT1A and 5 HT1B receptors in brain regions and its effects on male rat sexual behaviour . ^^^ In the present series of experiments we compared the effect of injecting serotonin ( 40 micrograms / cannula ) , the 5 HT1A agonist , 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) ( 5 . 0 micrograms / cannula ) , and the 5 HT1B / C agonist , trifluoromethyl phenyl piperazine ( TFMPP ) ( 1 . 0 micrograms / cannula ) , into the preoptic area , the nucleus accumbens and the nucleus raphe dorsalis . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Our results show that agents stimulating the 5 HT1a receptor ( 8 OH DPAT ) or the 5 HT1b receptor ( TFMPP ) or substances which release serotonin ( fenfluramine ) had no effect on the development of spinal serotonergic pathways . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
No 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , 5 HT 2 , or 5 HT uptake sites were found in any of the tumors , although all were detected in human or rat brain . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The respective 5 HT1A and 5 HT1B agonists , ( + / ) 8 hydroxydipropylaminotetralin ( 0 . 50 mg / kg s . c . ) and CGS 12066B maleate ( 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo [ 1 , 2 alquinoxaline ] , 1 : 2 maleate salt ; 3 . 0 mg / kg i . p . ) , did not increase oral activity . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The deduced amino acid sequence of HGCR 1 is 39 % , 55 % and 87 % identical to that for the human 5 HT1A , the human 5 HT1D and the rat 5 HT1B receptor , respectively . [ 3H ] 5 HT binding to transfected COS 7 cell membranes yields a pharmacological profile similar to that of 5 HT1B receptor . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Binding assays with rat brain membranes have shown that anpirtoline bound with a much higher affinity to 5 HT1B receptor ( Ki = 28 nM ) than to 5 HT1A ( Ki = 150 nM ) and 5 HT 2 ( Ki = 1 . 49 microM ) receptors . 3 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
By contrast , neither amoxapine nor amitriptyline can be considered as possible ligands of 5 HT1A and 5 HT1B receptors because their affinities for these sites are in the micromolar range ( or even worse ) . ^^^ By contrast , neither 5 HT1A nor 5 HT1B receptors were significantly affected in any brain region studied . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
At least seven receptor subtypes ( 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , 5 HT 2 , 5 HT 3 , 5 HT 4 ) have been identified in brain . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The biochemical and behavioural effects of isamoltane , a beta adrenoceptor and 5 HT1B receptor antagonist that has higher affinity for 5 HT1B receptors than for 5 HT1A receptors , on 5 HT neurotransmission in the rat brain were examined . ^^^ In binding experiments isamoltane was found to be about five times more potent as a ligand for the 5 HT1B receptor than for the 5 HT1A receptor ( Ki values 21 and 112 nmol / l , respectively ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
It displayed weak affinity for 5 HT1A ( pIC 50 = 5 . 9 ) and 5 HT1B ( pKi = 5 . 5 ) binding sites in rat brain . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Interaction of the alpha adrenoceptor agonist oxymetazoline with serotonin 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D receptors . ^^^ Oxymetazoline was recognized with nanomolar affinity by 5 HT1A , 5 HT1B and 5 HT1D binding sites and mimicked the effects of 5 hydroxytryptamine with about the same potency and intrinsic activity as the endogenous amine in the corresponding functional tests . ^^^ Thus , oxymetazoline is a full and potent agonist at 5 HT1A , 5 HT1B and 5 HT1D receptors and a partial agonist at 5 HT1C receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Much higher concentrations of ACTH ( 1 24 ) , up to 10 ( 4 ) M , were needed for the displacement of appropriate radiolabelled ligands from dopamine D 1 receptors , serotonin 5 HT1A , serotonin 5 HT1B , muscarinic M 1 acetylcholine and histamine H 1 receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The anticonflict effect of ipsapirone ( 5 mg / kg ) was dose dependently antagonized by the 5 HT1A receptor , alpha 1 adrenoceptor and dopamine receptor antagonist , NAN 190 ( 0 . 25 1 mg / kg ) and by the beta adrenoceptor blocker , SDZ 21009 , which also has a high affinity for 5 HT1A and 5 HT1B receptors ( 2 8 mg / kg ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The anti immobility effect of gepirone ( 10 mg / kg ) was dose dependently antagonized by the 5 HT1A receptor and alpha 1 adrenoceptor antagonist , NAN 190 ( 0 . 25 and 0 . 5 mg / kg ) , the beta adrenoceptor blocker with the affinity for 5 HT1A and 5 HT1B receptors , pindolol ( 2 and 4 mg / kg ) , the 5 HT1A , 5 HT 2 and dopamine receptor blocker spiperone ( 0 . 01 and 0 . 03 mg / kg ) and by the dopamine receptor antagonist , haloperidol ( 0 . 125 and 0 . 25 mg / kg ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Putative 5 HT1A agonists ( 8 OH DPAT , ipsapirone , and buspirone ) and 5 HT1B agonists ( TFMPP and m CPP ) affected neither basal nor forskolin dependent cyclic AMP accumulation . ^^^ Receptor binding studies suggest that NCB 20 cells are devoid of 5 HT1A and 5 HT1B receptor sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In addition , the drugs with antagonistic properties at the 5 HT1A , 5 HT1B , 5 HT1C , and 5 HT1D receptors block other 5 HT receptors or even entirely different receptors ( e . g . , beta adrenoceptors ) ; as a rule , they do not discriminate between the four 5 HT receptor subtypes . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT1A agonist , ( + ) 8 hydroxy 2 ( di N propylamino ) tetralin hydrobromide ( 8 OH DPAT ) and 5 HT1B agonist , m trifluoromethylphenylpiperazine HCl ( TFMPP ) , had no effect on flexion at 72 h in the intact rat but reduced rebound . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Administration of the nonselective 5 HT agonist quipazine , the 5 HT 1 agonist mCPP , the 5 HT 1a agonist 8 OH DPAT , the 5 HT 1b agonist CGS 12066B , and the 5HT 1c / 2 agonist DOI did not inhibit d amphetamine stimulated locomotor activity . ^^^ The combination of the 5 HT 1a agonist 8 OH DPAT and the 5 HT 1b agonist CGS 12066B , however , did inhibit d amphetamine stimulated locomotor activity . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
High affinity [ 3H ] 5 HT binding was unchanged using assay conditions [ 1 microM ( + / ) pindolol and 1 microM ( R ) ( + / ) SCH 23390 ) to pharmacologically mask 5 HT1A , 5 HT1B , and 5 HT1C receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In the rat , S CM GTNH 2 is 57 and 24 times more potent at 5 HT1B sites ( IC 50 = 28 nM ) than at 5 HT1A ( IC 50 = 1600 nM ) and 5 HT1C sites ( IC 50 = 670 nM ) , respectively . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
At this time , there is a general consensus that the 5 HT 1 family can be further subdivided into 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , and 5 HT1P subpopulations . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The inhibitory effect of TFMPP was mimicked by CGS 12066B ( 10 , 30 , and 100 microM ) , a 5 hydroxytryptamine1B ( 5 HT1B ) / 5 HT1D receptor agonist ; 1 ( m chlorophenyl ) piperazine ( 100 microM ) , a 5 HT1C / 5 HT1B receptor agonist ; and 5 carboxamidotryptamine ( 10 microM ) , a nonselective 5 HT 1 receptor agonist . 8 Hydroxy 2 ( di n propylamino ) tetralin ( 10 and 100 microM ) , a 5 HT1A receptor agonist , and quipazine ( 10 and 100 microM ) , a 5 HT 2 receptor agonist , did not have any significant effect . ^^^ These data suggest that , in guinea pig hippocampus , the K ( + ) evoked ACh release is modulated by a 5 HT 1 receptor distinct from the 5 HT1A , 5 HT1B , and 5 HT1C subtypes . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT receptor agonists examined in this study included the 5 HT1A agonist 8 hydroxy N , N dipropyl 2 aminotetralin ( 8 OH DPAT ) , the 5 HT1B agonist m trifluoromethylphenylpiperazine ( TFMPP ) , the 5 HT 2 agonist 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane ( DOI ) and the 5 HT 3 agonist phenylbiguanide ( PBG ) . 3 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
We describe the effects of central 5 HT depletion 1 ) on the behaviour of resident TMD S 3 rats in a territorial situation , 2 ) on the efficacy of eltoprazine to inhibit offensive aggression , and 3 ) on the 5 HT1A , 5 HT1B and 5 HT1C receptor binding in brains of rats previously used in behavioural studies . ^^^ Quantitative autoradiographic studies 5 weeks after 5 , 7 DHT treatment revealed a significant increase in radioligand binding to 5 HT1A , 5 HT1B and 5 HT1C sites in many brain regions studied , except for the raphe nuclei where [ 3H ] 8 OH DPAT binding to 5 HT1A sites was markedly reduced . ^^^ The 5 , 7 DHT induced overall upregulation of 5 HT1A , 5 HT1B and 5 HT1C binding sites suggests that these three receptor subtypes receive a tonic serotonergic influence . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Clonidine ( an alpha 2 agonist ) and 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT , a 5 HT1A agonist ) induced hyperphagia and 1 ( 3 trifluoromethylphenyl ) piperazine ( TFMPP , a 5 HT1B agonist ) induced hypophagia dose dependently in both rat lines . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Autoradiographic mapping of 5 HT 1 , 5 HT1A , 5 HT1B and 5 HT 2 receptors in the rat spinal cord . ^^^ The distribution of 5 HT 1 , 5 HT1A , 5 HT1B and 5 HT 2 receptors in the rat spinal cord was investigated with quantitative autoradiography . ^^^ It is shown that 5 HT 1 , 5 HT1A and 5 HT1B receptors are distributed within the spinal cord according to a rostro caudal gradient . ^^^ Both 5 HT 1 and 5 HT1A receptors are mainly present in the dorsal horn and 5 HT1B is present throughout the spinal cord , exhibiting high densities in the caudal most part of the dorsal horn in lamina 10 and in the sacral parasympathetic area . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Role of presynaptic serotonergic receptors on the mechanism of action of 5 HT1A and 5 HT1B agonists on masculine sexual behaviour : physiological and pharmacological implications . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Good correlations were found between species in the regional distribution of 5 HT 1 sites labelled with [ 3H ] 5 HT ( r = 0 . 73 ) , 5 HT1A sites labelled with [ 3H ] 8 OH DPAT ( r = 0 . 87 ) , and 5 HT1B versus 5 HT1D sites labelled with [ 3H ] 5 HT in the presence of ipsapirone and DOI ( r = 0 . 76 ) . ^^^ The distribution of [ 3H ] eltoprazine binding sites showed a good correlation with that of the 5 HT1B sites in rat ( r = 0 . 89 ) , and with that of the 5 HT1A sites in guinea pig ( r = 0 . 97 ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Since galanin in vitro selectively increases the KD value of 5 HT1A receptors without altering the binding of 5 HT1B or 5 HT 2 receptors , we have studied whether 5 HT1A receptor activation in turn may affect galanin binding in the ventral di and telencephalon and the substantia nigra of the rat . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The maximal density of [ 3H ] 8 hydroxy 2 ( di n propylamino ) tetralin [ ( 3H ] 8 OH DPAT ) binding ( Bmax ) to 5 HT1a receptors was decreased by 25 and 17 % in the hippocampus during chronic ethanol intoxication and withdrawal , respectively . [ 3H ] Ketanserin binding to 5 HT 2 receptors in the cortex , ( ) [ 125I ] iodo cyanopindolol [ ( 125I ] CYP ) binding to 5 HT1b receptors in the striatum and hypothalamus , and [ 3H ] 8 OH DPAT binding in the cortex were not affected by chronic ethanol administration . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Various 5 HT1A receptor agonists were found to inhibit carbachol ( 10 microM ) stimulated formation of total inositol phosphates in immature rat hippocampal slices with the following rank order of potency ( IC 50 values in nM ) : 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) ( 11 ) greater than ipsapirone ( 20 ) greater than gepirone ( 120 ) greater than RU 24969 ( 140 ) greater than buspirone ( 560 ) greater than 1 ( m trifluoromethylphenyl ) piperazine ( 1 , 500 ) greater than methysergide ( 5 , 644 ) ; selective 5 HT1B , 5 HT 2 , and 5 HT 3 receptor agonists were inactive . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The stimulatory action of 2 Me 5 HT and phenylbiguanide was blocked completely by granisetron , ondansetron and ICS 205 930 but not by other receptor antagonists such as ( + / ) pindolol ( a beta , 5 HT1A and 5 HT1B receptor antagonist ) , methy sergide ( a 5 HT 1 and 5 HT 2 receptor antagonist ) , ritanserin ( a 5 HT1C and 5 HT 2 receptor antagonist ) , SR 95103 ( gamma aminobutyric acidA receptor antagonist ) , scopolamine ( a muscarinic antagonist ) , ( ) eticlopride ( a D 2 receptor antagonist ) , SCH 23390 ( a D 1 5 HT2 / 1C receptor antagonist ) and prazosin ( an alpha 1 receptor antagonist ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
It is concluded that the anti idiotypic antibodies generated with anti 5 HT serum recognize the 5 HT1B , 5 HT1C , and 5 HT 2 receptor subtypes ; however , neither 5 HT1A receptors nor 5 HT uptake sites appear to react with these antibodies . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Receptor binding parameters in temporal cortex homogenates were assessed using [ 3H ] 5 HT in the presence of 100 nM 8 OH DPAT , 1 microM propranolol and 1 microM mesulergine to prevent labelling of the 5 HT1A , 5 HT1B and 5 HT1C sites , respectively . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Calculated ID 50 values correlated significantly with reported affinities ( r = 0 . 81 , n = 10 , P less than 0 . 01 ) for 5 HT1C but not for 5 HT 2 , 5 HT1A , 5 HT1B or 5 HT1D receptors . 2 . ^^^ ID 50 values of the ten antagonists against 5 hydroxytryptophan ( 5 HTP ) + carbidopa induced head shakes ( a 5 HT 2 mediated response ) correlated significantly ( r = 0 . 81 , n = 10 , P less than 0 . 01 ) with their affinities for 5 HT 2 but not for 5 HT1A , 5 HT1B , 5 HT1C or 5 HT1D receptors . 3 . ^^^ These ratios correlated highly significantly ( r = 0 . 91 , n = 10 , P less than 0 . 001 ) with the ratios of the affinities of the drugs for 5 HT1C ( but not for 5 HT1A , 5 HT1B or 5 HT1B or 5 HT1D receptors ) and with their affinities for 5 HT 2 receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Autoradiograms from brain sections incubated with 0 . 02 nM S CM G [ 125I ] TNH 2 showed a heterogeneous anatomical distribution of the labelling with high densities in regions rich in 5 HT1B or 5 HT1D binding sites , and with no labelling of those rich in 5 HT1A or 5 HT1C sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT 2 antagonists ( ketanserin , methergoline and methiothepin ) were potent antagonists . ( ) Alprenolol ( 5 HT1A and 5 HT1B receptor antagonist ) and the 5 HT 3 receptor antagonist , ICS 205 930 , were without an antagonistic effect . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Daily administration of LSD [ 130 micrograms / kg ( 0 . 27 mumol / kg ) intraperitoneally ( IP ) ] for 5 days produced a decrease in serotonin 2 ( 5 hydroxytryptamine 2 , 5 HT 2 ) binding in cortex ( measured 24 hours after the last drug administration ) but did not affect binding to other receptor systems ( 5 HT1A , 5 HT1B , beta adrenergic , alpha 1 or alpha 2 adrenergic , D 2 dopaminergic ) or to a recognition site for 5 HT uptake . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Since it was previously shown that the behavioural deficit was reduced by agonists at 5 HT1B receptors , it is proposed that the behavioural inhibition , resulting from an isolation induced increase in reactivity is bi directionally modulated by serotonergic drugs , where 5 HT1A agonists increase and 5 HT1B agonists decrease this inhibition . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The initial inhibitory phase of the dose response curve was not antagonized by naltrexone ( 300 nM ) , idazoxan ( 300 nM ) or propranolol ( 300 nM ) , indicating that neither opioid , alpha 2 nor beta receptors were involved in the inhibition . ( + / ) Cyanopindolol ( 300 nM ) was also devoid of any antagonist activity versus 8 OH DPAT , showing that the effect of the compound is not due to 5 HT1A or 5 HT1B agonist activity . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Eltoprazine interacts selectively with serotonin ( 5 HT ) receptor subtypes ( Ki values for 5 HT1A , 5 HT1B and 5 HT1C receptors are 40 , 52 and 81 nM respectively ) . ^^^ Taken together from a variety of neurochemical studies there is strong evidence both in vitro and in vivo that the pharmacological actions of eltoprazine can be attributed to an interaction with the 5 HT system , most probably via a ( partial ) agonistic action on 5 HT1A and 5 HT1B receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The other subtype agonists , such as ( + / ) 8 hydroxy dipropylaminotetralin hydrobromide ( 5 HT1A agonist ) , 1 ( 3 chlorophenyl ) piperazine dihydrochloride and 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo ( 1 , 2 a ) quinoxaline ( 5 HT1B ) and 2 methyl serotonin maleate ( 5 HT 3 ) , only elicited a small percentage of the maximum contraction to 5 HT . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT1A receptor agonist 8 OH DPAT , the 5 HT1B receptor agonist RU 24969 , the 5 HT 2 receptor agonists DOI , MK 212 and alpha methyl 5 HT and the 5 HT 3 agonist 2 methyl 5 HT all dose dependently inhibited the pressor response and dose dependently elevated the visceromotor threshold to noxious CRD . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Inhibition after i . c . v . administration was produced by 8 OH DPAT ( 5 HT1a ) , RU 24969 ( 5 HT1b ) , and 2 methyl serotonin ( 5 HT 3 ) , but not DOI ( 5 HT 2 ) which augmented propulsion . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
This demonstrates the preferential affinity of S CM GTNH 2 for 5 HT1B versus 5 HT1A and 5 HT1C binding sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Constriction of porcine arteriovenous anastomoses by indorenate is unrelated to 5 HT1A , 5 HT1B , 5 HT1C or 5 HT1D receptor subtypes . ^^^ These effects of indorenate were not appreciably modified after treatment with the 5 HT 2 receptor antagonist ketanserin ( 0 . 5 mg . kg 1 i . a . ) , but were markedly reduced after treatment with methiothepin ( 1 . 0 mg . kg 1 i . a . ) , which antagonizes not only 5 HT 2 receptors , but also the putative 5 HT1A , 5 HT1B 5 HT1C and 5 HT1D subtypes of 5 HT 1 like receptors . ^^^ It is therefore concluded that , like 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) and 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridinyl ) 1H indole ( RU 24969 ) , indorenate reduces both total common carotid and cephalic arteriovenous anastomotic blood flow in the pig by stimulating 5 HT 1 like receptors ; these receptors , however , do not seem to correspond to either 5 HT1A , 5 HT1B , 5 HT1C or 5 HT1D binding sites . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT 1 receptor family comprises five different pharmacologic subtypes , designated 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , and 5 HT1E , whose common property is to bind 5 HT with nanomolar affinity . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
As expected , 8 OH DPAT , a selective 5 HT1A receptor agonist , stimulated , and 5 HT1B agonists CGS 12066B and 1 ( trifluoromethylphenyl ) piperazine ( TFMPP ) failed to stimulate the 5 HT syndrome induced in rats by pargyline and 5 HTP administration . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Furthermore , 5 HT 1 receptors are not a homogeneous class , but are subdivided further into four subtypes : 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Among the most potent antagonists ( mean pKB value ) were the nonselective 5 HT receptor antagonists , methiothepin ( 7 . 30 ) and metergoline ( 6 . 86 ) , the 5 HT1A / 5 HT1D receptor ligand , 1 [ 2 ( 4 amino phenyl ) ethyl ] 4 ( 3 trifluoromethylphenyl ) piperazine ( 7 . 02 ) , the 5 HT1A / 5 HT1B / 5 HT1D receptor ligand , 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo [ 1 , 2 , a ] quinoxaline 1 ( 6 . 73 ) and yohimbine ( 6 . 37 ) . ^^^ Beta adrenoceptor antagonists with affinity for 5 HT1A and 5 HT1B receptors weakly antagonized the effect of 5 carboxamidotryptamine ( pKB values less than or equal to 5 . 32 ) , as did the 5 HT1c / 5 HT 2 receptor antagonist , mesulergine ( 5 . 30 ) and the yohimbine isomer , corynanthine ( 4 . 85 ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Experimental lesions followed by binding of [ 3H ] 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) , [ 125I ] cyanopindolol and [ 3H ] paroxetine to cryostat sections and coverslip autoradiography were used to localize 5 HT1A , 5 HT1B and 5 HT uptake sites in rat posterior cingulate cortex . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The purpose of the present study was to characterize the cardiorespiratory effects of activation of 5 HT1A , 5 HT1B and 5 HT 2 receptor subtypes at the intermediate area of the ventral surface of the medulla . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effect of the putative 5 HT1A agonists 8 OH DPAT and ipsapirone and 5 HT1B agonists TFMPP and m CPP on respiratory activity in rats has been examined . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Presently , 5 TH receptors have been divided into 5 HT 1 , 5 HT 2 and 5 HT 3 . 5 HT 1 receptors have been subdivided into 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
RU 24969 induced emesis in the cat : 5 HT 1 sites other than 5 HT1A , 5 HT1B or 5 HT1C implicated . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Preweanling ( postnatal day 17 18 ) Sprague Dawley rat pups were tested in both the absence and presence of milk following administration of various doses of the 5 HT1A agonists 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) or ipsapirone , the 5 HT1B agonist 1 ( 3 chlorophenyl ) piperazine ( mCPP ) or the 5 HT 2 agonist 1 ( 2 , 5 dimethoxy 4 iodo phenyl ) 2 aminopropane ( DOI ) . 8 OH DPAT decreased mouthing while ipsapirone , mCPP and DOI had no effect upon this behavior . ^^^ These functional responses to 5 HT1A , 5 HT1B and 5 HT 2 agonists in preweanling pups vary from those observed previously in neonates . ^^^ For instance , whereas inhibitory effects of 5 HT1A stimulation on mouthing are observed in both neonatal and preweanling pups , facilitory effects of 5 HT1B and 5 HT 2 stimulation are only seen in neonates . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The role of spinal cord 5 HT1A and 5 HT1B receptors in the modulation of a spinal nociceptive reflex . ^^^ The results show that in the mouse i . th . injection of both 5 HT1A and 5 HT1B receptor agonists has the ability to inhibit the tail flick reflex without interfering with the tail skin temperature . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The distribution pattern differs from that of other previously described receptors or binding sites ( e . g . monoamine oxidase , benzodiazepine , tryptamine , 5 hydroxytryptamine receptors ( 5 HT1A , 5 HT1B , 5 HT1C , 5HT2 ] , which suggests that a unique class of [ 3H ] norharman binding sites exists in the rat brain . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT 1 sites have been further divided into 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D and 5 HT1E sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Whereas tryptamine derivatives generally display little selectivity for the various populations of 5 HT receptors , N 1 n propyl 5 methoxy alpha methyltryptamine ( 3h ) binds with significant affinity ( Ki = 12 nM ) and selectivity at 5 HT 2 receptors relative to 5 HT1A ( Ki = 7100 nM ) , 5 HT1B ( Ki = 5000 nM ) , 5 HT1C ( Ki = 120 nM ) , and 5 HT1D ( Ki greater than 10 , 000 nM ) receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The prejunctional inhibitory receptor has been the most studied ; depending on the tissue , these subtypes may resemble 5 HT1A , 5 HT1B , 5 HT1C or 5 HT1D binding sites , or the contractile receptor in dog saphenous vein . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Serotonin ( 0 . 5 100 microM ) and the specific 5 HT 2 receptor agonist , 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane ( DOI ) ( 10 100 microM ) but not the 5 HT1A or 5 HT1B agonists , ( + / ) 8 hydroxy dipropylamino tetralin ( 8 OH DPAT ) or 5 methoxy 3 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridin ) 1H indole succinate ( RU 24969 ) induced dose dependent PKC translocations . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The mixed 5 HT 1A and 5 HT 1B agonist RU 24969 reversed catalepsy only at the highest dose tested . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The potencies of these agonists in inhibiting overflow were significantly correlated with their affinities for 5 HT1B and 5 HT1D binding sites , but not with those for 5 HT1A or 5 HT1C binding sites . 5 Aminotryptamine , methysergide , ipsapirone , cyanopindolol , SDZ 21009 and metergoline dit not produce a significant inhibition . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In view of the appreciable affinity of DP 5 CT for the 5 HT1D receptor subtype , the effects of the mixed 5 HT1B / 5 HT1D receptor agonist 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo ( 1 , 2 a ) quinoxaline ( CGS 12066B ) , and the mixed 5 HT1A / 5 HT1B / 5 HT1D receptor agonist 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydropyridine 4 yl ) 1H indole ( RU 24969 ) were also investigated . ^^^ The data suggest that central 5 HT1A receptors , but neither 5 HT1B nor 5 HT1D receptors , regulate plasma adrenaline and glucose levels . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Yet , regions enriched in 5 HT1A and 5 HT1C sites ( e . g . dentate gyrus and choroid plexus , respectively ) revealed relatively more [ 3H ] 5 HT binding as compared to [ 3H ] eltoprazine binding , whereas [ 3H ] eltoprazine binding was more pronounced in 5 HT1B receptor dense areas such as the dorsal subiculum , substantia nigra , ventral pallidum and globus pallidus . ^^^ The pharmacological and anatomical data indicate that eltoprazine binds to 5 HT1A , 5 HT1B and to a lesser extent to 5 HT1C binding sites in the rat brain . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The purpose of the present experiments was to determine whether serotonin 1A ( 5 HT1A ) and serotonin 1B ( 5 HT1B ) binding sites , recently characterized in the spinal cord of the rat , mediate differential effects of 5 HT on spinal nociceptive processing . ^^^ Several days after spinal transection at T 10 , rats were injected intraperitoneally at 20 min intervals , with increasing doses ( 0 , 0 . 1 , 0 . 4 , 2 . 0 , 9 . 0 mg / kg ) of either a 5 HT1A selective agonist ( 8 OH DPAT , buspirone ) or a 5 HT1B agonist ( mCPP , TFMPP ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
This rotationally restricted phenolic analogue of RU 24 , 969 is a potent ( 15 nM ) and selective ( 200x vs the 5 HT1A receptor , 150x vs the 5HT1D receptor ) functional agonist for the 5 HT1B receptor . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The anti aggressive drug eltoprazine preferentially binds to 5 HT1A and 5 HT1B receptor subtypes in rat brain : sensitivity to guanine nucleotides . ^^^ Competition with eltoprazine for [ 3H ] ligand binding to the various 5 HT 1 receptor subtypes revealed preferential binding to 5 HT1A ( IC 50 values ranging from 42 to 50 nM ) and 5 HT1B ( IC 50 values ranging from 25 to 38 nM ) recognition sites . ^^^ The data indicate that the anti aggressive drug eltoprazine preferentially binds to 5 HT1A and 5 HT1B receptor sites and that this interaction is modulated by guanine nucleotides . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The TFMPP induced anorexia was blocked by mesulergine ( a 5 HT1C and 5 HT 2 antagonist ) , metergoline ( a 5 HT1A , 5 HT1B , 5 HT1C and 5 HT 2 antagonist ) , mianserin ( a 5 HT1C and 5 HT 2 antagonist ) and attenuated by ketanserin and ritanserin ( 5 HT 2 antagonists ) . ^^^ The examined anorexia was not antagonized by cyanopindolol and compound 21009 ( 5 HT1A and 5 HT1B antagonists ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
As previously reported , 2 Me 5 HT possesses a low affinity ( Ki greater than 500 nM ) for 5 HT1A , 5 HT1B , 5 HT1C , and 5 HT 2 sites ; this agent also displays a low affinity for 5 HT1D ( Ki = 1220 nM ) and 5 HT1E ( Ki greater than 10 , 000 nM ) sites . ^^^ However , alpha Me 5 HT displays little selectivity for 5 HT1A , 5 HT1B , 5 HT1C , and 5 HT1D sites ( Ki = 42 , 85 , 150 , and 150 nM , respectively ) and a very low affinity for 5 HT1E ( Ki greater than 10 , 000 nM ) sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Serotonin ( 0 . 5 100 microM ) and the specific 5 HT 2 receptor agonist 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane ( DOI ) ( 0 . 01 10 microM ) but not the 5 HT1A or 5 HT1B agonists elicited time and dose related translocations in cortical slices . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Of the three different classes of 5 HT receptors which were examined , 5 HT1B sites exhibited the largest age dependent decrease in density , followed by 5 HT 2 sites , while 5 HT1A sites remained practically unchanged during aging . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT1A agonists , 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) , buspirone or TVXQ 7821 ( ipsapirone ) but not the 5 HT1B agonist RU 24969 , attenuated the hyperphagic response to 8 OH DPAT administered on the next day . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Three subtypes of 5 HT 1 binding sites , designated 5 HT1A , 5 HT1B , and 5 HT1C , can now be distinguished by improved binding assay with rather selective radioligands . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
It was found that galanin markedly decreased the Kd value of 5 HT1A binding , while there were no effects on the binding characteristics of the 5 HT1B or 5 HT 2 radioligands . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In light of observed amplificatory interactions between serotonergic and adrenergic stimuli in functional studies on vascular tissue and platelets , we investigated the distinction and possible interactions between alpha 1 , alpha 2 , beta 1 , and beta 2 adrenergic and 5 HT1A , 5 HT1B , and 5 HT 2 serotonergic receptor binding sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
RU 24969 , with high affinity for both 5 HT1A and 5 HT1B receptors , and 1 ( 2 methoxyphenyl ) piperazine , a 5 HT 1 compound , increased punished responding to a lesser extent , as did the 5 HT 2 antagonists ketanserin and ritanserin . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Eltoprazine , a mixed 5 HT1A / B agonist , and meta trifluoro methylphenyl piperazine HCl ( TFMPP ) , a more selective 5 HT1B agonist , specifically decrease aggressive behavior in several animal species and situations in both sexes without detriment to other social , exploratory , or motoric activities . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
It is concluded that 8 OH DPAT induced increase in serum corticosterone concentration results from its action at a site different than the adrenal cortex and is mediated by postsynaptic 5 HT1A receptors , whereas other subtypes ( 5 HT1B , 5 HT 2 , 5 HT 3 ) of 5 HT receptors do not participate in this response . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Three 5 HT receptor subtypes are reported to modulate the ASR in adult rats : 5 HT1A and 5 HT 2 receptor agonists facilitate the ASR , whereas 5 HT1B agonists decrease the response . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Physiological effects of selective 5 HT1a and 5 HT1b ligands in rat hippocampus : comparison to 5 HT . ^^^ The responses of CA 1 neurons to topical application of serotonin ( 5 HT ) and selective 5 HT1a and 5 HT1b agonists were examined with intracellular recording in the hippocampal slice . 5 HT produced a uniform hyperpolarizing response associated with an increase in K conductance as previously reported . ^^^ Topical application of the 5 HT1b ligand TFMPP on the slice did not produce the direct or antagonistic action seen with the 5 HT1a ligands . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The presence of subtypes of 5 HT 1 binding sites was investigated by selective displacements with 8 OH DPAT , mesulergine and ( + / ) SDZ 21 009 at appropriate concentrations to block 5 HT1A , 5 HT1C and 5 HT1B sites respectively . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Stimulation of 5 HT1A receptors with 8 hydroxy di N , N propylaminotetralin ( 8 OH DPAT ) and blockade of 5 HT1B receptors with cyanopindolol resulted in seizure protection . ^^^ In conclusion , the present study suggests that the inhibition of pilocarpine induced seizures may be mediated by stimulation of 5 HT1A and by blockade of 5 HT1B receptors , located probably on the cholinergic terminals . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Interactions with functional 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D receptors . ^^^ The effects of the compound were investigated in radioligand binding studies and in functional models for 5 HT1A , 5 HT1B , and 5 HT1D receptors ( inhibition of forskolin stimulated adenylate cyclase activity in calf hippocampus , rat and calf substantia nigra , respectively ) and 5 HT1C receptors ( stimulation of inositol phosphate production in pig choroid plexus ) . ^^^ GR 43175 displayed the following order of affinity for 5 HT recognition sites ( pKD values , log mol / l , in parentheses ) : 5 HT1D ( 7 . 54 ) greater than 5 HT1B ( 6 . 35 ) greater than 5 HT1A ( 6 . 13 ) much greater than 5 HT1C ( 4 . 13 ) greater than 5 HT 2 ( 3 . 67 ) . ^^^ The same order of potency was observed at functional 5 HT 1 receptors , at which GR 43175 acted as a full agonist , with the exception of the 5 HT1C receptor , where the compound was a weak antagonist ( pEC 50 or pKB values , log mol / l , in parentheses ) : 5 HT1D ( 6 . 28 ) greater than 5 HT1B ( 6 . 03 ) greater than 5 HT1A ( 5 . 57 ) much greater than 5 HT1C ( 4 . 25 ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In the drug challenge studies , we used two 5 HT 1 agonists , the 5 HT1B and 5 HT1C agonist , m chlorophenylpiperazine ( m CPP ) , and the 5 HT1A agonist , 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OHDPAT ) , to examine the effect of cortisol on their behavioral and neuroendocrine effects . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Moreover , 5 HT 1 is heterogenous and can be divided into 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D subtypes . 5 HT1B is probably related to the 5 HT autoreceptor controlling 5 HT release . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
RU 24969 , a 5 HT agonist with highest affinity at 5 HT1A and 5 HT1B receptors , increased plasma renin activity ( PRA ) and plasma renin concentration ( PRC ) as well as plasma corticosterone and prolactin concentrations in a dose dependent manner . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The results suggest that 5 HT innervations in the VTA may have an excitatory action possibly via 5 HT1B rather than 5 HT1A receptors on the mesolimbic DA system projecting to the ACC and that this DA system may also be regulated by glutamatergic and GABAergic ( via GABAA receptors ) inputs . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Central and peripheral 5 HT receptors can be divided into three receptor subtypes : 5 HT 1 ( 5 HT1A , 5 HT1B , 5 HT1C ) , 5 HT 2 and 5 HT 3 receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These antagonists covered the whole range of currently defined serotonin receptor types and subtypes : 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , 5 HT 2 , and 5 HT 3 . 6 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Carteolol and l propranolol , which are suggested to have anti migraine activity in man , were found to be active inhibitors of the binding of [ 125I ] ICYP to 5 HT1B recognition sites and of [ 3H ] 8 OH DPAT to 5 HT1A recognition sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Human 5 HT1A sites can be distinguished from human 5 HT1B , 5 HT 2 , and 5 HT 3 sites and from equivalent sites in rat and bovine cortex . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Radioligand binding techniques have demonstrated the existence of 5 hydroxytryptamine ( 5 HT ) binding subtypes : 5 HT 2 , 5 HT1A and 5 HT1B . ^^^ These techniques have also indicated that certain drugs appear to show sub type specificity : 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) , a 5 HT1A agonist ; 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydropyridin 4 yl ) 1 H indole ( RU 24969 ) , a 5 HT1B agonist ; and ritanserin , a 5 HT 2 antagonist . ( ) Propranolol is a 5 HT 1 antagonist of uncertain sub type specificity . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Neither the 5 HT1A agonist , 8 OH DPAT , nor mianserin , a 5 HT 2 and 5 HT1C antagonist , altered the induced RL receptor population , whereas the selective 5 HT1B agonist CGS 12066B reduced the increase in the RL receptor population with a potency equal to that of 5 HT . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT 1 like receptor mediating reduction of porcine carotid arteriovenous shunting by RU 24969 is not related to either the 5 HT1A or the 5 HT1B subtype . ^^^ Using the radioactive microsphere technique in anaesthetized pigs , we studied the systemic and carotid haemodynamic effects of intracarotid infusions ( 0 . 3 , 1 , 3 and 10 micrograms / kg . min ) of 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridinyl ) 1H indole succinate ( RU 24969 ) , a drug with high affinity for 5 HT1A and 5 HT1B recognition sites . ^^^ However , these responses were not modified after pretreatment with the putative 5 HT1A and 5 HT1B receptor antagonist , ( + / ) pindolol ( 4 . 0 mg / kg i . v . ) . ^^^ It is concluded that the RU 24969 induced reduction in common carotid and arteriovenous anastomotic blood flow is mediated mainly by 5 HT 1 like receptors , which do not seem to correspond to either the 5 HT1A or 5 HT1B receptor subtypes . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Present data show a differential action of 5 HT1A and 5 HT1B receptor subtypes in the control of rat masculine sexual behaviour . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Identification of 5 HT receptor subtypes 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , 5 HT 2 ( possibly A and B ) , 5 HT 3 subtypes , and possibly 5 HT 4 has encouraged the manufacture of 5 HT receptor inhibitors with greater subtype specificity . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
At 3 , 7 and 14 days post 5 , 7 DHT , competitive radioligand binding assays were performed using 2 nM [ 3H ] 5 HT and varying concentrations of trifluoromethylphenylpiperazine ( TFMPP ) , a drug which interacts with 5 HT1B and 5 HT1A binding sites ( affinity of 5 HT1B site greater than 5 HT1A site for TFMPP ) . ^^^ However , the binding capacity of the 5 HT1B site , as well as the 5 HT1A site , increased significantly by 7 and 14 days postlesion , respectively . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Primary cultures of astroglial cells were exposed to serotonin ( 5 HT ) or the selective receptor agonists 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH D PAT , for 5 HT1a receptors ) or trifluoro methyl phenyl piperazine ( TFMPP ) and m chlorophenylpiperazine ( mCPP ) ( for 5 HT1b receptors ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
No significant correlations were found between drug affinities for 125I R ( ) DOI labeled sites in rat cortex and 5 HT1A , 5 HT1B , 5 HT1D , or 5 HT 3 sites , as determined by previous investigators . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The potencies of the serotonin receptor agonists and antagonists were compared with their affinities for 5 HT1A , 5 HT1B , 5 HT1C , and 5 HT1D binding sites in pig or rat tissue membranes ; in addition , the potencies of the agonists were compared to their potencies in inhibiting adenylate cyclase activity in membranes of calf substantia nigra . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Characterization of a [ 3H ] 5 hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D subtypes . [ 3H ] 5 HT binding sites were analyzed in membranes prepared from the rabbit caudate nucleus ( CN ) . [ 3H ] 5 HT labeled both 5 HT1A and 5 HT1C recognition sites , defined by nanomolar affinity for 8 OH DPAT and mesulergine respectively ; however , these represented only a fraction of total specific [ 3H ] 5 HT binding . ^^^ The pharmacological profile of the non 5 HT1A / non 5 HT1C sites ( designated 5 HT1R ) also differed from that of 5 HT1B and 5 HT 2 sites , but was similar to that of the 5 HT1D site . ^^^ The present findings demonstrate the presence of a high affinity [ 3H ] 5 HT binding site in rabbit CN , designated 5 HT1R , that is different from previously defined 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , and 5 HT 2 sites . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Competition studies with selective drugs reveal alpha adrenergic , 5 HT1A and 5 HT1B components of [ 3H ] DE specific binding . ^^^ When phentolamine ( 500 nM ) is included to block alpha receptors and DPAT ( 100 nM ) or spiroxatrine ( 500 nM ) is included to block 5 HT1A receptors , specific binding is exclusively to sites with drug affinities characteristic of 5 HT1B receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In the present study , the affinities of these urapidil derivatives ( 5 acetyl , 5 formyl and 5 methyl urapidil ) for 5 HT receptors were investigated using 3H 8 hydroxy 2 ( di n propyl amino ) tetralin ( 3H 8 OH DPAT ) , 125I iodocyanopindolol ( 125I ICYP ) and 3H ketanserin for labelling 5 HT1A , 5 HT1B and 5 HT 2 binding sites , respectively . 3H Prazosin and 3H clonidine were used as selective alpha 1 and alpha 2 adrenoceptor radioligands , respectively . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The selective 5 HT1A agonists , 8 hydroxy 2 ( di n dipropylamino ) tetralin ( 8 OH DPAT ) and ipsapirone , and the 5 HT1A / 5 HT1B agonist , 1 ( m trifluoromethylphenyl ) piperazine , partially inhibited the carbachol stimulated [ 3H ] inositol phosphate formation in rat hippocampal slices . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These data indicate that [ 3H ] WB 4101 selectively labels the 5 HT1A serotonin receptor , whereas [ 3H ] LSD appears to label both the 5 HT1A and the 5 HT1B serotonin receptor subtypes . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In view of the fact that 8 OH DPAT has negligible affinity for the 5 HT1B site , the above results are consistent with its discriminative stimulus properties being mediated by the putative 5 HT1A receptor . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Evidence suggests that the above action of 8 OH DPAT is mediated by 5 HT1A receptors since it was antagonised by the 5 HT1A antagonist spiperone but not by the 5 HT 2 antagonist ketanserin and was not mimicked by the 5 HT1B agonist RU 24969 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Stereoselective blockade of central [ 3H ] 5 hydroxytryptamine binding to multiple sites ( 5 HT1A , 5 HT1B and 5 HT1C ) by mianserin and propranolol . ^^^ The interaction of the enantiomers of mianserin and propranolol with the binding of [ 3H ] 5 hydroxytryptamine ( [ 3H ] 5 HT ) to the 5 HT1A , 5 HT1B and 5 HT1C sites , and with the binding of [ 3H ] ketanserin to the 5 HT 2 site , has been evaluated in rat brain membranes . ^^^ A stereoselective interaction at the 5 HT1A , 5 HT1B and 5 HT1C sites was demonstrated for both compounds , with ( + ) mianserin being a more potent displacer than ( ) mianserin and ( ) propranolol being more potent than ( + ) propranolol . ^^^ The stereoselective association of mianserin and propranolol with the 5 HT1A , 5 HT1B and 5 HT1C sites may prove useful in the characterization of these sites . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Propranolol impaired neither the hypothermia induced by an agonist at the 5 HT 1A receptors : 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) nor the increase in spontaneous motor activity induced by an agonist at the 5 HT 1B receptors : 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydropyridin 4 yl ) 1 H indole ( Ru 24 , 969 ) . ^^^ It is concluded that the effect of propranolol is not the result of a blockade of 5 HT 1A , 5 HT 1B or 5 HT 2 , but is in part due to blockade of beta 1 adrenoceptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
A 5 HT1A agonist ( 8 OH DPAT ) blocked WDS , but like putative 5 HT1B ( RU 24969 ) and 5 HT 2 ( DOI ) agonists and the 5 HT antagonists methysergide ( non selective ) , ritanserin ( 5 HT 2 selective ) , and l propranolol ( 5 HT 1 selective ) , it did not block other antagonists behavioural effects of MK 771 . 6 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
SM 3997 possessed a high affinity towards 5 HT1A receptors , low affinity towards dopamine ( D 2 ) and 5 HT 2 receptors , and no affinity towards benzodiazepine ( BZ ) , GABA , 5 HT1B and adrenergic receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Responses of hippocampal pyramidal cells to putative serotonin 5 HT1A and 5 HT1B agonists : a comparative study with dorsal raphe neurons . ^^^ In low cerveau isol transected rats , the effects of microiontophoretic application of putative serotonin 5 HT1A and 5 HT1B agonists on the spontaneous firing rate of CA 1 pyramidal cells were compared to those of 5 HT . ^^^ In contrast to the large current dependent suppression of unit activity observed with 5 HT , the 5 HT1A compounds , ipsapirone , 8 OH DPAT ( 8 hydroxy 2 ( di n propylamino ) tetralin ) and LY 165163 ( p aminophenylethyl m trifluoromethylphenylpiperazine ) and the 5 HT1B compounds , mCPP ( m chlorophenylpiperazine ) and TFMPP ( trifluoromethylphenylpiperazine ) , produced only weak inhibition of spontaneous firing . ^^^ In summary , the inability of CA 1 pyramidal cells to distinguish the actions of 5 HT1A and 5 HT1B ligands is in sharp contrast to the striking differences observed for these compounds with dorsal raphe neurons . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Thus , 5 HT 1 receptors have been divided into subtypes based on their affinities for 1 : 5 HT1A sites have high affinity , while 5 HT1B sites have low affinity . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
H ] 1 [ 2 ( 4 aminophenyl ) ethyl ] 4 ( 3 trifluoromethylphenyl ) piperazine : a selective radioligand for 5 HT1A receptors in rat brain . 1 [ 2 ( 4 Aminophenyl ) ethyl ] 4 ( 3 trifluoromethylphenyl ) piperazine ( PAPP ) inhibits [ 3H ] 5 hydroxytryptamine ( 5 HT , serotonin ) binding to 5 HT1A and 5 HT1B sites in rat brain with apparent equilibrium dissociation constants ( KD ) of 2 . 9 and 328 nM , respectively . [ 3H ] PAPP was synthesized , its binding to central serotonin receptors was examined , and its potential usefulness as a 5 HT1A receptor radioligand was evaluated . ^^^ Spiperone and 8 hydroxy 2 ( di n propylamino ) tetralin , two compounds that discriminate [ 3H ] 5 HT binding to 5 HT1A and 5 HT1B sites , inhibited [ 3H ] PAPP binding in accordance with their much higher affinities for the 5 HT1A receptor subtype . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Logs of these KA values did not correlate with log Ki values for the inhibition of binding of the 5 HT 2 ligand [ 3H ] ketanserin ( r = 0 . 2253 , P greater than . 05 ) or log IC 50 values for inhibition of [ 3H ] 5 HT binding ( r = 0 . 5732 , P greater than 0 . 05 ) , which labels both 5 HT1A and 5 HT1B sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Finally , the beta adrenoceptor antagonist ( ) 21 009 which has different affinities for 5 HT1A , 5 HT1B and 5 HT1C recognition sites , yielded triphasic competition curves for [ 3H ] 5 HT binding in rat cortex membranes providing evidence that [ 3H ] 5 HT labels three distinct 5 HT 1 sites in these membranes . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These data demonstrate that centrally administered RDS 127 mimics the previously reported alterations in sexual behavior after systemic treatment and that RDS 127 is a high affinity 5 HT1A agent with low affinity at the 5 HT1B binding site . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The affinities of the compounds for 5 HT1B and 5 HT 2 binding sites in rat brain cortex membranes ( labelled by [ 125I ] cyanopindolol = [ 125I ] CYP in the presence of 30 mumol / l isoprenaline and [ 3H ] ketanserin , respectively ) , for 5 HT1A binding sites in pig and rat brain cortex membranes ( labelled by [ 3H ] 8 hydroxy 2 ( di n propylamino ) tetralin = [ 3H ] 8 OH DPAT ) and for 5 HT1C binding sites in pig choroid plexus membranes ( labelled by [ 3H ] mesulergine ) were also determined . ^^^ In contrast , significant correlations were found between the potencies or affinities of the drugs for the autoreceptors and their affinities at 5 HT1A or 5 HT1B binding sites ; the best correlations were obtained with the 5 HT1B binding site . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
It did not antagonise 5 HT1B mediated behaviour in mice or rats and appeared to have an antagonist action at pre but not post synaptic 5 HT1A receptors in rats . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Pharmacological differentiation and characterization of 5 HT1A , 5 HT1B , and 5 HT1C binding sites in rat frontal cortex . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Furthermore , it is proposed that 5 HT1A receptors mediate inhibitory effects , whereas 5 HT1B receptors mediate presynaptic , facilitatory effects of serotonin . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effect of a beta adrenergic agonist on behaviors mediated by 5 HT1A and 5 HT1B receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
DOI stimulus generalization occurred with the putative 5 HT 2 agonist DOM ( ED 50 = 0 . 49 mg / kg ) , but not with the 5 HT1A agonist 8 OH DPAT , or the 5 HT1B agonist TFMPP . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These compounds where also tested in radioligand binding studies using selective ligands for the various subtypes of 5 HT 1 and 5 HT 2 receptors . 5 HT1A , 5 HT1B and 5 HT1C recognition sites were labelled with [ 3H ] 8 OH DPAT ( [ 3H ] 8 hydroxy 2 ( di n propylamino ) tetralin ) in pig cortex membranes , [ 125I ] CYP ( [ 125I ] iodocyanopindolol ) in rat cortex and [ 3H ] mesulergine in pig choroid plexus membranes , respectively . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The `` non 5 HT1A ' ' sites labeled by 3H 5 HT in the presence of 0 . 1 microM 8 OH DPAT corresponded mainly to 5 HT1B sites . 5 HT1A binding was notably high in limbic regions ( dentate gyrus , CA 1 and CA 3 hippocampal regions , lateral septum , frontal cortex ) , whereas 5 HT1B binding was particularly concentrated in extrapyramidal areas ( caudate nucleus , globus pallidus , substantia nigra ) . ^^^ Except in the latter regions , where only one class of 5 HT 1 sites was found , both 5 HT1A and 5 HT1B sites existed in all areas examined . ^^^ The selective degeneration of serotoninergic neurons produced by an intracerebral injection of 5 , 7 dihydroxytryptamine was associated only with a significant loss of 5 HT1A binding to the dorsal raphe nucleus ( 60 % ) and of 5 HT1B binding to the substantia nigra ( 37 % ) . ^^^ These results are discussed in relation to the possible identity of 5 HT1A and / or 5 HT1B sites with the presynaptic 5 HT autoreceptors controlling nerve impulse flow and neurotransmitter release in serotoninergic neurons . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The density of [ 3H ] DPAT binding sites relative to the [ 3H ] 5 HT sites in the solubilized cortical membranes ( 35 % ) corresponds well with the proportion of 5 HT1a sites in the crude membranes determined by spiperone displacement ( 33 % ) , suggesting that both the 5 HT1a and 5 HT1b binding sites have been cosolubilized . [ 3H ] 5 HT binding in the soluble preparations was inhibited by GTP , suggesting that a receptor complex may have been solubilized . [ 3H ] Spiperone specific binding was not detectable in this preparation , suggesting that 5 HT 2 sites were not cosolubilized . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These data therefore demonstrate the presence of a homogeneous class of 5 HT 1 binding sites in bovine caudate that is pharmacologically distinct from previously defined 5 HT1A , 5 HT1B , 5 HT1C , 5 HT 2 , and 5 HT 3 receptor subtypes . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The role of putative 5 HT1A and 5 HT1B receptors in the control of feeding in rats . 8 hydroxy 2 ( di n propylamino ) tetraline ( 8 OH DPAT ) and 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridinyl ) 1H indole succinate ( RU 24969 ) , two agonists on the putative serotonin 1A and serotonin 1B receptors , were used for exploring the role of these sites in the inhibitory effect of serotonin ( 5 HT ) on feeding . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
This blockade was specific of 5 HT1A sites since the other serotoninergic sites , 5 HT1B , 5 HT 2 and also the presynaptic 5 HT 3 sites were not affected by the treatment . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Drug competition studies were performed using 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) to compete selectively for 5 HT1A sites , RU 24969 to compete for 5 HT1B sites and mesulergine to compete for 5 HT1C sites . ^^^ The results demonstrate that 5 HT1A , 5 HT1B and 5 HT1C binding sites are present in rat spinal cord . ^^^ In addition , approximately 33 % of total 5 HT 1 sites do not appear to represent either 5 HT1A , 5 HT1B or 5 HT1C binding sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT receptor agonists serotonin ( 1 100 nM ) , lysergic acid diethylamide ( 10 nM 1 microM ) and the 5 HT1B receptor agonists 1 ( m trifluoromethylphenyl ) piperazine ( 100 nM 1 microM ) and 1 ( m chlorophenyl ) piperazine ( 100 nM 3 microM ) concentration dependently decreased [ 3H ] 5 HT release , while 8 hydroxy 2 ( di n propylamino ) tetralin , a selective 5 HT1A receptor agonist , was inactive . ^^^ The actions of the effective agonists were reversed by quipazine , an antagonist with high affinity for 5 HT1B binding sites , but not by spiperone , a 5 HT1A receptor antagonist . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Our conclusion is that , in addition to the 5 HT1A receptor , the 5 HT1B receptor is also negatively coupled to adenylate cyclase . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The low affinity of 5 HT1B recognition sites for some 5 HT1A , 5 HT1C and 5 HT 2 selective compounds ( e . g . 8 OH DPAT , mesulergine , ketanserin ) suggests that 5 HT1B recognition sites are pharmacologically different from 5 HT1A , 5 HT1C and 5 HT 2 recognition sites . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Identification of a 5 HT 1 recognition site in human brain membranes different from 5 HT1A , 5 HT1B and 5 HT1C sites . ^^^ In human caudate and cortex membranes , [ 3H ] serotonin ( [ 3H ] 5 HT ) labels 5 HT1A and 5 HT1C recognition sites which show nanomolar affinity for 8 OH DPAT ( 8 hydroxy 2 ( di n propylamino ) tetralin ) and mesulergine respectively , whereas no 5 HT1B binding could be identified . ^^^ However , the majority of the sites labelled by [ 3H ] 5 HT ( greater than or equal to 60 % in cortex , 90 % in caudate ) are different from 5 HT1A , 5 HT1B and 5 HT1C sites . ^^^ In contrast , these sites showed low affinity for drugs with high affinity and / or selectivity for 5 HT1A ( 8 OH DPAT , buspirone ) , 5 HT1B ( 21 009 , RU 24969 ) , 5 HT1C ( mesulergine , mianserin ) and 5 HT 2 sites ( ketanserin , cinanserin ) . ^^^ The pharmacological profile of these sites is different from that of 5 HT1A , 5 HT1B , 5 HT1C , 5 HT 2 and 5 HT 3 sites but is consistent with the pharmacology of a 5 HT 1 like receptor . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The food intake suppressant effects of three serotonin agonists , m CPP ( a selective 5 HT1B agonist ) , 8 OHDPAT ( a selective 5 HT1A agonist ) and fenfluramine ( a 5 HT releasing agent ) were compared in three different rat strains : Wistar , Sprague Dawley ( SD ) and Fawn Hooded ( FH ) rats . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The use of agonists , shown to discriminate between subtypes of 5 HT 1 receptor revealed that a 5 HT1A receptor agonist mimicked the non selective effects of 5 HT , whereas a 5 HT1B receptor agonist mimicked the selective antinociceptive effects of 5 HT . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Sprague Dawley rat pups at 3 4 days prenatally were tested in both the absence and presence of milk following administration of various doses of either the 5 HT1A agonist 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OHDPAT ) , the 5 HT1B agonist 1 ( 3 chlorophenyl ) piperazine ( mCPP ) , or the 5 HT 2 agonist 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane ( DOI ) . ^^^ Thus it appears that 5 HT1A , 5 HT1B and 5 HT 2 receptor subtypes are present in the neonate and elicit differential behavioral responses upon stimulation with selective agonists . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT1A agonist , 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) at a dose of 1 mg / kg s . c . increased food intake in free feeding rats . 8 OH DPAT induced feeding was blocked by metergoline which has comparable affinity for 5 HT1A , 5 HT1B , 5 HT1C and 5 HT 2 receptors . ^^^ Blockade of the hyperphagia by spiperone suggests mediation by 5 HT1A rather than 5 HT1B receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The drug RU 24969 was found to have high affinity for 5 HT1A and 5 HT1B recognition sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
By contrast with this reduction of 5 hydroxytryptamine ( 5 HT ) function mediated by the 5 HT1A and 5 HT 2 receptor sub types , repeated lithium administration had no effect on the motor response to a putative 5 HT1B receptor agonist 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydropyridin 4 yl ) 1H indole ( RU 24969 , 3 mg / kg IP ) . alpha 2 adrenoceptor function , assessed by the sedation response to clonidine ( 0 . 25 mg / kg , IP ) , was also attenuated by repeated lithium administration . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In order to test the hypothesis that the mechanism of action of LSD and phenylisopropylamine hallucinogens is through stimulation of a specific brain serotonin receptor sub type , the affinities of these compounds for radiolabelled 5 HT 2 , 5 HT1A , 5 HT1B , and 5 HT1C receptors have been determined using recently developed in vitro radioligand binding methodologies . ^^^ The 5 HT1A , 5 HT1B , and 5 HT1C receptors were labelled with 3H OH DPAT , 3H 5 HT , and 3H mesulergine , respectively . ^^^ In general , the phenylisopropylamines displayed 10 100 fold higher affinities for the 5 HT 2 receptor than for the 5 HT1C receptor and 100 1000 fold higher affinities for the 5 HT 2 receptor than for the 5 HT1A or 5 HT1B receptor . ^^^ There was a strong correlation between hallucinogenic potencies and 5 HT 2 receptor affinities of the phenylisopropylamines ( r = 0 . 90 ) ; the correlation coefficients for the 5 HT1A , 5 HT1B , and 5 HT1C were 0 . 73 , 0 . 85 , and 0 . 78 , respectively . ^^^ Because there is no evidence that 5 HT1A selective or 5 HT1B selective agonists are hallucinogenic and because the phenylisopropylamines are potent hallucinogens , a 5 HT 2 receptor interaction is implicated and supports our previous suggestions to this effect . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Agonist binding to 5 HT1A , 5 HT1B , and 5 HT1D sites in rat brain and to 5 HT1A and 5 HT1D sites in bovine brain is sensitive to NEM . ^^^ These findings suggest that agonist binding to 5 HT1A , 5 HT1B , and 5 HT1D sites is sensitive to NEM alkylation . ^^^ These data suggest that NEM exerts its effects on 5 HT1A , 5 HT1B , and 5 HT1D binding sites by inactivating the G protein ( s ) associated with the 5 HT receptor subtypes . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Radioligand binding studies were performed to characterize serotonin 5 HT1D receptors in postmortem human prefrontal cortex and caudate homogenates . [ 3H ] 5 HT binding , in the presence of pindolol ( to block 5 HT1A and 5 HT1B receptors ) and mesulergine ( to block 5 HT1C receptors ) , was specific , saturable , reversible , and of high affinity . ^^^ In competition experiments , 8 hydroxydipropylaminotetralin , trifluoromethylphenylpiperazine , mesulergine , 4 bromo 2 , 5 dimethoxyphenylisopropylamine , and ICS 205 930 had low affinity for [ 3H ] 5 HT labeled 5 HT1D sites , indicating that the pharmacology of the 5 HT1D site is distinct from that of previously identified 5 HT1A , 5 HT1B , 5 HT1C , 5 HT 2 , and 5 HT 3 sites . 5 HT1D sites in human brain have a similar pharmacology to the 5 HT1D sites previously identified in rat , porcine and bovine brains . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Although 8 methoxy 2 ' chloro PAT bound irreversibly to different classes of 5 HT binding sites ( 5 HT1A , 5 HT1B , presynaptic sites ) , it can be considered a selective alkylating agent , since it exerted no action on 3H spiperone binding to 5 HT 2 sites , 3H muscimol binding to GABA sites , or 3H flunitrazepam binding to benzodiazepine sites . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Differential selectivities of RU 24969 and 8 OH DPAT for the purported 5 HT1A and 5 HT1B binding sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Although simple arylpiperazines are commonly considered to be moderately selective for 5 HT1B serotonin binding sites , N 4 substitution of such compounds can enhance their affinity for 5 HT1A sites and / or decrease their affinity for 5 HT1B sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
SCH 23390 had weak affinity for 5 HT1B ( IC 50 = 0 . 5 microM ) , 5 HT1A ( IC 50 = 2 . 6 microM ) and alpha 1 adrenergic receptors ( IC 50 = 4 . 4 microM ) . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
As 5 HT 1 receptors were first described using radioligand binding studies , a brief description of 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D receptor binding is given . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Stimulus generalization occurs among these agents regardless of which is used as the training drug , although stimulus generalization does not occur with 5 HT1A selective agonists [ e . g . , 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) ] or with 5 HT1B selective agonists [ e . g . , 1 ( 3 trifluoromethylphenyl ) piperazine ( TFMPP ) ] . 8 OH DPAT and TFMPP also serve as training drugs ; the 8 OH DPAT stimulus generalizes to other 5 HT1A agonists , but not to 5 HT1B or 5 HT 2 agonists , whereas the TFMPP stimulus generalizes to other 5 HT1B agonists , but not to 5 HT1A or 5 HT 2 agonists . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effect of selective 5 HT1A and 5 HT1B agonists on K+ evoked release of [ 3H ] 5 HT and the binding of [ 3H ] 5 HT were examined . ^^^ Further testing of the present results requires the development of new 5 HT 1 agonists which are selective ( 1000 fold difference ) for the 5 HT1A and 5 HT1B subsites . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In the presence of 1 microM ( + / ) pindolol [ to block 5 hydroxytryptamine ( 5 HT , serotonin ) 5 HT 1A and 5 HT 1B receptors ] and 100 nM mesulergine ( to block 5 HT 1C receptors ) , 2 . 0 nM [ 3H ] 5 HT binding to rat cortical homogenates is specific , saturable , and reversible . ^^^ Compounds with high affinity for 5 HT 1A ( 8 hydroxydipropylaminotetralin ) , 5 HT 1B ( trifluoromethylphenylpiperazine ) , 5 HT 1C ( mesulergine ) , 5 HT 2 ( 4 bromo 2 , 5 dimethoxyphenylisopropylamine ) , and 5 HT 3 ( ICS 205 930 ) receptors have low affinity for this site . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The different subpopulations of 5 HT 1 sites were investigated by the use of unlabeled selective compounds . 8 OH DPAT ( 8 hydroxy 2 [ N , N di n propyl amino ] tetralin ) was used to block [ 3H ] 5 HT binding to 5 HT1A , the beta blocker ( ) 21 009 ( 4 [ 3 ter butyl amino 2 hydroxy propoxy ] indol 2 carbonic acid isopropyl ester ) to 5 HT1B and the ergoline mesulergine to 5 HT1C recognition sites . 5 HT1D sites were defined as the binding sites remaining when both 8 OH DPAT and mesulergine were added to the incubation medium . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain : high affinity activation is related to a 5 HT 1 subtype different from 5 HT1A , 5 HT1B , and 5 HT1C . 5 HT binding sites of the 5 HT 1 type are heterogeneous and appear to comprise several subtypes ( 5 HT1A , 5 HT1B and 5 HT1C ) ; their physiological role is as yet unclear . ^^^ On the other hand , the high affinity activation of the enzyme induced by 5 HT , 5 methoxytryptamine , bufotenin , LSD , and the activation induced by TFMPP were not inhibited by spiperone ( 1 microM ) , by propranolol ( 3 microM ) , or by mesulergine ( 0 . 1 microM ) , which selectively block 5 HT1A , 5 HT1B , and 5 HT1C sites . ^^^ Therefore , these activations seem related to 5 HT 1 receptors but not to 5 HT1A , 5 HT1B , or 5 HT1C sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The attenuating effect of 5 HT was not mimicked by the 5 HT1A receptor agonist 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) and was not prevented by a 5 HT1A and 5 HT1B mixed receptor antagonist , propranolol , or by the 5 HT 3 receptor antagonists , cocaine and metoclopramide . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Electrophysiological responses of serotoninergic dorsal raphe neurons to 5 HT1A and 5 HT1B agonists . ^^^ A direct comparison was made of the effects of serotonin 5 HT1A and 5 HT1B selective compounds on the spontaneous firing rate of dorsal raphe serotoninergic neurons in chloral hydrate anesthetized rats . ^^^ Following intravenous administration , the 5 HT1A selective compounds ipsapirone ( TVX Q 7821 ) and LY 165163 potently inhibited single unit activity in a dose dependent manner whereas the 5 HT1B selective compounds , m chlorophenylpiperazine ( mCPP ) and trifluoromethylphenylpiperazine ( TFMPP ) , displayed only weak or irregular actions . ^^^ In summary , dorsal raphe 5 HT neurons appear highly responsive to 5 HT1A , but not to 5 HT1B compounds ; these findings are discussed with regard to the 5 HT receptor subtypes as candidates for the somatodendritic autoreceptor of dorsal raphe neurons . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The correlation of the release inhibiting potencies of serotonin receptor agonists with their affinities for 5 HT1B binding sites ( Engel et al . , 1986 ) was slightly improved by inclusion of RU 24969 , whereas that with the affinities for 5 HT1A binding sites ( which was worse than the former correlation ) was not changed . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The affinities of putative serotonin receptor agonists and antagonists for 5 HT1A , 5 HT1B , 5 HT1C , and 5 HT 2 receptors were assayed using radioligand binding assays . ^^^ When [ 3H ] DOB was used as the 5 HT 2 radioligand , quipazine was determined to be 100 fold more potent at 5 HT 2 receptors than at 5 HT1A receptors . 1 ( 3 trifluoromethylphenyl ) piperazine ( TFMPP ) , a putative specific 5 HT1B receptor agonist was apparently 10 fold more potent at 5 HT1B receptors than at 5 HT 2 receptors when [ 3H ] ketanserin was used as the 5 HT 2 radioligand . ^^^ Using the 5 HT 2 antagonist radioligand [ 3H ] ketanserin , a similar pattern of underestimating 5 HT 2 receptor selectivity and / or overestimating 5 HT1A or 5 HT1B receptor selectivity was observed for a series of serotonin receptor agonists . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The potencies of these agonists in inhibiting overflow were significantly correlated with their affinities for 5 HT1B binding sites , but not with their affinities for 5 HT1A , 5 HT1C or 5 HT 2 binding sites . 8 Hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) , a 5 HT1A receptor agonist , and ipsapirone , a partial agonist at these receptors , did not inhibit overflow . 2 . ^^^ The apparent pA 2 values of these antagonists tended to be correlated with their affinities for 5 HT1B ( but not 5 HT1A , 5 HT1C or 5 HT 2 ) binding sites . ^^^ Ketanserin , a 5 HT 2 receptor antagonist , and spiperone , which blocks 5 HT 2 and 5 HT1A but not 5 HT1B or 5 HT1C receptors , failed to antagonize the effect of 5 HT . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Similarity of the contractile effects of 5 HT in the rat stomach fundus and in the basilar artery coupled to the previous observations that receptors mediating 5 HT induced contractions in the fundus were not 5 HT 1 , 5 HT1A , 5 HT1B or 5 HT 2 led us to consider the possibility that 5 HT receptors in the canine basilar artery may resemble those in the rat stomach fundus . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Using 3H 5 HT or 3H 8 OH DPAT as the ligand , the same molecular weight of 55 , 000 60 , 000 daltons was calculated for the postsynaptic 5 HT1A and 5 HT1B sites in the hippocampus and cerebral cortex . ^^^ The curvilinear pattern of the radiation induced inactivation of 5 HT1A and 5 HT1B binding sites suggested that both sites belong to complex polymeric structures . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Frontal cortices and hippocampi from human brains obtained at autopsy without evidence of neurological disease were used in this study . [ 3H ] 5 HT was used to label both 5 HT1A and 5 HT1B receptor subtypes . 5 HT1A receptors were selectively labeled by [ 3H ] 8 hydroxy 2 [ di N propylamino ] tetralin , while 5 HT1B receptors were labeled by ( ) [ 125I ] iodocyanopindolol ( [ 125I ] CYP ) in the presence of 30 microM isoprenaline . ^^^ In contrast to 5 HT1A receptors , it was not possible to identify 5 HT receptors having the pharmacological properties of 5 HT1B sites in the human brain , using either [ 3H ] 5 HT or [ 125I ] CYP as ligands . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Comparison of the activities of 12 serotonin receptor agonists revealed that only 4 of the investigated tryptamine derivatives acted as full agonists on both tissues . 5 Carboxamidotryptamine , a drug with selective affinity for both 5 HT1A and 5 HT1B binding sites , though the most potent agonist on veins , failed to produce platelet aggregation but acted as a weak antagonist of the 5 HT induced reversible aggregation . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Photoaffinity labeling of the 5 hydroxytryptamine 1A receptor in rat hippocampus . 1 [ 2 ( 4 Azidophenyl ) ethyl ] 4 ( 3 trifluoromethylphenyl ) piperazine ( p azido PAPP ) inhibits [ 3H ] 5 hydroxytryptamine [ ( 3H ] 5 HT ) binding to 5 HT1A and 5 HT1B sites in rat brain with equilibrium dissociation constants ( KD ) of 0 . 9 nM and 230 nM , respectively . [ 3H ] p Azido PAPP was synthesized and its reversible and irreversible binding properties to the hippocampal 5 HT1A site characterized . [ 3H ] p Azido PAPP labeled a single class of sites in rat hippocampal membranes with a KD of 1 nM and a maximal binding density of 370 fmol / mg protein . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The results suggest that the 5 HT receptor mediating relaxation in the guinea pig ileum can be labelled with [ 125I ] LSD and that this receptor does not belong to the 5 HT 2 , 5 HT1A , 5 HT1B or 5 HT1C receptor subtypes . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
When used as a 5 HT1A / 5 HT1B antagonist , ( ) propranolol antagonized 5 HT whereas spiperone ( a 5 HT1A displacer ) did not . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The number of 5 HT 2 and 5 HT1A binding sites was decreased : the 5 HT1B binding sites remained unchanged . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
High affinity [ 3H ] serotonin ( 5 hydroxytryptamine , 5 HT ) binding sites from human frontal cortex can be divided into at least 3 pharmacological subtypes ( 5 HT1A , 5 HT1B and 5 HT 3 ) based on affinity for [ 3H ] serotonin and spiperone . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Finally , ( ) propranolol , used as a non selective 5 HT1A / 5 HT1B receptor antagonist , shifted to the right ( pA 2 = 7 . 91 ) the concentration response curve of 5 HT whereas the 5 HT1C receptor antagonist mesulergine was ineffective . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Spiperone inhibition of [ 3H ] 5 HT binding in cortex was consistent with displacement from two sites with dissociation constants ( KD ) of 24 nM ( 5 HT 1A site ) and 19 microM ( 5 HT 1B site ) for spiperone . ^^^ In the presence of 1 microM spiperone , a concentration that saturates the 5 HT 1A sites while having a minimal effect on 5 HT 1B sites , BrAcTFMPP displaced [ 3H ] 5 HT from a single site with a KD for BrAcTFMPP of 145 nM . ^^^ Thus , BrAcTFMPP and spiperone discriminate the same two subpopulations of [ 3H ] 5 HT binding sites and BrAcTFMPP displays a high affinity and a selectivity for 5 HT 1A sites versus both 5 HT 1B and 5 HT 2 sites . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Apparent distinction from the 5 HT1A , 5 HT1B and 5 HT1C subtypes . ^^^ It is concluded that the receptor to 5 HT conforms to general criteria defining 5 HT 1 like receptors but at the present time the receptor site can not be fitted to the designated 5 HT1A , 5 HT1B or 5 HT1C subtypes . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These results suggest the presence of three binding sites for [ 3H ] 5 HT , one blocked by low concentrations of spiperone ( 5 HT1A ) , one blocked by low concentrations of mianserin ( 5 HT1C ) , and one blocked only by high concentrations of both mianserin and spiperone ( 5 HT1B ) . ^^^ The hippocampus was rich in 5 HT1A sites , whereas the striatum contained mainly 5 HT1B and 5 HT1C sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
TFMPP displays a Kd of 6 nM for approximately two thirds of the 5 HT 1b binding sites and a Kd of 273 nM for the remaining one third of the 5 HT 1b sites . p NH 2 PE TFMPP , on the other hand , discriminates the 5 HT 1 sites in a manner similar to spiperone , displaying a 110 fold selectivity for the 5 HT 1a sites . p NH 2 PE TFMPP displays a Kd of about 3 nM for the 5 HT 1a sites . p NH 2 PE TFMPP does not discriminate subtypes within the 5 HT 1b binding sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Selective labeling of 5 HT1A and 5 HT1B binding sites in bovine brain . ^^^ Drug interactions with serotonin ( 1A ) 5 HT1A and serotonin ( 1B ) ( 5 HT1B ) binding sites were analyzed in bovine brain membranes . 5 HT1A binding sites were directly labeled with [ 3H ] 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) in bovine hippocampal membranes . 5 HT1B binding sites were labeled by [ 3H ] 5 HT in bovine striatal membranes where less than 15 % of specific binding sites are sensitive to nanomolar concentrations of 8 OH DPAT . ^^^ Each of the 12 agents tested was more potent at the 5 HT1A than 5 HT1B binding site . 5 HT , bufotenine , N , N dimethyltryptamine ( DMT ) and quipazine were only slightly more potent at the 5 HT1A binding site . ^^^ These findings suggest that 5 HT1A , and 5 HT1B binding sites have distinct pharmacological profiles and can be directly labeled with appropriate [ 3H ] ligands in specific brain regions . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Competition experiments for 5 [ 3H ] HT binding by several serotonin 1 agonists led to the identification of brain areas enriched in each one of the three subtypes of 5 HT 1 recognition sites already described ( 5 HT1A , 5 HT1B , 5 HT1C ) . ^^^ From the areas strongly enriched in 5 HT 1 sites , dentate gyrus and septal nucleus contained 5 HT1A sites , while globus pallidus , dorsal subiculum , substantia nigra and olivary pretectal nucleus were enriched in 5 HT1B . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The choroid plexus site exhibits a novel pharmacology that does not match the properties of 5 hydroxytryptamine 1a ( 5 HT1a ) , 5 HT1b , or 5 HT 2 serotonergic sites . 125I LSD binding to the choroid plexus site is potently inhibited by mianserin , serotonin , and ( + ) LSD . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In vitro autoradiographic techniques combined with computer assisted microdensitometry were used to analyze the characteristics and distribution of multiple recognition sites for the neurotransmitters acetylcholine ( M 1 and M 2 ) and serotonin ( 5 HT1A and 5 HT1B ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Determination of selective and nonselective compounds for the 5 HT 1A and 5 HT 1B receptor subtypes in rat frontal cortex . ^^^ The subtype specificity of the selective compounds was determined using either spiperone , a selective 5 HT 1A compound , or 1 ( m trifluoromethylphenyl ) piperazine , a selective 5 HT 1B compound , to preferentially inhibit one of the receptors . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Ligands reported as selective for 5 HT1A , 5 HT1B or 5 HT 2 subtypes did not show high affinity for these binding sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
This action was blocked by 5 HT 3 and gamma aminobutyric acidA ( GABAA ) receptor antagonists but not by 5 HT 2 , 5 HT1A , 5 HT1B or 5 HT1S receptor antagonists . ^^^ The inhibition of biting behavior was antagonized by intrathecal co administration of 5 HT1B and GABAA receptor antagonists while 5 HT1A , 5 HT1S , 5 HT 2 and 5 HT 3 receptor antagonists had no effect . 5 MeO DMT enhanced scratching behavior was inhibited by all the antagonists used except ketanserin and bicuculline , suggesting the involvement of 5 HT1A , 5 HT1B , 5 HT1S , 5 HT 3 and GABAA receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The Bmax value of the high affinity site of the 5 HT 1A receptor increased and the Bmax value of 5 HT 2 receptor decreased with no change in the low affinity site of the 5 HT 1A receptor nor in the 5 HT 1B receptor . 4 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Effects of 5 HT1A receptor agonist and 5 HT1B receptor agonist on single and paired rats ' behavior ] . ^^^ In this study we evaluated the effects of the 5 HT1A receptor agonist ( 8 hydroxy 2 ( di n propylamino ) tetralin , 8 OH DPAT ) and 5 HT1B receptor agonist ( 1 ( 3 trifluoromethylphenyl ) piperazine , TFMPP ) on the single and paired rats ' movement distance in an open field . ^^^ These findings suggest that both 5 HT1A receptors and 5 HT1B receptors affect the rats ' movement distance . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Among the dozen of 5 HT receptors identified so far , four receptors ( namely the 5 HT1A , 5 HT1B , 5 HT2A , and 5 HT2C receptors ) and the 5 HT uptake system have been the focus of studies aimed at detecting corticosteroid modulatory effects . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Inhibition studies with [ 3H ] 5 HT plus 100 nM 8 OH DPAT ( which inhibits binding to 5 HT1A receptors only ) representing total binding , indicated that no further displacement occurred when ligands preferentially selective for 5 HT1B , 5 HT1D alpha , 1D beta , or 5 HT2C were tested . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The present study assessed compounds displaying affinity for 5 HT1A , 5 HT1B , 5 HT2A and 5 HT2C receptors for their ability to substitute for , enhance or antagonize the discriminative stimulus effects of cocaine ( 10 mg / kg ) in rats . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The results : ( 1 ) confirm that both an alpha 1 adrenoceptor antagonist ( prazosin ) and 5 HT1A autoreceptor stimulants ( BMY 7378 and 8 OH DPAT ) may reduce cerebral 5 HT release ; ( 2 ) support that the BMY 7378 induced decrease in 5 HT release results from 5 HT1A autoreceptor agonism , rather than alpha 1 adrenoceptor blockade ; and ( 3 ) argue against `` physiological ' ' antagonism ( i . e . via blockade of beta adrenoceptors , 5 HT1B receptors or some other mechanism ) as an explanation for the reversal by pindolol of 5 HT1A autoreceptor agonist induced suppression of 5 HT release . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT 1 subfamily of receptors contains subtypes 5 HT1A , 5 HT1B , 5 HT1D , 5 HT1E , and 5 HT1F ; activation of all of them results in the inhibition of adenylylcyclase . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effects of the relatively specific serotonergic agonists 8 OH DPAT ( 5 HT1A ) , TFMPP ( 5 HT1B ) , and DOB ( 5 HT 2 ) were studied on defensive aggressive behavior in rats using the water competition test , 8 OH DPAT ( up to 0 . 25 mg / kg ) and TFMPP ( up to 1 mg / kg ) were found to be ineffective , whereas DOB ( up to 0 . 4 mg / kg ) significantly reduced aggressive behavior in this test as well as in the offensive aggression test of the resident intruder model . ^^^ These results , combined with those from other studies , suggest that stimulation of 5 HT1A , 5 HT1B , and 5 HT 2 receptors reduces offensive aggression , whereas defensive aggression is only decreased by 5 HT 2 stimulation . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Evidence that 5 hydroxytryptamine release in rat dorsal raph nucleus is controlled by 5 HT1A , 5 HT1B and 5 HT1D autoreceptors . ^^^ These results suggest that 5 HT release in the rat DRN is under the control of 5 HT1A , 5 HT1B and 5 HT1D autoreceptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Mutual influences are seen particularly with 5 HT1A , 5 HT1C and 5 HT 2 , but not with 5 HT1B , 5 HT1D or 5 HT 3 receptor mediated effects . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Microinjection of the nonselective 5 HT receptor antagonist methiothepin or the 5 HT1A / 5 HT1B antagonist pindolol prevented any cardiovascular change by subsequent microinjection of 5 HT into the NTS . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Within these hydrophobic regions , this receptor was found to be 41 36 % identical to the following serotonin [ 5 hydroxytryptamine ( 5 HT ) ] receptors : 5 HT 2 > 5 HT1D > 5 HT1C > 5 HT1B > 5 HT1A > 5 HT1E . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The modulatory effect of spinal serotonin ( 5 HT ) 1 receptors on nociception was studied in mice . 8 Hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) and buspirone , putative 5 HT1A agonists , m trifluoromethylphenyl piperazine ( TFMPP ) and 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo ( 1 , 2 1a ) quinoxaline ( CGS 12066B ) , 5 HT1B agonists , and 5 carboxamidotryptamine ( 5 CT ) , a mixed 5 HT1A and 5HT1B agonist , were used . ^^^ Spiperone , propranolol and pindolol ( mixed 5 HT1A and 5 HT1B antagonists ) effectively reversed both the tail flick facilitation and the antagonistic effect on morphine sulfate induced antinociception produced by 8 OH DPAT and 5 CT . ^^^ These results confirm and extend other reports on the facilitory role of 5 HT1A receptor subtype on nociceptive responses and support the involvement of 5 HT1B receptor subtype in the antinociceptive action of serotonin . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Final compounds were evaluated for in vitro activity on dopamine D 1 and D 2 , serotonin 5 HT1A , 5 HT1B , 5 HT1C , and 5 HT 2 , alpha 1 adrenergic , and sigma receptors by radioreceptor binding assay . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Both serotonin ( 5 HT ) releasers and agonists at 5 HT1A , 5 HT1B , and 5 HT 2 receptors reduce PPI in the rat . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Neither was 5 MT inhibition of SRC affected by blocking 5 HT1A ( with propranolol and spiperone ) , 5 HT1B ( with propranolol ) , or 5 HT1C ( with ketanserin ) receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
This is indicated by ( a ) lower contents of DA and 5 HT ; ( b ) fewer 5 HT immunostained fibers ; ( c ) lower densities of 5 HT1B , 5 HT 2 and D 2 receptors ; and ( d ) higher densities of 5 HT1A receptors in the CNS of P rats compared to the alcohol nonpreferring NP line of rats . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Pretreatment with propranolol ( beta adrenoceptor antagonist that also has binding affinity for 5 HT1A , 5 HT1B and 5 HT2C sites ) , MDL 72222 or ondansetron ( 5 HT 3 antagonists ) did not attenuate DOI induced hyperthermia . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT 1 and 5 HT 2 receptor antagonist metergoline ( 1 . 0 and 2 . 0 mg / kg i . p . ) and the 5 HT1A and 5 HT1B receptor antagonist ( + / ) cyanopindolol ( 3 . 0 and 8 . 0 mg / kg s . c . ) significantly antagonized the effect of d fenfluramine . ^^^ The 5 HT2A and 5 HT2C receptor antagonist mesulergine ( 0 . 1 and 0 . 3 mg / kg s . c . ) and the 5 HT2A receptor antagonist ketanserin ( 2 . 5 and 5 . 0 mg / kg i . p . ) did not significantly modify the effect , nor did the 5 HT1A and 5 HT1B receptor antagonist ( ) propranolol ( 20 40 nmol ) , injected bilaterally into the paraventricular nucleus of the hypothalamus . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Chronic treatment with fluvoxamine by osmotic minipumps fails to induce persistent functional changes in central 5 HT1A and 5 HT1B receptors , as measured by in vivo microdialysis in dorsal hippocampus of conscious rats . ^^^ This study investigated the alterations of the 5 HT1A and 5 HT1B autoreceptor function following chronic treatment with fluvoxamine using osmotic minipumps . ^^^ The 5 HT1A and 5 HT1B autoreceptor function were studied using microdialysis in the dorsal hippocampus . ^^^ The effect of the 5 HT1A receptor agonist 8 OH DPAT ( 0 . 3 mg / kg , SC ) and the 5 HT1B receptor agonist RU 24969 ( 100 nM through the dialysis probe for 30 min ) on 5 HT release was compared with rats chronically treated with saline . 8 OH DPAT decreased 5 HT release to 55 % and 60 % of baseline , while RU 24969 decreased 5 HT release to 66 % and 70 % of baseline value in the saline and fluvoxamine group , respectively . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effects of intra collicular injections of 5 HT 1 drugs on distractibility were studied in hooded rats trained to run toward illuminated targets for a food reward in a 2 choice runway . 8 hydroxy 2 ( di n propylamino ) tetraline ( 8 OH DPAT ) , a 5 HT1A receptor agonist , RU 24969 , a mixed 5 HT1A and 5 HT1B agonist , serotonin O carboxymethylglycyltyrosinamide ( S CM GTNH 2 ) , a mixed 5 HT1B and 5 HT1D receptor agonist and saline ( control ) were alternately injected . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In vitro binding and quantitative autoradiographic studies showed that neither 5 HT1A , 5 HT1B , 5 HT2A , nor 5 HT 3 receptor binding sites in various brain areas were affected by these treatments . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
To gain further insight into the operation of 5 HT autoreceptor mediated feedback control of 5 HT biosynthesis in serotonergic nerve terminal areas , the effect of the 5 HT1B and the 5 HT1A receptor agonists , TFMPP and 8 OH DPAT , respectively , were investigated in the rat central nervous system ( CNS ) using in vivo and in vitro neurochemical approaches . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Serotonin ( 5 HT ) receptors have been classified into several categories , and they are termed as 5 HT 1 , 5 HT 2 , 5 HT 3 , 5 HT 4 , 5 HT 5 , 5 HT 6 and 5 HT 7 type receptors . 5 HT 1 receptors have been further subdivided into 5 HT1A , 5 HT1B , 5 HT1D , 5 HT1E and 5 HT1F . 5 HT 2 receptors have been divided into 5 HT2A , 5 HT2B and 5 HT2C receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Due to the high level of expression of mRNA for the 5 hydroxytrytamine ( 5 ht 7 ) receptor in the hypothalamus and the high affinity of 5 HT for this receptor , [ 3H ] 5 HT binding was performed in rat hypothalamus to determine whether 5 ht 7 receptor binding sites are present in animal tissue . [ 3H ] 5 HT binding was performed in the presence of 100 nM pindolol , which is inactive at 5 ht 7 receptors but prevents the binding of [ 3H ] 5 HT to 5 HT1A and 5 HT1B receptor binding sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT1A , 5 HT1B and beta adrenergic receptor antagonists pindolol and cyanopindolol ( 6 mg / kg SC ) did not affect punished responding either , nor did the 5 HT1D receptor partial agonist and alpha 2 adrenergic receptor antagonist yohimbine ( 2 . 5 mg / kg SC ) or the histamine H 1 receptor antagonist mepyramine ( 1 mg / kg SC ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The aim of this study was to provide evidence that anpirtoline , which is an agonist at 5 HT1B and 5 HT1D receptors and also displays submicromolar affinity for 5 HT1A recognition sites , in addition , acts as an antagonist at 5 HT 3 receptors . 2 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These results are consistent with the disappearance of 5 HT1B receptors from thalamocortical axons after the second postnatal week and the maintenance of 5 HT1A receptors on some neurons . 6 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
On the other hand , spiperone ( 0 . 25 0 . 5 mg / kg ) , a dopamine , 5 HT1A and 5 HT2A receptor antagonist ; pindolol ( 4 8 mg / kg ) , a beta adrenoceptor , 5 HT1A and 5 HT1B receptor antagonist and zacopride ( 0 . 1 1 mg / kg ) a 5 HT 3 receptor antagonist , did not affect the analgesia induced by m CPP . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Despite comparable control Bmax values for 5 HT1A ( 84 + / 2 fmol / mg of protein ) and 5 HT1B ( 94 + / 4 fmol / mg ) subtypes , marked differences were noted in their 1 ) receptor production rates ( r = 0 . 349 versus 0 . 235 fmol / mg of protein / hr ) , 2 ) receptor degradation rate constants ( k = 0 . 0056 versus 0 . 0033 hr 1 ) , and 3 ) half lives of receptor recovery ( 124 . 1 versus 212 . 5 hr ) . ^^^ These data indicate that 1 ) comparable receptor steady state Bmax values for 5 HT receptor subtypes may be due to markedly different receptor kinetic parameters ( r and k ) , 2 ) differences in r and k are greater between 5 HT receptor families ( i . e . , 5 HT 1 versus 5 HT 2 ) than among subtypes within a family ( i . e . , 5 HT1A versus 5 HT1B ) , and , 3 ) despite marked changes in 5 HT2A receptor density , the percentage of receptors in the agonist labeled , high affinity state is maintained . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
It has recently been shown that the increase in external carotid blood flow induced by 5 hydroxy tryptamine ( 5 HT ) in the anaesthetized dog , being mimicked by 5 carboxamidotryptamine ( 5 CT ) , inhibited by methiothepin , vagosympathectomy and sympatho inhibitory drugs , and resistant to blockade by ritanserin and MDL 72222 , is mediated by stimulation of prejunctional 5 HT 1 like receptors leading to an inhibitory action on carotid sympathetic nerves ; these 5 HT 1 like receptors are unrelated to either the 5 HT1A , 5 HT1B or 5 HT1C ( now 5 HT2C ) receptor subtypes . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These studies not only demonstrate the existence of several classes of serotonin receptors called 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , 5 HT 2 , 5 HT 3 and 5 HT 4 , but led also to the development of novel agonists and antagonists for the stimulation or blockade of each of them . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The responsiveness of these hetereceptors was tested in parallel with those of the terminal 5 HT1B autoreceptors and of the postsynaptic 5 HT1A and alpha 2 adrenergic receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Using the conflict drinking test as a model , we studied in rats the effect of the nonselective beta adrenoceptor blockers pindolol and cyanopindolol which bind to 5 HT1A and 5 HT1B receptors , and of the selective beta 1 and beta 2 adrenoceptor antagonists betaxolol and ICI 118 , 551 , respectively , which have a negligible affinity for 5 HT receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effects of D 1997 in the basilar artery were not modified by incubation with either the 5 HT 2 receptor antagonist ketanserin ( 0 . 01 1 microM ) , the 5 HT 3 and 5 HT 4 receptor antagonist ICS 205930 ( tropisetron ; 0 . 1 10 microM ) , the 5 HT1A receptor antagonist spiroxatrine ( 0 . 01 1 microM ) , the beta adrenoceptor blocker with high affinity for 5 HT1A and 5 HT1B binding sites ( + / ) pindolol ( 0 . 01 1 microM ) , or the alpha 1 adrenoceptor antagonist prazosin ( 0 . 01 1 microM ) . ^^^ It is concluded that D 1997 contracts the canine basilar artery by stimulating 5 HT 1 like receptors unrelated to either the 5 HT1A or 5 HT1B receptor subtypes . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Our results show that neither of the two drugs altered the inhibition of adenylate cyclase activity induced by serotonin 1 ( 5 HT 1 ) receptor agonists nor did they alter 5 HT1A and 5 HT1B receptor densities . ^^^ These results reinforce the idea that the ability of antidepressants to decrease the activity of the beta adrenoceptor adenylate cyclase complex is not common to all antidepressants , and provide no evidence for the involvement of 5 HT1A and / or 5 HT1B in the mechanism of action of these drugs . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Pretreatment with propranolol ( beta adrenoceptor antagonist that also has high binding affinity for 5 HT1A , 5 HT1B and 5 HT2C sites ) , MDL 72222 and ondansetron ( 5 HT 3 antagonists ) attenuated DOM ' s effect on plasma prolactin , but did not attenuate DOM induced increases in either ACTH or corticosterone . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The serotonin 5 HT1B and 5 HT1A receptors bind certain beta adrenergic antagonists , such as propranolol and pindolol , with high affinity . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effects of N ethoxycarbonyl 2 ethoxy 1 , 2 dihydroquinoline ( EEDQ ) , an alkylating agent producing irreversible blockade of various membrane bound receptors in brain , were investigated on four different types of serotonin receptors , 5 HT1A , 5 HT1B , 5 HT2A and 5 HT 3 , in various brain regions in the rat . ^^^ Membrane binding assays and / or quantitative autoradiography with appropriate radioligands indicated that EEDQ inactivated 5 HT1A , 5 HT1B and 5 HT2A sites , but was poorly active on 5 HT 3 , benzodiazepine and `` R ' ' sites . ^^^ Among the receptors affected by EEDQ , hippocampal 5 HT1A sites were the most sensitive to the alkylating agent ( ID 50 approximately 1 mg / kg i . p . ) , followed by the cortical 5 HT2A ( ID 50 approximately 3 mg / kg i . p . ) and the striatal 5 HT1B ( ID 50 approximately 6 mg / kg i . p . ) sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
At a time when low dose ( 80 mg / kg ) p , p ' DDT elicited stimulus sensitive and spontaneous myoclonus , there were no significant changes in Bmax or Kd of 5 HT1A , 5 HT1B , 5 HT1C sites in cortex , striatum , brainstem or spinal cord , agonist or antagonist labelled 5 HT 2 sites in cortex , or 5 HT uptake sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Concentration response curves for inhibition of electrically stimulated 5 HT overflow by 8 OH DPAT ( 5 HT1a receptor agonist ) or RU 24969 ( 5 HT1b receptor agonist ) in the DRN or SCN respectively were obtained in slices prepared from both groups of animals . ^^^ These data suggest that down regulation of the 5 HT1b autoreceptors occurs in an axon terminal region ( SCN ) but that there is a sensitisation of 5 HT1a autoreceptor mechanisms controlling 5 HT overflow in the DRN . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Pretreatment with propranolol [ a beta adrenoceptor antagonist that also has high binding affinity for serotonin ( 5 HT ) 5 HT1A , 5 HT1B and 5 HT2C sites ] , bemesetron or ondansetron ( 5 HT 3 antagonists ) did not attenuate either DOM induced hypophagia or hyperthermia . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT1A and 5 HT1B receptor agonists 8 hydroxy 2 ( di n propyl amino ) tetralin and CP 93 , 129 , respectively , as well as the 5 HT 1 receptor agonist 5 carboxyamidotryptamine , were devoid of effect on the release of [ 3H ] noradrenaline . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In rat cortical membrane , KB 2796 inhibited specific [ 3H ] spiperone binding to 5 HT 2 receptors in a competitive manner ( Ki = 0 . 57 microM ) , but exhibited negligible affinity for radioligand binding to other 5 HT receptor subtypes such as 5 HT 1 , 5 HT1A , 5 HT1B , 5 HT1C and 5 HT 3 at a concentration of 10 or 100 microM . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Structural analysis by the comparative molecular field analysis method of the affinity of beta adrenoreceptor blocking agents for 5 HT1A and 5 HT1B receptors . ^^^ The affinities of 17 beta adrenoreceptor antagonists for 5 HT1A and 5 HT1B receptors were evaluated in binding assays . ^^^ CoMFA demonstrated the important contribution of steric parameters , evaluated at 92 % , compared to the electrostatic field ( evaluated at 8 % ) to explain the affinity for 5 HT1A and 5 HT1B receptors . ^^^ This study emphasizes also the importance of the occupancy of a hydrophobic pocket in the receptor site located near the area interacting with the aromatic moiety , and subsequently its use for the design of new , potent , specific antagonists of 5 HT1A and 5 HT1B receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The data indicate that ( ) penbutolol possesses 5 HT1A and 5 HT1B autoreceptor antagonist properties , and may be a useful tool in studies of central 5 HT receptor mediated function . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Perfusion of serotonin ( 5 HT ; 10 microM , for 30 min at a rate of 3 microliters / min ) , dissolved in Ringer ' s solution containing 10 microM eserine , showed no marked effect on the extracellular levels of ACh . 8 Hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ; 20 microM ) , a 5 HT1A agonist , increased ACh levels , whereas 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo [ 1 , 2 a ] quinoxaline ( CGS 12066B ; 100 microM ) , a 5 HT1B agonist , decreased it . ^^^ These results indicate that the 5 HT1A receptor , which exists in the dorsal hippocampus , enhances the spontaneous ACh release , and that the mechanism of serotonergic modulation of ACh release partly depends on both the stimulatory control via the 5 HT1A receptor and the suppressive one via the 5 HT1B receptor in the dorsal hippocampus of rats . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT inhibition of SRC and SAT is predominant and is mediated by 5 HT 1 like receptors , which , however , do not seem to correspond to 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , 5 HT1E , or 5 HT1F receptor subtypes . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The firing rate of dorsal raphe serotonergic neurons is under the control of somatodendritic 5 hydroxytryptamine 1A ( 5 HT1A ) autoreceptors , the release of serotonin from nerve terminals is under the control of 5 HT autoreceptors ( 5 HT1B subtype in rodents , 5 HT1D in other species ) , whereas the control of the activity of tryptophan hydroxylase , the rate limiting enzyme of serotonin synthesis , is complex , involving 5 HT1A but possibly other 5 HT receptors including the 5 HT1B / D subtype . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Kindling induced a persistent bilateral increase in 5 HT1A binding in the dentate gyrus , while 5 HT1B receptors increased only in a delayed fashion . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
EEDQ dose dependently reduced the Bmax of 5 HT1A ( 3H DPAT ) , 5 HT1B ( 125I CYP ) , 5 HT 2 ( 3H ketanserin ) and 5 HT2 / 1C ( 125I DOI ) receptors in cortical homogenates . ^^^ The rank order of sensitivity to EEDQ inactivation was : 5 HT1A > 5 HT1B > 5 HT 2 approximately 5 HT2 / 1C > > > 5 HT uptake sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
RU 24969 ( 7 . 5 mg kg 1 i . p . ) induced hyperlocomotion was inhibited by the ( ) , but not ( + ) isomers of pindolol ( 4 mg kg 1 ) and propranolol ( 20 mg kg 1 ) but not by metoprolol ( 10 mg kg 1 ) or ICI 118 , 551 ( 5 mg kg 1 ) , consistent with an involvement of 5 HT1A or 5 HT1B receptors . 5 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Several other agonists and antagonists that act at 5 HT1A , 5 HT1B , 5 HT 2 and 5 HT 3 receptors did not produce an altered response in the lesioned rats , nor were these substances effective in attenuating m CPP enhanced oral activity responses . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Carboxamidotryptamine insensitive 5 HT 1 like receptors are concentrated in guinea pig but not rat , claustrum . 5 CT ( 5 carboxamidotryptamine ) insensitive ( 5 HT1E / 5 HT1F ) 5 HT 1 like recognition sites have been mapped autoradiographically in rat and guinea pig brain using [ 3H ] 5 HT in the presence of 5 CT and mesulergine to mask 5 HT1A , 5 HT1B , 5 HT1D and 5 HT2C binding sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
When 8 OH DPAT ( 100 nM ) + chlorpromazine ( 500 nM ) , CGS 12066 B ( 200 nM ) + ritanserin ( 500 nM ) , and ( + / ) pindolol ( 1 microM ) were included to block 5 HT1A + 5 HT1C , 5 HT1B + 5 HT1C , and 5 HT1A + 5 HT1B receptor subtype respectively , the competition studies have shown that under these selective conditions dihydroergosine binds with the highest affinity for 5 HT1B ( Ki = 0 . 48 nM ) , with 8 . 7 times lower affinity for 5 HT1A ( Ki = 4 . 2 nM ) and with a moderate affinity for 5 HT1C ( Ki = 156 nM ) receptor subtype . ^^^ While our previous studies suggested that dihydroergosine stimulates 5 HT1A and inhibits 5 HT 2 receptors , this study suggests that the high affinity of this drug for 5 HT1B receptors should not be neglected . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Rats were then withdrawn from the pretreatment regimen for 7 days and their behavior rated following injections of 5 hydroxytryptamine1A ( 5 HT1A ) or 5 HT1B agonists . ^^^ Overall , the results indicate that , at least in the present behavioral paradigm , the effects of chronic cocaine administration are mediated by changes in 5 HT1A receptor sensitivity but not by changes in 5 HT1B receptor sensitivity . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The distribution of [ 125I ] GTI binding sites was largely comparable to that of [ 125I ] iodocyanopindolol ( [ 125I ] ICYP ) which labels 5 HT1B binding sites ( in the presence of 8 OH DPAT ( 8 hydroxy [ 2N dipropylamino ] tetralin ) and isoprenaline , to prevent binding to 5 HT1A and beta adrenoceptor binding sites ) , although a detailed analysis revealed differences . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The above results indicate that FLU given chronically has no effect on the responsiveness of 5 HT1A receptors , increases the responsiveness of 5 HT1B receptors and decreases those of 5 HT1C and 5 HT 2 receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In radioligand binding studies , SDZ 216 525 showed high affinity and selectivity for 5 HT1A sites ( pKD = 9 . 2 ) as compared to 5 HT1B , 5 HT1C , 5 HT1D , 5 HT 2 and 5 HT 3 sites ( pKD = 6 . 0 , 7 . 2 , 7 . 5 , 5 . 2 and 5 . 4 , respectively ) . ^^^ The effects of SDZ 216 525 , MDL 73005 and NAN 190 on 5 HT 1 receptor linked second messengers were characterised in the following tests : inhibition of forskolin stimulated adenylate cyclase activity in calf hippocampus ( 5 HT1A ) , rat substantia nigra ( 5 HT1B ) and calf substantia nigra ( 5 HT1D ) and stimulation of inositol phosphate production in pig choroid plexus ( 5 HT1C ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Within the conserved transmembrane domains , the sequences exhibit approximately 52 % , 59 % , 65 % , and 68 % amino acid identity with the known rat 5 HT1A , rat 5 HT1B , rat 5 HT1D , and human 5 HT1E receptors , respectively . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The obtained results indicate that ( + ) OXA administered repeatedly increases the reactivity of 5 HT1B receptors , decreases the reactivity of 5 HT 2 receptors , and has no effect on the reactivity of 5 HT1A ( pre and postsynaptic ) and 5 HT1C receptors . ( ) OXA given repeatedly decreases the reactivity of presynaptic 5 HT1A receptors and has no influence on the reactivity of postsynaptic 5 HT1A , 5 HT1B , 5 HT1C and 5 HT 2 receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Interestingly , the 5 HT1A and 5 HT1B receptor antagonist , cyanopindolol ( 100 , 300 and 1000 micrograms / kg i . v . ) , blocked the effects of 5 HT , but the block was not elicited in a dose dependent manner , with only the response induced by 0 . 3 microgram / min 5 CT being significantly antagonized by the highest dose of cyanopindolol ; however , this blockade was not selective . ^^^ These receptors , however , do not seem to correspond to either the 5 HT1A , 5 HT1B or 5 HT1C receptor subtypes . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In addition to demonstrating that 5 HT1a and 5 HT1b receptors are differentially regulated in different brain areas , these results show that in the brain regions examined both 5 HT1a and 5 HT1b receptors are primarily post synaptic . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Several serotonergic agonists were assayed to further analyse the type of receptors involved in the response to 5 HT . 5 methoxytryptamine ( 5 MOT ) , a mixed 5 HT 1 , 5 HT 2 and 5 HT 4 agonist , reproduced all the effects of 5 HT . 8 OH DPAT , a selective 5 HT1A agonist , trifluoromethylphenylpiperazine , a mixed 5 HT1B / C agonist , and m chlorophenylbiguanide , a 5 HT 3 agonist , did not induce any consistent contractile effects . ^^^ These results indicate that chicken ileum contains 5 HT 1 receptors similar to the 5 HT1D mammalian subtype but not the 5 HT1A , 5 HT1B , 5 HT1C or 5 HT 3 subtypes . 5 HT 2 receptors are also present and would appear to be located on smooth muscle . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The vascular responses of simian gastroepiploic arteries to 5 hydroxytryptamine ( 5 HT ) , 5 carboxamidotryptamine ( 5 CT , a selective 5 HT 1 like receptor agonist ) , 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT , a selective 5 HT1A receptor agonist ) , m trifluoromethylphenylpiperazine ( TFMPP , a selective 5 HT1B receptor agonist ) , noradrenaline and KCl were examined in isolated , cannulated and perfused preparations . 5 HT induced dose dependent vasoconstrictions more potently than noradrenaline did . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The agonists increased extraneuronal levels of DA in a dose dependent manner , suggesting receptor selectivity in the order of 5 HT1b > 5 HT 4 > > 5 HT 2 = 5 HT1a . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These results suggest that 5 HT receptor ( 5 HT1A , 5 HT 2 and 5 HT 3 but not 5 HT1B ) mediated mechanisms play an important role in the production of PSY SIA . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In this study we began by using autoradiography to determine that the SCN contain abundant 5 HT1A and 5 HT1B receptors , very few 5 HT1C and 5 HT 2 receptors , and no 5 HT 3 receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Quantitative ligand binding autoradiography was used to compare the density of various 5 HT receptor subtypes in the adult brain of control and neonatally 6 OHDA lesioned rats . 5 HT1A , 5 HT1B , 5HT1nonAB and 5 HT 2 sites were labeled with [ 3H ] 8 OH DPAT , [ 125I ] cyanopindolol , [ 3H ] 5 HT and [ 125I ] DOI , respectively , and measured in the rostral and caudal halves of neostriatum and selected forebrain or midbrain regions . 5 HT1A binding , measured after 6 months , was unchanged in all regions examined including the dorsal raphe nucleus . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The results of the present study show that , 5 days after rabies virus infection in rat , the total reversible high affinity binding of [ 3H ] 5 HT in the hippocampus is not affected , suggesting that 5 HT1A binding is not altered . 5 HT1B sites identified by [ 125I ] cyanopindolol binding are not affected in the cortex 3 and 5 days after the infection . ^^^ In contrast , [ 3H ] 5 HT binding determined in the presence of drugs masking 5 HT1A , 5 HT1B and 5 HT1C receptors , is markedly ( 50 % ) reduced 3 days after the viral infection . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
It was found that ( ) tertatolol binds to 5 HT 1 receptor subtypes in rat brain , particularly the 5 HT1A subtype in the hippocampus ( Ki = 5 . 9 nM ) . ( ) Tertatolol showed much lower affinity for 5 HT1B ( Ki = 118 . 4 nM ) , 5 HT1C ( Ki = 699 . 6 nM ) and 5 HT 2 ( Ki = 678 . 6 nM ) receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Two injections of the 5 HT 2 receptor antagonist cinanserin ( 30 nmol / 0 . 5 microliter ) in the paraventricular nucleus of the hypothalamus completely reversed the effect of stress on food intake . ( + / ) Cyanopindolol ( 3 and 8 mg / kg ) , an antagonist at 5 HT1A and 5 HT1B receptors , had no effect whereas 8 hydroxy 2 di n propylamino ) tetralin ( 30 300 micrograms / kg ) , an agonist at 5 HT1A receptors , significantly attenuated the hypophagia . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Chronic alcoholization alters the expression of 5 HT1A and 5 HT1B receptor subtypes in rat brain . ^^^ The expression of central 5 HT1A and 5 HT1B receptors was studied in several brain areas of rats subjected to a 2 week period of chronic alcoholization , followed by 18 h withdrawal . ^^^ These data suggest that altered sensitivity of chronically alcoholized rats to 5 HT1A and 5 HT1B receptor ligands may result from alcohol induced changes in the transcription of the genes encoding these receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT receptor identity of control and transfected C 6 glial / 5 HT1D beta cells was determined by reverse transcription polymerase chain reaction using primers specific for rat 5 HT1A , rat 5 HT1B , rat 5 HT1D alpha , human 5 HT1D beta , and rat 5 HT2A receptor genes . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In contrast , the following drugs were ineffective : ( + / ) 8 hydroxy dipropylaminotetralin hydrobromide ( 8 OH DPAT , 5 HT1A agonist ) , buspirone hydrochloride ( 5 HT1A agonist ) , 7 trifluoromethyl 4 ( 4 methyl l piperazinyl ) pyrrolo [ 1 , 2 a ] quinoxaline maleate ( CGS 12066B , 5 HT1B agonist ) , ketanserin tartrate ( 5 HT 2 antagonist ) , methysergide maleate ( 5 HT 2 antagonist ) , fluoxetine ( 5 HT uptake blocker ) , and saline ( vehicle ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
They received intrahippocampal microinjections of a 5 HT1A [ 8 hydroxy 2 ( di n propylamino ) tetralin or 8 OH DPAT ] , or a 5 HT1B [ 3 ( 1 , 2 , 5 , 6 tetrahydropyrid 4 yl ) pyrrolo [ 3 , 2 b ] pyrid 5 one or CP 93 , 129 ] receptor agonist , and a muscarinic receptor antagonist ( scopolamine ) . 8 OH DPAT ( 5 micrograms / microliters ) , like injections of saline , induced no change in performance levels . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Functional effects of the 5 HT1D receptor antagonist GR 127 , 935 at human 5 HT1D alpha , 5 HT1D beta , 5 HT1A and opossum 5 HT1B receptors . ^^^ GR 127 , 935 did not show 5 HT1D beta receptor mediated agonist activity in permanently transfected CHO K 1 cells , whereas at submicromolar and higher concentrations intrinsic agonist activity was observed in HeLa / 5 HT1A , OK / 5 HT1B and CHO K1 / 5 HT1D alpha cells . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The inhibitory effect of 5 CT was blocked by the 5 HT1 / 2 antagonist methiothepin ( 1 microM ) , the 5 HT1A antagonist S UH 301 ( 1 microM ) , and the 5 HT1B / 1D antagonist GR 127935 ( 1 microM ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
This higher concentration was , however , needed to fully saturate 5 HT1A and 5 HT1B receptors without interaction with 5 HT 7 receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Abnormalities in 5 HT1A and 5 HT1B receptor binding in severe seizure genetically epilepsy prone rats ( GEPR 9s ) . ^^^ These finding suggest that in addition to the innate reduction in 5 HT presynaptic markers , GEPR 9s also exhibit abnormalities in the density of 5 HT1A and 5 HT1B receptors in some regions of the brain . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The most intensively investigated 5 HT receptor subtypes have been the 5 HT1A receptor , the 5 HT1B receptor and the 5 HT2C receptor . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In the present study , we measured the affinity of acetaminophen at 5 HT 3 , as well as 5 HT1A , 5 HT1B , 5 HT1D , 5 HT 2 , 5 HT2C , 5 HT 4 , 5 HT 6 , 5 HT 7 and eleven other receptor sites and at serotonin and norepinephrine reuptake sites . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Interestingly , tertatolol ( 3 micrograms ) itself had an anxiolytic effect which was not antagonised by 8 OH DPAT ( 100 ng ) , suggesting the effect was not mediated by 5 HT1A receptors , and indeed other actions of tertatolol , such as those on 5 HT1B or beta adrenergic receptors could have been involved . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
HT levels through mechanisms involving not only 5 HT1A , but also 5 HT1B receptors . ^^^ Although the antagonism of the 8 OH DPAT induced decrease of 5 HT levels by ( ) pindolol and ( + / ) tertatolol is likely to be related to their 5 HT1A antagonist properties , their ability to increase extracellular 5 HT levels when given alone may involve interactions with 5 HT1B receptors at hippocampal 5 HT terminals . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Effects of dorsal rhizotomy and selective lesion of serotonergic and noradrenergic systems on 5 HT1A , 5 HT1B , and 5 HT 3 receptors in the rat spinal cord . ^^^ Autoradiographic studies were performed in combination with dorsal rhizotomy or selective lesion of descending serotonergic or noradrenergic systems in an attempt to identify the neuronal cell types endowed with the serotonin 5 HT1A , 5 HT1B and 5 HT 3 receptors in the rat spinal cord . ^^^ In addition , a significant decrease ( approximately 20 % ) in the binding of [ 3H ] 8 OH DPAT to 5 HT1A receptors and of [ 125I ] GTI to 5 HT1B receptors was also observed in the same spinal area in rhizotomized rats , suggesting that a small proportion of these receptors are also located on primary afferent fibres . ^^^ These data indicate that complex adaptive changes in the expression of 5 HT1A and 5 HT1B receptors occurred in the rat spinal cord following the lesion of descending monoaminergic systems . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT1A / 5 HT1B agonist 5 carboxamidotryptamine depressed activity in 20 of 25 neurons studied . ^^^ The 5 HT1A / 5 HT1B antagonist pindolol prevented the 5 carboxamidotryptamine induced changes , whereas the 5 HT1A antagonist spiroxatrine and the 5 HT 2 antagonists ketanserin and mianserin were ineffective . ^^^ These data provide electrophysiological evidence for the presence of 5 HT 1 receptors in the nTS , presumably of the 5 HT1B subclass , but cast further doubt on the contribution of 5 HT 2 and 5 HT1A receptors to the actions of serotonin in the nucleus . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Further supporting the relevance of 5 HT1B receptors to the activating effects of serotonin releasing agents , MDMA exhibits reciprocal cross tolerance with the 5 HT1B agonist RU 24969 , but not with either 5 HT1A or 5 HT 2 agonists or amphetamine . ^^^ Thus , studies of locomotor and investigatory responses can be used to demonstrate and differentiate the effects of direct agonists at 5 HT1A , 5 HT1B , and 5 HT 2 receptors as well as indirect serotonin agonists . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Among the numerous 5 HT receptor subtypes , several ( 5 HT1A , 5 HT1B , 5 HT 2 and 5 HT 3 ) could be involved in these etiologies . ^^^ The regional density of 5 HT1A , 5 HT1B , 5 HT2A and 5 HT2B receptors has been measured in the brains of parental strains , F ( 1 ) and F ( 2 ) populations by quantitative autoradiography . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Oligonucleotide primers were chosen based on unique regions of complementary DNA sequence for each of the 12 cloned rat serotonin receptor subtypes ( i . e . 5 HT1A , 5 HT1B , 5 HT1D , 5 HT1F , 5 HT2A , 5 HT2B , 5 HT2C , 5 HT 3 , 5 HT5A , 5 HT5B , 5 HT 6 and 5 HT 7 ) and high stringency conditions were used during polymerase chain reaction . ^^^ Within superior cervical ganglia , the presence of messenger RNA for 5 HT1A , 5 HT1B , 5 HT1D , 5 HT2A , 5 HT 3 , 5 HT 6 , and 5 HT 7 receptor subtypes was detected . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These data suggest that neither the 5 HT1A , 5 HT1B , 5 HT1D , 5 HT2A , 5 HT2B , 5 HT2C , 5 HT 3 , 5 HT 5 , 5 HT 6 , nor 5 HT 7 receptors are involved . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The antiaggressive potency of ( ) penbutolol involves both 5 HT1A and 5 HT1B receptors and beta adrenoceptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In tissues precontracted with U 46619 ( 10 nM ) and in the presence of 5 HT1A , 5 HT1B , 5 HT2A , 5 HT 3 , and 5 HT 4 receptor blockade , 5 CT and 5 MeOT caused endothelium independent relaxation with potency values of 7 . 5 + / 0 . 1 ( n = 21 ) and 5 . 7 + / 0 . 1 ( n = 4 ) , respectively . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The findings suggest that 5 HT1A , 5 HT1B and 5 HT 2 receptors are not implicated in 5 HT stimulated C 6 glial / 5 HT1D cell growth . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The release of [ 3H ] ACh was measured in presence of atropine ( muscarinic antagonist , 1 microM ) , physostigmine ( acetylcholinesterase inhibitor , 0 . 1 microM ) , oxotremorine ( muscarinic agonist , 0 . 01 microM 10 microM ) , mecamylamine ( nicotinic antagonist , 10 microM ) , methiothepin ( mixed 5 HT1 / 5 HT 2 antagonist , 10 microM ) , 8 OH DPAT ( 5 HT1A agonist , 1 microM ) , 2 methyl serotonin ( 5 HT 3 agonist , 1 microM ) and CP 93129 ( 5 HT1B agonist , 0 . 1 microM 100 microM ) , or without any drug application as a control . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These data indicate that ( 1 ) different 5 HT receptor subtypes ( 5 HT1A and 5 HT1B ) regulate dendritic and axon terminal 5 HT release ; ( 2 ) serotonin release from the dendrites may be regulated by the voltage sensitive N type Ca2+ channels ; ( 3 ) the 5 HT1A receptor mediated inhibition of serotonin release may be due to opening of voltage sensitive K+ channels . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Affinities for the 5 HT1A receptors were in the nanomolar range for the best compounds ( ( + ) 11a , 23 ) with a high selectivity versus other 5 HT ( 5 HT1B , 5 HT 2 , 5 HT 3 ) or dopamine ( D 1 , D 2 ) receptor subtypes . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Differential addressing of 5 HT1A and 5 HT1B receptors in transfected LLC PK 1 epithelial cells : a model of receptor targeting in neurons . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Serotonin and serotonin agonists with relative selectivity for the receptor subtypes 5 HT1A , 5 HT1B , 5 HT2A / 2C and 5 HT 3 all significantly ( P < 0 . 01 ) inhibited glutamate evoked firing of cells in the nucleus accumbens compared to the effects of an acidic saline control solution ( 30 60 nA , 60 s ejection currents for all ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
We have examined the effects of selective antagonists at 5 HT1A and 5 HT1B / D receptors ( WAY 100135 and GR 127935 , respectively ) on both the hyperlocomotor and anti immobility effects of RU 24969 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Pretreatment with propranolol ( beta adrenergic receptor antagonist that also has binding affinity for 5 HT1A , 5 HT1B and 5 HT2B sites ) , yohimbine ( alpha 2 noradrenergic antagonist that also has binding affinity for 5 HT2B sites ) , MDL 72222 or ondansetron ( 5 HT 3 antagonists ) did not attenuate m CPP induced hyperthermia . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In radioligand binding assays , PIT showed a low affinity ( pKi < 5 ) for a range of membrane receptors , including : alpha 1 , alpha 2 adrenoceptors , 5 HT1A , 5 HT1B , 5 HT 2 , 5 HT 3 , D 1 , D 2 , muscarinic , central benzodiazepine , H 1 , mu opioid , dihydropyridine and batrachotoxin receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
This agonist and antagonist profile is consistent with the presence of a 5 HT1B receptor . 8 OH DPAT ( 1 microM ) and renzapride ( 3 microM ) were without effect on forskolin stimulated cyclic AMP production and ketanserin ( 0 . 3 microM ) did not antagonize the inhibition produced by 5 HT , thus excluding the involvement of 5 HT1A , 5 HT 4 , and 5 HT 2 receptors . 6 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Serotonin exerted immunosuppressive effects on lipopolysaccharide ( LPS ) and phytohemagglutinin ( PHA ) stimulated proliferation of fish peripheral blood lymphocytes ( PBL ) . 8 OH DPAT ( an agonist of 5 HT1A receptors ) mimicked the inhibitory effects of serotonin on lymphocyte proliferation , whereas addition of spiperone ( an antagonist of 5 HT1A and 5 HT1B receptors ) reversed these inhibitory effects , indicating that 5 HT1A receptors may be implicated in serotonin induced immunosuppression . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In this review , the functional interactions between serotonin ( 5 HT ) and other neuronal systems are discussed with the focus on microdialysis studies in the mammalian brain ( mainly rats ) . 5 HT release is negatively regulated not only by somatodendritic 5 HT1A and terminal 5 HT1B ( 5 HT1D ) autoreceptors but also by alpha 2 adrenergic and mu opioid heteroreceptors that are located on serotonergic nerve terminals . 5 HT by itself is involved in the inhibitory effects of noradrenaline release and the facilitatory regulation of dopamine release via multiple 5 HT receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Both sarpogrelate and M 1 had no affinity for 5 HT1A receptors , but these substances , at a concentration of 10 microM , displaced the specific binding to the 5 HT1B receptors of [ 125I ] iodocyanopindolol , resulting in Ki values of 0 . 881 and 0 . 859 microM , respectively . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The first set of experiments was carried out to confirm the influence of 5 HT1A , 5 HT1B , 5 HT2A / 2C receptor agonists on the activation of the hypothalamic pituitary adrenal axis . ^^^ Plasma corticosterone levels were measured , and a double immunolabeling procedure was used to determine whether the neuronal activity marker , c Fos protein ( Fos ) , could be found within brain neurons containing CRH after treatments with 5 HT1A , 5 HT1B , 5 HT2A / 2C receptor agonists . ^^^ The effects of the 5 HT1A , 5 HT1B , 5 HT2A / 2C receptor agonists on food intake and VO 2 were measured in rats treated with the CRH antagonist , alpha helical CRH ( 9 41 ) . ^^^ In both experiments rats were intraperitoneally injected with either a vehicle ( NaCl 0 . 9 % ) , the 5 HT1A receptor agonist ( + / ) 8 hydroxy 2 ( di n propylamino ) tetralin hydrobromide ( 8 OH DPAT ) , the 5 HT1B receptor agonist 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridinyl ) 1H indole succinate ( RU 24969 ) , or the 5 HT2A / 2C receptor agonist ( + / ) 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane HCl ( DOI ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In contrast , little substitution was observed following administration of 8 OH DPAT , a potent 5 HT1A agonist , the 5 HT1B agonist CP 94 , 253 , or the serotonin reuptake inhibitor sertraline . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Autoradiography of tissue sections exposed to [ 3H ] 8 OH DPAT ( 8 hydroxy dipropylaminotetraline ) or to [ 125I ] cyanopindolol plus isoproterenol showed that 5 HT1A and 5 HT1B receptors , respectively , were present in the superficial SC layers . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Both E and DHE are 5 HT1A , 5 HT1B , 5 HT1D , and 5 HT1F receptor agonists . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The role of 5 HT1A and 5 HT1B receptors in antidepressant drug actions in the mouse forced swimming test . ^^^ The present study was designed in order to further evaluate the mode of action of antidepressants in the forced swimming test , by using selective agonists and antagonists at 5 HT1A and 5 HT1B receptor sites . ^^^ The anti immobility effects of the selective serotonin reuptake inhibitors in the forced swimming test seem to be mediated by presynaptic 5 HT1A receptors as well as postsynaptic 5 HT1B receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
It is concluded that : ( 1 ) serotonin interacts with the mesolimbic dopaminergic system through 5 HT1B , but not 5 HT1A , receptors : and ( 2 ) serotonin interaction with the mesolimbic dopaminergic system involves postjunctional 5 HT1B heteroreceptors located in the ventral subicular area , which modulate the activity of glutamatergic hippocampo accumbens pathways and only secondarily alter DA levels in the n . acc . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Adult male Sprague Dawley rats were administered the 5 HT subtype selective receptor agonists 8 OH DPAT ( 0 . 5 2 . 0 mg / kg ) , buspirone ( 2 8 mg / kg ) ( 5 HT1A ) , TFMPP ( 0 . 125 2 . 0 mg / kg ) ( 5 HT1B ) , DOI ( 0 . 125 2 . 0 mg / kg ) ( 5 HT2A ) and m CPBG ( 1 . 25 20 . 0 mg / kg ) ( 5 HT 3 ) , subcutaneously . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Potentiation of fluoxetine induced penile erections by combined blockade of 5 HT1A and 5 HT1B receptors . ^^^ Selective blockade of 5 HT1A autoreceptors with WAY 100 , 635 ( ( N ( 2 [ 4 ( 2 methoxyphenyl ) 1 piperazinyl ] ethyl ) N ( 2 pyridinyl ) cyclo hexanecarboxamide ) ( 0 . 16 mg / kg , s . c . ) , or of 5 HT1B autoreceptors with GR 127 , 935 ( N [ 4 methoxy 3 ( 4 methylpiperazin 1 yl ) phenyl ] 2 ' methyl 4 ' ( 5 me thyl 1 , 2 , 4 oxadiazol 3 yl ) biphenyl 4 carboxamide ) ( 2 . 5 mg / kg , s . c . ) , slightly ( 1 . 5 to 2 fold ) increased fluoxetine induced penile erections . ^^^ Combined blockade of 5 HT1A and 5 HT1B autoreceptors markedly enhances the actions of serotonin reuptake inhibitors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Serotonin transporter antagonists enhance serotonergic neurotransmission by decreasing the functional activity of the 5 HT1A and 5 HT1B autoreceptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Modulation of the discriminative stimulus properties of cocaine : comparison of the effects of fluoxetine with 5 HT1A and 5 HT1B receptor agonists . ^^^ In substitution tests , the 5 HT1A receptor partial agonists buspirone and gepirone , the 5 HT1A / B receptor agonist RU 24969 and the 5 HT1B / 2C receptor agonist m trifluoromethyl phenylpiperazine ( TFMPP ) failed to substitute for the cocaine stimulus , although RU 24969 did engender a maximum of 72 % cocaine lever responding . ^^^ Whereas 5 HT agonists do not fully substitute for cocaine , the present results demonstrate that 5 HT1B , but not 5 HT1A , receptor agonists can modulate the discriminative stimulus properties of cocaine in a manner similar to that observed following administration of the 5 HT reuptake inhibitor fluoxetine . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT1a antagonist NAN 190 and the 5 HT1b agonist CGS 12066 B , applied both systemically and locally , blocked the effect of FFA . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
We have studied the effects of the purportedly selective 5 HT1A receptor antagonist ( + ) WAY 100135 on electrically stimulated 5 hydroxytryptamine ( 5 HT ) efflux in the ventrolateral geniculate nucleus ( vLGN ) , and its affinity at human 5 HT1B and 5 HT1D receptors stably expressed in Chinese hamster ovary ( CHO ) cells . 2 . ^^^ In conclusion , ( + ) WAY 100135 was found to be not a selective 5 HT1A autoreceptor antagonist but may act as a partial agonist at the 5 HT1B / 1D receptor , displaying agonist or antagonist properties depending on the stimulation protocol used and the resultant 5 HT ' tone ' at the receptor . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Potentiation of the fluoxetine induced increase in dialysate levels of serotonin ( 5 HT ) in the frontal cortex of freely moving rats by combined blockade of 5 HT1A and 5 HT1B receptors with WAY 100 , 635 and GR 127 , 935 . ^^^ The present data demonstrate that combined blockade of 5 HT1A and 5 HT1B autoreceptors markedly and selectively potentiates the fluoxetine induced increase in dialysate levels of 5 HT versus DA and NAD in the FCx of freely moving rats . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The blockade of postsynaptic 5 HT1A , 5 HT1B , 5 HT 3 or 5 HT 4 receptors and 5 HT inhibition of synthesis and its depletion did no alter learning by themselves . 6 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Upon applying the drugs to the spinal cord alone , 5 HT was found to have a dual effect on phrenic motoneuron firing : ( 1 ) a facilitatory effect mediated by 5 HT2A receptors and ( 2 ) a depressive effect on their inspiratory discharge mediated by non 5 HT1A , non 5 HT2A , non 5 HT 3 receptors , possibly of the 5 HT1B subtype . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Spinal application of 5 HT1B ( but not 5 HT1A ) receptor agonists depressed the phrenic activity and the effect was prevented by pretreatment with 5 HT1B ( but not 5 HT1A , 5 HT2A and 5 HT 3 ) receptor antagonists . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Numerous studies have demonstrated that activation of serotonin 5 HT1A or 5 HT1B receptor decreases aggression in male mammals . ^^^ To determine whether female mammals also show decreased aggression in response to 5 HT1A or 5 HT1B activation , we assessed the effects of the serotonin receptor agonists 8 OH DPAT ( 5 HT1A ) and CGS 12066A ( 5 HT1B ) on aggression in female Syrian hamsters . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
This study tested whether the lateral septum ( LS ) and medial preoptic area ( MPO ) , which are part of the neuroanatomical substrate for aggression and contain androgen , estrogen , 5 HT1A and 5 HT1B receptors , represent sites where these modulatory effects occur . ^^^ They were microinjected with either CGS12066B , a 5 HT1B agonist ( 400 microM LS , 200 microM MPO ) ; 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) , a 5 HT1A agonist ( 10 microM LS , 5 microM MPO ) ; or combined CGS + 8 OH DPAT treatment and tested for aggression 15 min later . ^^^ The findings demonstrate regional variation in the ability of androgens and estrogens to modulate 5 HT1A and 5 HT1B agonist mediated reductions in aggression . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Effect of a selective 5 HT reuptake inhibitor in combination with 5 HT1A and 5 HT1B receptor antagonists on extracellular 5 HT in rat frontal cortex in vivo . 1 . ^^^ Here , we investigated whether blockade of the terminal 5 HT1B autoreceptor influences a selective 5 HT reuptake inhibitor in the same way , and whether there is an additional effect of blocking both the 5 HT1A and 5 HT1B autoreceptors . 2 . ^^^ In summary , our results suggest that selective 5 HT reuptake inhibitors may cause a large increase in 5 HT in the frontal cortex when 5 HT autoreceptors on both the somatodendrites ( 5 HT1A ) and nerve terminals ( 5 HT1B ) are blocked . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Using intracerebral microdialysis in awake rats with separate probes in the frontal cortex or dorsal hippocampus , we studied the ability of 8 mg / kg s . c . ( ) penbutolol , a beta adrenoceptor antagonist with antagonist action at 5 HT1A and 5 HT1B receptors , and 0 . 3 mg / kg s . c . ^^^ The results suggest that only a combined blockade of 5 HT1A and 5 HT1B receptors potentiates the effect of citalopram on extracellular concentrations of serotonin in the dorsal hippocampus . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
MDL 74 , 721 demonstrated nanomolar affinity for 5 HT1A ( 12 . 7 + / 0 . 3 nM ) and 5 HT1D ( 41 . 3 + / 10 . 9 nM ) but considerably lower affinity for 5 HT1B receptors ( > 1000 nM ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
While age related declines in the number of 5 HT1B and 5 HT 2 receptors have been reported , little information is available describing the region specific effects of aging on the functional dynamics of equilibrium binding at 5 HT receptors , including the 5 HT1A receptor subtype . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Binding experiments at cloned human 5 HT1A , 5 HT1B , and 5 HT1D receptors show that these derivatives are potent and selective ligands for 5 HT1B / 1D subtypes with increased binding selectivity versus the 5 HT1A receptor when compared to 1 naphthylpiperazine ( 1 NP ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The G protein coupling behavior of four human 5 hydroxytryptamine receptor subtypes ( 5 HT1A , 5 HT1B , 5 HT1D , and 5 HT1E ) has been studied in membranes from Sf 9 cells expressing the individual receptors . ^^^ The 5 HT1A and 5 HT1B receptors exhibited both high and low affinity states for agonist , with the majority of the receptors in a low affinity state . ^^^ Addition of purified G protein subunits to membranes expressing either 5 HT1A or 5 HT1B receptors shifted the majority of the receptors to a high affinity state in the absence , but not in the presence , of guanine nucleotides . ^^^ A significantly higher affinity for agonist was observed with both receptors in the presence of alphai 3 subunits compared with either alphai 2 or alphao subunits , while a significantly lower concentration of alpha subunits was required for a maximal affinity shift of 5 HT1A receptors compared with 5 HT1B receptors ( EC 50 values of 6 . 4 and 12 . 0 nM , respectively ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The present studies extend this initial finding to four additional 5 HT agonists with different selectivity for 5 HT1A , 5 HT1B , or 5 HT2C receptors : CGS 12066B ( 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo [ 1 , 2a ] quinoxaline maleate ) , mCPP [ 1 ( 3 chlorophenyl ) piperazine diHCl ] , RU 24969 [ 5 methoxy 3 ( 1 , 2 , 3 , 4 tetrahydro 4 pyridinyl ] 1H indole succinate and 8 OH DPAT [ ( + / ) 8 hydroxy 2 ( di n propylamino ) tetralin HBr ] . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT1B receptor agonist , CP 93 , 129 ( 3 ( 1 , 2 , 5 , 6 tetrahydropyrid 4 yl ) pyrrolo [ 3 , 2 b ] pyrid 5 one ) , the 5 HT1A / B receptor antagonist cyanopindolol , and the 5 HT1A receptor antagonist WAY 100635 ( N [ 2 [ 4 ( 2 methoxypheny ] ) 1 piperazinyl ] ethyl ] N ( 2 pyridinyl ) cyclohexanecarboxamide trihydrochloride ) , were applied directly onto the spinal cord , and single unit responses were counted separately for A beta , A delta , C fibre responses and post discharge according to the latencies . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The importance of blockade of 5 HT 1B / D receptors in the raph region , their possible interaction with 5 HT 1A receptors , and consequent inhibition of 5 HT release in terminal 5 HT 1B / D receptor containing regions are discussed . 4 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Studies of the effects of aging on the density and / or affinity of 5 HT1A and 5 HT1B / 1D receptors are also warranted . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
This effect by ( ) pindolol is in all probability indirect since this compound lacks affinity for 5 HT2A / C receptors , and could be explained by reported antagonism of inhibitory serotonergic somato dendritic 5 HT1A autoreceptors , although other possibilities related to 5 HT1B receptors or beta adrenoceptors can not be excluded at this time . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effect of systemic administration of the 5 HT1A and 5 HT1B antagonist , ( + / ) pindolol ( 10 mg / kg ) , to increase 5 HT levels in hippocampus , was also not affected by chronic ECS . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
No changes were found after a single afterdischarge . 5 HT 4 receptors , which colocalize with 5 HT1A receptors on hippocampal neurons , were not modified in kindled tissue . [ 3H ] 5 HT uptake and its release as well as the 5 HT1B autoreceptor function did not differ from shams in hippocampal synaptosomes at stages 2 and 5 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The selective 5 HT1A receptor agonist 8 OH DPAT and the selective 5 HT ( 1B / 1D ) receptor agonists sumatriptan and L 694 , 247 inhibited the pressor response , whereas the 5 HT1B receptor agonists CGS 12066B and CP 93 , 129 and the 5 HT2C receptor agonist m CPP did not modify the pressor sympathetic responses . 4 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The drug influence was investigated in three behavioral tests : 8 OH DPAT ( 5 HT1A agonist ) induced behavioral syndrome in rats , m chlorophenylpiperazine ( m CPP , 5 HT1B agonist ) induced hypothermia in mice and L 5 hydroxytryptophan ( L 5 HTP ) induced head twitches ( 5 HT2A stimulation ) in rats . ^^^ The results indicate that EMD 57445 does not interact with 5 HT ( 5 HT1A , 5 HT1B , 5 HT2A ) receptor subpopulations and does not affect 5 HT metabolism . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Interaction studies were performed with S 15535 ( presynaptic 5 HT1A receptor agonist ) and methiothepin ( 5 HT1B autoreceptor antagonist ) in an attempt to attenuate or potentiate antidepressant like activity . ( + / ) Pindolol was tested in combination with selective agonists and antagonists at 5 HT 1 , 5 HT 2 and 5 HT 3 receptor subtypes . ^^^ The results of the present study suggest that pindolol is acting at presynaptic 5 HT1B serotonergic receptors , in addition to the 5 HT1A subtype , in augmenting the activity of antidepressants in the mouse forced swimming test . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Although clozapine displays significant affinity to 5 HT1A , 5 HT1B , 5 HT2A and 5 HT2C receptors , the present results suggest that blockade of these receptors is not responsible for clozapine ' s anticataleptic activity . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In contrast , the sensitivity of the alpha 2 adrenergic and terminal 5 HT1B autoreceptors , as well as that of the postsynaptic 5 HT1A receptor after 21 day treatment was unchanged . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
We therefore investigated the 5 HT1A , 5 HT1B and 5 HT2A receptor density in 18 22 different regions in the brain of portacaval shunted rats by means of radioligand binding with autoradiographical evaluation . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The results of these studies can be summarized as follows : ( 1 ) chronic unpredictable stress produces high corticosteroid levels in rats ; ( 2 ) chronic stress also results in changes in specific 5 HT receptors ( increases in cortical 5 HT2A and decreases in hipocampal 5 HT1A and 5 HT1B ) ; ( 3 ) chronic antidepressant administration prevents many of the 5 HT receptor changes observed after stress ; and ( 4 ) chronic antidepressant administration reverses the overactivity of the HPA axis . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
This effect was mimicked by 5 HT1B agonists ( CP 93 , 129 and anpirtoline ) , but not by a 5 HT1A agonist ( 8 OH DPAT ) , indicating that 5 HT1B receptors mediate the inhibition of EPSCs . 4 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
This decrease may be explained by antagonism of inhibitory 5 HT1B / 1D receptors on raphe cell bodies , leading to a local increase in 5 HT , which , in turn , stimulated 5 HT1A receptors to decrease cell firing , and hence 5 HT release from terminals . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In conclusion , serotonergic caudal raphe neurons are spontaneously active in vitro ; they receive prominent glutamatergic synaptic inputs . 5 Hydroxytryptamine regulates serotonergic neuronal activity of the caudal raphe by decreasing spontaneous activity via somatodendritic 5 HT1A receptors and by inhibiting excitatory synaptic transmission onto these neurons via presynaptic 5 HT1B receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT 1 like receptors mediating inhibition of sympathetic vasopressor outflow in the pithed rat : operational correlation with the 5 HT1A , 5 HT1B and 5 HT1D subtypes . 1 . ^^^ Intravenous ( i . v . ) continuous infusions of 5 HT and the 5 HT 1 receptor agonists , 8 OH DPAT ( 5 HT1A ) , indorenate ( 5 HT1A ) , CP 93 , 129 ( 5 HT1B ) and sumatriptan ( 5 HT ( 1B / 1D ) ) , resulted in a dose dependent inhibition of sympathetically induced vasopressor responses . 3 . ^^^ The above results suggest that the 5 HT 1 like receptors , which inhibit the sympathetic vasopressor outflow in pithed rats , display the pharmacological profile of the 5 HT1A , 5 HT1B and 5 HT1D , but not that of 5 HT 7 , receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These studies thus confirm the potential for decreasing ethanol consumption and ethanol preference of 5 HT1A agonists and 5 HT 3 antagonists , but failed to find any selective effects for agents acting at 5 HT1B or 5 HT 2 receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Clonidine potentiates the effects of 5 HT1A , 5 HT1B and 5 HT2A / 2C antagonists and 8 OH DPAT in the mouse forced swimming test . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Alterations in the activity of the central 5 HT system are important in understanding the pathophysiology of depression , and therefore , we examined whether this model was associated with changes in the expression of 5 HT1A receptor , 5 HT1B receptor , and 5 HT transporter mRNA in the dorsal raphe nucleus and the hippocampus . ^^^ The expression of 5 HT transporter , 5 HT1A receptor , and 5 HT1B receptor mRNA was examined in the dorsal raphe nucleus and in the CA 1 of the hippocampus by means of quantitative in situ hybridisation histochemistry . ^^^ No changes in 5 HT1A receptor and 5 HT1B receptor mRNA expression were observed in any of the regions examined in these animals . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Although the serotonin agonists for the 5 HT1B , 2C , 3 receptors were ineffective , the effects were mimicked by the 5 HT1A receptor agonists ( 8 OH DPAT , 5 CT ) and prevented by the 5 HT1A receptor antagonist NAN 190 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Thus , the present data suggest that the comparable effects of SSRIs in DRN and MRN innervated forebrain regions are not explained by a preferential attenuation of 5 HT release by terminal 5 HT1B autoreceptors in hippocampus , an area with a low inhibitory influence of somatodendritic 5 HT1A receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In addition , serotonin appears to regulate the response of the SCN circadian clock to light through postsynaptic 5 HT1A or 5 ht 7 receptors , as well as presynaptic 5 HT1B heteroreceptors on RHT terminals . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Reverse transcriptase polymerase chain reaction ( RT PCR ) revealed expression of 5 HT1A , 5 HT1B , 5 HT1D , 5 HT1F , 5 HT2A , 5 HT2B , 5 HT2C , 5 HT5B , 5 HT 6 and 5 HT 7 receptor mRNAs in astrocytes derived from 2 day old rats and cultured for 10 12 days . ^^^ The functional expression of 5 HT 1 receptor subtypes was investigated by measuring the ability of 5 HT 1 receptor agonists : 8 OH DPAT ( 5 HT1A receptors ) , RU 24969 ( 5 HT1A , 5 HT1B , 5 HT1D , and 5 HT1F receptors ) or sumatriptan ( 5 HT1B , 5 HT1D , and 5 HT1F receptors ) to modulate forskolin or isoproterenol stimulated cAMP production . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effect of CP 94 , 253 was dose dependently blocked by the 5 HT1B / 1D receptor partial agonist 2 ' methyl 4 ' ( 5 methyl [ 1 , 2 , 4 ] oxadiazol 3 yl ) biphenyl 4 carboxylic acid [ 4 methodoxy 3 ( 4 methyl piperazin 1 yl ) phenyl ] amide ( GR 127 , 935 ) ( 0 . 3 10 mg / kg ) but was unaffected by the 5 HT1A receptor antagonist 4 iodo N [ 2 [ 4 ( methoxyphenyl ) 1 piperazinyl ] ethyl ] N 2 pyridinyl benzamide ( p MPPI ; 1 10 mg / kg ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Although 5 CT has a high affinity with 5 HT1A receptors , the 5 HT1A and 5 HT1B and beta receptor antagonist , ( ) popranolol , did not affect 5 CT induced hyperglycemia . ^^^ These results indicate that 5 CT induced hyperglycemia is elicited by facilitation of adrenaline release from the adrenal gland and that 5 CT induced hyperglycemia is mediated by the 5 HT 7 receptor unrelated to 5 HT1A , 5 HT1B , 5 HT 2 , 5 HT 3 , 5 HT 4 or 5 HT 5 receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Removal of the endothelium did not change the response to 5 HT in the presence of the 5 HT ( 1B / D ) receptor antagonist GR 127935 and the 5 HT1A and 5 HT1B receptor antagonist pindolol . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These results demonstrate that , under the present experimental conditions , activation of central 5 HT1A , 5 HT1B , and 5 HT 2 receptors reduced ethanol intake and reinforced behaviour in an operant paradigm . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Although 5 HT1A receptors are involved in controlling the activity of serotonergic neurons , 5 HT1A knockout mice had normal levels of 5 HT and 5 hydroxyindoleacetic acid , possibly because of an up regulation of 5 HT1B autoreceptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effects of 5 HT1A , 5 HT1B and 5 HT1D receptor agonists on trigeminal nociceptive neurotransmission in anaesthetized rats . ^^^ In contrast , the selective 5 HT1B receptor agonist , CP 93 , 129 ( 3 ( 1 , 2 , 5 , 6 tetrahydropyrid 4 yl ) pyrrolo [ 3 , 2 b ] pyrid 5 one ) , and the 5 HT1A receptor selective agonist 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) had no effect in this assay at up to 3 mg kg ( 1 ) , i . v . . ^^^ Brain penetrant , triptan 5 HT1B / 1D receptor agonists may therefore mediate their central trigeminal anti nociceptive action in the rat via 5 HT1D , but not 5 HT1B or 5 HT1A , receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Mutagenesis of the human 5 HT1B receptor : differences from the closely related 5 HT1A receptor and the role of residue F 331 in signal transduction . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Similar studies on human cloned receptors confirmed that xanomeline is an agonist at human cloned 5 HT1A and 5 HT1B receptors . ^^^ These studies indicate that xanomeline is a potent agonist at 5 HT1A and 5 HT1B receptors and an antagonist at 5 HT 2 receptor subtypes . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5 HT1A and 5 HT1B receptor agonists 8 OH DPAT and anpirtoline , as evidenced by use of the corresponding new and selective receptor antagonists NAD 299 and NAS 181 . 1 . ^^^ In the present study the role of 5 HT1A and 5 HT1B receptors in the mediation of male rat ejaculatory behaviour was examined by use of selective agonists and antagonists acting at these 5 HT receptor subtypes . 2 . ^^^ The present results demonstrate opposite effects , facilitation and inhibition , of male rat ejaculatory behaviour by stimulation of 5 HT1A and 5 HT1B receptors , respectively , suggesting that the SSRI induced inhibition of male ejaculatory dysfunction is due to 5 HT1B receptor stimulation . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Differential membrane targeting and pharmacological characterization of chimeras of rat serotonin 5 HT1A and 5 HT1B receptors expressed in epithelial LLC PK 1 cells . ^^^ The serotonin 5 HT1A and 5 HT1B receptors are two structurally related but pharmacologically distinguishable 5 HT receptor types . ^^^ In brain , the 5 HT1A receptor is localized on the soma and dendrites of neurons , whereas the 5 HT1B receptor is targeted to the axon terminals . ^^^ Further investigations on the mechanisms responsible for their differential targeting were done by constructing chimeras of 5 HT1A and 5 HT1B receptors still able to bind specifically [ 3H ] lysergic acid diethylamide and selective agonists and antagonists . ^^^ Further inclusion of the C terminal domain of the 5 HT1A receptor in their sequence led to a basolateral localization , whereas that of the 5 HT1B receptor allowed an apical targeting , suggesting the existence of a targeting signal in this portion of the receptor ( s ) . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
However , 5 HT1A receptors , 5 HT1B receptors ( or both ) have been claimed to mediate this effect of RU 24969 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Differential addressing of 5 HT1A and 5 HT1B receptors in epithelial cells and neurons . ^^^ The 5 HT1A and 5 HT1B serotonin receptors are expressed in a variety of neurons in the central nervous system . ^^^ While the 5 HT1A receptor is found on somas and dendrites , the 5 HT1B receptor has been suggested to be localized predominantly on axon terminals . ^^^ In epithelial cells , 5 HT1A receptors are found on both apical and basolateral membranes while 5 HT1B receptors are found exclusively in intracellular vesicles . ^^^ Using 5 HT1A and 5 HT1B knockout mice and the binary tTA / tetO system , we generated mice expressing these receptors in striatal neurons . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Synergism between 5 HT1B / 1D and 5 HT1A receptor antagonists on turnover and release of 5 HT in guinea pig brain in vivo . ^^^ The effects on 5 HT turnover ( 5 HIAA / 5 HT ratio ) and extracellular 5 HT and 5 HIAA levels ( in vivo microdialysis in freely moving animals ) were analysed in guinea pig brains following the 5 HT1B receptor antagonist , GR 127935 [ N [ 4 methoxy 3 ( 4 methyl 1 piperazinyl ) phenyl ] 2 ' methyl 4 ' ( 5 methyl 1 , 2 , 4 oxadiazol 3 yl ) [ 1 , 1 biphenyl ] 4 carboxamide ] , or the 5 HT1A receptor antagonist , WAY 100635 ( N [ 2 [ 4 ( 2 methoxyphenyl ) 1 piperazinyl ] ethyl ] N ( 2 pyridinyl ) cyclohexanecarboxamide trihydrochloride ) , administered alone or in combination . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Their receptor binding profiles ( 5 HT1A , 5 HT1B ) and analgesic activity ( hot plate , acetic acid induced writhing ) have been studied . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Using a blinded methodology , animals were injected with normal saline , vehicle , or one of seven serotonin antagonists given at a dose that maintains serotonin receptor subtype specificity : WAY 100135 ( 5 HT1A ) , methiothepin mesylate ( 5 HT1B / 1D / 2 ) , mesulergine hydrochloride ( 5 HT2A / 2B ) , GR 127935 ( 5 HT1D ) , SR 46349 ( 5 HT 2 ) , ondansetron ( 5 HT 3 ) , or GR 125487 ( 5 HT 4 ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The direct 5 HT1A / 1B agonist RU 24969 decreases PPI in wild type but not 5 HT1B knockout mice . ^^^ As the direct 5 HT1A agonist 8 OH DPAT increases PPI in mice , the unmasking of these effects may also contribute to the PPI increasing effects of 5 HT releasers in 5 HT1B knockout mice . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
RU 24969 , a 5 HT1A / 1B agonist , elevates brain stimulation reward thresholds : an effect reversed by GR 127935 , a 5 HT1B / 1D antagonist . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The selective 5 HT1A receptor antagonist ( + ) WAY 100135 , previously found to be an agonist at the h 5 HT1D heteroreceptor regulating glutamate release , could not interact with the h 5 HT1B autoreceptor when added at 1 microM . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In addition , pretreatment with GR 127935 , but not with the 5 HT1A antagonist WAY 100635 , prevented the effects of both 5 HT1B agonists . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Androgens and estrogens modulate 5 HT1A and 5 HT1B agonist effects on aggression . ^^^ Intermale offensive aggressive behavior is facilitated by gonadal steroids and inhibited by serotonin ( 5 HT ) , presumably through its effects at 5 HT1A and 5 HT1B receptor sites . ^^^ Two weeks later , they were given 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT , a 5 HT1A agonist ; 0 . 1 or 1 . 0 mg / kg ) , CGS12066B ( a 5 HT1B agonist ; 4 . 0 or 8 . 0 mg / kg ) , 0 . 1 or 1 . 0 mg / kg 8 OH DPAT + 4 . 0 mg / kg CGS12066B , or vehicle , and tested for aggression . ^^^ The results demonstrate differential effects of the steroidal environment on the ability of 5 HT1A and 5 HT1B agonists to modulate aggression , with estrogens producing a more restrictive environment than androgens for serotonergic inhibition of male typical aggressive behavior . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Perfusion with 5 carboxamidotryptamine , anpirtoline , pindobind 5 HT1A , and isamoltane demonstrated the involvement of 5 HT1A and 5 HT1B receptors in facilitating DA release . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In conclusion , the results of the present study suggest that lithium may be acting through 5 HT1B receptors , whereas the action of carbamazepine and sodium valproate seems to involve 5 HT1A receptors in the mouse forced swimming test . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Magnitude of 5 HT1B and 5 HT1A receptor activation in guinea pig and rat brain : evidence from sumatriptan dimer mediated [ 35S ] GTPgammaS binding responses . ^^^ The present study reports on G protein activation by recombinant 5 HT receptors and by native 5 HT1A and 5 HT1B receptors in guinea pig and rat brain using agonist stimulated [ 35S ] GTPgammaS binding responses mediated by a new 5 HT ligand , a dimer of sumatriptan . ^^^ Dimerization of sumatriptan increased the binding affinity for h 5 HT1B ( pKi : 9 . 22 vs . 7 . 79 for sumatriptan ) , h 5 HT1D ( 9 . 07 vs . 8 . 08 ) and also h 5 HT1A receptors ( 7 . 80 vs . 6 . 40 ) , while the binding affinity for h 5 ht1E ( 6 . 67 vs . 6 . 19 ) and h 5 ht1F ( 7 . 37 vs . 7 . 78 ) receptors was not affected . ^^^ In conclusion , the sumatriptan dimer stimulates G protein activation via 5 HT1B receptors besides 5 HT1A receptors in guinea pig and rat brain . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
F 11356 has subnanomolar affinity for cloned human and nonhuman 5 HT1B and 5 HT1D receptors , and its affinity for 5 HT1A and other 5 HT receptors , including the 5 ht1F subtype , is 50 fold lower and micromolar , respectively . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Identification and role of serotonin 5 HT1A and 5 HT1B receptors in primary cultures of rat embryonic rostral raphe nucleus neurons . ^^^ The presence of 5 HT1A and 5 HT1B receptors in serotoninergic neurons was assessed using binding assays . ^^^ The involvement of 5 HT1A and 5 HT1B receptors in the control of the synthesis and release of [ 3H ] 5 HT was studied using biochemical approaches with several serotoninergic receptor ligands . ^^^ A mean decrease of 30 % in [ 3H ] 5 HT synthesis and release was observed in the presence of 5 HT ( 10 ( 8 ) M ) , the 5 HT1A agonist 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) , the 5HT1B / 1A agonist 5 methoxy 3 ( 1 , 2 , 5 , 6 tetrahydro 4 pyridinyl ) 1H indole ( RU 24969 ) , the 5 HT1B agonist 3 ( 1 , 2 , 5 , 6 tetrahydropyrid 4 yl ) pyrrolo [ 3 , 2 b ] pyrid 5 one ( CP 93 , 129 ) , and the 5 HT ( 1D / 1B ) agonist sumatriptan . ^^^ Paradoxically , extracellular levels of [ 3H ] 5 HT increased in the presence of 8 OH DPAT and RU 24969 at 10 ( 6 ) M . 5 HT uptake experiments showed that these two agonists interacted with the 5 HT transporter . 5 HT 1 binding sites ( 620 fmol / mg of protein ) and 5 HT1A ( 482 fmol / mg of protein ) and 5 HT1B ( 127 fmol / mg of protein ) receptors were detected in 12 day in vitro cell cultures . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
It is concluded that 5 HT1A , 5 HT2A+2C , and to a lesser extent 5 HT1B receptors , but not 5 HT 3 receptors are involved in the effects of serotonin agonists on ACTH secretion . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
RESULTS : By RT PCR , 5 HT1b , 5 HT2A and 5 HT2B mRNAs were detected in all of the 14 patients . 5 HT1A , 5 HT1D , and 5 HT1E mRNAs were detected in only some patients . ^^^ By ribonuclease protection assay , 5 HT1B and 5 HT2A signals were detected in all patients examined , but neither 5 HT1A , 5 HT1D nor 5 HT2B signal was detected in any patient . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Consistent with a previous report , 3 microM and not 100 nM pindolol was required to occupy fully 5 HT1A and 5 HT1B receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
RT PCR products corresponding to the human 5 HT2A , 5 HT1B and 5 HT1F receptors were expressed in high levels , mRNAs coding for 5 HT 7 , 5 HT1A and 5 HT1D receptors were only weakly expressed . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Differential coupling of serotonin 5 HT1A and 5 HT1B receptors to activation of ERK 2 and inhibition of adenylyl cyclase in transfected CHO cells . ^^^ We have sought to compare directly the coupling of 5 HT1A and 5 HT1B receptors to adenylyl cyclase and to the mitogen activated protein kinase ERK 2 ( extracellular signal regulated kinase 2 ) . ^^^ We found that 5 HT1B receptors couple better to activation of ERK 2 and inhibition of adenylyl cyclase than do 5 HT1A receptors . 5 HT stimulated a maximal fourfold increase in ERK 2 activity in nontransfected cells that express endogenous 5 HT1B receptors at a very low density and a maximal 13 fold increase in transfected cells expressing 230 fmol of 5 HT1B receptor / mg of membrane protein . ^^^ Similarly , 5 HT1A , but not 5 HT1B , receptors were found to cause significant inhibition of forskolin stimulated cyclic AMP accumulation only when expressed at high densities . ^^^ These findings demonstrate that although both 5 HT1A and 5 HT1B receptors have been shown to couple to G proteins of the Gi class , they exhibit differences in coupling to ERK 2 and adenylyl cyclase . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Their receptor binding profiles ( 5 HT1A , 5 HT1B ) and analgesic activity ( hot plate , acetic acid induced writhing ) have been studied . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effect of 5 HT was mimicked by the 5 HT 2 receptor agonist , alpha methyl 5 hydroxytryptamine ( alpha methyl 5 HT ) , but not by the 5 HT1A receptor agonist , ( + / ) 8 hydroxydipropylaminotetralin hydrobromide ( 8 OH DPAT ) , or the 5 HT1B agonist , CGS 12066A . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Actions of roxindole at recombinant human dopamine D 2 , D 3 and D 4 and serotonin 5 HT1A , 5 HT1B and 5 HT1D receptors . ^^^ The present study determined its affinity and agonist efficacy at recombinant human ( h ) dopamine hD 2 , hD 3 and hD 4 and serotonin ( 5 HT ) h 5 HT1A , h 5 HT1B and h 5 HT1D receptors . ^^^ D 2 or D 4 receptors and 5 HT1A vs . 5 HT1B or 5 HT1D receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In addition , the drug has been shown to act preferentially on 5 HT1A and 5 HT1B receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The synthesized compounds were able to bind on some serotonin ( 5 HT1A , 5 HT2A ) and dopamine ( D 2 , D 3 ) receptors , while displaying poor or no affinity for 5 HT1B , 5 HT2C , 5 HT 3 , and 5 HT 4 subtypes . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Effect of reserpine on behavioural responses to agonists at 5 HT1A , 5 HT1B , 5 HT2A , and 5 HT2C receptor subtypes . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Modulation of dialysate levels of dopamine , noradrenaline , and serotonin ( 5 HT ) in the frontal cortex of freely moving rats by ( ) pindolol alone and in association with 5 HT reuptake inhibitors : comparative roles of beta adrenergic , 5 HT1A , and 5 HT1B receptors . ( ) Pindolol , which possesses significant affinity for 5 HT1A , 5 HT1B , and beta 1 / 2 adrenergic receptors ( AR ) s , dose dependently increased extracellular levels of dopamine ( DA ) and noradrenaline ( NAD ) versus 5 HT , in dialysates of the frontal cortex ( FCX ) , but not accumbens and striatum , of freely moving rats . ^^^ The selective 5 HT1A receptor antagonist , WAY 100 , 635 , slightly attenuated the ( ) pindolol induced increase in DA and NAD levels , while the selective 5 HT1B antagonist , SB 224 , 289 , was ineffective . ^^^ These data suggest that ( ) pindolol facilitates frontocortical dopaminergic ( and adrenergic ) transmission primarily by activation of beta 1 / 2 ARs and , to a lesser degree , by stimulation of 5 HT1A receptors , whereas 5 HT1B receptors are not involved . ( ) Pindolol potentiated the increase in FCX levels of 5 HT elicited by the 5 HT reuptake inhibitors , fluoxetine and duloxetine , and also enhanced their ability to elevate FCX levels of DA though not of NAD . ^^^ In conclusion , ( ) pindolol modulates , both alone and together with 5 HT reuptake inhibitors , dopaminergic , adrenergic , and serotonergic transmission in the FCX via a complex pattern of actions at beta 1 / 2 ARs , 5 HT1A , and 5 HT1B receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Altered emotional states in knockout mice lacking 5 HT1A or 5 HT1B receptors . ^^^ Specifically , we have created mice that lack or express reduced levels of two serotonin receptors : 5 HT1A and 5 HT1B receptors . ^^^ As a result , the 5 HT1A and 5 HT1B receptors control the tone of the serotonergic system and mediate some of the postsynaptic effects of serotonin . ^^^ However , when analyzed in a number of behavioral paradigms , the 5 HT1A and 5 HT1B knockout mice display a number of contrasting phenotypes . ^^^ While the 5 HT1B knockout mice are more aggressive , more reactive , and less anxious than the wild types , the 5 HT1A knockouts are less reactive , more anxious , and possibly less aggressive than the wild types . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
It is suggested that blockade of inhibitory 5 HT1A autoreceptors discloses inhibitory effects of the selective serotonin re uptake inhibitor citalopram on male rat ejaculatory behavior mediated via stimulation of 5 HT1B receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
It is concluded that the discriminatory stimulus properties of eltoprazine in the pigeon are mediated by 5 HT1A and 5 HT1B receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
There was a significant correlation between vasoconstrictor potency and 5 HT1B and 5 HT1D receptor affinity , but not with 5 HT1A , 5 ht1F or 5 HT 2 receptor affinity . 4 The 5 HT1B / 1D receptor antagonist GR 55562 ( 10 7 10 6 M ) inhibited the contractile responses to sumatriptan and 5 CT in a competitive manner with a pKB value for GR 55562 of 7 . 4 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Enhancement of 5 HT1B and 5 HT1D receptor antagonist effects on extracellular 5 HT levels in the guinea pig brain following concurrent 5 HT1A or 5 HT re uptake site blockade . ^^^ The effects of selective serotonin re uptake inhibitor ( SSRI ) , paroxetine , and 5 HT1A , 5 HT1B and 5 HT1B / 1D receptor antagonists on in vivo extracellular 5 HT levels in the guinea pig frontal cortex and dorsal hippocampus were investigated using the technique of microdialysis . ^^^ The aim of the study was to further investigate the autoreceptor roles of the 5 HT1A , 5 HT1B and 5 HT1D receptors in the median vs dorsal raphe nuclei . ^^^ In the frontal cortex , 5 HT1A ( WAY 100635 , 1 mg / kg i . p . ) or 5 HT1B ( SB 224289 , 4 mg / kg i . p . ) receptor antagonists had no effect on extracellular levels of 5 HT , whilst the mixed 5 HT1B / 1D receptor antagonist ( GR 127935 , 0 . 3 mg / kg i . p ) produced a significant decrease in extracellular 5 HT levels . ^^^ In the dorsal hippocampus , whilst 5 HT1A receptor antagonism elicited by administration of WAY 100635 had no effect , both 5 HT1B and mixed 5 HT1B / 1D receptor blockade significantly increased extracellular 5 HT levels . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Because specific 5 HT1A , 5 HT1B , and AVP V1A binding sites were observed within the AH by in vitro autoradiography , the hamsters were tested for offensive aggression after microinjections of AVP in combination with either the 5 HT1A agonist 8 hydroxy 2 ( di n propylamino ) tetraline ( DPAT ) or the 5 HT1B agonist CGS 12066A ( CGS ) directly within the AH . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Serotonin and an agonist of 5 HT 3 receptor channels , 2 methyl 5HT , evoked Na+ influx , whereas the agonists of other serotonergic receptor subtypes , i . e . , 5 HT1A and 5 HT1B receptors , failed to induce Na+ influx in these cells . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Altogether , these data indicate that in the mouse , the firing of 5 HT neurons in the dorsal raphe nucleus is under both an inhibitory control through 5 HT1A receptors and an excitatory influence through 5 HT1B receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Likewise , the stimulation or blockade of presynaptic 5 HT1A , 5 HT1B , 5 HT ( 2A / 2C ) and 5 HT 3 receptors , postsynaptic 5 HT ( 2B / 2C ) and 5 HT 4 receptors and 5 HT uptake / transporter sites modulate these processes . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Differential adaptation of brain 5 HT1A and 5 HT1B receptors and 5 HT transporter in rats treated chronically with fluoxetine . ^^^ Binding studies showed that this treatment affected neither 5 HT1A nor 5 HT1B binding sites in all brain areas examined . ^^^ However , a significant decrease ( 38 % ) in 5 HT1A mRNA levels in the anterior raphe area ( but not forebrain regions ) and increases in 5 HT1B mRNA levels in the striatum ( +127 % ) and the cerebral cortex ( +34 % ) were noted in fluoxetine treated rats . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
However , when constructed in the presence of WAY 100635 ( 10 nM ) the selective and silent 5 HT1A antagonist , there was a significant ( P < 0 . 001 ) rightward shift of the CP 93129 concentration response curve in the paroxetine treated rats but not in the controls , implying a desensitisation of the 5 HT1B autoreceptor by paroxetine . ^^^ These data suggest that chronic paroxetine treatment may desensitise 5 HT1B autoreceptors in the dorsal raphe nucleus but that this effect is unmasked only when the dominant 5 HT1A autoreceptor control is antagonised . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The suppressant actions of RU 24969 on amphetamine self administration and CR responding involve stimulation of 5 HT1B receptors , since they were reversed by the 5 HT1B / 1D antagonist GR 127935 ( 3 mg / kg ) , but not by the 5 HT1A antagonist WAY 100635 ( 1 mg / kg ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Converging evidence suggests that the administration of 5 HT2A / 2C or 5 HT 4 receptor agonists or 5 HT1A or 5 HT 3 and 5 HT1B receptor antagonists prevents memory impairment and facilitates learning in situations involving a high cognitive demand . ^^^ In contrast , antagonists for 5 HT2A / 2C and 5 HT 4 , or agonists for 5 HT1A or 5 HT 3 and 5 HT1B generally have opposite effects . ^^^ A better understanding of the role played by these and other serotonin receptor subtypes in learning and memory is likely to result from the recent availability of highly specific ligands , such as 5 HT1A , 5 HT1B , 5 HT2A receptor antagonists , and new molecular tools , such as gene knock out mice , especially inducible mice in which a specific genetic alteration can be restricted both temporally and anatomically . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Somatodendritic localization of 5 HT1A and preterminal axonal localization of 5 HT1B serotonin receptors in adult rat brain . ^^^ The 5 HT1A and 5 HT1B receptors of serotonin play important roles as auto and heteroreceptors controlling the release of serotonin itself and of other neurotransmitters / modulators in the central nervous system ( CNS ) . ^^^ To determine the precise localization of these receptors , we examined their respective cellular and subcellular distributions in the nucleus raphe dorsalis and hippocampal formation ( 5 HT1A ) and in the globus pallidus and substantia nigra ( 5 HT1B ) , using light and electron microscopic immunocytochemistry with specific antibodies . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
USVs between 30 and 80 kHz , grid crossing , and rectal temperature were measured in separate groups of mouse pups following subcutaneous administration of 5 HT1A and 5 HT1B receptor agonists and antagonists , the neurosteroid allopregnanolone , or the benzodiazepine midazolam . ^^^ RESULTS : The 5 HT1A agonists ( + ) 8 OH DPAT ( 0 . 01 0 . 1 mg / kg ) and flesinoxan ( 0 . 3 1 . 0 mg / kg ) , the selective 5 HT1B agonist CP 94 , 253 ( 0 . 03 30 . 0 mg / kg ) , and the mixed 5 HT1B / 2C receptor agonist TFMPP ( 0 . 1 10 . 0 mg / kg ) dose dependently reduced USVs . ^^^ These effects were reversed by the 5 HT1A receptor antagonist WAY 100 , 635 ( 0 . 1 mg / kg ) or the 5 HT1B / D receptor antagonist GR 127935 ( 0 . 1 mg / kg ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Their receptor binding profiles ( 5 HT1A , 5 HT1B ) and analgesic activity ( hot plate , acetic acid induced writhing ) have been studied . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
First , our data are consistent with the primacy of 5 HT1A autoreceptors in restraining the elevation of 5 HT levels induced by SSRIs , whereas nerve terminal 5 HT1B autoreceptors appear to have an accessory role in this regard . ^^^ In particular , emerging data suggest that somatodendritic 5 HT1A autoreceptor and nerve terminal 5 HT1B autoreceptor mediated feedback may be relatively more important in the control of 5 HT output in dorsal raphe frontal cortex and median raphe dorsal hippocampus systems , respectively . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Their receptor binding profiles ( 5 HT1A , 5 HT1B , M 1 , M 2 , neuronal nicotinic receptor ) and analgesic activity ( hot plate , acetic acid induced writhing ) have been studied . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
It is hypothesized that the delayed maximal increase in extracellular 5 HT contents after fluoxetine treatment , due to negative feedback regulations induced by the activation of 5 HT1A and 5 HT1B autoreceptors , is not the primary cause for the delayed normalization of corticosteroid receptor numbers that regulates the HPA axis functioning . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Altered expression and functions of serotonin 5 HT1A and 5 HT1B receptors in knock out mice lacking the 5 HT transporter . ^^^ Possible adaptive changes in 5 HT neurotransmission in knock out mice that do not express the 5 HT transporter were investigated with special focus on 5 HT1A and 5 HT1B receptors . ^^^ As expected from actions mediated by functional 5 HT1A and 5 HT1B autoreceptors , a decrease in brain 5 HT turnover rate after i . p . administration of ipsapirone ( a 5 HT1A agonist ) , and an increased 5 HT outflow in the substantia nigra upon local application of GR 127935 ( a 5 HT1B / 1D antagonist ) were observed in 5 HTT+ / + mice . ^^^ Such effects were not detected in 5 HTT / mice , further confirming the occurrence of marked alterations of 5 HT1A and 5 HT1B autoreceptors in these animals . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Effects of serotonergic 5 HT1A and 5 HT1B ligands on ventral pallidal neuronal activity . ^^^ To clarify the role of the 5 HT system in limbic outputs , the present study compared the effects of the 5 HT1A agonist 8 OH DPAT and the 5 HT1B agonist CP 94253 with the non selective 5 HT agonist TFMPP on the firing rate of ventral pallidal ( VP ) neurons recorded in chloral hydrate anesthetized rats . 8 OH DPAT ( 0 . 25 256 microg / kg i . v . ) dose dependently enhanced ( 9 / 26 neurons ) or suppressed ( 8 / 26 ) activity , and the 5 HT1A antagonist ( + ) WAY 100135 often attenuated these responses . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Basal 5 HT levels , and the effects of challenges with the 5 HT1A receptor agonist 8 OH DPAT and the 5 HT1B antagonist GR 127935 on 5 HT levels were determined using in vivo microdialysis . ^^^ Rats which had undergone chronic rTMS showed reduced responses to both challenges , indicating subsensitivity of both the presynaptic 5 HT1A autoreceptors situated somatodendritically in the raphe nuclei and the 5 HT1B autoreceptors situated on nerve terminals . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
OBJECTIVE : Given reports that ( + / ) pindolol , a beta adrenergic 5 HT1A / 1B receptor antagonist , accelerates the onset of the therapeutic effect of certain antidepressant drugs in major depression , the aim of this study was to assess the effect of sustained ( + / ) pindolol administration on the sensitivity of pre and postsynaptic 5 HT1A receptors , terminal 5 HT1B autoreceptors and on overall 5 HT neurotransmission . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT1A receptor agonist 8 OH DPAT ( 0 . 01 to 1 microM ) and the 5 HT1B receptor agonist CGS 12066A ( 0 . 01 to 1 microM ) inhibited the electrically stimulated [ 3H ] serotonin and [ 3H ] GABA release . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Their receptor binding profiles ( 5 HT1A , 5 HT1B ) and analgesic activity ( hot plate , acetic acid induced writhing ) have been studied . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Results showed that the 5 HT releaser d fenfluramine , the selective serotonin reuptake inhibitor fluoxetine , the 5 HT1A receptor agonist 8 hydroxy 2 [ di n propylamino ] tetralin , the partial 5 HT1A receptor agonist buspirone , and the 5 HT1B / 5 HT2C receptor agonist 1 ( 3 trifluoromethylphenyl ) piperazine , but not the 5 HT2A / 5 HT2C receptor agonist 1 ( 2 , 5 dimethoxy 4 iodophenylaminopropane ) 2 , selectively reduced responding on a lever leading to presentation of an ethanol paired conditioned stimulus . ^^^ Results are consistent with involvement of the dopaminergic and 5 HT systems , in particular activation of 5 HT1A and 5 HT1B receptor subtypes , in mediation of the conditioned or secondary reinforcing properties of ethanol . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In the presence of ketanserin , 5 HT decreased the discharge rate ; a similar effect was observed when the 5 HT1A receptor agonist 8 OH DPAT or the 5 HT1B receptor agonist CGS 12066B was applied . ^^^ The inhibitory effects can be attributed to activation of 5 HT1A and 5 HT1B receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Region specific decrease in 5 HT1A and 5 HT1B binding sites after intra hippocampal ibotenic acid injections in the rat . ^^^ The cellular location of 5 HT1A and 5 HT1B binding sites in the hippocampus was investigated using a stereotaxic unilateral lesion of the CA 1 field by ibotenic acid , followed by autoradiography on brain sections with the specific ligands [ 3H ] 8 OH DPAT and S CM G [ 125I ] TNH 2 , respectively . ^^^ As compared to the contralateral side of the lesion , the ipsilateral side exhibited a decrease in the density of 5 HT1A binding sites in the strata oriens and radiatum of CA 1 , and of 5 HT1B binding sites in the dorsal subiculum and stratum oriens of CA 1 . ^^^ The results demonstrate that 5 HT1A binding sites are located on dendrites whereas 5 HT1B binding sites are located on axon terminals of CA 1 pyramidal cells . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effect of CP 93 , 129 was prevented by SB 224289 , but not by WAY 100635 , selective 5 HT1B and 5 HT1A receptor antagonists , respectively . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The results are discussed in the context of an increase in the effectiveness of postsynaptic 5 HT 1A and 5 HT 1B receptors and a decrease in the effectiveness of presynaptic 5 HT 1A ( somatodendritic ) and 5 HT 1B ( terminal ) receptors following adaptation to stress . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Intrathecal administration of a 5 HT1A receptor agonist , 8 hydroxy 2 ( di n propylamino ) tetraline ( 8 OH DPAT ; 1 , 10 , and 30 microg ) , or a 5 HT1B receptor agonist , 1 , 4 dihydro 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridinyl ) 5H pyrrol ( 3 , 2 b ) pyridin 5 one ( CP 93129 ; 1 and 10 microg ) , produced no significant change in the number of flinches . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Regional changes in density of serotonin transporter in the brain of 5 HT1A and 5 HT1B knockout mice , and of serotonin innervation in the 5 HT1B knockout . 5 HT1A knockout ( KO ) mice display an anxious like phenotype , whereas 5 HT1B KOs are over aggressive . ^^^ To identify serotoninergic correlates of these altered behaviors , autoradiographic measurements of 5 HT1A and 5 HT1B serotonin ( 5 HT ) receptors and transporter ( 5 HTT ) were obtained using the radioligands [ 3H ] 8 OH DPAT , [ 125I ] cyanopindolol and [ 3H ] citalopram , respectively . ^^^ By comparison to wild type , density of 5 HT1B receptors was unchanged throughout brain in 5 HT1A KOs , and that of 5 HT1A receptors in 5 HT1B KOs . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In addition , the 5 HT1A receptor antagonist WAY 100635 ( 0 . 3 , 1 mg / kg ) and the 5 HT1B receptor antagonists GR 127935 ( 1 , 2 mg / kg ) and SB 224289 ( 2 10 mg / kg ) did not affect d fenfluramine induced hypophagia . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
We have now used autoradiographic receptor binding techniques to determine the location of 5 HT1A and 5 HT1B binding sites in the laminated optic tectum . 5 HT1A binding sites , as labeled with [ 3H ] 8 hydroxy dipropylaminotetralin ( 8 OH DPAT ) , were highest in the superficial , retinorecipient layers of the tectum , intermediate in layers 6 and 7 and low in the remaining layers . ^^^ We conclude that both 5 HT1A and 5 HT1B receptors are present in the adult frog tectum and that changes in their activation levels can produce changes in retinotectal transmission levels that drive visual plasticity in opposite directions . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Central administration of 5 HT agonists specific to 5 HT1A , 5 HT1B , 5 HT2A or 5 HT2C receptors increased CRH mRNA in the PVN by 15 50 % , POMC mRNA in the anterior pituitary by 15 27 % and ACTH secretion three to five fold , whereas a specific 5 HT 3 agonist had no effect . ^^^ It is concluded that 5 HT via activation of 5 HT1A , 5 HT2A , 5 HT2C and possibly also 5 HT1B receptors increases the synthesis of CRH in the PVN and POMC in the anterior pituitary lobe , which results in increased ACTH secretion . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Behavioural , electrophysiological and microdialysis studies have shown that serotonin ( 5 HT ) receptors , mainly 5 HT1A , 5 HT1B and 5 HT2C sub types , exert a key role in modulating antidepressant activity . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Recent advances in understanding the role of 5 HT in parkinsonism and the generation of side effects of dopamine replacement therapy ( e . g . wearing off and levodopa induced dyskinesia ) have identified 5 HT1A , 5 HT1B and 5 HT2C receptors as potential therapeutic targets in Parkinson ' s disease . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These changes were associated with marked increases in the levels of mRNAs encoding the serotonin transporter , the 5 HT1A and 5 HT1B receptors and the BDNF receptor tyrosine kinase B ( TrkB ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Coactivation of purinergic ( P 2Y ) receptors reduces agonist efficacy at serotonin 1B ( 5 HT 1B ) , but not 5 HT 1A receptors . ^^^ Herein , we report that pretreatment for 5 min with the P 2Y receptor agonist ATP reduced agonist responsiveness at the 5 HT 1A , but not at the 5 HT 1B , receptor . ^^^ ATP pretreatment blocked the inhibitory effect produced by 5 HT 2C receptor activation on the 5 HT 1A , but not the 5 HT 1B , receptor response , suggesting that the 5 HT 1A receptor itself was the target for PLD / PKC action . ^^^ Moreover , this work underscores the importance of time as a variable in receptor signaling cross talk and serves to further illustrate differences between the 5 HT 1A and 5 HT 1B receptor systems . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The influence of the pre and postweaning maternal environment on the offspring ' s phenotype was examined in 5 HT1A and 5 HT1B receptor knockout mice ( KO1A and KO1B , respectively ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
HT 1A / 1B receptor mediated effects of the selective serotonin reuptake inhibitor , citalopram , on sleep : studies in 5 HT 1A and 5 HT 1B knockout mice . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Intracerebroventricular infusion of 5 HT agonists selective for the 5 HT1A , 5 HT1B , 5 HT2A and 5 HT2C receptor increased oxytocin mRNA in the SON and PVN . ^^^ We conclude that stimulation with 5 hydroxytryptophan or 5 HT agonists increases mRNA expression of oxytocin in the PVN and the SON via stimulation of at least 5 HT1A , 5 HT1B , 5 HT2A and 5 HT2C receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
RESULTS : Citalopram induced LA was dose dependently attenuated by the 5 HT1B / 1D receptor antagonists , S 18127 , GR 125 , 743 and GR 127 , 935 , and by the selective 5 HT1B antagonist , SB 224 , 289 , but unaffected by the selective 5 HT1A antagonist , WAY 100 , 635 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Operant learning and differential reinforcement of low rate 36 s responding in 5 HT1A and 5 HT1B receptor knockout mice . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The differential effects of food restriction on 5 HT1A and 5 HT1B receptor mediated control of serotonergic transmission in the hippocampus and hypothalamus of rats . ^^^ We recorded basal 5 HT release in the hypothalamus and hippocampus , and the sensitivity of the somatodendritic 5 HT1A autoreceptors in the raphe nuclei , and the nerve terminal 5 HT1B autoreceptors which together regulate the synthesis and release of 5 HT in these regions . ^^^ Sensitivity of the somatodendritic 5 HT1A autoreceptors was assessed by measuring the reduction in extracellular 5 HT induced by systemic administration of the 5 HT1A receptor agonist 8 hydroxy 2 di n ( propylamino ) tetralin ( 8 OH DPAT ) , while sensitivity of nerve terminal 5 HT1B autoreceptors was measured by observing the increase in 5 HT release after systemic injection of the 5 HT1B receptor antagonist GR 127935 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Systemic administration of the mixed 5 HT1B / 1D receptor antagonist GR 127935 ( 4 mg / kg ) in chronically treated wild type mice potentiated the effect of a paroxetine challenge dose on [ 5 HT ] ext in the ventral hippocampus , whereas systemic administration of the selective 5 HT1A receptor antagonist WAY 100635 did not . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The serotonin activity in the brainstem is primarily under the control of 5 HT1A somatodendritic receptors , although some data also suggest the involvement of 5 HT1B receptors . ^^^ METHODS : The effects of acetaminophen ( 600 mg / kg intraperitoneal ) followed by different doses of antagonists ( WAY 100635 [ 0 . 2 0 . 8 mg / kg subcutaneous ] and SB 216641 [ 0 . 2 0 . 8 mg / kg subcutaneous ] ) or agonists ( 8 OH DPAT [ 0 . 25 1 mg / kg subcutaneous ] and CP 93129 [ 0 . 125 0 . 5 mg / kg subcutaneous ] ) of 5 HT1A and 5 HT1B receptors , respectively , were determined in the hot plate test in mice . ^^^ CONCLUSIONS : These results suggest that the combination of acetaminophen with compounds having 5 HT1A and 5 HT1B antagonist properties could be a new strategy to improve the analgesia of acetaminophen , thanks to its mild serotonergic properties . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In this paper , studies focusing on anxiety using 5 HT1A receptor knockout ( 1AKO ) and 5 HT1B receptor knockout ( 1BKO ) mice are reviewed . 1AKO mice on different genetic background strains have initially been described as more anxious . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
While the A 1 adenosine receptor does not distinguish between Gi1alpha and Gtalpha sequences , the 5 HT1A and 5 HT1B serotonin and M 2 muscarinic receptors can couple with Gi 1 but not Gt . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
These data demonstrate that raphe pallidus inputs to hypoglossal motoneurones are predominantly glutamatergic in nature , with 5 HT decreasing the release of glutamate from these projections as a result of activation of 5 HT1A and / or 5 HT1B receptors located on presynaptic terminals . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Recently , the excessive aggressive and impulsive traits of neuronal NO synthase knockout ( nNOS / ) mice were shown to be caused by reductions in serotonin ( 5 HT ) turnover and deficient 5 HT1A and 5 HT1B receptor function in brain regions regulating emotion . ^^^ The consistently high levels of aggression observed in nNOS / mice could be reversed by 5 HT precursors and by treatment with specific 5 HT1A and 5 HT1B receptor agonists . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The role of 5 HT1A and 5 HT1B receptors in entrainment function was studied in Otsuka Long Evans Tokushima fatty ( OLETF ) rats and control Long Evans Tokushima Otsuka ( LETO ) rats . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Acceleration of onset of action in schedule induced polydipsia : combinations of SSRI and 5 HT1A and 5 HT1B receptor antagonists . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Effects of combined administration of 5 HT1A and / or 5 HT1B receptor antagonists and paroxetine or fluoxetine in the forced swimming test in rats . ^^^ Clinical data suggest that coadministration of pindolol , a 5 HT1A / 5 HT1B / beta adrenoceptor antagonist , and selective serotonin reuptake inhibitors ( SSRIs ) may shorten the time of onset of a clinical action and may increase beneficial effects of the therapy of drug resistant depression . ^^^ The aim of the present study was to investigate effects of a 5 HT1A antagonist ( WAY 100635 ) , 5 HT1B antagonists ( SB 216641 and GR 127935 ) or pindolol , given in combination with paroxetine or fluoxetine ( SSRIs ) , in the forced swimming test in rats ( Porsolt test ) . ^^^ The obtained results seem to indicate that blockade of 5 HT1B receptors , but not 5 HT1A ones , can facilitate the antidepressant like effect of paroxetine in the forced swimming test in rats . ^^^ No interaction was observed between fluoxetine and 5 HT1A / 5 HT1B receptor antagonists . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In vivo microdialysis in conscious rats was used to evaluate the effect of 5 HT1A agonist ( + / ) 8 hydroxy 2 ( n dipropylamino ) tetralin ( 8 OH DPAT ) , 5 HT2A / 2C agonist ( + / ) 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane ( DOI ) and 5 HT1B receptor agonist 3 ( 1 , 2 , 5 , 6 tetrahydropyrid 4 yl ) pyrrolo [ 3 , 2 b ] pyrid 5 one ( CP 93129 ) on the veratridine evoked glutamate ( Glu ) and aspartate ( Asp ) release in the rat prefrontal cortex . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
We also investigated GR 46611 ( 3 [ 3 ( 2 dimethylaminoethyl ) 1H indol 5 yl ] N ( 4 methoxybenzyl ) acrylamide ) , which has agonist activity predominantly at 5 HT1B and 5 HT1D receptors but also at the 5 HT1A receptor . ^^^ Both 5 HT1A and 5 HT1B / 1D agonists may offer a promising means of reducing bladder hyperactivity and increasing bladder capacity in patients with chronic SCI . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Co infusion of the 5 HT1B receptor antagonist SB 216641 ( 10 microM ) , but not the 5 HT1A receptor antagonist WAY 100635 ( 10 microM ) or the 5 HT1D / 1A receptor antagonist BRL 15572 ( 10 microM ) , antagonized not only the effects of intra tegmental CP 93129 ( 80 microM ) on VTA DA and NAC DA but also on VTA GABA . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In pharmacological bioassays on isolated ring shaped auricle preparations of Sepia officinalis , the action of the specific 5 hydroxytryptamine ( 5 HT ) agonists 8 OH DPAT ( 5 HT1a ) , CP 93129 ( 5 HT1b ) , TFMPP ( 5 HT1b ) and RS 67333 ( 5 HT 4 ) on these autonomously contractile compartments was studied . 8 OH DPAT and CP 93129 induced mainly positive effects on frequency and tone on the isotonically suspended auricles . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In radioligand binding experiments , urgosedin had significant binding affinities on alpha1 / alpha2 , 5 HT1A , 5 HT1B and 5 HT2A receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Expression of the mRNAs of the 5 hydroxytryptamine ( 5 HT ) receptors ( 5 HT1A , 5 HT1B , and 5 HT2C ) , which have been suggested to be involved in the ejaculation process , were examined by semiquantitative reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Effects of triiodothyronine and fluoxetine on 5 HT1A and 5 HT1B autoreceptor activity in rat brain : regional differences . ^^^ Fluoxetine alone induced a trend towards desensitization of 5 HT1A autoreceptors as shown by a reduction in the effect of 8 OH DPAT to lower 5 HT levels in frontal cortex , and desensitized 5 HT1B autoreceptors in frontal cortex . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Serotonin 5 HT1A , 5 HT1B , and 5 HT2A receptor mRNA expression in subjects with major depression , bipolar disorder , and schizophrenia . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Chronic fluoxetine induced desensitization of 5 HT1A and 5 HT1B autoreceptors : regional differences and effects of WAY 100635 . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The 5 HT1A , 5 HT1B , and 5 HT 2 receptor subtypes were chosen for their implication in depression and their location in / or next to these regions . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Thirteen kilobases of DNA including the complete coding regions of 5 HT1A , 5 HT1B , and 5 HT 2 were sequenced in 216 highly inbred lines extracted from two North American populations in California and North Carolina . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The anticonvulsant action of both SKF 99101 ( 15 mg kg ( 1 ) i . p . ) and RU 24969 ( 2 . 5 mg kg ( 1 ) i . p . ) was dose dependently abolished by the selective 5 HT1B receptor antagonist SB 224289 ( 0 . 1 3 mg kg ( 1 ) p . o . , 3 h pretest ) but was unaffected by the selective 5 HT1A receptor antagonist WAY 100635 ( 0 . 01 0 . 3 mg kg ( 1 ) s . c . , 1 h pretest ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Because 5 HT dysregulation is associated with several common psychiatric disorders , the potential for epistasis among genetic variants in the 5 HT transporter ( SERT ) , 5 HT1B terminal autoreceptor and the 5 HT1A somatodendritic autoreceptor should be examined . ^^^ Parameters representing extracellular 5 HT clearance rates ( SERT ) , 5 HT release levels ( 5 HT1B ) and inhibitory thresholds ( the amount of extracellular 5 HT above which cell firing is inhibited , an indication of 5 HT1A autoreceptor sensitivity ) were varied to simulate genetic deletion ( i . e . knockout ) of each component singly , and in combination . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Male Swiss mice were acutely administered HG 1 at active doses in association with GABA antagonists such as flumazenil , bicuculline and picrotoxine , then , with 5 HT1A ( NAN 190 , WAY 100635 ) and 5 HT1B receptor antagonist ( methiothepine ) . ^^^ Finally , we tried to potentiate non active doses of HG 1 with 5 HT1A ( 8 OHDPAT ) and 5 HT1B receptor agonists ( anpirtoline ) in the mouse elevated plus maze . ^^^ HG 1 mechanism of action in the mouse elevated plus maze seems to associate a GABA ergic component exerting a limited regulation of 5 HT neuronal activity and a major serotonergic component , which seems to implicate presynaptic 5 HT1A and 5 HT1B receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Several doses of the 5 HT receptor agonists 8 hydroxy 2 ( di n propylamino ) tetraline ( 8 OH DPAT , 5 HT1A ) , 1 , 4 dihydro 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridinyl ) 5H pyrrolo [ 3 , 2 b ] pyridin 5 one dihydrochloride ( CP 93129 , 5 HT1B ) , alpha methyl 5 hydroxytryptamine maleate ( m 5 HT , 5 HT 2 ) , 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane ( DOI , 5 HT2C ) , and 1 ( m chlorophenyl ) biguanide ( 5 HT 3 ) were subsequently infused via the microdialysis probe . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Role of 5 HT1A and 5 HT1B receptors in the hypophagic effect of 5 HT on the structure of feeding behavior . ^^^ In order to reveal the involvement of 5 HT1A and 5 HT1B receptors in the paraventricular nucleus of the hypothalamus ( PVN ) on serotonin induced hypophagia , we examined the effects of intra PVN injections of serotonin in WAY 100635 or SB 216641 pretreated rats on the structure of feeding behavior . ^^^ Blockade of 5 HT1A or 5 HT1B receptors in the paraventricular nucleus was effected by WAY 100635 ( 2 microg ) or SB 216641 ( 2 microg ) pretreatment ; ten minutes later , 5 HT ( 2 microg ) was applied into the same nucleus , then food intake and meal patterns were measured in a 30 minute period . ^^^ CONCLUSIONS : The hypophagic effect induced by 5 HT requires activation of 5 HT1A and 5 HT1B receptors , and the specific contribution of these subtype receptors is different , since the 5 HT1A subtype showed higher behavioral selectivity . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Wheel running alters serotonin ( 5 HT ) transporter , 5 HT1A , 5 HT1B , and alpha 1b adrenergic receptor mRNA in the rat raphe nuclei . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Role of 5 HT1A and 5 HT1B receptors in the antinociceptive effect of tramadol . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
This is made evident after administration of 5 HT ( 2A / 2C ) , and 5 HT 4 receptor agonists , or 5 HT1A , 5 HT 3 and probably 5 HT1B receptor antagonists . ^^^ A better understanding of the role played in cognition by these and other serotonin receptor subtypes is likely to result from the recent availability of highly specific ligands such as 5 HT1A , 5 HT1B , and 5 HT2A receptor antagonists , and new molecular tools such as gene knock out mice , especially inducible mice for which the genetic alteration can be restricted both temporally and anatomically . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Stimulation of the lateral hypothalamus produces antinociception mediated by 5 HT1A , 5 HT1B and 5 HT 3 receptors in the rat spinal cord dorsal horn . ^^^ Intrathecal injections of the selective 5 HT1A , 5 HT1B , 5 HT 3 receptor antagonists , WAY 100135 , SB 224289 , and tropisetron , respectively , and the non specific antagonist methysergide , were given . ^^^ These results suggest that the lateral hypothalamus modifies nociception in part by activating spinally projecting serotonin neurons that act at 5 HT1A , 5 HT1B , and 5 HT 3 receptors in the dorsal horn . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effects of 5 HT were mimicked by 5 carboxamidotryptamine ( a 5 HT 1 receptor agonist ) and L 694 247 ( a selective 5 HT1D receptor agonist ) , but not by 8 hydroxy 2 dipropylaminotetralin ( a 5 HT1A receptor agonist ) , CGS 12066B ( a 5 HT1B receptor agonist ) , alpha methyl 5 HT ( a 5 HT 2 receptor agonist ) , 1 ( 3 chlorophenyl ) piperazine ( a 5 HT2C receptor agonist ) or 1 phenylbiguanide ( a 5 HT 3 receptor agonist ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In particular , phenotypic changes in mice bearing inactivation mutations of 5 HT1A and 5 HT1B receptors , 5 HT transporter , 5 HT neuron specific transcription factor Pet 1 , monoamine oxidase A and genes related to 5 HT signalling will be discussed and major findings highlighted . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The ( postsynaptic ) 5 HT1B and to a lesser extent , the 5 HT1A receptor seems to play a prominent role , at least in rodents , in the modulation of ( offensive ) aggression . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
For this purpose , we used antibodies for the 5 HT1A , 5 HT1B , 5 HT2A , 5 HT2C and 5 HT 3 receptors , and for the 5 HT transporter , as well as antibodies for cytokeratin 20 ( as a marker of Merkel cells ) and neurofilament H ( a marker of type 1 sensory nerve terminals ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Finally , the results of studies using DRL behavior highlight important roles for central beta 1 adrenergic receptors , as well as 5 HT1A , 5 HT1B , 5 HT2A , and 5 HT2C receptors , in the mediation of antidepressant like behavioral effects . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
In contrast , MDMA induced generalised anxiety , as measured by the emergence test , seems unlikely to involve the 5 HT 1A , 5 HT 1B or 5 HT 2A , 5 HT 2B or 5 HT 2C receptors . . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The template was N substituted to give a series of compounds showing binding to human cloned 5 HT1A , 5 HT1B and 5 HT1D receptors with pKi ' s greater than 9 and selectivities up to 1000 fold against other serotonin , dopamine and adrenergic receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
PROCEDURE : Amounts of mRNA coding for 7 subtypes of 5 HTRs ( 5 HT1A , 5 HT1B , 5 HT1D , 5 HT1F , 5 HT2A , 5 HT2B , and 5 HT 4 ) were measured by quantitative real time reverse transcriptase PCR assay . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
The effects of T 3 , alone and together with the SSRI fluoxetine , on mRNA levels for the 5 HT1A and 5 HT1B autoreceptors , which mediate serotonergic neurotransmission by feedback actions at the levels of cell firing ( somatodendritic 5 HT1A autoreceptors ) and neurotransmitter release ( nerve terminal 5 HT1B autoreceptors ) were also determined . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
At one end of a spectrum is combination therapies that maintain the benefits associated with SSRIs but attempt to either improve efficacy or reduce side effects by adding additional mechanisms ( 5 HT1A , 5 HT1B , 5 HT1D , 5 HT2C , alpha 2A ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Pretreatment with the 5 HT ( 2C / 2B ) antagonist SB 206553 , but not with the 5 HT1A antagonist WAY 100635 , the 5 HT1B antagonist SB 224289 or the 5 HT 3 antagonist Y 25130 inhibited the fluoxetine induced increase in escape behaviour and the associated elevated LC Fos response . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
SB 649915 , a novel , potent 5 HT1A and 5 HT1B autoreceptor antagonist and 5 HT re uptake inhibitor in native tissue . ^^^ It has been proven that selective serotonin re uptake inhibitors are effective antidepressants but the delay to therapeutic onset of these agents is thought to be due to the time required for 5 HT1A , and possibly 5 HT1B , autoreceptor desensitisation . ^^^ Therefore an agent incorporating 5 HT re uptake inhibition coupled with 5 HT1A and / or 5 HT1B autoreceptor antagonism may provide a fast acting clinical agent . ^^^ The current studies describe the in vitro profile of SB 649915 ( 6 [ ( 1 { 2 [ ( 2 methylquinolin 5 yl ) oxy ] ethyl } piperidin 4 yl ) methyl ] 2H 1 , 4 benzoxazin 3 ( 4H ) one ) , a novel compound which has high affinity for human recombinant 5 HT1A , 5 HT1B and 5 HT1D receptors ( pKi values of 8 . 6 , 8 . 0 , 8 . 8 , respectively ) and the human recombinant 5 HT transporter ( pKi value of 9 . 3 ) . ^^^ SB 649915 also displays high affinity for rat , guinea pig , mouse and marmoset native tissue 5 HT1A , 5 HT1B and 5 HT1D receptors and rat native tissue 5 HT transporters ( pKi values > or=7 . 5 ) . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Synthesis and SAR of highly potent dual 5 HT1A and 5 HT1B antagonists as potential antidepressant drugs . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Measurement of 5 HT1A autoreceptors in the median raphe and 5 HT1B receptors in the SCN also showed no effect of LL . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
One tube RT PCR was performed using primers specific for human 5 HT1A , 5 HT1B , 5 HT1E , 5 HT2A , 5 HT2B , 5 HT2C , 5 HT 3 , 5 HT 4 , 5 HT 6 , and 5 HT 7 receptors . ^^^ Both PHA stimulated human and monkey PBMCs express mRNAs for 5 HT1A , 5 HT1B , 5 HT1E , 5 HT2A , 5 HT 3 , 5 HT 4 , 5 HT 6 receptor types / subtypes . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Among 5 HT 1 receptors , the 5 HT1A receptor transcript is expressed densely in E14 . 5 16 . 5 thalamus , in hippocampus , and in a medial to lateral gradient in cortex , whereas the 5 HT1B receptor mRNA is expressed in more lateral parts of the dorsal thalamus and in the striatum at these ages . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Most previous studies of suicide have analyzed polymorphisms of the receptors 5 HT1A , 5 HT1B , 5 HT2A , fewer have examined 5 HT1F . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Quantitative mapping of tryptophan hydroxylase 2 , 5 HT1A , 5 HT1B , and serotonin transporter expression across the anteroposterior axis of the rat dorsal and median raphe nuclei . ^^^ To foster uniform definitions of locations within these nuclei , we have quantitatively mapped gene expression in DRN and MRN for tryptophan hydroxylase 2 ( Tph 2 ) , the serotonin transporter , as well as 5 HT1A and 5 HT1B receptors . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Genes regulating the synthesis ( TPH ) , storage ( VMAT 2 ) , membrane uptake ( HTT ) , and metabolism ( MAOA ) of 5 HT , as well as a number of 5 HT receptors ( HTR1A , HTR1B , HTR2A , HTR2C , and HTR5A ) , have been studied and this initial research is reviewed here . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
Single nucleotide polymorphisms ( SNPs ) in five serotonin receptor genes ( HTR1A , HTR1B , HTR2A , HTR2C and HTR 6 ) and the 5 HT transporter linked polymorphic region ( 5 HTTLPR ) were genotyped . ^^^
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08908 and P28222	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In contrast , DV 7028 had no affinity for 5 HT1A , 5 HT1B and 5 HT1D receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
No significant binding ( Ki greater than 10 mumol / l ) of DAU 6285 to serotonergic 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , and 5 HT 2 receptors as well as to adrenergic alpha 1 , alpha 2 , dopaminergic D 1 , D 2 or muscarinic M 1 M3 receptor subtypes was found . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effect of metergoline ( 1 mg . kg 1 ) , a substance with a very high affinity for the 5 HT1D receptor as well as for the 5 HT1A , 5 HT1B , 5 HT1C and 5 HT 2 receptors , was studied on the responses to 5 HT and sumatriptan . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effects of the following serotoninergic drugs were tested : the 5 HT1A receptor agonist 8 OH DPAT , the 5 HT1B receptor agonist trifluoromethyl phenylpiperazine ( TFMPP ) , CGS 12066 B and RU 24969 , the 5 HT1A / 1B antagonist ( + / ) pindolol , the 5 HT2 / 1C receptor antagonist ritanserin , the 5 HT2 / 1C receptor agonist DL 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane ( DOI ) , the 5 HT 3 receptor antagonist BRL 43694 , the unselective 5 HT receptor antagonist methiothepin , and carbidopa + L 5 hydroxytryptophan ( L 5 HTP ) to achieve a general , unselective stimulation of multiple 5 HT receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT 2 receptor displayed a genomic organization quite different from the 5 HT1A , 5 HT1B and 5 HT1D receptor subtypes . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The results of these and other published studies suggest roles for 5 hydroxytryptamine 1B ( 5 HT1B ) , 5 HT1C , and , possibly , sigma receptors in the mediation of the TFMPP stimulus and indicate a lack of involvement of 5 HT1A , 5 HT 2 , dopaminergic , and adrenergic mechanisms in this behavior . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The role of 5 HT1A and 5 HT1B receptors in spinal nociceptive transmission and in the modulation of NMDA induced behaviour . ^^^ The effects on nociception of intrathecal ( i . th . ) administration of selective 5 HT1A and 5 HT1B agonists were studied in rats . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Recently , we reported on a series of arylpiperazines 4 which exhibit high affinity for the serotonin 5 HT 1A and 5 HT 1B binding sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The anticonflict effect of m CPP ( 0 . 25 mg / kg ) was antagonized by the non selective 5 HT antagonist metergoline ( 1 4 mg / kg ) and by the beta adrenoceptor blocker SDZ 21009 ( 2 and 4 mg / kg ) with affinity for 5 HT1A and 5 HT1B receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Long term mCPP treatment led to a 36 % increase in [ 3H ] 8 hydroxy 2 ( di n propylamino ) tetralin ( [ 3H ] 8 OH DPAT ) binding to 5 HT1a receptors in hippocampus and a 74 % decrease in [ 3H ] ketanserin binding to 5 HT 2 receptors in cortex , while ( ) [ 125I ] iodocyanopindolol ( [ 125I ] CYP ) binding to 5 HT1b receptors in hypothalamus and striatum was unchanged . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These properties were shared by the benzodiazepine anxiolytic chlordiazepoxide but not by the specific 5 HT 2 antagonists ketanserin and altanserin , nor by the 5 HT1A and 5 HT1B antagonists cyanopindolol and pindolol . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In radioligand binding studies anpirtoline displayed submicromolar affinity for 5 HT1A , 5 HT1B and 5 HT 3 receptor recognition sites ( Ki = 151 , 28 and 30 nM , respectively ) and more modest affinity for 5 HT 2 receptor recognition sites ( Ki = 1 . 48 microM ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In the first study , rats were pretreated with saline , a 5 HT1A receptor agonist ( 8 hydroxy 2 ( di n propylamino ) tetralin , 1 . 0 mg / kg ) , a 5 HT1B receptor agonist [ 5 methoyx 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridinyl ) 1H indole butane dioate ( RU 24969 ) , 2 . 5 mg / kg ] or a 5 HT1C / 5 HT 2 receptor agonist ( 2 , 5 dimethoxy 4 iodoamphetamine , 1 . 0 mg / kg ) twice daily for 3 days . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
On the other hand , the non selective 5 HT antagonist metergoline ( 0 . 5 4 mg / kg ) , the 5 HT1A antagonist NAN 190 ( 0 . 5 2 mg / kg ) , the beta adrenoceptor blockers with high affinity for 5 HT1A and 5 HT1B receptors : pindolol and SDZ 21009 ( 2 8 mg / kg ) and the agonist / antagonist of 5 HT1A receptors ipsapirone ( 2 . 5 and 5 mg / kg ) did not affect the 8 OH DPAT induced hypoactivity . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Pretreatment with spiperone ( 5 HT1A / 5 HT2 / D2 antagonist ) , propranolol or CGP361A ( beta adrenoceptor antagonists that also have binding affinities for 5 HT1A and 5 HT1B sites ) and MDL 72222 ( 5 HT 3 antagonist ) did not attenuate DOI induced suppression of food intake . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
On the other hand , the 5 HT1A , 5 HT1B and beta adrenoceptor antagonists pindolol ( 2 mg / kg ) and cyanopindolol ( 2 mg / kg ) , the 5 HT1A receptor agonist / antagonist ipsapirone ( 10 and 35 mg / kg ) and haloperidol ( 0 . 25 and 0 . 5 mg / kg ) showed a tendency towards enhancing the TFMPP or m CPP induced hyperthermia . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The voltammetric DOPAC signal in the Locus coeruleus , used as a measure of NE neuronal activity , was increased after systemic application of the 5 HT1B agonist CGS 12066B , the 5 HT 2 antagonist ritanserin , and , to a lesser extent , by ipsapirone , a 5 HT1A agonist . ^^^ The findings suggest that the NE neuronal system of the Locus coeruleus is stimulated by 5 HT1A and 5 HT1B receptor activation and inhibited by 5 HT 2 receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The results indicate that sertraline and citalopram given repeatedly decrease the responsiveness of 5 HT1A ( presynaptic ) and 5 HT 2 receptors but increase the responsiveness of 5 HT1B receptors to respective agonists . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The non selective 5 HT 1 like and 5 HT 2 receptor antagonist , methiothepin ( 2 . 0 mg / kg , i . p . ) and the beta adrenoceptor antagonist propranolol ( 16 . 0 mg / kg , s . c . ) , which is a putative antagonist at 5 HT1A and 5 HT1B receptor subtypes , significantly potentiated the arousal effect of RU 24969 . ^^^ The putative 5 HT1A and 5 HT1B receptor antagonist , cyanopinolol ( 4 . 0 mg / kg , s . c . ) , mixed 5 HT1A receptor agonist / antagonist MDL 72832 ( 1 . 0 mg / kg , s . c . ) and the alpha 1 adrenoceptor antagonist prazosin ( 2 . 0 mg / kg ) did not affect the vigilance , altered by RU 24969 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
To explore whether the inhibitory actions of endogenous serotonin on rat male sexual behavior were mediated via the stimulation of the 5 hydroxytryptamine1A ( 5 HT1A ) or 5 HT1B receptor subtypes , two series of studies were undertaken . ^^^ In the second series , a possible synergistic effect of a subthreshold dose of 5 HTP ( 12 . 5 mg / kg ) with low doses of the selective 5 HT1B agonist 1 ( m trifluoro methylphenyl ) piperazine ( TFMPP , 0 . 125 mg / kg ) or the selective 5 HT1A agonist 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT , 0 . 0625 mg / kg ) was investigated . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The ability of 5 HT1A and 5 HT1B agonists to alter a spinal animal ' s nociceptive threshold was examined using two analgesiometric tests . ^^^ Similar to the effects noted with 5 HT1A agonists , administration of 5 HT1B agonists RU 24969 , mCPP and TFMPP resulted in a hyperalgesic response with an overall percent maximal increase of 43 + / 6 % for the ventroflexion reflex , 51 + / 6 % for the dorsiflexion reflex and 38 + / 9 % for the lateral flexion reflex . ^^^ In the tail flick analgesiometric test , administration of the 5 HT1A agonists 8 OH DPAT and ipsapirone and the 5 HT1B agonists RU 24969 and mCPP resulted in a significant dose dependent increase in tail flick latencies when compared to predrug baseline values , indicating a decrease in nociceptive sensitivity to noxious thermal stimuli . ^^^ No differences in magnitude of the effect of the two receptor subtypes were found , indicating that stimulation of either 5 HT1A or 5 HT1B receptors was equipotent in producing the antinociceptive tail flick response . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The laminar distribution and density of other high affinity 3H 5 HT binding sites present in rat spinal cord , 5 HT1A , 5 HT1B and 5 HT1C , was also determined . ^^^ A similar spatial pattern of receptor density was observed for 5 HT1A , 5 HT1B and 5 HT1C receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
RU 24969 ( 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydropyridin 4 yl ) 1H indole ) , at doses of 5 . 6 10 mg / kg , and eltoprazine ( 5 . 6 mg / kg ) , both mixed 5 HT1A / B agonists , substituted completely for 8 OH DPAT , whereas 3 . 0 10 mg / kg of the 5 HT1B / C agonist TFMPP ( 1 ( m trifluromethylphenyl ) piperazine ) and 0 . 1 3 . 0 of the 5 HT 3 antagonist MDL 72222 ( 3 tropanyl 3 , 5 dichlorobenzoate ) yielded only saline appropriate responses . ^^^ Substitution for 8 OH DPAT by eltoprazine and RU 24969 , which does not occur in rats , provides in vivo support for the suggestion that the absence of a 5 HT1B receptor in the pigeon allows more complete expression of 5 HT1A mediated effects . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The present study was aimed at characterizing this receptor with respect to the currently recognized 5 HT 1 receptor subtypes ( 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D ) . ^^^ The concentration response curve for 5 carboxamidotryptamine ( 5 CT , a 5 HT 1 like receptor agonist ) was unaffected by propranolol ( 10 microM ) , which is reported to have affinity for 5 HT1A , 5 HT1B and 5 HT1C recognition sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In contrast , pretreatment with various doses of metergoline ( 5 HT1 / 5 HT 2 antagonist ) , propranolol ( beta adrenoceptor antagonist that also has binding affinity for 5 HT1A , 5 HT1B and 5 HT1C sites ) , mesulergine and mianserin ( 5 HT1C / 5 HT 2 antagonists ) attenuated m CPP induced increases in plasma prolactin . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The facilitory effect in infant and young rats was counteracted by methiothepine but not by ritanserin , suggesting that it is mediated through 5 HT1A or 5 HT1B receptor subtypes . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Brain 5 HT1A and 5 HT1B receptors are important targets for drug induced modulation of 5 HT function in vivo . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Functional interaction between 5 HT1B and 5 HT1A or 5 HT 2 receptors in mice . ^^^ The present results suggest that a functional interaction exists between 5 HT1B and 5 HT1A or 5 HT 2 receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
We performed acute dose response and time course behavioral studies in 1 day old rats with the putative selective agonists 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) ( 5 HT1A ) , 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydropyridin 4 yl ) 1H indole ( RU 24969 ) ( 5 HT1B ) , and ( + ) 1 ( 2 , 5 dimethoxy 4 iodo phenyl aminopropane ) 2 ( DOI ) ( 5 HT2 / 1C ) . ^^^ These studies suggest that functional and differential activity of 5 HT1A , 5 HT1B , and 5 HT2 / 1C receptors occurs much earlier in the rat than previously appreciated . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Furthermore , SR 46349B displayed moderate affinity for the 5 HT1C receptor and had no affinity for the other 5 HT 1 subclass ( 5 HT1A , 5 HT1B or 5 HT1D ) , dopamine ( D 1 or D 2 ) , `` alpha ' ' adrenergic ( alpha 1 or alpha 2 ) , sodium and calcium channel and histamine ( H 1 ) receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Rats were treated by intraperitoneal injection for four weeks with either RU 24969 , a 5 HT1B and 5 HT1A agonist or imipramine , a 5 HT uptake inhibitor . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
However , when 1 [ 1H Indol 4 yloxy ] 3 [ isopropylamino ] 2 propanol ( pindolol ) , a drug that acts at both beta adrenergic receptors and at 5 HT1A and 5 HT1B receptors , was coadministered with quipazine there was a reversal of the quipazine effect on aggression only in TP dominant rats . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These data suggest that the 5 HT induced increase in intragastric pressure in the spinal and bilaterally vagotomized rat is mediated by an atypical 5 HT 1 like receptor , which , based on the low agonist potency of 5 carboxamidotryptamine and RU 24969 and the resistance to blockade by metergoline , does not seem to correspond to either the 5 HT1A , 5 HT1B , 5 HT1C or the 5 HT1D receptor subtypes . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The eltoprazine stimulus generalized to the structurally related experimental drug fluprazine , the mixed 5 HT1a / 1b agonist 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydropyridinyl ) 1H indole , ( RU 24969 ) , the 5 HT1b / 1c agonist 1 [ 3 ( trifluoromethyl ) phenyl ] piperazine , ( TFMPP ) , the 5 HT1a agonist 8 hydroxy 2 ( di n propylamino ) tetralin HB , ( 8 OH DPAT ) , and the beta adrenergic / 5 HT 1 antagonists ( + / ) pindolol and ( + / ) propranolol . ^^^ The eltoprazine cue partially generalized to the cues of the 5 HT1a agonists flesinoxan and buspirone , ( m CPP ) , the 5 HT1b / 1c agonist 1 , 3 chlorophenyl piperazine dihydrochloride and the 5 HT1c / 2 antagonist mesulergine , and did not generalize to the 5 HT2 / 1c agonist DOI . ^^^ The present data show that eltoprazine can serve as a discriminative stimulus in rats and suggest that specifically 5 HT 1 ( i . e . , 5 HT1a and 5 HT1b ) receptors are involved in the stimulus properties of eltoprazine . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Autoradiographic analyses of the effects of adrenalectomy and corticosterone on 5 HT1A and 5 HT1B receptors in the dorsal hippocampus and cortex of the rat . ^^^ Quantitative autoradiography was used to evaluate the effects of adrenalectomy ( ADX ) and corticosterone ( CORT ) on binding at 5 HT1A and 5 HT1B receptors in the dorsal hippocampus and cortex of the rat . ^^^ It is suggested that decreases in binding at 5 HT1A and 5 HT1B / 1D receptors resulting from chronic exposure to high levels of CORT may also occur in animals that fail to adapt to chronic severe stress . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Concentration response relationships for 8 hydroxy 2 ( di n propylamino ) tetralin ( 5 HT1A agonist ) ( 0 . 3 100 microM ) , CGS 12066B maleate ( 5 HT1B agonist ) ( 0 . 01 30 microM ) , alpha methylserotonin maleate ( 5 HT 2 agonist ) ( 0 . 01 30 microM ) , 1 ( m chlorophenyl ) biguanide ( 5 HT 3 agonist ) ( 0 . 1 100 microM ) and serotonin ( 0 . 1 300 microM ) were studied in vitro using 2 mm segments of bovine proximal left anterior descending coronary artery . ^^^ Contractions induced by 8 hydroxy 2 ( di n propylamino ) tetralin or alpha methylserotonin maleate were attenuated by pretreatment with S ( ) propranolol ( 2 . 6 microM ) , a relatively selective 5 HT1A and 5 HT1B receptor antagonist , and ketanserin ( 0 . 3 microM ) , a selective 5 HT 2 receptor antagonist , respectively . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Stimulation of 5 HT1A and 5 HT1B receptors in brain regions and its effects on male rat sexual behaviour . ^^^ In the present series of experiments we compared the effect of injecting serotonin ( 40 micrograms / cannula ) , the 5 HT1A agonist , 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) ( 5 . 0 micrograms / cannula ) , and the 5 HT1B / C agonist , trifluoromethyl phenyl piperazine ( TFMPP ) ( 1 . 0 micrograms / cannula ) , into the preoptic area , the nucleus accumbens and the nucleus raphe dorsalis . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Our results show that agents stimulating the 5 HT1a receptor ( 8 OH DPAT ) or the 5 HT1b receptor ( TFMPP ) or substances which release serotonin ( fenfluramine ) had no effect on the development of spinal serotonergic pathways . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
No 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , 5 HT 2 , or 5 HT uptake sites were found in any of the tumors , although all were detected in human or rat brain . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Selective agonists exist for the 5 HT1A , 5 HT1B and 5 HT 3 receptors and selective antagonists for the 5 HT 2 and 5 HT 3 receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The amplitude of the GABAB synaptic potential was reduced by the 5 HT1B receptor agonists 1 [ 3 ( trifluoromethyl ) phenyl ] piperazine ( 300 nM ) and 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo [ 1 , 2 a ] quinoxaline ( 1 microM ) , but not by the 5 HT1A agonist N , N dipropyl 5 carboxamidotryptamine ( 1 microM ) or the 5 HT 2 agonist ( + / ) 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 amino propane ( 10 microM ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The respective 5 HT1A and 5 HT1B agonists , ( + / ) 8 hydroxydipropylaminotetralin ( 0 . 50 mg / kg s . c . ) and CGS 12066B maleate ( 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo [ 1 , 2 alquinoxaline ] , 1 : 2 maleate salt ; 3 . 0 mg / kg i . p . ) , did not increase oral activity . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The deduced amino acid sequence of HGCR 1 is 39 % , 55 % and 87 % identical to that for the human 5 HT1A , the human 5 HT1D and the rat 5 HT1B receptor , respectively . [ 3H ] 5 HT binding to transfected COS 7 cell membranes yields a pharmacological profile similar to that of 5 HT1B receptor . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Binding assays with rat brain membranes have shown that anpirtoline bound with a much higher affinity to 5 HT1B receptor ( Ki = 28 nM ) than to 5 HT1A ( Ki = 150 nM ) and 5 HT 2 ( Ki = 1 . 49 microM ) receptors . 3 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
By contrast , neither amoxapine nor amitriptyline can be considered as possible ligands of 5 HT1A and 5 HT1B receptors because their affinities for these sites are in the micromolar range ( or even worse ) . ^^^ By contrast , neither 5 HT1A nor 5 HT1B receptors were significantly affected in any brain region studied . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
At least seven receptor subtypes ( 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , 5 HT 2 , 5 HT 3 , 5 HT 4 ) have been identified in brain . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The biochemical and behavioural effects of isamoltane , a beta adrenoceptor and 5 HT1B receptor antagonist that has higher affinity for 5 HT1B receptors than for 5 HT1A receptors , on 5 HT neurotransmission in the rat brain were examined . ^^^ In binding experiments isamoltane was found to be about five times more potent as a ligand for the 5 HT1B receptor than for the 5 HT1A receptor ( Ki values 21 and 112 nmol / l , respectively ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
It displayed weak affinity for 5 HT1A ( pIC 50 = 5 . 9 ) and 5 HT1B ( pKi = 5 . 5 ) binding sites in rat brain . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Interaction of the alpha adrenoceptor agonist oxymetazoline with serotonin 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D receptors . ^^^ Oxymetazoline was recognized with nanomolar affinity by 5 HT1A , 5 HT1B and 5 HT1D binding sites and mimicked the effects of 5 hydroxytryptamine with about the same potency and intrinsic activity as the endogenous amine in the corresponding functional tests . ^^^ Thus , oxymetazoline is a full and potent agonist at 5 HT1A , 5 HT1B and 5 HT1D receptors and a partial agonist at 5 HT1C receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Much higher concentrations of ACTH ( 1 24 ) , up to 10 ( 4 ) M , were needed for the displacement of appropriate radiolabelled ligands from dopamine D 1 receptors , serotonin 5 HT1A , serotonin 5 HT1B , muscarinic M 1 acetylcholine and histamine H 1 receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The anticonflict effect of ipsapirone ( 5 mg / kg ) was dose dependently antagonized by the 5 HT1A receptor , alpha 1 adrenoceptor and dopamine receptor antagonist , NAN 190 ( 0 . 25 1 mg / kg ) and by the beta adrenoceptor blocker , SDZ 21009 , which also has a high affinity for 5 HT1A and 5 HT1B receptors ( 2 8 mg / kg ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The anti immobility effect of gepirone ( 10 mg / kg ) was dose dependently antagonized by the 5 HT1A receptor and alpha 1 adrenoceptor antagonist , NAN 190 ( 0 . 25 and 0 . 5 mg / kg ) , the beta adrenoceptor blocker with the affinity for 5 HT1A and 5 HT1B receptors , pindolol ( 2 and 4 mg / kg ) , the 5 HT1A , 5 HT 2 and dopamine receptor blocker spiperone ( 0 . 01 and 0 . 03 mg / kg ) and by the dopamine receptor antagonist , haloperidol ( 0 . 125 and 0 . 25 mg / kg ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Putative 5 HT1A agonists ( 8 OH DPAT , ipsapirone , and buspirone ) and 5 HT1B agonists ( TFMPP and m CPP ) affected neither basal nor forskolin dependent cyclic AMP accumulation . ^^^ Receptor binding studies suggest that NCB 20 cells are devoid of 5 HT1A and 5 HT1B receptor sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In addition , the drugs with antagonistic properties at the 5 HT1A , 5 HT1B , 5 HT1C , and 5 HT1D receptors block other 5 HT receptors or even entirely different receptors ( e . g . , beta adrenoceptors ) ; as a rule , they do not discriminate between the four 5 HT receptor subtypes . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT1A agonist , ( + ) 8 hydroxy 2 ( di N propylamino ) tetralin hydrobromide ( 8 OH DPAT ) and 5 HT1B agonist , m trifluoromethylphenylpiperazine HCl ( TFMPP ) , had no effect on flexion at 72 h in the intact rat but reduced rebound . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Administration of the nonselective 5 HT agonist quipazine , the 5 HT 1 agonist mCPP , the 5 HT 1a agonist 8 OH DPAT , the 5 HT 1b agonist CGS 12066B , and the 5HT 1c / 2 agonist DOI did not inhibit d amphetamine stimulated locomotor activity . ^^^ The combination of the 5 HT 1a agonist 8 OH DPAT and the 5 HT 1b agonist CGS 12066B , however , did inhibit d amphetamine stimulated locomotor activity . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
High affinity [ 3H ] 5 HT binding was unchanged using assay conditions [ 1 microM ( + / ) pindolol and 1 microM ( R ) ( + / ) SCH 23390 ) to pharmacologically mask 5 HT1A , 5 HT1B , and 5 HT1C receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In the rat , S CM GTNH 2 is 57 and 24 times more potent at 5 HT1B sites ( IC 50 = 28 nM ) than at 5 HT1A ( IC 50 = 1600 nM ) and 5 HT1C sites ( IC 50 = 670 nM ) , respectively . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
At this time , there is a general consensus that the 5 HT 1 family can be further subdivided into 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , and 5 HT1P subpopulations . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The inhibitory effect of TFMPP was mimicked by CGS 12066B ( 10 , 30 , and 100 microM ) , a 5 hydroxytryptamine1B ( 5 HT1B ) / 5 HT1D receptor agonist ; 1 ( m chlorophenyl ) piperazine ( 100 microM ) , a 5 HT1C / 5 HT1B receptor agonist ; and 5 carboxamidotryptamine ( 10 microM ) , a nonselective 5 HT 1 receptor agonist . 8 Hydroxy 2 ( di n propylamino ) tetralin ( 10 and 100 microM ) , a 5 HT1A receptor agonist , and quipazine ( 10 and 100 microM ) , a 5 HT 2 receptor agonist , did not have any significant effect . ^^^ These data suggest that , in guinea pig hippocampus , the K ( + ) evoked ACh release is modulated by a 5 HT 1 receptor distinct from the 5 HT1A , 5 HT1B , and 5 HT1C subtypes . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT receptor agonists examined in this study included the 5 HT1A agonist 8 hydroxy N , N dipropyl 2 aminotetralin ( 8 OH DPAT ) , the 5 HT1B agonist m trifluoromethylphenylpiperazine ( TFMPP ) , the 5 HT 2 agonist 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane ( DOI ) and the 5 HT 3 agonist phenylbiguanide ( PBG ) . 3 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
We describe the effects of central 5 HT depletion 1 ) on the behaviour of resident TMD S 3 rats in a territorial situation , 2 ) on the efficacy of eltoprazine to inhibit offensive aggression , and 3 ) on the 5 HT1A , 5 HT1B and 5 HT1C receptor binding in brains of rats previously used in behavioural studies . ^^^ Quantitative autoradiographic studies 5 weeks after 5 , 7 DHT treatment revealed a significant increase in radioligand binding to 5 HT1A , 5 HT1B and 5 HT1C sites in many brain regions studied , except for the raphe nuclei where [ 3H ] 8 OH DPAT binding to 5 HT1A sites was markedly reduced . ^^^ The 5 , 7 DHT induced overall upregulation of 5 HT1A , 5 HT1B and 5 HT1C binding sites suggests that these three receptor subtypes receive a tonic serotonergic influence . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Clonidine ( an alpha 2 agonist ) and 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT , a 5 HT1A agonist ) induced hyperphagia and 1 ( 3 trifluoromethylphenyl ) piperazine ( TFMPP , a 5 HT1B agonist ) induced hypophagia dose dependently in both rat lines . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Autoradiographic mapping of 5 HT 1 , 5 HT1A , 5 HT1B and 5 HT 2 receptors in the rat spinal cord . ^^^ The distribution of 5 HT 1 , 5 HT1A , 5 HT1B and 5 HT 2 receptors in the rat spinal cord was investigated with quantitative autoradiography . ^^^ It is shown that 5 HT 1 , 5 HT1A and 5 HT1B receptors are distributed within the spinal cord according to a rostro caudal gradient . ^^^ Both 5 HT 1 and 5 HT1A receptors are mainly present in the dorsal horn and 5 HT1B is present throughout the spinal cord , exhibiting high densities in the caudal most part of the dorsal horn in lamina 10 and in the sacral parasympathetic area . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Role of presynaptic serotonergic receptors on the mechanism of action of 5 HT1A and 5 HT1B agonists on masculine sexual behaviour : physiological and pharmacological implications . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Good correlations were found between species in the regional distribution of 5 HT 1 sites labelled with [ 3H ] 5 HT ( r = 0 . 73 ) , 5 HT1A sites labelled with [ 3H ] 8 OH DPAT ( r = 0 . 87 ) , and 5 HT1B versus 5 HT1D sites labelled with [ 3H ] 5 HT in the presence of ipsapirone and DOI ( r = 0 . 76 ) . ^^^ The distribution of [ 3H ] eltoprazine binding sites showed a good correlation with that of the 5 HT1B sites in rat ( r = 0 . 89 ) , and with that of the 5 HT1A sites in guinea pig ( r = 0 . 97 ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Since galanin in vitro selectively increases the KD value of 5 HT1A receptors without altering the binding of 5 HT1B or 5 HT 2 receptors , we have studied whether 5 HT1A receptor activation in turn may affect galanin binding in the ventral di and telencephalon and the substantia nigra of the rat . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Various 5 HT1A receptor agonists were found to inhibit carbachol ( 10 microM ) stimulated formation of total inositol phosphates in immature rat hippocampal slices with the following rank order of potency ( IC 50 values in nM ) : 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) ( 11 ) greater than ipsapirone ( 20 ) greater than gepirone ( 120 ) greater than RU 24969 ( 140 ) greater than buspirone ( 560 ) greater than 1 ( m trifluoromethylphenyl ) piperazine ( 1 , 500 ) greater than methysergide ( 5 , 644 ) ; selective 5 HT1B , 5 HT 2 , and 5 HT 3 receptor agonists were inactive . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The stimulatory action of 2 Me 5 HT and phenylbiguanide was blocked completely by granisetron , ondansetron and ICS 205 930 but not by other receptor antagonists such as ( + / ) pindolol ( a beta , 5 HT1A and 5 HT1B receptor antagonist ) , methy sergide ( a 5 HT 1 and 5 HT 2 receptor antagonist ) , ritanserin ( a 5 HT1C and 5 HT 2 receptor antagonist ) , SR 95103 ( gamma aminobutyric acidA receptor antagonist ) , scopolamine ( a muscarinic antagonist ) , ( ) eticlopride ( a D 2 receptor antagonist ) , SCH 23390 ( a D 1 5 HT2 / 1C receptor antagonist ) and prazosin ( an alpha 1 receptor antagonist ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
It is concluded that the anti idiotypic antibodies generated with anti 5 HT serum recognize the 5 HT1B , 5 HT1C , and 5 HT 2 receptor subtypes ; however , neither 5 HT1A receptors nor 5 HT uptake sites appear to react with these antibodies . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Receptor binding parameters in temporal cortex homogenates were assessed using [ 3H ] 5 HT in the presence of 100 nM 8 OH DPAT , 1 microM propranolol and 1 microM mesulergine to prevent labelling of the 5 HT1A , 5 HT1B and 5 HT1C sites , respectively . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Calculated ID 50 values correlated significantly with reported affinities ( r = 0 . 81 , n = 10 , P less than 0 . 01 ) for 5 HT1C but not for 5 HT 2 , 5 HT1A , 5 HT1B or 5 HT1D receptors . 2 . ^^^ ID 50 values of the ten antagonists against 5 hydroxytryptophan ( 5 HTP ) + carbidopa induced head shakes ( a 5 HT 2 mediated response ) correlated significantly ( r = 0 . 81 , n = 10 , P less than 0 . 01 ) with their affinities for 5 HT 2 but not for 5 HT1A , 5 HT1B , 5 HT1C or 5 HT1D receptors . 3 . ^^^ These ratios correlated highly significantly ( r = 0 . 91 , n = 10 , P less than 0 . 001 ) with the ratios of the affinities of the drugs for 5 HT1C ( but not for 5 HT1A , 5 HT1B or 5 HT1B or 5 HT1D receptors ) and with their affinities for 5 HT 2 receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Autoradiograms from brain sections incubated with 0 . 02 nM S CM G [ 125I ] TNH 2 showed a heterogeneous anatomical distribution of the labelling with high densities in regions rich in 5 HT1B or 5 HT1D binding sites , and with no labelling of those rich in 5 HT1A or 5 HT1C sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The maximal density of [ 3H ] 8 hydroxy 2 ( di n propylamino ) tetralin [ ( 3H ] 8 OH DPAT ) binding ( Bmax ) to 5 HT1a receptors was decreased by 25 and 17 % in the hippocampus during chronic ethanol intoxication and withdrawal , respectively . [ 3H ] Ketanserin binding to 5 HT 2 receptors in the cortex , ( ) [ 125I ] iodo cyanopindolol [ ( 125I ] CYP ) binding to 5 HT1b receptors in the striatum and hypothalamus , and [ 3H ] 8 OH DPAT binding in the cortex were not affected by chronic ethanol administration . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT 2 antagonists ( ketanserin , methergoline and methiothepin ) were potent antagonists . ( ) Alprenolol ( 5 HT1A and 5 HT1B receptor antagonist ) and the 5 HT 3 receptor antagonist , ICS 205 930 , were without an antagonistic effect . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Daily administration of LSD [ 130 micrograms / kg ( 0 . 27 mumol / kg ) intraperitoneally ( IP ) ] for 5 days produced a decrease in serotonin 2 ( 5 hydroxytryptamine 2 , 5 HT 2 ) binding in cortex ( measured 24 hours after the last drug administration ) but did not affect binding to other receptor systems ( 5 HT1A , 5 HT1B , beta adrenergic , alpha 1 or alpha 2 adrenergic , D 2 dopaminergic ) or to a recognition site for 5 HT uptake . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Since it was previously shown that the behavioural deficit was reduced by agonists at 5 HT1B receptors , it is proposed that the behavioural inhibition , resulting from an isolation induced increase in reactivity is bi directionally modulated by serotonergic drugs , where 5 HT1A agonists increase and 5 HT1B agonists decrease this inhibition . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The initial inhibitory phase of the dose response curve was not antagonized by naltrexone ( 300 nM ) , idazoxan ( 300 nM ) or propranolol ( 300 nM ) , indicating that neither opioid , alpha 2 nor beta receptors were involved in the inhibition . ( + / ) Cyanopindolol ( 300 nM ) was also devoid of any antagonist activity versus 8 OH DPAT , showing that the effect of the compound is not due to 5 HT1A or 5 HT1B agonist activity . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Eltoprazine interacts selectively with serotonin ( 5 HT ) receptor subtypes ( Ki values for 5 HT1A , 5 HT1B and 5 HT1C receptors are 40 , 52 and 81 nM respectively ) . ^^^ Taken together from a variety of neurochemical studies there is strong evidence both in vitro and in vivo that the pharmacological actions of eltoprazine can be attributed to an interaction with the 5 HT system , most probably via a ( partial ) agonistic action on 5 HT1A and 5 HT1B receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The other subtype agonists , such as ( + / ) 8 hydroxy dipropylaminotetralin hydrobromide ( 5 HT1A agonist ) , 1 ( 3 chlorophenyl ) piperazine dihydrochloride and 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo ( 1 , 2 a ) quinoxaline ( 5 HT1B ) and 2 methyl serotonin maleate ( 5 HT 3 ) , only elicited a small percentage of the maximum contraction to 5 HT . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT1A receptor agonist 8 OH DPAT , the 5 HT1B receptor agonist RU 24969 , the 5 HT 2 receptor agonists DOI , MK 212 and alpha methyl 5 HT and the 5 HT 3 agonist 2 methyl 5 HT all dose dependently inhibited the pressor response and dose dependently elevated the visceromotor threshold to noxious CRD . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Inhibition after i . c . v . administration was produced by 8 OH DPAT ( 5 HT1a ) , RU 24969 ( 5 HT1b ) , and 2 methyl serotonin ( 5 HT 3 ) , but not DOI ( 5 HT 2 ) which augmented propulsion . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
This demonstrates the preferential affinity of S CM GTNH 2 for 5 HT1B versus 5 HT1A and 5 HT1C binding sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Constriction of porcine arteriovenous anastomoses by indorenate is unrelated to 5 HT1A , 5 HT1B , 5 HT1C or 5 HT1D receptor subtypes . ^^^ These effects of indorenate were not appreciably modified after treatment with the 5 HT 2 receptor antagonist ketanserin ( 0 . 5 mg . kg 1 i . a . ) , but were markedly reduced after treatment with methiothepin ( 1 . 0 mg . kg 1 i . a . ) , which antagonizes not only 5 HT 2 receptors , but also the putative 5 HT1A , 5 HT1B 5 HT1C and 5 HT1D subtypes of 5 HT 1 like receptors . ^^^ It is therefore concluded that , like 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) and 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridinyl ) 1H indole ( RU 24969 ) , indorenate reduces both total common carotid and cephalic arteriovenous anastomotic blood flow in the pig by stimulating 5 HT 1 like receptors ; these receptors , however , do not seem to correspond to either 5 HT1A , 5 HT1B , 5 HT1C or 5 HT1D binding sites . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT 1 receptor family comprises five different pharmacologic subtypes , designated 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , and 5 HT1E , whose common property is to bind 5 HT with nanomolar affinity . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
As expected , 8 OH DPAT , a selective 5 HT1A receptor agonist , stimulated , and 5 HT1B agonists CGS 12066B and 1 ( trifluoromethylphenyl ) piperazine ( TFMPP ) failed to stimulate the 5 HT syndrome induced in rats by pargyline and 5 HTP administration . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Furthermore , 5 HT 1 receptors are not a homogeneous class , but are subdivided further into four subtypes : 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Among the most potent antagonists ( mean pKB value ) were the nonselective 5 HT receptor antagonists , methiothepin ( 7 . 30 ) and metergoline ( 6 . 86 ) , the 5 HT1A / 5 HT1D receptor ligand , 1 [ 2 ( 4 amino phenyl ) ethyl ] 4 ( 3 trifluoromethylphenyl ) piperazine ( 7 . 02 ) , the 5 HT1A / 5 HT1B / 5 HT1D receptor ligand , 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo [ 1 , 2 , a ] quinoxaline 1 ( 6 . 73 ) and yohimbine ( 6 . 37 ) . ^^^ Beta adrenoceptor antagonists with affinity for 5 HT1A and 5 HT1B receptors weakly antagonized the effect of 5 carboxamidotryptamine ( pKB values less than or equal to 5 . 32 ) , as did the 5 HT1c / 5 HT 2 receptor antagonist , mesulergine ( 5 . 30 ) and the yohimbine isomer , corynanthine ( 4 . 85 ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Experimental lesions followed by binding of [ 3H ] 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) , [ 125I ] cyanopindolol and [ 3H ] paroxetine to cryostat sections and coverslip autoradiography were used to localize 5 HT1A , 5 HT1B and 5 HT uptake sites in rat posterior cingulate cortex . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The purpose of the present study was to characterize the cardiorespiratory effects of activation of 5 HT1A , 5 HT1B and 5 HT 2 receptor subtypes at the intermediate area of the ventral surface of the medulla . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effect of the putative 5 HT1A agonists 8 OH DPAT and ipsapirone and 5 HT1B agonists TFMPP and m CPP on respiratory activity in rats has been examined . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Presently , 5 TH receptors have been divided into 5 HT 1 , 5 HT 2 and 5 HT 3 . 5 HT 1 receptors have been subdivided into 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
RU 24969 induced emesis in the cat : 5 HT 1 sites other than 5 HT1A , 5 HT1B or 5 HT1C implicated . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Preweanling ( postnatal day 17 18 ) Sprague Dawley rat pups were tested in both the absence and presence of milk following administration of various doses of the 5 HT1A agonists 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) or ipsapirone , the 5 HT1B agonist 1 ( 3 chlorophenyl ) piperazine ( mCPP ) or the 5 HT 2 agonist 1 ( 2 , 5 dimethoxy 4 iodo phenyl ) 2 aminopropane ( DOI ) . 8 OH DPAT decreased mouthing while ipsapirone , mCPP and DOI had no effect upon this behavior . ^^^ These functional responses to 5 HT1A , 5 HT1B and 5 HT 2 agonists in preweanling pups vary from those observed previously in neonates . ^^^ For instance , whereas inhibitory effects of 5 HT1A stimulation on mouthing are observed in both neonatal and preweanling pups , facilitory effects of 5 HT1B and 5 HT 2 stimulation are only seen in neonates . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The role of spinal cord 5 HT1A and 5 HT1B receptors in the modulation of a spinal nociceptive reflex . ^^^ The results show that in the mouse i . th . injection of both 5 HT1A and 5 HT1B receptor agonists has the ability to inhibit the tail flick reflex without interfering with the tail skin temperature . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The distribution pattern differs from that of other previously described receptors or binding sites ( e . g . monoamine oxidase , benzodiazepine , tryptamine , 5 hydroxytryptamine receptors ( 5 HT1A , 5 HT1B , 5 HT1C , 5HT2 ] , which suggests that a unique class of [ 3H ] norharman binding sites exists in the rat brain . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT 1 sites have been further divided into 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D and 5 HT1E sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Whereas tryptamine derivatives generally display little selectivity for the various populations of 5 HT receptors , N 1 n propyl 5 methoxy alpha methyltryptamine ( 3h ) binds with significant affinity ( Ki = 12 nM ) and selectivity at 5 HT 2 receptors relative to 5 HT1A ( Ki = 7100 nM ) , 5 HT1B ( Ki = 5000 nM ) , 5 HT1C ( Ki = 120 nM ) , and 5 HT1D ( Ki greater than 10 , 000 nM ) receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The prejunctional inhibitory receptor has been the most studied ; depending on the tissue , these subtypes may resemble 5 HT1A , 5 HT1B , 5 HT1C or 5 HT1D binding sites , or the contractile receptor in dog saphenous vein . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Serotonin ( 0 . 5 100 microM ) and the specific 5 HT 2 receptor agonist , 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane ( DOI ) ( 10 100 microM ) but not the 5 HT1A or 5 HT1B agonists , ( + / ) 8 hydroxy dipropylamino tetralin ( 8 OH DPAT ) or 5 methoxy 3 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridin ) 1H indole succinate ( RU 24969 ) induced dose dependent PKC translocations . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The mixed 5 HT 1A and 5 HT 1B agonist RU 24969 reversed catalepsy only at the highest dose tested . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The potencies of these agonists in inhibiting overflow were significantly correlated with their affinities for 5 HT1B and 5 HT1D binding sites , but not with those for 5 HT1A or 5 HT1C binding sites . 5 Aminotryptamine , methysergide , ipsapirone , cyanopindolol , SDZ 21009 and metergoline dit not produce a significant inhibition . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In view of the appreciable affinity of DP 5 CT for the 5 HT1D receptor subtype , the effects of the mixed 5 HT1B / 5 HT1D receptor agonist 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo ( 1 , 2 a ) quinoxaline ( CGS 12066B ) , and the mixed 5 HT1A / 5 HT1B / 5 HT1D receptor agonist 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydropyridine 4 yl ) 1H indole ( RU 24969 ) were also investigated . ^^^ The data suggest that central 5 HT1A receptors , but neither 5 HT1B nor 5 HT1D receptors , regulate plasma adrenaline and glucose levels . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The anti aggressive drug eltoprazine preferentially binds to 5 HT1A and 5 HT1B receptor subtypes in rat brain : sensitivity to guanine nucleotides . ^^^ Competition with eltoprazine for [ 3H ] ligand binding to the various 5 HT 1 receptor subtypes revealed preferential binding to 5 HT1A ( IC 50 values ranging from 42 to 50 nM ) and 5 HT1B ( IC 50 values ranging from 25 to 38 nM ) recognition sites . ^^^ The data indicate that the anti aggressive drug eltoprazine preferentially binds to 5 HT1A and 5 HT1B receptor sites and that this interaction is modulated by guanine nucleotides . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The TFMPP induced anorexia was blocked by mesulergine ( a 5 HT1C and 5 HT 2 antagonist ) , metergoline ( a 5 HT1A , 5 HT1B , 5 HT1C and 5 HT 2 antagonist ) , mianserin ( a 5 HT1C and 5 HT 2 antagonist ) and attenuated by ketanserin and ritanserin ( 5 HT 2 antagonists ) . ^^^ The examined anorexia was not antagonized by cyanopindolol and compound 21009 ( 5 HT1A and 5 HT1B antagonists ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
As previously reported , 2 Me 5 HT possesses a low affinity ( Ki greater than 500 nM ) for 5 HT1A , 5 HT1B , 5 HT1C , and 5 HT 2 sites ; this agent also displays a low affinity for 5 HT1D ( Ki = 1220 nM ) and 5 HT1E ( Ki greater than 10 , 000 nM ) sites . ^^^ However , alpha Me 5 HT displays little selectivity for 5 HT1A , 5 HT1B , 5 HT1C , and 5 HT1D sites ( Ki = 42 , 85 , 150 , and 150 nM , respectively ) and a very low affinity for 5 HT1E ( Ki greater than 10 , 000 nM ) sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Serotonin ( 0 . 5 100 microM ) and the specific 5 HT 2 receptor agonist 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane ( DOI ) ( 0 . 01 10 microM ) but not the 5 HT1A or 5 HT1B agonists elicited time and dose related translocations in cortical slices . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Yet , regions enriched in 5 HT1A and 5 HT1C sites ( e . g . dentate gyrus and choroid plexus , respectively ) revealed relatively more [ 3H ] 5 HT binding as compared to [ 3H ] eltoprazine binding , whereas [ 3H ] eltoprazine binding was more pronounced in 5 HT1B receptor dense areas such as the dorsal subiculum , substantia nigra , ventral pallidum and globus pallidus . ^^^ The pharmacological and anatomical data indicate that eltoprazine binds to 5 HT1A , 5 HT1B and to a lesser extent to 5 HT1C binding sites in the rat brain . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
This rotationally restricted phenolic analogue of RU 24 , 969 is a potent ( 15 nM ) and selective ( 200x vs the 5 HT1A receptor , 150x vs the 5HT1D receptor ) functional agonist for the 5 HT1B receptor . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Of the three different classes of 5 HT receptors which were examined , 5 HT1B sites exhibited the largest age dependent decrease in density , followed by 5 HT 2 sites , while 5 HT1A sites remained practically unchanged during aging . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT1A agonists , 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) , buspirone or TVXQ 7821 ( ipsapirone ) but not the 5 HT1B agonist RU 24969 , attenuated the hyperphagic response to 8 OH DPAT administered on the next day . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Three subtypes of 5 HT 1 binding sites , designated 5 HT1A , 5 HT1B , and 5 HT1C , can now be distinguished by improved binding assay with rather selective radioligands . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
It was found that galanin markedly decreased the Kd value of 5 HT1A binding , while there were no effects on the binding characteristics of the 5 HT1B or 5 HT 2 radioligands . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In light of observed amplificatory interactions between serotonergic and adrenergic stimuli in functional studies on vascular tissue and platelets , we investigated the distinction and possible interactions between alpha 1 , alpha 2 , beta 1 , and beta 2 adrenergic and 5 HT1A , 5 HT1B , and 5 HT 2 serotonergic receptor binding sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
RU 24969 , with high affinity for both 5 HT1A and 5 HT1B receptors , and 1 ( 2 methoxyphenyl ) piperazine , a 5 HT 1 compound , increased punished responding to a lesser extent , as did the 5 HT 2 antagonists ketanserin and ritanserin . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The purpose of the present experiments was to determine whether serotonin 1A ( 5 HT1A ) and serotonin 1B ( 5 HT1B ) binding sites , recently characterized in the spinal cord of the rat , mediate differential effects of 5 HT on spinal nociceptive processing . ^^^ Several days after spinal transection at T 10 , rats were injected intraperitoneally at 20 min intervals , with increasing doses ( 0 , 0 . 1 , 0 . 4 , 2 . 0 , 9 . 0 mg / kg ) of either a 5 HT1A selective agonist ( 8 OH DPAT , buspirone ) or a 5 HT1B agonist ( mCPP , TFMPP ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Eltoprazine , a mixed 5 HT1A / B agonist , and meta trifluoro methylphenyl piperazine HCl ( TFMPP ) , a more selective 5 HT1B agonist , specifically decrease aggressive behavior in several animal species and situations in both sexes without detriment to other social , exploratory , or motoric activities . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
It is concluded that 8 OH DPAT induced increase in serum corticosterone concentration results from its action at a site different than the adrenal cortex and is mediated by postsynaptic 5 HT1A receptors , whereas other subtypes ( 5 HT1B , 5 HT 2 , 5 HT 3 ) of 5 HT receptors do not participate in this response . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Three 5 HT receptor subtypes are reported to modulate the ASR in adult rats : 5 HT1A and 5 HT 2 receptor agonists facilitate the ASR , whereas 5 HT1B agonists decrease the response . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Physiological effects of selective 5 HT1a and 5 HT1b ligands in rat hippocampus : comparison to 5 HT . ^^^ The responses of CA 1 neurons to topical application of serotonin ( 5 HT ) and selective 5 HT1a and 5 HT1b agonists were examined with intracellular recording in the hippocampal slice . 5 HT produced a uniform hyperpolarizing response associated with an increase in K conductance as previously reported . ^^^ Topical application of the 5 HT1b ligand TFMPP on the slice did not produce the direct or antagonistic action seen with the 5 HT1a ligands . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The presence of subtypes of 5 HT 1 binding sites was investigated by selective displacements with 8 OH DPAT , mesulergine and ( + / ) SDZ 21 009 at appropriate concentrations to block 5 HT1A , 5 HT1C and 5 HT1B sites respectively . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Stimulation of 5 HT1A receptors with 8 hydroxy di N , N propylaminotetralin ( 8 OH DPAT ) and blockade of 5 HT1B receptors with cyanopindolol resulted in seizure protection . ^^^ In conclusion , the present study suggests that the inhibition of pilocarpine induced seizures may be mediated by stimulation of 5 HT1A and by blockade of 5 HT1B receptors , located probably on the cholinergic terminals . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Interactions with functional 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D receptors . ^^^ The effects of the compound were investigated in radioligand binding studies and in functional models for 5 HT1A , 5 HT1B , and 5 HT1D receptors ( inhibition of forskolin stimulated adenylate cyclase activity in calf hippocampus , rat and calf substantia nigra , respectively ) and 5 HT1C receptors ( stimulation of inositol phosphate production in pig choroid plexus ) . ^^^ GR 43175 displayed the following order of affinity for 5 HT recognition sites ( pKD values , log mol / l , in parentheses ) : 5 HT1D ( 7 . 54 ) greater than 5 HT1B ( 6 . 35 ) greater than 5 HT1A ( 6 . 13 ) much greater than 5 HT1C ( 4 . 13 ) greater than 5 HT 2 ( 3 . 67 ) . ^^^ The same order of potency was observed at functional 5 HT 1 receptors , at which GR 43175 acted as a full agonist , with the exception of the 5 HT1C receptor , where the compound was a weak antagonist ( pEC 50 or pKB values , log mol / l , in parentheses ) : 5 HT1D ( 6 . 28 ) greater than 5 HT1B ( 6 . 03 ) greater than 5 HT1A ( 5 . 57 ) much greater than 5 HT1C ( 4 . 25 ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In the drug challenge studies , we used two 5 HT 1 agonists , the 5 HT1B and 5 HT1C agonist , m chlorophenylpiperazine ( m CPP ) , and the 5 HT1A agonist , 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OHDPAT ) , to examine the effect of cortisol on their behavioral and neuroendocrine effects . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Moreover , 5 HT 1 is heterogenous and can be divided into 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D subtypes . 5 HT1B is probably related to the 5 HT autoreceptor controlling 5 HT release . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
RU 24969 , a 5 HT agonist with highest affinity at 5 HT1A and 5 HT1B receptors , increased plasma renin activity ( PRA ) and plasma renin concentration ( PRC ) as well as plasma corticosterone and prolactin concentrations in a dose dependent manner . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Central and peripheral 5 HT receptors can be divided into three receptor subtypes : 5 HT 1 ( 5 HT1A , 5 HT1B , 5 HT1C ) , 5 HT 2 and 5 HT 3 receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These antagonists covered the whole range of currently defined serotonin receptor types and subtypes : 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , 5 HT 2 , and 5 HT 3 . 6 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Carteolol and l propranolol , which are suggested to have anti migraine activity in man , were found to be active inhibitors of the binding of [ 125I ] ICYP to 5 HT1B recognition sites and of [ 3H ] 8 OH DPAT to 5 HT1A recognition sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Human 5 HT1A sites can be distinguished from human 5 HT1B , 5 HT 2 , and 5 HT 3 sites and from equivalent sites in rat and bovine cortex . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Radioligand binding techniques have demonstrated the existence of 5 hydroxytryptamine ( 5 HT ) binding subtypes : 5 HT 2 , 5 HT1A and 5 HT1B . ^^^ These techniques have also indicated that certain drugs appear to show sub type specificity : 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) , a 5 HT1A agonist ; 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydropyridin 4 yl ) 1 H indole ( RU 24969 ) , a 5 HT1B agonist ; and ritanserin , a 5 HT 2 antagonist . ( ) Propranolol is a 5 HT 1 antagonist of uncertain sub type specificity . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Neither the 5 HT1A agonist , 8 OH DPAT , nor mianserin , a 5 HT 2 and 5 HT1C antagonist , altered the induced RL receptor population , whereas the selective 5 HT1B agonist CGS 12066B reduced the increase in the RL receptor population with a potency equal to that of 5 HT . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT 1 like receptor mediating reduction of porcine carotid arteriovenous shunting by RU 24969 is not related to either the 5 HT1A or the 5 HT1B subtype . ^^^ Using the radioactive microsphere technique in anaesthetized pigs , we studied the systemic and carotid haemodynamic effects of intracarotid infusions ( 0 . 3 , 1 , 3 and 10 micrograms / kg . min ) of 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridinyl ) 1H indole succinate ( RU 24969 ) , a drug with high affinity for 5 HT1A and 5 HT1B recognition sites . ^^^ However , these responses were not modified after pretreatment with the putative 5 HT1A and 5 HT1B receptor antagonist , ( + / ) pindolol ( 4 . 0 mg / kg i . v . ) . ^^^ It is concluded that the RU 24969 induced reduction in common carotid and arteriovenous anastomotic blood flow is mediated mainly by 5 HT 1 like receptors , which do not seem to correspond to either the 5 HT1A or 5 HT1B receptor subtypes . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The results suggest that 5 HT innervations in the VTA may have an excitatory action possibly via 5 HT1B rather than 5 HT1A receptors on the mesolimbic DA system projecting to the ACC and that this DA system may also be regulated by glutamatergic and GABAergic ( via GABAA receptors ) inputs . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Present data show a differential action of 5 HT1A and 5 HT1B receptor subtypes in the control of rat masculine sexual behaviour . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Identification of 5 HT receptor subtypes 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , 5 HT 2 ( possibly A and B ) , 5 HT 3 subtypes , and possibly 5 HT 4 has encouraged the manufacture of 5 HT receptor inhibitors with greater subtype specificity . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
At 3 , 7 and 14 days post 5 , 7 DHT , competitive radioligand binding assays were performed using 2 nM [ 3H ] 5 HT and varying concentrations of trifluoromethylphenylpiperazine ( TFMPP ) , a drug which interacts with 5 HT1B and 5 HT1A binding sites ( affinity of 5 HT1B site greater than 5 HT1A site for TFMPP ) . ^^^ However , the binding capacity of the 5 HT1B site , as well as the 5 HT1A site , increased significantly by 7 and 14 days postlesion , respectively . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Primary cultures of astroglial cells were exposed to serotonin ( 5 HT ) or the selective receptor agonists 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH D PAT , for 5 HT1a receptors ) or trifluoro methyl phenyl piperazine ( TFMPP ) and m chlorophenylpiperazine ( mCPP ) ( for 5 HT1b receptors ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
No significant correlations were found between drug affinities for 125I R ( ) DOI labeled sites in rat cortex and 5 HT1A , 5 HT1B , 5 HT1D , or 5 HT 3 sites , as determined by previous investigators . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The potencies of the serotonin receptor agonists and antagonists were compared with their affinities for 5 HT1A , 5 HT1B , 5 HT1C , and 5 HT1D binding sites in pig or rat tissue membranes ; in addition , the potencies of the agonists were compared to their potencies in inhibiting adenylate cyclase activity in membranes of calf substantia nigra . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Characterization of a [ 3H ] 5 hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D subtypes . [ 3H ] 5 HT binding sites were analyzed in membranes prepared from the rabbit caudate nucleus ( CN ) . [ 3H ] 5 HT labeled both 5 HT1A and 5 HT1C recognition sites , defined by nanomolar affinity for 8 OH DPAT and mesulergine respectively ; however , these represented only a fraction of total specific [ 3H ] 5 HT binding . ^^^ The pharmacological profile of the non 5 HT1A / non 5 HT1C sites ( designated 5 HT1R ) also differed from that of 5 HT1B and 5 HT 2 sites , but was similar to that of the 5 HT1D site . ^^^ The present findings demonstrate the presence of a high affinity [ 3H ] 5 HT binding site in rabbit CN , designated 5 HT1R , that is different from previously defined 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , and 5 HT 2 sites . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Competition studies with selective drugs reveal alpha adrenergic , 5 HT1A and 5 HT1B components of [ 3H ] DE specific binding . ^^^ When phentolamine ( 500 nM ) is included to block alpha receptors and DPAT ( 100 nM ) or spiroxatrine ( 500 nM ) is included to block 5 HT1A receptors , specific binding is exclusively to sites with drug affinities characteristic of 5 HT1B receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These data indicate that [ 3H ] WB 4101 selectively labels the 5 HT1A serotonin receptor , whereas [ 3H ] LSD appears to label both the 5 HT1A and the 5 HT1B serotonin receptor subtypes . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In view of the fact that 8 OH DPAT has negligible affinity for the 5 HT1B site , the above results are consistent with its discriminative stimulus properties being mediated by the putative 5 HT1A receptor . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Evidence suggests that the above action of 8 OH DPAT is mediated by 5 HT1A receptors since it was antagonised by the 5 HT1A antagonist spiperone but not by the 5 HT 2 antagonist ketanserin and was not mimicked by the 5 HT1B agonist RU 24969 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Stereoselective blockade of central [ 3H ] 5 hydroxytryptamine binding to multiple sites ( 5 HT1A , 5 HT1B and 5 HT1C ) by mianserin and propranolol . ^^^ The interaction of the enantiomers of mianserin and propranolol with the binding of [ 3H ] 5 hydroxytryptamine ( [ 3H ] 5 HT ) to the 5 HT1A , 5 HT1B and 5 HT1C sites , and with the binding of [ 3H ] ketanserin to the 5 HT 2 site , has been evaluated in rat brain membranes . ^^^ A stereoselective interaction at the 5 HT1A , 5 HT1B and 5 HT1C sites was demonstrated for both compounds , with ( + ) mianserin being a more potent displacer than ( ) mianserin and ( ) propranolol being more potent than ( + ) propranolol . ^^^ The stereoselective association of mianserin and propranolol with the 5 HT1A , 5 HT1B and 5 HT1C sites may prove useful in the characterization of these sites . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Propranolol impaired neither the hypothermia induced by an agonist at the 5 HT 1A receptors : 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) nor the increase in spontaneous motor activity induced by an agonist at the 5 HT 1B receptors : 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydropyridin 4 yl ) 1 H indole ( Ru 24 , 969 ) . ^^^ It is concluded that the effect of propranolol is not the result of a blockade of 5 HT 1A , 5 HT 1B or 5 HT 2 , but is in part due to blockade of beta 1 adrenoceptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
A 5 HT1A agonist ( 8 OH DPAT ) blocked WDS , but like putative 5 HT1B ( RU 24969 ) and 5 HT 2 ( DOI ) agonists and the 5 HT antagonists methysergide ( non selective ) , ritanserin ( 5 HT 2 selective ) , and l propranolol ( 5 HT 1 selective ) , it did not block other antagonists behavioural effects of MK 771 . 6 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In the present study , the affinities of these urapidil derivatives ( 5 acetyl , 5 formyl and 5 methyl urapidil ) for 5 HT receptors were investigated using 3H 8 hydroxy 2 ( di n propyl amino ) tetralin ( 3H 8 OH DPAT ) , 125I iodocyanopindolol ( 125I ICYP ) and 3H ketanserin for labelling 5 HT1A , 5 HT1B and 5 HT 2 binding sites , respectively . 3H Prazosin and 3H clonidine were used as selective alpha 1 and alpha 2 adrenoceptor radioligands , respectively . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The selective 5 HT1A agonists , 8 hydroxy 2 ( di n dipropylamino ) tetralin ( 8 OH DPAT ) and ipsapirone , and the 5 HT1A / 5 HT1B agonist , 1 ( m trifluoromethylphenyl ) piperazine , partially inhibited the carbachol stimulated [ 3H ] inositol phosphate formation in rat hippocampal slices . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
SM 3997 possessed a high affinity towards 5 HT1A receptors , low affinity towards dopamine ( D 2 ) and 5 HT 2 receptors , and no affinity towards benzodiazepine ( BZ ) , GABA , 5 HT1B and adrenergic receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Responses of hippocampal pyramidal cells to putative serotonin 5 HT1A and 5 HT1B agonists : a comparative study with dorsal raphe neurons . ^^^ In low cerveau isol transected rats , the effects of microiontophoretic application of putative serotonin 5 HT1A and 5 HT1B agonists on the spontaneous firing rate of CA 1 pyramidal cells were compared to those of 5 HT . ^^^ In contrast to the large current dependent suppression of unit activity observed with 5 HT , the 5 HT1A compounds , ipsapirone , 8 OH DPAT ( 8 hydroxy 2 ( di n propylamino ) tetralin ) and LY 165163 ( p aminophenylethyl m trifluoromethylphenylpiperazine ) and the 5 HT1B compounds , mCPP ( m chlorophenylpiperazine ) and TFMPP ( trifluoromethylphenylpiperazine ) , produced only weak inhibition of spontaneous firing . ^^^ In summary , the inability of CA 1 pyramidal cells to distinguish the actions of 5 HT1A and 5 HT1B ligands is in sharp contrast to the striking differences observed for these compounds with dorsal raphe neurons . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Thus , 5 HT 1 receptors have been divided into subtypes based on their affinities for 1 : 5 HT1A sites have high affinity , while 5 HT1B sites have low affinity . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
H ] 1 [ 2 ( 4 aminophenyl ) ethyl ] 4 ( 3 trifluoromethylphenyl ) piperazine : a selective radioligand for 5 HT1A receptors in rat brain . 1 [ 2 ( 4 Aminophenyl ) ethyl ] 4 ( 3 trifluoromethylphenyl ) piperazine ( PAPP ) inhibits [ 3H ] 5 hydroxytryptamine ( 5 HT , serotonin ) binding to 5 HT1A and 5 HT1B sites in rat brain with apparent equilibrium dissociation constants ( KD ) of 2 . 9 and 328 nM , respectively . [ 3H ] PAPP was synthesized , its binding to central serotonin receptors was examined , and its potential usefulness as a 5 HT1A receptor radioligand was evaluated . ^^^ Spiperone and 8 hydroxy 2 ( di n propylamino ) tetralin , two compounds that discriminate [ 3H ] 5 HT binding to 5 HT1A and 5 HT1B sites , inhibited [ 3H ] PAPP binding in accordance with their much higher affinities for the 5 HT1A receptor subtype . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Logs of these KA values did not correlate with log Ki values for the inhibition of binding of the 5 HT 2 ligand [ 3H ] ketanserin ( r = 0 . 2253 , P greater than . 05 ) or log IC 50 values for inhibition of [ 3H ] 5 HT binding ( r = 0 . 5732 , P greater than 0 . 05 ) , which labels both 5 HT1A and 5 HT1B sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Finally , the beta adrenoceptor antagonist ( ) 21 009 which has different affinities for 5 HT1A , 5 HT1B and 5 HT1C recognition sites , yielded triphasic competition curves for [ 3H ] 5 HT binding in rat cortex membranes providing evidence that [ 3H ] 5 HT labels three distinct 5 HT 1 sites in these membranes . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These data demonstrate that centrally administered RDS 127 mimics the previously reported alterations in sexual behavior after systemic treatment and that RDS 127 is a high affinity 5 HT1A agent with low affinity at the 5 HT1B binding site . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Furthermore , it is proposed that 5 HT1A receptors mediate inhibitory effects , whereas 5 HT1B receptors mediate presynaptic , facilitatory effects of serotonin . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effect of a beta adrenergic agonist on behaviors mediated by 5 HT1A and 5 HT1B receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
DOI stimulus generalization occurred with the putative 5 HT 2 agonist DOM ( ED 50 = 0 . 49 mg / kg ) , but not with the 5 HT1A agonist 8 OH DPAT , or the 5 HT1B agonist TFMPP . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These compounds where also tested in radioligand binding studies using selective ligands for the various subtypes of 5 HT 1 and 5 HT 2 receptors . 5 HT1A , 5 HT1B and 5 HT1C recognition sites were labelled with [ 3H ] 8 OH DPAT ( [ 3H ] 8 hydroxy 2 ( di n propylamino ) tetralin ) in pig cortex membranes , [ 125I ] CYP ( [ 125I ] iodocyanopindolol ) in rat cortex and [ 3H ] mesulergine in pig choroid plexus membranes , respectively . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The `` non 5 HT1A ' ' sites labeled by 3H 5 HT in the presence of 0 . 1 microM 8 OH DPAT corresponded mainly to 5 HT1B sites . 5 HT1A binding was notably high in limbic regions ( dentate gyrus , CA 1 and CA 3 hippocampal regions , lateral septum , frontal cortex ) , whereas 5 HT1B binding was particularly concentrated in extrapyramidal areas ( caudate nucleus , globus pallidus , substantia nigra ) . ^^^ Except in the latter regions , where only one class of 5 HT 1 sites was found , both 5 HT1A and 5 HT1B sites existed in all areas examined . ^^^ The selective degeneration of serotoninergic neurons produced by an intracerebral injection of 5 , 7 dihydroxytryptamine was associated only with a significant loss of 5 HT1A binding to the dorsal raphe nucleus ( 60 % ) and of 5 HT1B binding to the substantia nigra ( 37 % ) . ^^^ These results are discussed in relation to the possible identity of 5 HT1A and / or 5 HT1B sites with the presynaptic 5 HT autoreceptors controlling nerve impulse flow and neurotransmitter release in serotoninergic neurons . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The affinities of the compounds for 5 HT1B and 5 HT 2 binding sites in rat brain cortex membranes ( labelled by [ 125I ] cyanopindolol = [ 125I ] CYP in the presence of 30 mumol / l isoprenaline and [ 3H ] ketanserin , respectively ) , for 5 HT1A binding sites in pig and rat brain cortex membranes ( labelled by [ 3H ] 8 hydroxy 2 ( di n propylamino ) tetralin = [ 3H ] 8 OH DPAT ) and for 5 HT1C binding sites in pig choroid plexus membranes ( labelled by [ 3H ] mesulergine ) were also determined . ^^^ In contrast , significant correlations were found between the potencies or affinities of the drugs for the autoreceptors and their affinities at 5 HT1A or 5 HT1B binding sites ; the best correlations were obtained with the 5 HT1B binding site . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
It did not antagonise 5 HT1B mediated behaviour in mice or rats and appeared to have an antagonist action at pre but not post synaptic 5 HT1A receptors in rats . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Pharmacological differentiation and characterization of 5 HT1A , 5 HT1B , and 5 HT1C binding sites in rat frontal cortex . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The role of putative 5 HT1A and 5 HT1B receptors in the control of feeding in rats . 8 hydroxy 2 ( di n propylamino ) tetraline ( 8 OH DPAT ) and 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridinyl ) 1H indole succinate ( RU 24969 ) , two agonists on the putative serotonin 1A and serotonin 1B receptors , were used for exploring the role of these sites in the inhibitory effect of serotonin ( 5 HT ) on feeding . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
This blockade was specific of 5 HT1A sites since the other serotoninergic sites , 5 HT1B , 5 HT 2 and also the presynaptic 5 HT 3 sites were not affected by the treatment . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Drug competition studies were performed using 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) to compete selectively for 5 HT1A sites , RU 24969 to compete for 5 HT1B sites and mesulergine to compete for 5 HT1C sites . ^^^ The results demonstrate that 5 HT1A , 5 HT1B and 5 HT1C binding sites are present in rat spinal cord . ^^^ In addition , approximately 33 % of total 5 HT 1 sites do not appear to represent either 5 HT1A , 5 HT1B or 5 HT1C binding sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT receptor agonists serotonin ( 1 100 nM ) , lysergic acid diethylamide ( 10 nM 1 microM ) and the 5 HT1B receptor agonists 1 ( m trifluoromethylphenyl ) piperazine ( 100 nM 1 microM ) and 1 ( m chlorophenyl ) piperazine ( 100 nM 3 microM ) concentration dependently decreased [ 3H ] 5 HT release , while 8 hydroxy 2 ( di n propylamino ) tetralin , a selective 5 HT1A receptor agonist , was inactive . ^^^ The actions of the effective agonists were reversed by quipazine , an antagonist with high affinity for 5 HT1B binding sites , but not by spiperone , a 5 HT1A receptor antagonist . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The density of [ 3H ] DPAT binding sites relative to the [ 3H ] 5 HT sites in the solubilized cortical membranes ( 35 % ) corresponds well with the proportion of 5 HT1a sites in the crude membranes determined by spiperone displacement ( 33 % ) , suggesting that both the 5 HT1a and 5 HT1b binding sites have been cosolubilized . [ 3H ] 5 HT binding in the soluble preparations was inhibited by GTP , suggesting that a receptor complex may have been solubilized . [ 3H ] Spiperone specific binding was not detectable in this preparation , suggesting that 5 HT 2 sites were not cosolubilized . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These data therefore demonstrate the presence of a homogeneous class of 5 HT 1 binding sites in bovine caudate that is pharmacologically distinct from previously defined 5 HT1A , 5 HT1B , 5 HT1C , 5 HT 2 , and 5 HT 3 receptor subtypes . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Sprague Dawley rat pups at 3 4 days prenatally were tested in both the absence and presence of milk following administration of various doses of either the 5 HT1A agonist 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OHDPAT ) , the 5 HT1B agonist 1 ( 3 chlorophenyl ) piperazine ( mCPP ) , or the 5 HT 2 agonist 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane ( DOI ) . ^^^ Thus it appears that 5 HT1A , 5 HT1B and 5 HT 2 receptor subtypes are present in the neonate and elicit differential behavioral responses upon stimulation with selective agonists . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT1A agonist , 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) at a dose of 1 mg / kg s . c . increased food intake in free feeding rats . 8 OH DPAT induced feeding was blocked by metergoline which has comparable affinity for 5 HT1A , 5 HT1B , 5 HT1C and 5 HT 2 receptors . ^^^ Blockade of the hyperphagia by spiperone suggests mediation by 5 HT1A rather than 5 HT1B receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Our conclusion is that , in addition to the 5 HT1A receptor , the 5 HT1B receptor is also negatively coupled to adenylate cyclase . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The low affinity of 5 HT1B recognition sites for some 5 HT1A , 5 HT1C and 5 HT 2 selective compounds ( e . g . 8 OH DPAT , mesulergine , ketanserin ) suggests that 5 HT1B recognition sites are pharmacologically different from 5 HT1A , 5 HT1C and 5 HT 2 recognition sites . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Identification of a 5 HT 1 recognition site in human brain membranes different from 5 HT1A , 5 HT1B and 5 HT1C sites . ^^^ In human caudate and cortex membranes , [ 3H ] serotonin ( [ 3H ] 5 HT ) labels 5 HT1A and 5 HT1C recognition sites which show nanomolar affinity for 8 OH DPAT ( 8 hydroxy 2 ( di n propylamino ) tetralin ) and mesulergine respectively , whereas no 5 HT1B binding could be identified . ^^^ However , the majority of the sites labelled by [ 3H ] 5 HT ( greater than or equal to 60 % in cortex , 90 % in caudate ) are different from 5 HT1A , 5 HT1B and 5 HT1C sites . ^^^ In contrast , these sites showed low affinity for drugs with high affinity and / or selectivity for 5 HT1A ( 8 OH DPAT , buspirone ) , 5 HT1B ( 21 009 , RU 24969 ) , 5 HT1C ( mesulergine , mianserin ) and 5 HT 2 sites ( ketanserin , cinanserin ) . ^^^ The pharmacological profile of these sites is different from that of 5 HT1A , 5 HT1B , 5 HT1C , 5 HT 2 and 5 HT 3 sites but is consistent with the pharmacology of a 5 HT 1 like receptor . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The food intake suppressant effects of three serotonin agonists , m CPP ( a selective 5 HT1B agonist ) , 8 OHDPAT ( a selective 5 HT1A agonist ) and fenfluramine ( a 5 HT releasing agent ) were compared in three different rat strains : Wistar , Sprague Dawley ( SD ) and Fawn Hooded ( FH ) rats . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The use of agonists , shown to discriminate between subtypes of 5 HT 1 receptor revealed that a 5 HT1A receptor agonist mimicked the non selective effects of 5 HT , whereas a 5 HT1B receptor agonist mimicked the selective antinociceptive effects of 5 HT . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The drug RU 24969 was found to have high affinity for 5 HT1A and 5 HT1B recognition sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In order to test the hypothesis that the mechanism of action of LSD and phenylisopropylamine hallucinogens is through stimulation of a specific brain serotonin receptor sub type , the affinities of these compounds for radiolabelled 5 HT 2 , 5 HT1A , 5 HT1B , and 5 HT1C receptors have been determined using recently developed in vitro radioligand binding methodologies . ^^^ The 5 HT1A , 5 HT1B , and 5 HT1C receptors were labelled with 3H OH DPAT , 3H 5 HT , and 3H mesulergine , respectively . ^^^ In general , the phenylisopropylamines displayed 10 100 fold higher affinities for the 5 HT 2 receptor than for the 5 HT1C receptor and 100 1000 fold higher affinities for the 5 HT 2 receptor than for the 5 HT1A or 5 HT1B receptor . ^^^ There was a strong correlation between hallucinogenic potencies and 5 HT 2 receptor affinities of the phenylisopropylamines ( r = 0 . 90 ) ; the correlation coefficients for the 5 HT1A , 5 HT1B , and 5 HT1C were 0 . 73 , 0 . 85 , and 0 . 78 , respectively . ^^^ Because there is no evidence that 5 HT1A selective or 5 HT1B selective agonists are hallucinogenic and because the phenylisopropylamines are potent hallucinogens , a 5 HT 2 receptor interaction is implicated and supports our previous suggestions to this effect . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Agonist binding to 5 HT1A , 5 HT1B , and 5 HT1D sites in rat brain and to 5 HT1A and 5 HT1D sites in bovine brain is sensitive to NEM . ^^^ These findings suggest that agonist binding to 5 HT1A , 5 HT1B , and 5 HT1D sites is sensitive to NEM alkylation . ^^^ These data suggest that NEM exerts its effects on 5 HT1A , 5 HT1B , and 5 HT1D binding sites by inactivating the G protein ( s ) associated with the 5 HT receptor subtypes . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Radioligand binding studies were performed to characterize serotonin 5 HT1D receptors in postmortem human prefrontal cortex and caudate homogenates . [ 3H ] 5 HT binding , in the presence of pindolol ( to block 5 HT1A and 5 HT1B receptors ) and mesulergine ( to block 5 HT1C receptors ) , was specific , saturable , reversible , and of high affinity . ^^^ In competition experiments , 8 hydroxydipropylaminotetralin , trifluoromethylphenylpiperazine , mesulergine , 4 bromo 2 , 5 dimethoxyphenylisopropylamine , and ICS 205 930 had low affinity for [ 3H ] 5 HT labeled 5 HT1D sites , indicating that the pharmacology of the 5 HT1D site is distinct from that of previously identified 5 HT1A , 5 HT1B , 5 HT1C , 5 HT 2 , and 5 HT 3 sites . 5 HT1D sites in human brain have a similar pharmacology to the 5 HT1D sites previously identified in rat , porcine and bovine brains . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
By contrast with this reduction of 5 hydroxytryptamine ( 5 HT ) function mediated by the 5 HT1A and 5 HT 2 receptor sub types , repeated lithium administration had no effect on the motor response to a putative 5 HT1B receptor agonist 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydropyridin 4 yl ) 1H indole ( RU 24969 , 3 mg / kg IP ) . alpha 2 adrenoceptor function , assessed by the sedation response to clonidine ( 0 . 25 mg / kg , IP ) , was also attenuated by repeated lithium administration . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
As 5 HT 1 receptors were first described using radioligand binding studies , a brief description of 5 HT1A , 5 HT1B , 5 HT1C and 5 HT1D receptor binding is given . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Stimulus generalization occurs among these agents regardless of which is used as the training drug , although stimulus generalization does not occur with 5 HT1A selective agonists [ e . g . , 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) ] or with 5 HT1B selective agonists [ e . g . , 1 ( 3 trifluoromethylphenyl ) piperazine ( TFMPP ) ] . 8 OH DPAT and TFMPP also serve as training drugs ; the 8 OH DPAT stimulus generalizes to other 5 HT1A agonists , but not to 5 HT1B or 5 HT 2 agonists , whereas the TFMPP stimulus generalizes to other 5 HT1B agonists , but not to 5 HT1A or 5 HT 2 agonists . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effect of selective 5 HT1A and 5 HT1B agonists on K+ evoked release of [ 3H ] 5 HT and the binding of [ 3H ] 5 HT were examined . ^^^ Further testing of the present results requires the development of new 5 HT 1 agonists which are selective ( 1000 fold difference ) for the 5 HT1A and 5 HT1B subsites . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Although 8 methoxy 2 ' chloro PAT bound irreversibly to different classes of 5 HT binding sites ( 5 HT1A , 5 HT1B , presynaptic sites ) , it can be considered a selective alkylating agent , since it exerted no action on 3H spiperone binding to 5 HT 2 sites , 3H muscimol binding to GABA sites , or 3H flunitrazepam binding to benzodiazepine sites . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Differential selectivities of RU 24969 and 8 OH DPAT for the purported 5 HT1A and 5 HT1B binding sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Although simple arylpiperazines are commonly considered to be moderately selective for 5 HT1B serotonin binding sites , N 4 substitution of such compounds can enhance their affinity for 5 HT1A sites and / or decrease their affinity for 5 HT1B sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
SCH 23390 had weak affinity for 5 HT1B ( IC 50 = 0 . 5 microM ) , 5 HT1A ( IC 50 = 2 . 6 microM ) and alpha 1 adrenergic receptors ( IC 50 = 4 . 4 microM ) . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In the presence of 1 microM ( + / ) pindolol [ to block 5 hydroxytryptamine ( 5 HT , serotonin ) 5 HT 1A and 5 HT 1B receptors ] and 100 nM mesulergine ( to block 5 HT 1C receptors ) , 2 . 0 nM [ 3H ] 5 HT binding to rat cortical homogenates is specific , saturable , and reversible . ^^^ Compounds with high affinity for 5 HT 1A ( 8 hydroxydipropylaminotetralin ) , 5 HT 1B ( trifluoromethylphenylpiperazine ) , 5 HT 1C ( mesulergine ) , 5 HT 2 ( 4 bromo 2 , 5 dimethoxyphenylisopropylamine ) , and 5 HT 3 ( ICS 205 930 ) receptors have low affinity for this site . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The different subpopulations of 5 HT 1 sites were investigated by the use of unlabeled selective compounds . 8 OH DPAT ( 8 hydroxy 2 [ N , N di n propyl amino ] tetralin ) was used to block [ 3H ] 5 HT binding to 5 HT1A , the beta blocker ( ) 21 009 ( 4 [ 3 ter butyl amino 2 hydroxy propoxy ] indol 2 carbonic acid isopropyl ester ) to 5 HT1B and the ergoline mesulergine to 5 HT1C recognition sites . 5 HT1D sites were defined as the binding sites remaining when both 8 OH DPAT and mesulergine were added to the incubation medium . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain : high affinity activation is related to a 5 HT 1 subtype different from 5 HT1A , 5 HT1B , and 5 HT1C . 5 HT binding sites of the 5 HT 1 type are heterogeneous and appear to comprise several subtypes ( 5 HT1A , 5 HT1B and 5 HT1C ) ; their physiological role is as yet unclear . ^^^ On the other hand , the high affinity activation of the enzyme induced by 5 HT , 5 methoxytryptamine , bufotenin , LSD , and the activation induced by TFMPP were not inhibited by spiperone ( 1 microM ) , by propranolol ( 3 microM ) , or by mesulergine ( 0 . 1 microM ) , which selectively block 5 HT1A , 5 HT1B , and 5 HT1C sites . ^^^ Therefore , these activations seem related to 5 HT 1 receptors but not to 5 HT1A , 5 HT1B , or 5 HT1C sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The attenuating effect of 5 HT was not mimicked by the 5 HT1A receptor agonist 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) and was not prevented by a 5 HT1A and 5 HT1B mixed receptor antagonist , propranolol , or by the 5 HT 3 receptor antagonists , cocaine and metoclopramide . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Electrophysiological responses of serotoninergic dorsal raphe neurons to 5 HT1A and 5 HT1B agonists . ^^^ A direct comparison was made of the effects of serotonin 5 HT1A and 5 HT1B selective compounds on the spontaneous firing rate of dorsal raphe serotoninergic neurons in chloral hydrate anesthetized rats . ^^^ Following intravenous administration , the 5 HT1A selective compounds ipsapirone ( TVX Q 7821 ) and LY 165163 potently inhibited single unit activity in a dose dependent manner whereas the 5 HT1B selective compounds , m chlorophenylpiperazine ( mCPP ) and trifluoromethylphenylpiperazine ( TFMPP ) , displayed only weak or irregular actions . ^^^ In summary , dorsal raphe 5 HT neurons appear highly responsive to 5 HT1A , but not to 5 HT1B compounds ; these findings are discussed with regard to the 5 HT receptor subtypes as candidates for the somatodendritic autoreceptor of dorsal raphe neurons . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The correlation of the release inhibiting potencies of serotonin receptor agonists with their affinities for 5 HT1B binding sites ( Engel et al . , 1986 ) was slightly improved by inclusion of RU 24969 , whereas that with the affinities for 5 HT1A binding sites ( which was worse than the former correlation ) was not changed . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The affinities of putative serotonin receptor agonists and antagonists for 5 HT1A , 5 HT1B , 5 HT1C , and 5 HT 2 receptors were assayed using radioligand binding assays . ^^^ When [ 3H ] DOB was used as the 5 HT 2 radioligand , quipazine was determined to be 100 fold more potent at 5 HT 2 receptors than at 5 HT1A receptors . 1 ( 3 trifluoromethylphenyl ) piperazine ( TFMPP ) , a putative specific 5 HT1B receptor agonist was apparently 10 fold more potent at 5 HT1B receptors than at 5 HT 2 receptors when [ 3H ] ketanserin was used as the 5 HT 2 radioligand . ^^^ Using the 5 HT 2 antagonist radioligand [ 3H ] ketanserin , a similar pattern of underestimating 5 HT 2 receptor selectivity and / or overestimating 5 HT1A or 5 HT1B receptor selectivity was observed for a series of serotonin receptor agonists . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Using 3H 5 HT or 3H 8 OH DPAT as the ligand , the same molecular weight of 55 , 000 60 , 000 daltons was calculated for the postsynaptic 5 HT1A and 5 HT1B sites in the hippocampus and cerebral cortex . ^^^ The curvilinear pattern of the radiation induced inactivation of 5 HT1A and 5 HT1B binding sites suggested that both sites belong to complex polymeric structures . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Frontal cortices and hippocampi from human brains obtained at autopsy without evidence of neurological disease were used in this study . [ 3H ] 5 HT was used to label both 5 HT1A and 5 HT1B receptor subtypes . 5 HT1A receptors were selectively labeled by [ 3H ] 8 hydroxy 2 [ di N propylamino ] tetralin , while 5 HT1B receptors were labeled by ( ) [ 125I ] iodocyanopindolol ( [ 125I ] CYP ) in the presence of 30 microM isoprenaline . ^^^ In contrast to 5 HT1A receptors , it was not possible to identify 5 HT receptors having the pharmacological properties of 5 HT1B sites in the human brain , using either [ 3H ] 5 HT or [ 125I ] CYP as ligands . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Comparison of the activities of 12 serotonin receptor agonists revealed that only 4 of the investigated tryptamine derivatives acted as full agonists on both tissues . 5 Carboxamidotryptamine , a drug with selective affinity for both 5 HT1A and 5 HT1B binding sites , though the most potent agonist on veins , failed to produce platelet aggregation but acted as a weak antagonist of the 5 HT induced reversible aggregation . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Photoaffinity labeling of the 5 hydroxytryptamine 1A receptor in rat hippocampus . 1 [ 2 ( 4 Azidophenyl ) ethyl ] 4 ( 3 trifluoromethylphenyl ) piperazine ( p azido PAPP ) inhibits [ 3H ] 5 hydroxytryptamine [ ( 3H ] 5 HT ) binding to 5 HT1A and 5 HT1B sites in rat brain with equilibrium dissociation constants ( KD ) of 0 . 9 nM and 230 nM , respectively . [ 3H ] p Azido PAPP was synthesized and its reversible and irreversible binding properties to the hippocampal 5 HT1A site characterized . [ 3H ] p Azido PAPP labeled a single class of sites in rat hippocampal membranes with a KD of 1 nM and a maximal binding density of 370 fmol / mg protein . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The potencies of these agonists in inhibiting overflow were significantly correlated with their affinities for 5 HT1B binding sites , but not with their affinities for 5 HT1A , 5 HT1C or 5 HT 2 binding sites . 8 Hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) , a 5 HT1A receptor agonist , and ipsapirone , a partial agonist at these receptors , did not inhibit overflow . 2 . ^^^ The apparent pA 2 values of these antagonists tended to be correlated with their affinities for 5 HT1B ( but not 5 HT1A , 5 HT1C or 5 HT 2 ) binding sites . ^^^ Ketanserin , a 5 HT 2 receptor antagonist , and spiperone , which blocks 5 HT 2 and 5 HT1A but not 5 HT1B or 5 HT1C receptors , failed to antagonize the effect of 5 HT . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Similarity of the contractile effects of 5 HT in the rat stomach fundus and in the basilar artery coupled to the previous observations that receptors mediating 5 HT induced contractions in the fundus were not 5 HT 1 , 5 HT1A , 5 HT1B or 5 HT 2 led us to consider the possibility that 5 HT receptors in the canine basilar artery may resemble those in the rat stomach fundus . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Finally , ( ) propranolol , used as a non selective 5 HT1A / 5 HT1B receptor antagonist , shifted to the right ( pA 2 = 7 . 91 ) the concentration response curve of 5 HT whereas the 5 HT1C receptor antagonist mesulergine was ineffective . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Spiperone inhibition of [ 3H ] 5 HT binding in cortex was consistent with displacement from two sites with dissociation constants ( KD ) of 24 nM ( 5 HT 1A site ) and 19 microM ( 5 HT 1B site ) for spiperone . ^^^ In the presence of 1 microM spiperone , a concentration that saturates the 5 HT 1A sites while having a minimal effect on 5 HT 1B sites , BrAcTFMPP displaced [ 3H ] 5 HT from a single site with a KD for BrAcTFMPP of 145 nM . ^^^ Thus , BrAcTFMPP and spiperone discriminate the same two subpopulations of [ 3H ] 5 HT binding sites and BrAcTFMPP displays a high affinity and a selectivity for 5 HT 1A sites versus both 5 HT 1B and 5 HT 2 sites . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Apparent distinction from the 5 HT1A , 5 HT1B and 5 HT1C subtypes . ^^^ It is concluded that the receptor to 5 HT conforms to general criteria defining 5 HT 1 like receptors but at the present time the receptor site can not be fitted to the designated 5 HT1A , 5 HT1B or 5 HT1C subtypes . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These results suggest the presence of three binding sites for [ 3H ] 5 HT , one blocked by low concentrations of spiperone ( 5 HT1A ) , one blocked by low concentrations of mianserin ( 5 HT1C ) , and one blocked only by high concentrations of both mianserin and spiperone ( 5 HT1B ) . ^^^ The hippocampus was rich in 5 HT1A sites , whereas the striatum contained mainly 5 HT1B and 5 HT1C sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The results suggest that the 5 HT receptor mediating relaxation in the guinea pig ileum can be labelled with [ 125I ] LSD and that this receptor does not belong to the 5 HT 2 , 5 HT1A , 5 HT1B or 5 HT1C receptor subtypes . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
When used as a 5 HT1A / 5 HT1B antagonist , ( ) propranolol antagonized 5 HT whereas spiperone ( a 5 HT1A displacer ) did not . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The number of 5 HT 2 and 5 HT1A binding sites was decreased : the 5 HT1B binding sites remained unchanged . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
High affinity [ 3H ] serotonin ( 5 hydroxytryptamine , 5 HT ) binding sites from human frontal cortex can be divided into at least 3 pharmacological subtypes ( 5 HT1A , 5 HT1B and 5 HT 3 ) based on affinity for [ 3H ] serotonin and spiperone . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
TFMPP displays a Kd of 6 nM for approximately two thirds of the 5 HT 1b binding sites and a Kd of 273 nM for the remaining one third of the 5 HT 1b sites . p NH 2 PE TFMPP , on the other hand , discriminates the 5 HT 1 sites in a manner similar to spiperone , displaying a 110 fold selectivity for the 5 HT 1a sites . p NH 2 PE TFMPP displays a Kd of about 3 nM for the 5 HT 1a sites . p NH 2 PE TFMPP does not discriminate subtypes within the 5 HT 1b binding sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Selective labeling of 5 HT1A and 5 HT1B binding sites in bovine brain . ^^^ Drug interactions with serotonin ( 1A ) 5 HT1A and serotonin ( 1B ) ( 5 HT1B ) binding sites were analyzed in bovine brain membranes . 5 HT1A binding sites were directly labeled with [ 3H ] 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) in bovine hippocampal membranes . 5 HT1B binding sites were labeled by [ 3H ] 5 HT in bovine striatal membranes where less than 15 % of specific binding sites are sensitive to nanomolar concentrations of 8 OH DPAT . ^^^ Each of the 12 agents tested was more potent at the 5 HT1A than 5 HT1B binding site . 5 HT , bufotenine , N , N dimethyltryptamine ( DMT ) and quipazine were only slightly more potent at the 5 HT1A binding site . ^^^ These findings suggest that 5 HT1A , and 5 HT1B binding sites have distinct pharmacological profiles and can be directly labeled with appropriate [ 3H ] ligands in specific brain regions . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Competition experiments for 5 [ 3H ] HT binding by several serotonin 1 agonists led to the identification of brain areas enriched in each one of the three subtypes of 5 HT 1 recognition sites already described ( 5 HT1A , 5 HT1B , 5 HT1C ) . ^^^ From the areas strongly enriched in 5 HT 1 sites , dentate gyrus and septal nucleus contained 5 HT1A sites , while globus pallidus , dorsal subiculum , substantia nigra and olivary pretectal nucleus were enriched in 5 HT1B . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The choroid plexus site exhibits a novel pharmacology that does not match the properties of 5 hydroxytryptamine 1a ( 5 HT1a ) , 5 HT1b , or 5 HT 2 serotonergic sites . 125I LSD binding to the choroid plexus site is potently inhibited by mianserin , serotonin , and ( + ) LSD . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In vitro autoradiographic techniques combined with computer assisted microdensitometry were used to analyze the characteristics and distribution of multiple recognition sites for the neurotransmitters acetylcholine ( M 1 and M 2 ) and serotonin ( 5 HT1A and 5 HT1B ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Determination of selective and nonselective compounds for the 5 HT 1A and 5 HT 1B receptor subtypes in rat frontal cortex . ^^^ The subtype specificity of the selective compounds was determined using either spiperone , a selective 5 HT 1A compound , or 1 ( m trifluoromethylphenyl ) piperazine , a selective 5 HT 1B compound , to preferentially inhibit one of the receptors . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Ligands reported as selective for 5 HT1A , 5 HT1B or 5 HT 2 subtypes did not show high affinity for these binding sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
This action was blocked by 5 HT 3 and gamma aminobutyric acidA ( GABAA ) receptor antagonists but not by 5 HT 2 , 5 HT1A , 5 HT1B or 5 HT1S receptor antagonists . ^^^ The inhibition of biting behavior was antagonized by intrathecal co administration of 5 HT1B and GABAA receptor antagonists while 5 HT1A , 5 HT1S , 5 HT 2 and 5 HT 3 receptor antagonists had no effect . 5 MeO DMT enhanced scratching behavior was inhibited by all the antagonists used except ketanserin and bicuculline , suggesting the involvement of 5 HT1A , 5 HT1B , 5 HT1S , 5 HT 3 and GABAA receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The Bmax value of the high affinity site of the 5 HT 1A receptor increased and the Bmax value of 5 HT 2 receptor decreased with no change in the low affinity site of the 5 HT 1A receptor nor in the 5 HT 1B receptor . 4 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Effects of 5 HT1A receptor agonist and 5 HT1B receptor agonist on single and paired rats ' behavior ] . ^^^ In this study we evaluated the effects of the 5 HT1A receptor agonist ( 8 hydroxy 2 ( di n propylamino ) tetralin , 8 OH DPAT ) and 5 HT1B receptor agonist ( 1 ( 3 trifluoromethylphenyl ) piperazine , TFMPP ) on the single and paired rats ' movement distance in an open field . ^^^ These findings suggest that both 5 HT1A receptors and 5 HT1B receptors affect the rats ' movement distance . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Among the dozen of 5 HT receptors identified so far , four receptors ( namely the 5 HT1A , 5 HT1B , 5 HT2A , and 5 HT2C receptors ) and the 5 HT uptake system have been the focus of studies aimed at detecting corticosteroid modulatory effects . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Inhibition studies with [ 3H ] 5 HT plus 100 nM 8 OH DPAT ( which inhibits binding to 5 HT1A receptors only ) representing total binding , indicated that no further displacement occurred when ligands preferentially selective for 5 HT1B , 5 HT1D alpha , 1D beta , or 5 HT2C were tested . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The present study assessed compounds displaying affinity for 5 HT1A , 5 HT1B , 5 HT2A and 5 HT2C receptors for their ability to substitute for , enhance or antagonize the discriminative stimulus effects of cocaine ( 10 mg / kg ) in rats . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The results : ( 1 ) confirm that both an alpha 1 adrenoceptor antagonist ( prazosin ) and 5 HT1A autoreceptor stimulants ( BMY 7378 and 8 OH DPAT ) may reduce cerebral 5 HT release ; ( 2 ) support that the BMY 7378 induced decrease in 5 HT release results from 5 HT1A autoreceptor agonism , rather than alpha 1 adrenoceptor blockade ; and ( 3 ) argue against `` physiological ' ' antagonism ( i . e . via blockade of beta adrenoceptors , 5 HT1B receptors or some other mechanism ) as an explanation for the reversal by pindolol of 5 HT1A autoreceptor agonist induced suppression of 5 HT release . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT 1 subfamily of receptors contains subtypes 5 HT1A , 5 HT1B , 5 HT1D , 5 HT1E , and 5 HT1F ; activation of all of them results in the inhibition of adenylylcyclase . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effects of the relatively specific serotonergic agonists 8 OH DPAT ( 5 HT1A ) , TFMPP ( 5 HT1B ) , and DOB ( 5 HT 2 ) were studied on defensive aggressive behavior in rats using the water competition test , 8 OH DPAT ( up to 0 . 25 mg / kg ) and TFMPP ( up to 1 mg / kg ) were found to be ineffective , whereas DOB ( up to 0 . 4 mg / kg ) significantly reduced aggressive behavior in this test as well as in the offensive aggression test of the resident intruder model . ^^^ These results , combined with those from other studies , suggest that stimulation of 5 HT1A , 5 HT1B , and 5 HT 2 receptors reduces offensive aggression , whereas defensive aggression is only decreased by 5 HT 2 stimulation . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Evidence that 5 hydroxytryptamine release in rat dorsal raph nucleus is controlled by 5 HT1A , 5 HT1B and 5 HT1D autoreceptors . ^^^ These results suggest that 5 HT release in the rat DRN is under the control of 5 HT1A , 5 HT1B and 5 HT1D autoreceptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Mutual influences are seen particularly with 5 HT1A , 5 HT1C and 5 HT 2 , but not with 5 HT1B , 5 HT1D or 5 HT 3 receptor mediated effects . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Microinjection of the nonselective 5 HT receptor antagonist methiothepin or the 5 HT1A / 5 HT1B antagonist pindolol prevented any cardiovascular change by subsequent microinjection of 5 HT into the NTS . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Within these hydrophobic regions , this receptor was found to be 41 36 % identical to the following serotonin [ 5 hydroxytryptamine ( 5 HT ) ] receptors : 5 HT 2 > 5 HT1D > 5 HT1C > 5 HT1B > 5 HT1A > 5 HT1E . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The modulatory effect of spinal serotonin ( 5 HT ) 1 receptors on nociception was studied in mice . 8 Hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) and buspirone , putative 5 HT1A agonists , m trifluoromethylphenyl piperazine ( TFMPP ) and 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo ( 1 , 2 1a ) quinoxaline ( CGS 12066B ) , 5 HT1B agonists , and 5 carboxamidotryptamine ( 5 CT ) , a mixed 5 HT1A and 5HT1B agonist , were used . ^^^ Spiperone , propranolol and pindolol ( mixed 5 HT1A and 5 HT1B antagonists ) effectively reversed both the tail flick facilitation and the antagonistic effect on morphine sulfate induced antinociception produced by 8 OH DPAT and 5 CT . ^^^ These results confirm and extend other reports on the facilitory role of 5 HT1A receptor subtype on nociceptive responses and support the involvement of 5 HT1B receptor subtype in the antinociceptive action of serotonin . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Final compounds were evaluated for in vitro activity on dopamine D 1 and D 2 , serotonin 5 HT1A , 5 HT1B , 5 HT1C , and 5 HT 2 , alpha 1 adrenergic , and sigma receptors by radioreceptor binding assay . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Both serotonin ( 5 HT ) releasers and agonists at 5 HT1A , 5 HT1B , and 5 HT 2 receptors reduce PPI in the rat . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Neither was 5 MT inhibition of SRC affected by blocking 5 HT1A ( with propranolol and spiperone ) , 5 HT1B ( with propranolol ) , or 5 HT1C ( with ketanserin ) receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
This is indicated by ( a ) lower contents of DA and 5 HT ; ( b ) fewer 5 HT immunostained fibers ; ( c ) lower densities of 5 HT1B , 5 HT 2 and D 2 receptors ; and ( d ) higher densities of 5 HT1A receptors in the CNS of P rats compared to the alcohol nonpreferring NP line of rats . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Pretreatment with propranolol ( beta adrenoceptor antagonist that also has binding affinity for 5 HT1A , 5 HT1B and 5 HT2C sites ) , MDL 72222 or ondansetron ( 5 HT 3 antagonists ) did not attenuate DOI induced hyperthermia . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT 1 and 5 HT 2 receptor antagonist metergoline ( 1 . 0 and 2 . 0 mg / kg i . p . ) and the 5 HT1A and 5 HT1B receptor antagonist ( + / ) cyanopindolol ( 3 . 0 and 8 . 0 mg / kg s . c . ) significantly antagonized the effect of d fenfluramine . ^^^ The 5 HT2A and 5 HT2C receptor antagonist mesulergine ( 0 . 1 and 0 . 3 mg / kg s . c . ) and the 5 HT2A receptor antagonist ketanserin ( 2 . 5 and 5 . 0 mg / kg i . p . ) did not significantly modify the effect , nor did the 5 HT1A and 5 HT1B receptor antagonist ( ) propranolol ( 20 40 nmol ) , injected bilaterally into the paraventricular nucleus of the hypothalamus . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Chronic treatment with fluvoxamine by osmotic minipumps fails to induce persistent functional changes in central 5 HT1A and 5 HT1B receptors , as measured by in vivo microdialysis in dorsal hippocampus of conscious rats . ^^^ This study investigated the alterations of the 5 HT1A and 5 HT1B autoreceptor function following chronic treatment with fluvoxamine using osmotic minipumps . ^^^ The 5 HT1A and 5 HT1B autoreceptor function were studied using microdialysis in the dorsal hippocampus . ^^^ The effect of the 5 HT1A receptor agonist 8 OH DPAT ( 0 . 3 mg / kg , SC ) and the 5 HT1B receptor agonist RU 24969 ( 100 nM through the dialysis probe for 30 min ) on 5 HT release was compared with rats chronically treated with saline . 8 OH DPAT decreased 5 HT release to 55 % and 60 % of baseline , while RU 24969 decreased 5 HT release to 66 % and 70 % of baseline value in the saline and fluvoxamine group , respectively . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effects of intra collicular injections of 5 HT 1 drugs on distractibility were studied in hooded rats trained to run toward illuminated targets for a food reward in a 2 choice runway . 8 hydroxy 2 ( di n propylamino ) tetraline ( 8 OH DPAT ) , a 5 HT1A receptor agonist , RU 24969 , a mixed 5 HT1A and 5 HT1B agonist , serotonin O carboxymethylglycyltyrosinamide ( S CM GTNH 2 ) , a mixed 5 HT1B and 5 HT1D receptor agonist and saline ( control ) were alternately injected . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In vitro binding and quantitative autoradiographic studies showed that neither 5 HT1A , 5 HT1B , 5 HT2A , nor 5 HT 3 receptor binding sites in various brain areas were affected by these treatments . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
To gain further insight into the operation of 5 HT autoreceptor mediated feedback control of 5 HT biosynthesis in serotonergic nerve terminal areas , the effect of the 5 HT1B and the 5 HT1A receptor agonists , TFMPP and 8 OH DPAT , respectively , were investigated in the rat central nervous system ( CNS ) using in vivo and in vitro neurochemical approaches . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Serotonin ( 5 HT ) receptors have been classified into several categories , and they are termed as 5 HT 1 , 5 HT 2 , 5 HT 3 , 5 HT 4 , 5 HT 5 , 5 HT 6 and 5 HT 7 type receptors . 5 HT 1 receptors have been further subdivided into 5 HT1A , 5 HT1B , 5 HT1D , 5 HT1E and 5 HT1F . 5 HT 2 receptors have been divided into 5 HT2A , 5 HT2B and 5 HT2C receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Despite comparable control Bmax values for 5 HT1A ( 84 + / 2 fmol / mg of protein ) and 5 HT1B ( 94 + / 4 fmol / mg ) subtypes , marked differences were noted in their 1 ) receptor production rates ( r = 0 . 349 versus 0 . 235 fmol / mg of protein / hr ) , 2 ) receptor degradation rate constants ( k = 0 . 0056 versus 0 . 0033 hr 1 ) , and 3 ) half lives of receptor recovery ( 124 . 1 versus 212 . 5 hr ) . ^^^ These data indicate that 1 ) comparable receptor steady state Bmax values for 5 HT receptor subtypes may be due to markedly different receptor kinetic parameters ( r and k ) , 2 ) differences in r and k are greater between 5 HT receptor families ( i . e . , 5 HT 1 versus 5 HT 2 ) than among subtypes within a family ( i . e . , 5 HT1A versus 5 HT1B ) , and , 3 ) despite marked changes in 5 HT2A receptor density , the percentage of receptors in the agonist labeled , high affinity state is maintained . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
It has recently been shown that the increase in external carotid blood flow induced by 5 hydroxy tryptamine ( 5 HT ) in the anaesthetized dog , being mimicked by 5 carboxamidotryptamine ( 5 CT ) , inhibited by methiothepin , vagosympathectomy and sympatho inhibitory drugs , and resistant to blockade by ritanserin and MDL 72222 , is mediated by stimulation of prejunctional 5 HT 1 like receptors leading to an inhibitory action on carotid sympathetic nerves ; these 5 HT 1 like receptors are unrelated to either the 5 HT1A , 5 HT1B or 5 HT1C ( now 5 HT2C ) receptor subtypes . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Due to the high level of expression of mRNA for the 5 hydroxytrytamine ( 5 ht 7 ) receptor in the hypothalamus and the high affinity of 5 HT for this receptor , [ 3H ] 5 HT binding was performed in rat hypothalamus to determine whether 5 ht 7 receptor binding sites are present in animal tissue . [ 3H ] 5 HT binding was performed in the presence of 100 nM pindolol , which is inactive at 5 ht 7 receptors but prevents the binding of [ 3H ] 5 HT to 5 HT1A and 5 HT1B receptor binding sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT1A , 5 HT1B and beta adrenergic receptor antagonists pindolol and cyanopindolol ( 6 mg / kg SC ) did not affect punished responding either , nor did the 5 HT1D receptor partial agonist and alpha 2 adrenergic receptor antagonist yohimbine ( 2 . 5 mg / kg SC ) or the histamine H 1 receptor antagonist mepyramine ( 1 mg / kg SC ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The aim of this study was to provide evidence that anpirtoline , which is an agonist at 5 HT1B and 5 HT1D receptors and also displays submicromolar affinity for 5 HT1A recognition sites , in addition , acts as an antagonist at 5 HT 3 receptors . 2 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These results are consistent with the disappearance of 5 HT1B receptors from thalamocortical axons after the second postnatal week and the maintenance of 5 HT1A receptors on some neurons . 6 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
On the other hand , spiperone ( 0 . 25 0 . 5 mg / kg ) , a dopamine , 5 HT1A and 5 HT2A receptor antagonist ; pindolol ( 4 8 mg / kg ) , a beta adrenoceptor , 5 HT1A and 5 HT1B receptor antagonist and zacopride ( 0 . 1 1 mg / kg ) a 5 HT 3 receptor antagonist , did not affect the analgesia induced by m CPP . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These studies not only demonstrate the existence of several classes of serotonin receptors called 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , 5 HT 2 , 5 HT 3 and 5 HT 4 , but led also to the development of novel agonists and antagonists for the stimulation or blockade of each of them . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The responsiveness of these hetereceptors was tested in parallel with those of the terminal 5 HT1B autoreceptors and of the postsynaptic 5 HT1A and alpha 2 adrenergic receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Using the conflict drinking test as a model , we studied in rats the effect of the nonselective beta adrenoceptor blockers pindolol and cyanopindolol which bind to 5 HT1A and 5 HT1B receptors , and of the selective beta 1 and beta 2 adrenoceptor antagonists betaxolol and ICI 118 , 551 , respectively , which have a negligible affinity for 5 HT receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effects of D 1997 in the basilar artery were not modified by incubation with either the 5 HT 2 receptor antagonist ketanserin ( 0 . 01 1 microM ) , the 5 HT 3 and 5 HT 4 receptor antagonist ICS 205930 ( tropisetron ; 0 . 1 10 microM ) , the 5 HT1A receptor antagonist spiroxatrine ( 0 . 01 1 microM ) , the beta adrenoceptor blocker with high affinity for 5 HT1A and 5 HT1B binding sites ( + / ) pindolol ( 0 . 01 1 microM ) , or the alpha 1 adrenoceptor antagonist prazosin ( 0 . 01 1 microM ) . ^^^ It is concluded that D 1997 contracts the canine basilar artery by stimulating 5 HT 1 like receptors unrelated to either the 5 HT1A or 5 HT1B receptor subtypes . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Our results show that neither of the two drugs altered the inhibition of adenylate cyclase activity induced by serotonin 1 ( 5 HT 1 ) receptor agonists nor did they alter 5 HT1A and 5 HT1B receptor densities . ^^^ These results reinforce the idea that the ability of antidepressants to decrease the activity of the beta adrenoceptor adenylate cyclase complex is not common to all antidepressants , and provide no evidence for the involvement of 5 HT1A and / or 5 HT1B in the mechanism of action of these drugs . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Pretreatment with propranolol ( beta adrenoceptor antagonist that also has high binding affinity for 5 HT1A , 5 HT1B and 5 HT2C sites ) , MDL 72222 and ondansetron ( 5 HT 3 antagonists ) attenuated DOM ' s effect on plasma prolactin , but did not attenuate DOM induced increases in either ACTH or corticosterone . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The serotonin 5 HT1B and 5 HT1A receptors bind certain beta adrenergic antagonists , such as propranolol and pindolol , with high affinity . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
At a time when low dose ( 80 mg / kg ) p , p ' DDT elicited stimulus sensitive and spontaneous myoclonus , there were no significant changes in Bmax or Kd of 5 HT1A , 5 HT1B , 5 HT1C sites in cortex , striatum , brainstem or spinal cord , agonist or antagonist labelled 5 HT 2 sites in cortex , or 5 HT uptake sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Concentration response curves for inhibition of electrically stimulated 5 HT overflow by 8 OH DPAT ( 5 HT1a receptor agonist ) or RU 24969 ( 5 HT1b receptor agonist ) in the DRN or SCN respectively were obtained in slices prepared from both groups of animals . ^^^ These data suggest that down regulation of the 5 HT1b autoreceptors occurs in an axon terminal region ( SCN ) but that there is a sensitisation of 5 HT1a autoreceptor mechanisms controlling 5 HT overflow in the DRN . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Pretreatment with propranolol [ a beta adrenoceptor antagonist that also has high binding affinity for serotonin ( 5 HT ) 5 HT1A , 5 HT1B and 5 HT2C sites ] , bemesetron or ondansetron ( 5 HT 3 antagonists ) did not attenuate either DOM induced hypophagia or hyperthermia . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT1A and 5 HT1B receptor agonists 8 hydroxy 2 ( di n propyl amino ) tetralin and CP 93 , 129 , respectively , as well as the 5 HT 1 receptor agonist 5 carboxyamidotryptamine , were devoid of effect on the release of [ 3H ] noradrenaline . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In rat cortical membrane , KB 2796 inhibited specific [ 3H ] spiperone binding to 5 HT 2 receptors in a competitive manner ( Ki = 0 . 57 microM ) , but exhibited negligible affinity for radioligand binding to other 5 HT receptor subtypes such as 5 HT 1 , 5 HT1A , 5 HT1B , 5 HT1C and 5 HT 3 at a concentration of 10 or 100 microM . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effects of N ethoxycarbonyl 2 ethoxy 1 , 2 dihydroquinoline ( EEDQ ) , an alkylating agent producing irreversible blockade of various membrane bound receptors in brain , were investigated on four different types of serotonin receptors , 5 HT1A , 5 HT1B , 5 HT2A and 5 HT 3 , in various brain regions in the rat . ^^^ Membrane binding assays and / or quantitative autoradiography with appropriate radioligands indicated that EEDQ inactivated 5 HT1A , 5 HT1B and 5 HT2A sites , but was poorly active on 5 HT 3 , benzodiazepine and `` R ' ' sites . ^^^ Among the receptors affected by EEDQ , hippocampal 5 HT1A sites were the most sensitive to the alkylating agent ( ID 50 approximately 1 mg / kg i . p . ) , followed by the cortical 5 HT2A ( ID 50 approximately 3 mg / kg i . p . ) and the striatal 5 HT1B ( ID 50 approximately 6 mg / kg i . p . ) sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT inhibition of SRC and SAT is predominant and is mediated by 5 HT 1 like receptors , which , however , do not seem to correspond to 5 HT1A , 5 HT1B , 5 HT1C , 5 HT1D , 5 HT1E , or 5 HT1F receptor subtypes . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The firing rate of dorsal raphe serotonergic neurons is under the control of somatodendritic 5 hydroxytryptamine 1A ( 5 HT1A ) autoreceptors , the release of serotonin from nerve terminals is under the control of 5 HT autoreceptors ( 5 HT1B subtype in rodents , 5 HT1D in other species ) , whereas the control of the activity of tryptophan hydroxylase , the rate limiting enzyme of serotonin synthesis , is complex , involving 5 HT1A but possibly other 5 HT receptors including the 5 HT1B / D subtype . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Kindling induced a persistent bilateral increase in 5 HT1A binding in the dentate gyrus , while 5 HT1B receptors increased only in a delayed fashion . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
EEDQ dose dependently reduced the Bmax of 5 HT1A ( 3H DPAT ) , 5 HT1B ( 125I CYP ) , 5 HT 2 ( 3H ketanserin ) and 5 HT2 / 1C ( 125I DOI ) receptors in cortical homogenates . ^^^ The rank order of sensitivity to EEDQ inactivation was : 5 HT1A > 5 HT1B > 5 HT 2 approximately 5 HT2 / 1C > > > 5 HT uptake sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Structural analysis by the comparative molecular field analysis method of the affinity of beta adrenoreceptor blocking agents for 5 HT1A and 5 HT1B receptors . ^^^ The affinities of 17 beta adrenoreceptor antagonists for 5 HT1A and 5 HT1B receptors were evaluated in binding assays . ^^^ CoMFA demonstrated the important contribution of steric parameters , evaluated at 92 % , compared to the electrostatic field ( evaluated at 8 % ) to explain the affinity for 5 HT1A and 5 HT1B receptors . ^^^ This study emphasizes also the importance of the occupancy of a hydrophobic pocket in the receptor site located near the area interacting with the aromatic moiety , and subsequently its use for the design of new , potent , specific antagonists of 5 HT1A and 5 HT1B receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The data indicate that ( ) penbutolol possesses 5 HT1A and 5 HT1B autoreceptor antagonist properties , and may be a useful tool in studies of central 5 HT receptor mediated function . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Perfusion of serotonin ( 5 HT ; 10 microM , for 30 min at a rate of 3 microliters / min ) , dissolved in Ringer ' s solution containing 10 microM eserine , showed no marked effect on the extracellular levels of ACh . 8 Hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ; 20 microM ) , a 5 HT1A agonist , increased ACh levels , whereas 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo [ 1 , 2 a ] quinoxaline ( CGS 12066B ; 100 microM ) , a 5 HT1B agonist , decreased it . ^^^ These results indicate that the 5 HT1A receptor , which exists in the dorsal hippocampus , enhances the spontaneous ACh release , and that the mechanism of serotonergic modulation of ACh release partly depends on both the stimulatory control via the 5 HT1A receptor and the suppressive one via the 5 HT1B receptor in the dorsal hippocampus of rats . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Rats were then withdrawn from the pretreatment regimen for 7 days and their behavior rated following injections of 5 hydroxytryptamine1A ( 5 HT1A ) or 5 HT1B agonists . ^^^ Overall , the results indicate that , at least in the present behavioral paradigm , the effects of chronic cocaine administration are mediated by changes in 5 HT1A receptor sensitivity but not by changes in 5 HT1B receptor sensitivity . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The distribution of [ 125I ] GTI binding sites was largely comparable to that of [ 125I ] iodocyanopindolol ( [ 125I ] ICYP ) which labels 5 HT1B binding sites ( in the presence of 8 OH DPAT ( 8 hydroxy [ 2N dipropylamino ] tetralin ) and isoprenaline , to prevent binding to 5 HT1A and beta adrenoceptor binding sites ) , although a detailed analysis revealed differences . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The above results indicate that FLU given chronically has no effect on the responsiveness of 5 HT1A receptors , increases the responsiveness of 5 HT1B receptors and decreases those of 5 HT1C and 5 HT 2 receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
RU 24969 ( 7 . 5 mg kg 1 i . p . ) induced hyperlocomotion was inhibited by the ( ) , but not ( + ) isomers of pindolol ( 4 mg kg 1 ) and propranolol ( 20 mg kg 1 ) but not by metoprolol ( 10 mg kg 1 ) or ICI 118 , 551 ( 5 mg kg 1 ) , consistent with an involvement of 5 HT1A or 5 HT1B receptors . 5 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Several other agonists and antagonists that act at 5 HT1A , 5 HT1B , 5 HT 2 and 5 HT 3 receptors did not produce an altered response in the lesioned rats , nor were these substances effective in attenuating m CPP enhanced oral activity responses . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Carboxamidotryptamine insensitive 5 HT 1 like receptors are concentrated in guinea pig but not rat , claustrum . 5 CT ( 5 carboxamidotryptamine ) insensitive ( 5 HT1E / 5 HT1F ) 5 HT 1 like recognition sites have been mapped autoradiographically in rat and guinea pig brain using [ 3H ] 5 HT in the presence of 5 CT and mesulergine to mask 5 HT1A , 5 HT1B , 5 HT1D and 5 HT2C binding sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
When 8 OH DPAT ( 100 nM ) + chlorpromazine ( 500 nM ) , CGS 12066 B ( 200 nM ) + ritanserin ( 500 nM ) , and ( + / ) pindolol ( 1 microM ) were included to block 5 HT1A + 5 HT1C , 5 HT1B + 5 HT1C , and 5 HT1A + 5 HT1B receptor subtype respectively , the competition studies have shown that under these selective conditions dihydroergosine binds with the highest affinity for 5 HT1B ( Ki = 0 . 48 nM ) , with 8 . 7 times lower affinity for 5 HT1A ( Ki = 4 . 2 nM ) and with a moderate affinity for 5 HT1C ( Ki = 156 nM ) receptor subtype . ^^^ While our previous studies suggested that dihydroergosine stimulates 5 HT1A and inhibits 5 HT 2 receptors , this study suggests that the high affinity of this drug for 5 HT1B receptors should not be neglected . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In radioligand binding studies , SDZ 216 525 showed high affinity and selectivity for 5 HT1A sites ( pKD = 9 . 2 ) as compared to 5 HT1B , 5 HT1C , 5 HT1D , 5 HT 2 and 5 HT 3 sites ( pKD = 6 . 0 , 7 . 2 , 7 . 5 , 5 . 2 and 5 . 4 , respectively ) . ^^^ The effects of SDZ 216 525 , MDL 73005 and NAN 190 on 5 HT 1 receptor linked second messengers were characterised in the following tests : inhibition of forskolin stimulated adenylate cyclase activity in calf hippocampus ( 5 HT1A ) , rat substantia nigra ( 5 HT1B ) and calf substantia nigra ( 5 HT1D ) and stimulation of inositol phosphate production in pig choroid plexus ( 5 HT1C ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Within the conserved transmembrane domains , the sequences exhibit approximately 52 % , 59 % , 65 % , and 68 % amino acid identity with the known rat 5 HT1A , rat 5 HT1B , rat 5 HT1D , and human 5 HT1E receptors , respectively . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The obtained results indicate that ( + ) OXA administered repeatedly increases the reactivity of 5 HT1B receptors , decreases the reactivity of 5 HT 2 receptors , and has no effect on the reactivity of 5 HT1A ( pre and postsynaptic ) and 5 HT1C receptors . ( ) OXA given repeatedly decreases the reactivity of presynaptic 5 HT1A receptors and has no influence on the reactivity of postsynaptic 5 HT1A , 5 HT1B , 5 HT1C and 5 HT 2 receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Interestingly , the 5 HT1A and 5 HT1B receptor antagonist , cyanopindolol ( 100 , 300 and 1000 micrograms / kg i . v . ) , blocked the effects of 5 HT , but the block was not elicited in a dose dependent manner , with only the response induced by 0 . 3 microgram / min 5 CT being significantly antagonized by the highest dose of cyanopindolol ; however , this blockade was not selective . ^^^ These receptors , however , do not seem to correspond to either the 5 HT1A , 5 HT1B or 5 HT1C receptor subtypes . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In addition to demonstrating that 5 HT1a and 5 HT1b receptors are differentially regulated in different brain areas , these results show that in the brain regions examined both 5 HT1a and 5 HT1b receptors are primarily post synaptic . . ^^^ Quantitative autoradiography was used to determine the effect of acute serotonergic denervation with 5 , 7 dihydroxytryptamine ( 5 , 7 DHT ) or serotonin 5HT1a and 5 HT1b receptors in male rats . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Several serotonergic agonists were assayed to further analyse the type of receptors involved in the response to 5 HT . 5 methoxytryptamine ( 5 MOT ) , a mixed 5 HT 1 , 5 HT 2 and 5 HT 4 agonist , reproduced all the effects of 5 HT . 8 OH DPAT , a selective 5 HT1A agonist , trifluoromethylphenylpiperazine , a mixed 5 HT1B / C agonist , and m chlorophenylbiguanide , a 5 HT 3 agonist , did not induce any consistent contractile effects . ^^^ These results indicate that chicken ileum contains 5 HT 1 receptors similar to the 5 HT1D mammalian subtype but not the 5 HT1A , 5 HT1B , 5 HT1C or 5 HT 3 subtypes . 5 HT 2 receptors are also present and would appear to be located on smooth muscle . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The vascular responses of simian gastroepiploic arteries to 5 hydroxytryptamine ( 5 HT ) , 5 carboxamidotryptamine ( 5 CT , a selective 5 HT 1 like receptor agonist ) , 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT , a selective 5 HT1A receptor agonist ) , m trifluoromethylphenylpiperazine ( TFMPP , a selective 5 HT1B receptor agonist ) , noradrenaline and KCl were examined in isolated , cannulated and perfused preparations . 5 HT induced dose dependent vasoconstrictions more potently than noradrenaline did . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The agonists increased extraneuronal levels of DA in a dose dependent manner , suggesting receptor selectivity in the order of 5 HT1b > 5 HT 4 > > 5 HT 2 = 5 HT1a . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These results suggest that 5 HT receptor ( 5 HT1A , 5 HT 2 and 5 HT 3 but not 5 HT1B ) mediated mechanisms play an important role in the production of PSY SIA . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In this study we began by using autoradiography to determine that the SCN contain abundant 5 HT1A and 5 HT1B receptors , very few 5 HT1C and 5 HT 2 receptors , and no 5 HT 3 receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Quantitative ligand binding autoradiography was used to compare the density of various 5 HT receptor subtypes in the adult brain of control and neonatally 6 OHDA lesioned rats . 5 HT1A , 5 HT1B , 5HT1nonAB and 5 HT 2 sites were labeled with [ 3H ] 8 OH DPAT , [ 125I ] cyanopindolol , [ 3H ] 5 HT and [ 125I ] DOI , respectively , and measured in the rostral and caudal halves of neostriatum and selected forebrain or midbrain regions . 5 HT1A binding , measured after 6 months , was unchanged in all regions examined including the dorsal raphe nucleus . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The results of the present study show that , 5 days after rabies virus infection in rat , the total reversible high affinity binding of [ 3H ] 5 HT in the hippocampus is not affected , suggesting that 5 HT1A binding is not altered . 5 HT1B sites identified by [ 125I ] cyanopindolol binding are not affected in the cortex 3 and 5 days after the infection . ^^^ In contrast , [ 3H ] 5 HT binding determined in the presence of drugs masking 5 HT1A , 5 HT1B and 5 HT1C receptors , is markedly ( 50 % ) reduced 3 days after the viral infection . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
It was found that ( ) tertatolol binds to 5 HT 1 receptor subtypes in rat brain , particularly the 5 HT1A subtype in the hippocampus ( Ki = 5 . 9 nM ) . ( ) Tertatolol showed much lower affinity for 5 HT1B ( Ki = 118 . 4 nM ) , 5 HT1C ( Ki = 699 . 6 nM ) and 5 HT 2 ( Ki = 678 . 6 nM ) receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Two injections of the 5 HT 2 receptor antagonist cinanserin ( 30 nmol / 0 . 5 microliter ) in the paraventricular nucleus of the hypothalamus completely reversed the effect of stress on food intake . ( + / ) Cyanopindolol ( 3 and 8 mg / kg ) , an antagonist at 5 HT1A and 5 HT1B receptors , had no effect whereas 8 hydroxy 2 di n propylamino ) tetralin ( 30 300 micrograms / kg ) , an agonist at 5 HT1A receptors , significantly attenuated the hypophagia . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Chronic alcoholization alters the expression of 5 HT1A and 5 HT1B receptor subtypes in rat brain . ^^^ The expression of central 5 HT1A and 5 HT1B receptors was studied in several brain areas of rats subjected to a 2 week period of chronic alcoholization , followed by 18 h withdrawal . ^^^ These data suggest that altered sensitivity of chronically alcoholized rats to 5 HT1A and 5 HT1B receptor ligands may result from alcohol induced changes in the transcription of the genes encoding these receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT receptor identity of control and transfected C 6 glial / 5 HT1D beta cells was determined by reverse transcription polymerase chain reaction using primers specific for rat 5 HT1A , rat 5 HT1B , rat 5 HT1D alpha , human 5 HT1D beta , and rat 5 HT2A receptor genes . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In contrast , the following drugs were ineffective : ( + / ) 8 hydroxy dipropylaminotetralin hydrobromide ( 8 OH DPAT , 5 HT1A agonist ) , buspirone hydrochloride ( 5 HT1A agonist ) , 7 trifluoromethyl 4 ( 4 methyl l piperazinyl ) pyrrolo [ 1 , 2 a ] quinoxaline maleate ( CGS 12066B , 5 HT1B agonist ) , ketanserin tartrate ( 5 HT 2 antagonist ) , methysergide maleate ( 5 HT 2 antagonist ) , fluoxetine ( 5 HT uptake blocker ) , and saline ( vehicle ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
They received intrahippocampal microinjections of a 5 HT1A [ 8 hydroxy 2 ( di n propylamino ) tetralin or 8 OH DPAT ] , or a 5 HT1B [ 3 ( 1 , 2 , 5 , 6 tetrahydropyrid 4 yl ) pyrrolo [ 3 , 2 b ] pyrid 5 one or CP 93 , 129 ] receptor agonist , and a muscarinic receptor antagonist ( scopolamine ) . 8 OH DPAT ( 5 micrograms / microliters ) , like injections of saline , induced no change in performance levels . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Functional effects of the 5 HT1D receptor antagonist GR 127 , 935 at human 5 HT1D alpha , 5 HT1D beta , 5 HT1A and opossum 5 HT1B receptors . ^^^ GR 127 , 935 did not show 5 HT1D beta receptor mediated agonist activity in permanently transfected CHO K 1 cells , whereas at submicromolar and higher concentrations intrinsic agonist activity was observed in HeLa / 5 HT1A , OK / 5 HT1B and CHO K1 / 5 HT1D alpha cells . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The inhibitory effect of 5 CT was blocked by the 5 HT1 / 2 antagonist methiothepin ( 1 microM ) , the 5 HT1A antagonist S UH 301 ( 1 microM ) , and the 5 HT1B / 1D antagonist GR 127935 ( 1 microM ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
This higher concentration was , however , needed to fully saturate 5 HT1A and 5 HT1B receptors without interaction with 5 HT 7 receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Abnormalities in 5 HT1A and 5 HT1B receptor binding in severe seizure genetically epilepsy prone rats ( GEPR 9s ) . ^^^ These finding suggest that in addition to the innate reduction in 5 HT presynaptic markers , GEPR 9s also exhibit abnormalities in the density of 5 HT1A and 5 HT1B receptors in some regions of the brain . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The most intensively investigated 5 HT receptor subtypes have been the 5 HT1A receptor , the 5 HT1B receptor and the 5 HT2C receptor . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In the present study , we measured the affinity of acetaminophen at 5 HT 3 , as well as 5 HT1A , 5 HT1B , 5 HT1D , 5 HT 2 , 5 HT2C , 5 HT 4 , 5 HT 6 , 5 HT 7 and eleven other receptor sites and at serotonin and norepinephrine reuptake sites . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Interestingly , tertatolol ( 3 micrograms ) itself had an anxiolytic effect which was not antagonised by 8 OH DPAT ( 100 ng ) , suggesting the effect was not mediated by 5 HT1A receptors , and indeed other actions of tertatolol , such as those on 5 HT1B or beta adrenergic receptors could have been involved . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
HT levels through mechanisms involving not only 5 HT1A , but also 5 HT1B receptors . ^^^ Although the antagonism of the 8 OH DPAT induced decrease of 5 HT levels by ( ) pindolol and ( + / ) tertatolol is likely to be related to their 5 HT1A antagonist properties , their ability to increase extracellular 5 HT levels when given alone may involve interactions with 5 HT1B receptors at hippocampal 5 HT terminals . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Effects of dorsal rhizotomy and selective lesion of serotonergic and noradrenergic systems on 5 HT1A , 5 HT1B , and 5 HT 3 receptors in the rat spinal cord . ^^^ Autoradiographic studies were performed in combination with dorsal rhizotomy or selective lesion of descending serotonergic or noradrenergic systems in an attempt to identify the neuronal cell types endowed with the serotonin 5 HT1A , 5 HT1B and 5 HT 3 receptors in the rat spinal cord . ^^^ In addition , a significant decrease ( approximately 20 % ) in the binding of [ 3H ] 8 OH DPAT to 5 HT1A receptors and of [ 125I ] GTI to 5 HT1B receptors was also observed in the same spinal area in rhizotomized rats , suggesting that a small proportion of these receptors are also located on primary afferent fibres . ^^^ These data indicate that complex adaptive changes in the expression of 5 HT1A and 5 HT1B receptors occurred in the rat spinal cord following the lesion of descending monoaminergic systems . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT1A / 5 HT1B agonist 5 carboxamidotryptamine depressed activity in 20 of 25 neurons studied . ^^^ The 5 HT1A / 5 HT1B antagonist pindolol prevented the 5 carboxamidotryptamine induced changes , whereas the 5 HT1A antagonist spiroxatrine and the 5 HT 2 antagonists ketanserin and mianserin were ineffective . ^^^ These data provide electrophysiological evidence for the presence of 5 HT 1 receptors in the nTS , presumably of the 5 HT1B subclass , but cast further doubt on the contribution of 5 HT 2 and 5 HT1A receptors to the actions of serotonin in the nucleus . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Further supporting the relevance of 5 HT1B receptors to the activating effects of serotonin releasing agents , MDMA exhibits reciprocal cross tolerance with the 5 HT1B agonist RU 24969 , but not with either 5 HT1A or 5 HT 2 agonists or amphetamine . ^^^ Thus , studies of locomotor and investigatory responses can be used to demonstrate and differentiate the effects of direct agonists at 5 HT1A , 5 HT1B , and 5 HT 2 receptors as well as indirect serotonin agonists . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The antiaggressive potency of ( ) penbutolol involves both 5 HT1A and 5 HT1B receptors and beta adrenoceptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In tissues precontracted with U 46619 ( 10 nM ) and in the presence of 5 HT1A , 5 HT1B , 5 HT2A , 5 HT 3 , and 5 HT 4 receptor blockade , 5 CT and 5 MeOT caused endothelium independent relaxation with potency values of 7 . 5 + / 0 . 1 ( n = 21 ) and 5 . 7 + / 0 . 1 ( n = 4 ) , respectively . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The findings suggest that 5 HT1A , 5 HT1B and 5 HT 2 receptors are not implicated in 5 HT stimulated C 6 glial / 5 HT1D cell growth . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Affinities for the 5 HT1A receptors were in the nanomolar range for the best compounds ( ( + ) 11a , 23 ) with a high selectivity versus other 5 HT ( 5 HT1B , 5 HT 2 , 5 HT 3 ) or dopamine ( D 1 , D 2 ) receptor subtypes . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Differential addressing of 5 HT1A and 5 HT1B receptors in transfected LLC PK 1 epithelial cells : a model of receptor targeting in neurons . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The release of [ 3H ] ACh was measured in presence of atropine ( muscarinic antagonist , 1 microM ) , physostigmine ( acetylcholinesterase inhibitor , 0 . 1 microM ) , oxotremorine ( muscarinic agonist , 0 . 01 microM 10 microM ) , mecamylamine ( nicotinic antagonist , 10 microM ) , methiothepin ( mixed 5 HT1 / 5 HT 2 antagonist , 10 microM ) , 8 OH DPAT ( 5 HT1A agonist , 1 microM ) , 2 methyl serotonin ( 5 HT 3 agonist , 1 microM ) and CP 93129 ( 5 HT1B agonist , 0 . 1 microM 100 microM ) , or without any drug application as a control . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These data indicate that ( 1 ) different 5 HT receptor subtypes ( 5 HT1A and 5 HT1B ) regulate dendritic and axon terminal 5 HT release ; ( 2 ) serotonin release from the dendrites may be regulated by the voltage sensitive N type Ca2+ channels ; ( 3 ) the 5 HT1A receptor mediated inhibition of serotonin release may be due to opening of voltage sensitive K+ channels . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Among the numerous 5 HT receptor subtypes , several ( 5 HT1A , 5 HT1B , 5 HT 2 and 5 HT 3 ) could be involved in these etiologies . ^^^ The regional density of 5 HT1A , 5 HT1B , 5 HT2A and 5 HT2B receptors has been measured in the brains of parental strains , F ( 1 ) and F ( 2 ) populations by quantitative autoradiography . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Oligonucleotide primers were chosen based on unique regions of complementary DNA sequence for each of the 12 cloned rat serotonin receptor subtypes ( i . e . 5 HT1A , 5 HT1B , 5 HT1D , 5 HT1F , 5 HT2A , 5 HT2B , 5 HT2C , 5 HT 3 , 5 HT5A , 5 HT5B , 5 HT 6 and 5 HT 7 ) and high stringency conditions were used during polymerase chain reaction . ^^^ Within superior cervical ganglia , the presence of messenger RNA for 5 HT1A , 5 HT1B , 5 HT1D , 5 HT2A , 5 HT 3 , 5 HT 6 , and 5 HT 7 receptor subtypes was detected . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These data suggest that neither the 5 HT1A , 5 HT1B , 5 HT1D , 5 HT2A , 5 HT2B , 5 HT2C , 5 HT 3 , 5 HT 5 , 5 HT 6 , nor 5 HT 7 receptors are involved . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
We have examined the effects of selective antagonists at 5 HT1A and 5 HT1B / D receptors ( WAY 100135 and GR 127935 , respectively ) on both the hyperlocomotor and anti immobility effects of RU 24969 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Pretreatment with propranolol ( beta adrenergic receptor antagonist that also has binding affinity for 5 HT1A , 5 HT1B and 5 HT2B sites ) , yohimbine ( alpha 2 noradrenergic antagonist that also has binding affinity for 5 HT2B sites ) , MDL 72222 or ondansetron ( 5 HT 3 antagonists ) did not attenuate m CPP induced hyperthermia . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In radioligand binding assays , PIT showed a low affinity ( pKi < 5 ) for a range of membrane receptors , including : alpha 1 , alpha 2 adrenoceptors , 5 HT1A , 5 HT1B , 5 HT 2 , 5 HT 3 , D 1 , D 2 , muscarinic , central benzodiazepine , H 1 , mu opioid , dihydropyridine and batrachotoxin receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
This agonist and antagonist profile is consistent with the presence of a 5 HT1B receptor . 8 OH DPAT ( 1 microM ) and renzapride ( 3 microM ) were without effect on forskolin stimulated cyclic AMP production and ketanserin ( 0 . 3 microM ) did not antagonize the inhibition produced by 5 HT , thus excluding the involvement of 5 HT1A , 5 HT 4 , and 5 HT 2 receptors . 6 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Serotonin exerted immunosuppressive effects on lipopolysaccharide ( LPS ) and phytohemagglutinin ( PHA ) stimulated proliferation of fish peripheral blood lymphocytes ( PBL ) . 8 OH DPAT ( an agonist of 5 HT1A receptors ) mimicked the inhibitory effects of serotonin on lymphocyte proliferation , whereas addition of spiperone ( an antagonist of 5 HT1A and 5 HT1B receptors ) reversed these inhibitory effects , indicating that 5 HT1A receptors may be implicated in serotonin induced immunosuppression . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Serotonin and serotonin agonists with relative selectivity for the receptor subtypes 5 HT1A , 5 HT1B , 5 HT2A / 2C and 5 HT 3 all significantly ( P < 0 . 01 ) inhibited glutamate evoked firing of cells in the nucleus accumbens compared to the effects of an acidic saline control solution ( 30 60 nA , 60 s ejection currents for all ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In this review , the functional interactions between serotonin ( 5 HT ) and other neuronal systems are discussed with the focus on microdialysis studies in the mammalian brain ( mainly rats ) . 5 HT release is negatively regulated not only by somatodendritic 5 HT1A and terminal 5 HT1B ( 5 HT1D ) autoreceptors but also by alpha 2 adrenergic and mu opioid heteroreceptors that are located on serotonergic nerve terminals . 5 HT by itself is involved in the inhibitory effects of noradrenaline release and the facilitatory regulation of dopamine release via multiple 5 HT receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Both sarpogrelate and M 1 had no affinity for 5 HT1A receptors , but these substances , at a concentration of 10 microM , displaced the specific binding to the 5 HT1B receptors of [ 125I ] iodocyanopindolol , resulting in Ki values of 0 . 881 and 0 . 859 microM , respectively . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The first set of experiments was carried out to confirm the influence of 5 HT1A , 5 HT1B , 5 HT2A / 2C receptor agonists on the activation of the hypothalamic pituitary adrenal axis . ^^^ Plasma corticosterone levels were measured , and a double immunolabeling procedure was used to determine whether the neuronal activity marker , c Fos protein ( Fos ) , could be found within brain neurons containing CRH after treatments with 5 HT1A , 5 HT1B , 5 HT2A / 2C receptor agonists . ^^^ The effects of the 5 HT1A , 5 HT1B , 5 HT2A / 2C receptor agonists on food intake and VO 2 were measured in rats treated with the CRH antagonist , alpha helical CRH ( 9 41 ) . ^^^ In both experiments rats were intraperitoneally injected with either a vehicle ( NaCl 0 . 9 % ) , the 5 HT1A receptor agonist ( + / ) 8 hydroxy 2 ( di n propylamino ) tetralin hydrobromide ( 8 OH DPAT ) , the 5 HT1B receptor agonist 5 methoxy 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridinyl ) 1H indole succinate ( RU 24969 ) , or the 5 HT2A / 2C receptor agonist ( + / ) 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane HCl ( DOI ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In contrast , little substitution was observed following administration of 8 OH DPAT , a potent 5 HT1A agonist , the 5 HT1B agonist CP 94 , 253 , or the serotonin reuptake inhibitor sertraline . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Autoradiography of tissue sections exposed to [ 3H ] 8 OH DPAT ( 8 hydroxy dipropylaminotetraline ) or to [ 125I ] cyanopindolol plus isoproterenol showed that 5 HT1A and 5 HT1B receptors , respectively , were present in the superficial SC layers . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Both E and DHE are 5 HT1A , 5 HT1B , 5 HT1D , and 5 HT1F receptor agonists . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The role of 5 HT1A and 5 HT1B receptors in antidepressant drug actions in the mouse forced swimming test . ^^^ The present study was designed in order to further evaluate the mode of action of antidepressants in the forced swimming test , by using selective agonists and antagonists at 5 HT1A and 5 HT1B receptor sites . ^^^ The anti immobility effects of the selective serotonin reuptake inhibitors in the forced swimming test seem to be mediated by presynaptic 5 HT1A receptors as well as postsynaptic 5 HT1B receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
It is concluded that : ( 1 ) serotonin interacts with the mesolimbic dopaminergic system through 5 HT1B , but not 5 HT1A , receptors : and ( 2 ) serotonin interaction with the mesolimbic dopaminergic system involves postjunctional 5 HT1B heteroreceptors located in the ventral subicular area , which modulate the activity of glutamatergic hippocampo accumbens pathways and only secondarily alter DA levels in the n . acc . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Adult male Sprague Dawley rats were administered the 5 HT subtype selective receptor agonists 8 OH DPAT ( 0 . 5 2 . 0 mg / kg ) , buspirone ( 2 8 mg / kg ) ( 5 HT1A ) , TFMPP ( 0 . 125 2 . 0 mg / kg ) ( 5 HT1B ) , DOI ( 0 . 125 2 . 0 mg / kg ) ( 5 HT2A ) and m CPBG ( 1 . 25 20 . 0 mg / kg ) ( 5 HT 3 ) , subcutaneously . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Potentiation of fluoxetine induced penile erections by combined blockade of 5 HT1A and 5 HT1B receptors . ^^^ Selective blockade of 5 HT1A autoreceptors with WAY 100 , 635 ( ( N ( 2 [ 4 ( 2 methoxyphenyl ) 1 piperazinyl ] ethyl ) N ( 2 pyridinyl ) cyclo hexanecarboxamide ) ( 0 . 16 mg / kg , s . c . ) , or of 5 HT1B autoreceptors with GR 127 , 935 ( N [ 4 methoxy 3 ( 4 methylpiperazin 1 yl ) phenyl ] 2 ' methyl 4 ' ( 5 me thyl 1 , 2 , 4 oxadiazol 3 yl ) biphenyl 4 carboxamide ) ( 2 . 5 mg / kg , s . c . ) , slightly ( 1 . 5 to 2 fold ) increased fluoxetine induced penile erections . ^^^ Combined blockade of 5 HT1A and 5 HT1B autoreceptors markedly enhances the actions of serotonin reuptake inhibitors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Serotonin transporter antagonists enhance serotonergic neurotransmission by decreasing the functional activity of the 5 HT1A and 5 HT1B autoreceptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Modulation of the discriminative stimulus properties of cocaine : comparison of the effects of fluoxetine with 5 HT1A and 5 HT1B receptor agonists . ^^^ In substitution tests , the 5 HT1A receptor partial agonists buspirone and gepirone , the 5 HT1A / B receptor agonist RU 24969 and the 5 HT1B / 2C receptor agonist m trifluoromethyl phenylpiperazine ( TFMPP ) failed to substitute for the cocaine stimulus , although RU 24969 did engender a maximum of 72 % cocaine lever responding . ^^^ Whereas 5 HT agonists do not fully substitute for cocaine , the present results demonstrate that 5 HT1B , but not 5 HT1A , receptor agonists can modulate the discriminative stimulus properties of cocaine in a manner similar to that observed following administration of the 5 HT reuptake inhibitor fluoxetine . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT1a antagonist NAN 190 and the 5 HT1b agonist CGS 12066 B , applied both systemically and locally , blocked the effect of FFA . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
We have studied the effects of the purportedly selective 5 HT1A receptor antagonist ( + ) WAY 100135 on electrically stimulated 5 hydroxytryptamine ( 5 HT ) efflux in the ventrolateral geniculate nucleus ( vLGN ) , and its affinity at human 5 HT1B and 5 HT1D receptors stably expressed in Chinese hamster ovary ( CHO ) cells . 2 . ^^^ In conclusion , ( + ) WAY 100135 was found to be not a selective 5 HT1A autoreceptor antagonist but may act as a partial agonist at the 5 HT1B / 1D receptor , displaying agonist or antagonist properties depending on the stimulation protocol used and the resultant 5 HT ' tone ' at the receptor . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Potentiation of the fluoxetine induced increase in dialysate levels of serotonin ( 5 HT ) in the frontal cortex of freely moving rats by combined blockade of 5 HT1A and 5 HT1B receptors with WAY 100 , 635 and GR 127 , 935 . ^^^ The present data demonstrate that combined blockade of 5 HT1A and 5 HT1B autoreceptors markedly and selectively potentiates the fluoxetine induced increase in dialysate levels of 5 HT versus DA and NAD in the FCx of freely moving rats . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The blockade of postsynaptic 5 HT1A , 5 HT1B , 5 HT 3 or 5 HT 4 receptors and 5 HT inhibition of synthesis and its depletion did no alter learning by themselves . 6 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Effect of a selective 5 HT reuptake inhibitor in combination with 5 HT1A and 5 HT1B receptor antagonists on extracellular 5 HT in rat frontal cortex in vivo . 1 . ^^^ Here , we investigated whether blockade of the terminal 5 HT1B autoreceptor influences a selective 5 HT reuptake inhibitor in the same way , and whether there is an additional effect of blocking both the 5 HT1A and 5 HT1B autoreceptors . 2 . ^^^ In summary , our results suggest that selective 5 HT reuptake inhibitors may cause a large increase in 5 HT in the frontal cortex when 5 HT autoreceptors on both the somatodendrites ( 5 HT1A ) and nerve terminals ( 5 HT1B ) are blocked . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Using intracerebral microdialysis in awake rats with separate probes in the frontal cortex or dorsal hippocampus , we studied the ability of 8 mg / kg s . c . ( ) penbutolol , a beta adrenoceptor antagonist with antagonist action at 5 HT1A and 5 HT1B receptors , and 0 . 3 mg / kg s . c . ^^^ The results suggest that only a combined blockade of 5 HT1A and 5 HT1B receptors potentiates the effect of citalopram on extracellular concentrations of serotonin in the dorsal hippocampus . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Upon applying the drugs to the spinal cord alone , 5 HT was found to have a dual effect on phrenic motoneuron firing : ( 1 ) a facilitatory effect mediated by 5 HT2A receptors and ( 2 ) a depressive effect on their inspiratory discharge mediated by non 5 HT1A , non 5 HT2A , non 5 HT 3 receptors , possibly of the 5 HT1B subtype . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Spinal application of 5 HT1B ( but not 5 HT1A ) receptor agonists depressed the phrenic activity and the effect was prevented by pretreatment with 5 HT1B ( but not 5 HT1A , 5 HT2A and 5 HT 3 ) receptor antagonists . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Numerous studies have demonstrated that activation of serotonin 5 HT1A or 5 HT1B receptor decreases aggression in male mammals . ^^^ To determine whether female mammals also show decreased aggression in response to 5 HT1A or 5 HT1B activation , we assessed the effects of the serotonin receptor agonists 8 OH DPAT ( 5 HT1A ) and CGS 12066A ( 5 HT1B ) on aggression in female Syrian hamsters . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
This study tested whether the lateral septum ( LS ) and medial preoptic area ( MPO ) , which are part of the neuroanatomical substrate for aggression and contain androgen , estrogen , 5 HT1A and 5 HT1B receptors , represent sites where these modulatory effects occur . ^^^ They were microinjected with either CGS12066B , a 5 HT1B agonist ( 400 microM LS , 200 microM MPO ) ; 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) , a 5 HT1A agonist ( 10 microM LS , 5 microM MPO ) ; or combined CGS + 8 OH DPAT treatment and tested for aggression 15 min later . ^^^ The findings demonstrate regional variation in the ability of androgens and estrogens to modulate 5 HT1A and 5 HT1B agonist mediated reductions in aggression . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The G protein coupling behavior of four human 5 hydroxytryptamine receptor subtypes ( 5 HT1A , 5 HT1B , 5 HT1D , and 5 HT1E ) has been studied in membranes from Sf 9 cells expressing the individual receptors . ^^^ The 5 HT1A and 5 HT1B receptors exhibited both high and low affinity states for agonist , with the majority of the receptors in a low affinity state . ^^^ Addition of purified G protein subunits to membranes expressing either 5 HT1A or 5 HT1B receptors shifted the majority of the receptors to a high affinity state in the absence , but not in the presence , of guanine nucleotides . ^^^ A significantly higher affinity for agonist was observed with both receptors in the presence of alphai 3 subunits compared with either alphai 2 or alphao subunits , while a significantly lower concentration of alpha subunits was required for a maximal affinity shift of 5 HT1A receptors compared with 5 HT1B receptors ( EC 50 values of 6 . 4 and 12 . 0 nM , respectively ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The present studies extend this initial finding to four additional 5 HT agonists with different selectivity for 5 HT1A , 5 HT1B , or 5 HT2C receptors : CGS 12066B ( 7 trifluoromethyl 4 ( 4 methyl 1 piperazinyl ) pyrrolo [ 1 , 2a ] quinoxaline maleate ) , mCPP [ 1 ( 3 chlorophenyl ) piperazine diHCl ] , RU 24969 [ 5 methoxy 3 ( 1 , 2 , 3 , 4 tetrahydro 4 pyridinyl ] 1H indole succinate and 8 OH DPAT [ ( + / ) 8 hydroxy 2 ( di n propylamino ) tetralin HBr ] . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT1B receptor agonist , CP 93 , 129 ( 3 ( 1 , 2 , 5 , 6 tetrahydropyrid 4 yl ) pyrrolo [ 3 , 2 b ] pyrid 5 one ) , the 5 HT1A / B receptor antagonist cyanopindolol , and the 5 HT1A receptor antagonist WAY 100635 ( N [ 2 [ 4 ( 2 methoxypheny ] ) 1 piperazinyl ] ethyl ] N ( 2 pyridinyl ) cyclohexanecarboxamide trihydrochloride ) , were applied directly onto the spinal cord , and single unit responses were counted separately for A beta , A delta , C fibre responses and post discharge according to the latencies . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The importance of blockade of 5 HT 1B / D receptors in the raph region , their possible interaction with 5 HT 1A receptors , and consequent inhibition of 5 HT release in terminal 5 HT 1B / D receptor containing regions are discussed . 4 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
MDL 74 , 721 demonstrated nanomolar affinity for 5 HT1A ( 12 . 7 + / 0 . 3 nM ) and 5 HT1D ( 41 . 3 + / 10 . 9 nM ) but considerably lower affinity for 5 HT1B receptors ( > 1000 nM ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
While age related declines in the number of 5 HT1B and 5 HT 2 receptors have been reported , little information is available describing the region specific effects of aging on the functional dynamics of equilibrium binding at 5 HT receptors , including the 5 HT1A receptor subtype . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Binding experiments at cloned human 5 HT1A , 5 HT1B , and 5 HT1D receptors show that these derivatives are potent and selective ligands for 5 HT1B / 1D subtypes with increased binding selectivity versus the 5 HT1A receptor when compared to 1 naphthylpiperazine ( 1 NP ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The selective 5 HT1A receptor agonist 8 OH DPAT and the selective 5 HT ( 1B / 1D ) receptor agonists sumatriptan and L 694 , 247 inhibited the pressor response , whereas the 5 HT1B receptor agonists CGS 12066B and CP 93 , 129 and the 5 HT2C receptor agonist m CPP did not modify the pressor sympathetic responses . 4 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The drug influence was investigated in three behavioral tests : 8 OH DPAT ( 5 HT1A agonist ) induced behavioral syndrome in rats , m chlorophenylpiperazine ( m CPP , 5 HT1B agonist ) induced hypothermia in mice and L 5 hydroxytryptophan ( L 5 HTP ) induced head twitches ( 5 HT2A stimulation ) in rats . ^^^ The results indicate that EMD 57445 does not interact with 5 HT ( 5 HT1A , 5 HT1B , 5 HT2A ) receptor subpopulations and does not affect 5 HT metabolism . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Interaction studies were performed with S 15535 ( presynaptic 5 HT1A receptor agonist ) and methiothepin ( 5 HT1B autoreceptor antagonist ) in an attempt to attenuate or potentiate antidepressant like activity . ( + / ) Pindolol was tested in combination with selective agonists and antagonists at 5 HT 1 , 5 HT 2 and 5 HT 3 receptor subtypes . ^^^ The results of the present study suggest that pindolol is acting at presynaptic 5 HT1B serotonergic receptors , in addition to the 5 HT1A subtype , in augmenting the activity of antidepressants in the mouse forced swimming test . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Although clozapine displays significant affinity to 5 HT1A , 5 HT1B , 5 HT2A and 5 HT2C receptors , the present results suggest that blockade of these receptors is not responsible for clozapine ' s anticataleptic activity . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In contrast , the sensitivity of the alpha 2 adrenergic and terminal 5 HT1B autoreceptors , as well as that of the postsynaptic 5 HT1A receptor after 21 day treatment was unchanged . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
We therefore investigated the 5 HT1A , 5 HT1B and 5 HT2A receptor density in 18 22 different regions in the brain of portacaval shunted rats by means of radioligand binding with autoradiographical evaluation . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Studies of the effects of aging on the density and / or affinity of 5 HT1A and 5 HT1B / 1D receptors are also warranted . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
This effect by ( ) pindolol is in all probability indirect since this compound lacks affinity for 5 HT2A / C receptors , and could be explained by reported antagonism of inhibitory serotonergic somato dendritic 5 HT1A autoreceptors , although other possibilities related to 5 HT1B receptors or beta adrenoceptors can not be excluded at this time . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effect of systemic administration of the 5 HT1A and 5 HT1B antagonist , ( + / ) pindolol ( 10 mg / kg ) , to increase 5 HT levels in hippocampus , was also not affected by chronic ECS . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
No changes were found after a single afterdischarge . 5 HT 4 receptors , which colocalize with 5 HT1A receptors on hippocampal neurons , were not modified in kindled tissue . [ 3H ] 5 HT uptake and its release as well as the 5 HT1B autoreceptor function did not differ from shams in hippocampal synaptosomes at stages 2 and 5 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The results of these studies can be summarized as follows : ( 1 ) chronic unpredictable stress produces high corticosteroid levels in rats ; ( 2 ) chronic stress also results in changes in specific 5 HT receptors ( increases in cortical 5 HT2A and decreases in hipocampal 5 HT1A and 5 HT1B ) ; ( 3 ) chronic antidepressant administration prevents many of the 5 HT receptor changes observed after stress ; and ( 4 ) chronic antidepressant administration reverses the overactivity of the HPA axis . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
This effect was mimicked by 5 HT1B agonists ( CP 93 , 129 and anpirtoline ) , but not by a 5 HT1A agonist ( 8 OH DPAT ) , indicating that 5 HT1B receptors mediate the inhibition of EPSCs . 4 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
This decrease may be explained by antagonism of inhibitory 5 HT1B / 1D receptors on raphe cell bodies , leading to a local increase in 5 HT , which , in turn , stimulated 5 HT1A receptors to decrease cell firing , and hence 5 HT release from terminals . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In conclusion , serotonergic caudal raphe neurons are spontaneously active in vitro ; they receive prominent glutamatergic synaptic inputs . 5 Hydroxytryptamine regulates serotonergic neuronal activity of the caudal raphe by decreasing spontaneous activity via somatodendritic 5 HT1A receptors and by inhibiting excitatory synaptic transmission onto these neurons via presynaptic 5 HT1B receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT 1 like receptors mediating inhibition of sympathetic vasopressor outflow in the pithed rat : operational correlation with the 5 HT1A , 5 HT1B and 5 HT1D subtypes . 1 . ^^^ Intravenous ( i . v . ) continuous infusions of 5 HT and the 5 HT 1 receptor agonists , 8 OH DPAT ( 5 HT1A ) , indorenate ( 5 HT1A ) , CP 93 , 129 ( 5 HT1B ) and sumatriptan ( 5 HT ( 1B / 1D ) ) , resulted in a dose dependent inhibition of sympathetically induced vasopressor responses . 3 . ^^^ The above results suggest that the 5 HT 1 like receptors , which inhibit the sympathetic vasopressor outflow in pithed rats , display the pharmacological profile of the 5 HT1A , 5 HT1B and 5 HT1D , but not that of 5 HT 7 , receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These studies thus confirm the potential for decreasing ethanol consumption and ethanol preference of 5 HT1A agonists and 5 HT 3 antagonists , but failed to find any selective effects for agents acting at 5 HT1B or 5 HT 2 receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Clonidine potentiates the effects of 5 HT1A , 5 HT1B and 5 HT2A / 2C antagonists and 8 OH DPAT in the mouse forced swimming test . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Alterations in the activity of the central 5 HT system are important in understanding the pathophysiology of depression , and therefore , we examined whether this model was associated with changes in the expression of 5 HT1A receptor , 5 HT1B receptor , and 5 HT transporter mRNA in the dorsal raphe nucleus and the hippocampus . ^^^ The expression of 5 HT transporter , 5 HT1A receptor , and 5 HT1B receptor mRNA was examined in the dorsal raphe nucleus and in the CA 1 of the hippocampus by means of quantitative in situ hybridisation histochemistry . ^^^ No changes in 5 HT1A receptor and 5 HT1B receptor mRNA expression were observed in any of the regions examined in these animals . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Removal of the endothelium did not change the response to 5 HT in the presence of the 5 HT ( 1B / D ) receptor antagonist GR 127935 and the 5 HT1A and 5 HT1B receptor antagonist pindolol . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These results demonstrate that , under the present experimental conditions , activation of central 5 HT1A , 5 HT1B , and 5 HT 2 receptors reduced ethanol intake and reinforced behaviour in an operant paradigm . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Although the serotonin agonists for the 5 HT1B , 2C , 3 receptors were ineffective , the effects were mimicked by the 5 HT1A receptor agonists ( 8 OH DPAT , 5 CT ) and prevented by the 5 HT1A receptor antagonist NAN 190 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Thus , the present data suggest that the comparable effects of SSRIs in DRN and MRN innervated forebrain regions are not explained by a preferential attenuation of 5 HT release by terminal 5 HT1B autoreceptors in hippocampus , an area with a low inhibitory influence of somatodendritic 5 HT1A receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In addition , serotonin appears to regulate the response of the SCN circadian clock to light through postsynaptic 5 HT1A or 5 ht 7 receptors , as well as presynaptic 5 HT1B heteroreceptors on RHT terminals . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Reverse transcriptase polymerase chain reaction ( RT PCR ) revealed expression of 5 HT1A , 5 HT1B , 5 HT1D , 5 HT1F , 5 HT2A , 5 HT2B , 5 HT2C , 5 HT5B , 5 HT 6 and 5 HT 7 receptor mRNAs in astrocytes derived from 2 day old rats and cultured for 10 12 days . ^^^ The functional expression of 5 HT 1 receptor subtypes was investigated by measuring the ability of 5 HT 1 receptor agonists : 8 OH DPAT ( 5 HT1A receptors ) , RU 24969 ( 5 HT1A , 5 HT1B , 5 HT1D , and 5 HT1F receptors ) or sumatriptan ( 5 HT1B , 5 HT1D , and 5 HT1F receptors ) to modulate forskolin or isoproterenol stimulated cAMP production . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effect of CP 94 , 253 was dose dependently blocked by the 5 HT1B / 1D receptor partial agonist 2 ' methyl 4 ' ( 5 methyl [ 1 , 2 , 4 ] oxadiazol 3 yl ) biphenyl 4 carboxylic acid [ 4 methodoxy 3 ( 4 methyl piperazin 1 yl ) phenyl ] amide ( GR 127 , 935 ) ( 0 . 3 10 mg / kg ) but was unaffected by the 5 HT1A receptor antagonist 4 iodo N [ 2 [ 4 ( methoxyphenyl ) 1 piperazinyl ] ethyl ] N 2 pyridinyl benzamide ( p MPPI ; 1 10 mg / kg ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Although 5 CT has a high affinity with 5 HT1A receptors , the 5 HT1A and 5 HT1B and beta receptor antagonist , ( ) popranolol , did not affect 5 CT induced hyperglycemia . ^^^ These results indicate that 5 CT induced hyperglycemia is elicited by facilitation of adrenaline release from the adrenal gland and that 5 CT induced hyperglycemia is mediated by the 5 HT 7 receptor unrelated to 5 HT1A , 5 HT1B , 5 HT 2 , 5 HT 3 , 5 HT 4 or 5 HT 5 receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Differential membrane targeting and pharmacological characterization of chimeras of rat serotonin 5 HT1A and 5 HT1B receptors expressed in epithelial LLC PK 1 cells . ^^^ The serotonin 5 HT1A and 5 HT1B receptors are two structurally related but pharmacologically distinguishable 5 HT receptor types . ^^^ In brain , the 5 HT1A receptor is localized on the soma and dendrites of neurons , whereas the 5 HT1B receptor is targeted to the axon terminals . ^^^ Further investigations on the mechanisms responsible for their differential targeting were done by constructing chimeras of 5 HT1A and 5 HT1B receptors still able to bind specifically [ 3H ] lysergic acid diethylamide and selective agonists and antagonists . ^^^ Further inclusion of the C terminal domain of the 5 HT1A receptor in their sequence led to a basolateral localization , whereas that of the 5 HT1B receptor allowed an apical targeting , suggesting the existence of a targeting signal in this portion of the receptor ( s ) . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Although 5 HT1A receptors are involved in controlling the activity of serotonergic neurons , 5 HT1A knockout mice had normal levels of 5 HT and 5 hydroxyindoleacetic acid , possibly because of an up regulation of 5 HT1B autoreceptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effects of 5 HT1A , 5 HT1B and 5 HT1D receptor agonists on trigeminal nociceptive neurotransmission in anaesthetized rats . ^^^ In contrast , the selective 5 HT1B receptor agonist , CP 93 , 129 ( 3 ( 1 , 2 , 5 , 6 tetrahydropyrid 4 yl ) pyrrolo [ 3 , 2 b ] pyrid 5 one ) , and the 5 HT1A receptor selective agonist 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) had no effect in this assay at up to 3 mg kg ( 1 ) , i . v . . ^^^ Brain penetrant , triptan 5 HT1B / 1D receptor agonists may therefore mediate their central trigeminal anti nociceptive action in the rat via 5 HT1D , but not 5 HT1B or 5 HT1A , receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Mutagenesis of the human 5 HT1B receptor : differences from the closely related 5 HT1A receptor and the role of residue F 331 in signal transduction . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Similar studies on human cloned receptors confirmed that xanomeline is an agonist at human cloned 5 HT1A and 5 HT1B receptors . ^^^ These studies indicate that xanomeline is a potent agonist at 5 HT1A and 5 HT1B receptors and an antagonist at 5 HT 2 receptor subtypes . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5 HT1A and 5 HT1B receptor agonists 8 OH DPAT and anpirtoline , as evidenced by use of the corresponding new and selective receptor antagonists NAD 299 and NAS 181 . 1 . ^^^ In the present study the role of 5 HT1A and 5 HT1B receptors in the mediation of male rat ejaculatory behaviour was examined by use of selective agonists and antagonists acting at these 5 HT receptor subtypes . 2 . ^^^ The present results demonstrate opposite effects , facilitation and inhibition , of male rat ejaculatory behaviour by stimulation of 5 HT1A and 5 HT1B receptors , respectively , suggesting that the SSRI induced inhibition of male ejaculatory dysfunction is due to 5 HT1B receptor stimulation . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The direct 5 HT1A / 1B agonist RU 24969 decreases PPI in wild type but not 5 HT1B knockout mice . ^^^ As the direct 5 HT1A agonist 8 OH DPAT increases PPI in mice , the unmasking of these effects may also contribute to the PPI increasing effects of 5 HT releasers in 5 HT1B knockout mice . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
RU 24969 , a 5 HT1A / 1B agonist , elevates brain stimulation reward thresholds : an effect reversed by GR 127935 , a 5 HT1B / 1D antagonist . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
However , 5 HT1A receptors , 5 HT1B receptors ( or both ) have been claimed to mediate this effect of RU 24969 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Differential addressing of 5 HT1A and 5 HT1B receptors in epithelial cells and neurons . ^^^ The 5 HT1A and 5 HT1B serotonin receptors are expressed in a variety of neurons in the central nervous system . ^^^ While the 5 HT1A receptor is found on somas and dendrites , the 5 HT1B receptor has been suggested to be localized predominantly on axon terminals . ^^^ In epithelial cells , 5 HT1A receptors are found on both apical and basolateral membranes while 5 HT1B receptors are found exclusively in intracellular vesicles . ^^^ Using 5 HT1A and 5 HT1B knockout mice and the binary tTA / tetO system , we generated mice expressing these receptors in striatal neurons . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Synergism between 5 HT1B / 1D and 5 HT1A receptor antagonists on turnover and release of 5 HT in guinea pig brain in vivo . ^^^ The effects on 5 HT turnover ( 5 HIAA / 5 HT ratio ) and extracellular 5 HT and 5 HIAA levels ( in vivo microdialysis in freely moving animals ) were analysed in guinea pig brains following the 5 HT1B receptor antagonist , GR 127935 [ N [ 4 methoxy 3 ( 4 methyl 1 piperazinyl ) phenyl ] 2 ' methyl 4 ' ( 5 methyl 1 , 2 , 4 oxadiazol 3 yl ) [ 1 , 1 biphenyl ] 4 carboxamide ] , or the 5 HT1A receptor antagonist , WAY 100635 ( N [ 2 [ 4 ( 2 methoxyphenyl ) 1 piperazinyl ] ethyl ] N ( 2 pyridinyl ) cyclohexanecarboxamide trihydrochloride ) , administered alone or in combination . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Their receptor binding profiles ( 5 HT1A , 5 HT1B ) and analgesic activity ( hot plate , acetic acid induced writhing ) have been studied . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Using a blinded methodology , animals were injected with normal saline , vehicle , or one of seven serotonin antagonists given at a dose that maintains serotonin receptor subtype specificity : WAY 100135 ( 5 HT1A ) , methiothepin mesylate ( 5 HT1B / 1D / 2 ) , mesulergine hydrochloride ( 5 HT2A / 2B ) , GR 127935 ( 5 HT1D ) , SR 46349 ( 5 HT 2 ) , ondansetron ( 5 HT 3 ) , or GR 125487 ( 5 HT 4 ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The selective 5 HT1A receptor antagonist ( + ) WAY 100135 , previously found to be an agonist at the h 5 HT1D heteroreceptor regulating glutamate release , could not interact with the h 5 HT1B autoreceptor when added at 1 microM . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In addition , pretreatment with GR 127935 , but not with the 5 HT1A antagonist WAY 100635 , prevented the effects of both 5 HT1B agonists . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Androgens and estrogens modulate 5 HT1A and 5 HT1B agonist effects on aggression . ^^^ Intermale offensive aggressive behavior is facilitated by gonadal steroids and inhibited by serotonin ( 5 HT ) , presumably through its effects at 5 HT1A and 5 HT1B receptor sites . ^^^ Two weeks later , they were given 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT , a 5 HT1A agonist ; 0 . 1 or 1 . 0 mg / kg ) , CGS12066B ( a 5 HT1B agonist ; 4 . 0 or 8 . 0 mg / kg ) , 0 . 1 or 1 . 0 mg / kg 8 OH DPAT + 4 . 0 mg / kg CGS12066B , or vehicle , and tested for aggression . ^^^ The results demonstrate differential effects of the steroidal environment on the ability of 5 HT1A and 5 HT1B agonists to modulate aggression , with estrogens producing a more restrictive environment than androgens for serotonergic inhibition of male typical aggressive behavior . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Perfusion with 5 carboxamidotryptamine , anpirtoline , pindobind 5 HT1A , and isamoltane demonstrated the involvement of 5 HT1A and 5 HT1B receptors in facilitating DA release . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In conclusion , the results of the present study suggest that lithium may be acting through 5 HT1B receptors , whereas the action of carbamazepine and sodium valproate seems to involve 5 HT1A receptors in the mouse forced swimming test . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Magnitude of 5 HT1B and 5 HT1A receptor activation in guinea pig and rat brain : evidence from sumatriptan dimer mediated [ 35S ] GTPgammaS binding responses . ^^^ The present study reports on G protein activation by recombinant 5 HT receptors and by native 5 HT1A and 5 HT1B receptors in guinea pig and rat brain using agonist stimulated [ 35S ] GTPgammaS binding responses mediated by a new 5 HT ligand , a dimer of sumatriptan . ^^^ Dimerization of sumatriptan increased the binding affinity for h 5 HT1B ( pKi : 9 . 22 vs . 7 . 79 for sumatriptan ) , h 5 HT1D ( 9 . 07 vs . 8 . 08 ) and also h 5 HT1A receptors ( 7 . 80 vs . 6 . 40 ) , while the binding affinity for h 5 ht1E ( 6 . 67 vs . 6 . 19 ) and h 5 ht1F ( 7 . 37 vs . 7 . 78 ) receptors was not affected . ^^^ In conclusion , the sumatriptan dimer stimulates G protein activation via 5 HT1B receptors besides 5 HT1A receptors in guinea pig and rat brain . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
RT PCR products corresponding to the human 5 HT2A , 5 HT1B and 5 HT1F receptors were expressed in high levels , mRNAs coding for 5 HT 7 , 5 HT1A and 5 HT1D receptors were only weakly expressed . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
F 11356 has subnanomolar affinity for cloned human and nonhuman 5 HT1B and 5 HT1D receptors , and its affinity for 5 HT1A and other 5 HT receptors , including the 5 ht1F subtype , is 50 fold lower and micromolar , respectively . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Identification and role of serotonin 5 HT1A and 5 HT1B receptors in primary cultures of rat embryonic rostral raphe nucleus neurons . ^^^ The presence of 5 HT1A and 5 HT1B receptors in serotoninergic neurons was assessed using binding assays . ^^^ The involvement of 5 HT1A and 5 HT1B receptors in the control of the synthesis and release of [ 3H ] 5 HT was studied using biochemical approaches with several serotoninergic receptor ligands . ^^^ A mean decrease of 30 % in [ 3H ] 5 HT synthesis and release was observed in the presence of 5 HT ( 10 ( 8 ) M ) , the 5 HT1A agonist 8 hydroxy 2 ( di n propylamino ) tetralin ( 8 OH DPAT ) , the 5HT1B / 1A agonist 5 methoxy 3 ( 1 , 2 , 5 , 6 tetrahydro 4 pyridinyl ) 1H indole ( RU 24969 ) , the 5 HT1B agonist 3 ( 1 , 2 , 5 , 6 tetrahydropyrid 4 yl ) pyrrolo [ 3 , 2 b ] pyrid 5 one ( CP 93 , 129 ) , and the 5 HT ( 1D / 1B ) agonist sumatriptan . ^^^ Paradoxically , extracellular levels of [ 3H ] 5 HT increased in the presence of 8 OH DPAT and RU 24969 at 10 ( 6 ) M . 5 HT uptake experiments showed that these two agonists interacted with the 5 HT transporter . 5 HT 1 binding sites ( 620 fmol / mg of protein ) and 5 HT1A ( 482 fmol / mg of protein ) and 5 HT1B ( 127 fmol / mg of protein ) receptors were detected in 12 day in vitro cell cultures . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
It is concluded that 5 HT1A , 5 HT2A+2C , and to a lesser extent 5 HT1B receptors , but not 5 HT 3 receptors are involved in the effects of serotonin agonists on ACTH secretion . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
RESULTS : By RT PCR , 5 HT1b , 5 HT2A and 5 HT2B mRNAs were detected in all of the 14 patients . 5 HT1A , 5 HT1D , and 5 HT1E mRNAs were detected in only some patients . ^^^ By ribonuclease protection assay , 5 HT1B and 5 HT2A signals were detected in all patients examined , but neither 5 HT1A , 5 HT1D nor 5 HT2B signal was detected in any patient . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Consistent with a previous report , 3 microM and not 100 nM pindolol was required to occupy fully 5 HT1A and 5 HT1B receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Differential coupling of serotonin 5 HT1A and 5 HT1B receptors to activation of ERK 2 and inhibition of adenylyl cyclase in transfected CHO cells . ^^^ We have sought to compare directly the coupling of 5 HT1A and 5 HT1B receptors to adenylyl cyclase and to the mitogen activated protein kinase ERK 2 ( extracellular signal regulated kinase 2 ) . ^^^ We found that 5 HT1B receptors couple better to activation of ERK 2 and inhibition of adenylyl cyclase than do 5 HT1A receptors . 5 HT stimulated a maximal fourfold increase in ERK 2 activity in nontransfected cells that express endogenous 5 HT1B receptors at a very low density and a maximal 13 fold increase in transfected cells expressing 230 fmol of 5 HT1B receptor / mg of membrane protein . ^^^ Similarly , 5 HT1A , but not 5 HT1B , receptors were found to cause significant inhibition of forskolin stimulated cyclic AMP accumulation only when expressed at high densities . ^^^ These findings demonstrate that although both 5 HT1A and 5 HT1B receptors have been shown to couple to G proteins of the Gi class , they exhibit differences in coupling to ERK 2 and adenylyl cyclase . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Their receptor binding profiles ( 5 HT1A , 5 HT1B ) and analgesic activity ( hot plate , acetic acid induced writhing ) have been studied . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effect of 5 HT was mimicked by the 5 HT 2 receptor agonist , alpha methyl 5 hydroxytryptamine ( alpha methyl 5 HT ) , but not by the 5 HT1A receptor agonist , ( + / ) 8 hydroxydipropylaminotetralin hydrobromide ( 8 OH DPAT ) , or the 5 HT1B agonist , CGS 12066A . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Actions of roxindole at recombinant human dopamine D 2 , D 3 and D 4 and serotonin 5 HT1A , 5 HT1B and 5 HT1D receptors . ^^^ The present study determined its affinity and agonist efficacy at recombinant human ( h ) dopamine hD 2 , hD 3 and hD 4 and serotonin ( 5 HT ) h 5 HT1A , h 5 HT1B and h 5 HT1D receptors . ^^^ D 2 or D 4 receptors and 5 HT1A vs . 5 HT1B or 5 HT1D receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Altered emotional states in knockout mice lacking 5 HT1A or 5 HT1B receptors . ^^^ Specifically , we have created mice that lack or express reduced levels of two serotonin receptors : 5 HT1A and 5 HT1B receptors . ^^^ As a result , the 5 HT1A and 5 HT1B receptors control the tone of the serotonergic system and mediate some of the postsynaptic effects of serotonin . ^^^ However , when analyzed in a number of behavioral paradigms , the 5 HT1A and 5 HT1B knockout mice display a number of contrasting phenotypes . ^^^ While the 5 HT1B knockout mice are more aggressive , more reactive , and less anxious than the wild types , the 5 HT1A knockouts are less reactive , more anxious , and possibly less aggressive than the wild types . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In addition , the drug has been shown to act preferentially on 5 HT1A and 5 HT1B receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The synthesized compounds were able to bind on some serotonin ( 5 HT1A , 5 HT2A ) and dopamine ( D 2 , D 3 ) receptors , while displaying poor or no affinity for 5 HT1B , 5 HT2C , 5 HT 3 , and 5 HT 4 subtypes . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Effect of reserpine on behavioural responses to agonists at 5 HT1A , 5 HT1B , 5 HT2A , and 5 HT2C receptor subtypes . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Modulation of dialysate levels of dopamine , noradrenaline , and serotonin ( 5 HT ) in the frontal cortex of freely moving rats by ( ) pindolol alone and in association with 5 HT reuptake inhibitors : comparative roles of beta adrenergic , 5 HT1A , and 5 HT1B receptors . ( ) Pindolol , which possesses significant affinity for 5 HT1A , 5 HT1B , and beta 1 / 2 adrenergic receptors ( AR ) s , dose dependently increased extracellular levels of dopamine ( DA ) and noradrenaline ( NAD ) versus 5 HT , in dialysates of the frontal cortex ( FCX ) , but not accumbens and striatum , of freely moving rats . ^^^ The selective 5 HT1A receptor antagonist , WAY 100 , 635 , slightly attenuated the ( ) pindolol induced increase in DA and NAD levels , while the selective 5 HT1B antagonist , SB 224 , 289 , was ineffective . ^^^ These data suggest that ( ) pindolol facilitates frontocortical dopaminergic ( and adrenergic ) transmission primarily by activation of beta 1 / 2 ARs and , to a lesser degree , by stimulation of 5 HT1A receptors , whereas 5 HT1B receptors are not involved . ( ) Pindolol potentiated the increase in FCX levels of 5 HT elicited by the 5 HT reuptake inhibitors , fluoxetine and duloxetine , and also enhanced their ability to elevate FCX levels of DA though not of NAD . ^^^ In conclusion , ( ) pindolol modulates , both alone and together with 5 HT reuptake inhibitors , dopaminergic , adrenergic , and serotonergic transmission in the FCX via a complex pattern of actions at beta 1 / 2 ARs , 5 HT1A , and 5 HT1B receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
It is concluded that the discriminatory stimulus properties of eltoprazine in the pigeon are mediated by 5 HT1A and 5 HT1B receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
There was a significant correlation between vasoconstrictor potency and 5 HT1B and 5 HT1D receptor affinity , but not with 5 HT1A , 5 ht1F or 5 HT 2 receptor affinity . 4 The 5 HT1B / 1D receptor antagonist GR 55562 ( 10 7 10 6 M ) inhibited the contractile responses to sumatriptan and 5 CT in a competitive manner with a pKB value for GR 55562 of 7 . 4 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Altogether , these data indicate that in the mouse , the firing of 5 HT neurons in the dorsal raphe nucleus is under both an inhibitory control through 5 HT1A receptors and an excitatory influence through 5 HT1B receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Likewise , the stimulation or blockade of presynaptic 5 HT1A , 5 HT1B , 5 HT ( 2A / 2C ) and 5 HT 3 receptors , postsynaptic 5 HT ( 2B / 2C ) and 5 HT 4 receptors and 5 HT uptake / transporter sites modulate these processes . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Enhancement of 5 HT1B and 5 HT1D receptor antagonist effects on extracellular 5 HT levels in the guinea pig brain following concurrent 5 HT1A or 5 HT re uptake site blockade . ^^^ The effects of selective serotonin re uptake inhibitor ( SSRI ) , paroxetine , and 5 HT1A , 5 HT1B and 5 HT1B / 1D receptor antagonists on in vivo extracellular 5 HT levels in the guinea pig frontal cortex and dorsal hippocampus were investigated using the technique of microdialysis . ^^^ The aim of the study was to further investigate the autoreceptor roles of the 5 HT1A , 5 HT1B and 5 HT1D receptors in the median vs dorsal raphe nuclei . ^^^ In the frontal cortex , 5 HT1A ( WAY 100635 , 1 mg / kg i . p . ) or 5 HT1B ( SB 224289 , 4 mg / kg i . p . ) receptor antagonists had no effect on extracellular levels of 5 HT , whilst the mixed 5 HT1B / 1D receptor antagonist ( GR 127935 , 0 . 3 mg / kg i . p ) produced a significant decrease in extracellular 5 HT levels . ^^^ In the dorsal hippocampus , whilst 5 HT1A receptor antagonism elicited by administration of WAY 100635 had no effect , both 5 HT1B and mixed 5 HT1B / 1D receptor blockade significantly increased extracellular 5 HT levels . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Because specific 5 HT1A , 5 HT1B , and AVP V1A binding sites were observed within the AH by in vitro autoradiography , the hamsters were tested for offensive aggression after microinjections of AVP in combination with either the 5 HT1A agonist 8 hydroxy 2 ( di n propylamino ) tetraline ( DPAT ) or the 5 HT1B agonist CGS 12066A ( CGS ) directly within the AH . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Serotonin and an agonist of 5 HT 3 receptor channels , 2 methyl 5HT , evoked Na+ influx , whereas the agonists of other serotonergic receptor subtypes , i . e . , 5 HT1A and 5 HT1B receptors , failed to induce Na+ influx in these cells . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
It is suggested that blockade of inhibitory 5 HT1A autoreceptors discloses inhibitory effects of the selective serotonin re uptake inhibitor citalopram on male rat ejaculatory behavior mediated via stimulation of 5 HT1B receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Converging evidence suggests that the administration of 5 HT2A / 2C or 5 HT 4 receptor agonists or 5 HT1A or 5 HT 3 and 5 HT1B receptor antagonists prevents memory impairment and facilitates learning in situations involving a high cognitive demand . ^^^ In contrast , antagonists for 5 HT2A / 2C and 5 HT 4 , or agonists for 5 HT1A or 5 HT 3 and 5 HT1B generally have opposite effects . ^^^ A better understanding of the role played by these and other serotonin receptor subtypes in learning and memory is likely to result from the recent availability of highly specific ligands , such as 5 HT1A , 5 HT1B , 5 HT2A receptor antagonists , and new molecular tools , such as gene knock out mice , especially inducible mice in which a specific genetic alteration can be restricted both temporally and anatomically . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Somatodendritic localization of 5 HT1A and preterminal axonal localization of 5 HT1B serotonin receptors in adult rat brain . ^^^ The 5 HT1A and 5 HT1B receptors of serotonin play important roles as auto and heteroreceptors controlling the release of serotonin itself and of other neurotransmitters / modulators in the central nervous system ( CNS ) . ^^^ To determine the precise localization of these receptors , we examined their respective cellular and subcellular distributions in the nucleus raphe dorsalis and hippocampal formation ( 5 HT1A ) and in the globus pallidus and substantia nigra ( 5 HT1B ) , using light and electron microscopic immunocytochemistry with specific antibodies . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Differential adaptation of brain 5 HT1A and 5 HT1B receptors and 5 HT transporter in rats treated chronically with fluoxetine . ^^^ Binding studies showed that this treatment affected neither 5 HT1A nor 5 HT1B binding sites in all brain areas examined . ^^^ However , a significant decrease ( 38 % ) in 5 HT1A mRNA levels in the anterior raphe area ( but not forebrain regions ) and increases in 5 HT1B mRNA levels in the striatum ( +127 % ) and the cerebral cortex ( +34 % ) were noted in fluoxetine treated rats . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
However , when constructed in the presence of WAY 100635 ( 10 nM ) the selective and silent 5 HT1A antagonist , there was a significant ( P < 0 . 001 ) rightward shift of the CP 93129 concentration response curve in the paroxetine treated rats but not in the controls , implying a desensitisation of the 5 HT1B autoreceptor by paroxetine . ^^^ These data suggest that chronic paroxetine treatment may desensitise 5 HT1B autoreceptors in the dorsal raphe nucleus but that this effect is unmasked only when the dominant 5 HT1A autoreceptor control is antagonised . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The suppressant actions of RU 24969 on amphetamine self administration and CR responding involve stimulation of 5 HT1B receptors , since they were reversed by the 5 HT1B / 1D antagonist GR 127935 ( 3 mg / kg ) , but not by the 5 HT1A antagonist WAY 100635 ( 1 mg / kg ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Altered expression and functions of serotonin 5 HT1A and 5 HT1B receptors in knock out mice lacking the 5 HT transporter . ^^^ Possible adaptive changes in 5 HT neurotransmission in knock out mice that do not express the 5 HT transporter were investigated with special focus on 5 HT1A and 5 HT1B receptors . ^^^ As expected from actions mediated by functional 5 HT1A and 5 HT1B autoreceptors , a decrease in brain 5 HT turnover rate after i . p . administration of ipsapirone ( a 5 HT1A agonist ) , and an increased 5 HT outflow in the substantia nigra upon local application of GR 127935 ( a 5 HT1B / 1D antagonist ) were observed in 5 HTT+ / + mice . ^^^ Such effects were not detected in 5 HTT / mice , further confirming the occurrence of marked alterations of 5 HT1A and 5 HT1B autoreceptors in these animals . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
USVs between 30 and 80 kHz , grid crossing , and rectal temperature were measured in separate groups of mouse pups following subcutaneous administration of 5 HT1A and 5 HT1B receptor agonists and antagonists , the neurosteroid allopregnanolone , or the benzodiazepine midazolam . ^^^ RESULTS : The 5 HT1A agonists ( + ) 8 OH DPAT ( 0 . 01 0 . 1 mg / kg ) and flesinoxan ( 0 . 3 1 . 0 mg / kg ) , the selective 5 HT1B agonist CP 94 , 253 ( 0 . 03 30 . 0 mg / kg ) , and the mixed 5 HT1B / 2C receptor agonist TFMPP ( 0 . 1 10 . 0 mg / kg ) dose dependently reduced USVs . ^^^ These effects were reversed by the 5 HT1A receptor antagonist WAY 100 , 635 ( 0 . 1 mg / kg ) or the 5 HT1B / D receptor antagonist GR 127935 ( 0 . 1 mg / kg ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Their receptor binding profiles ( 5 HT1A , 5 HT1B ) and analgesic activity ( hot plate , acetic acid induced writhing ) have been studied . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
First , our data are consistent with the primacy of 5 HT1A autoreceptors in restraining the elevation of 5 HT levels induced by SSRIs , whereas nerve terminal 5 HT1B autoreceptors appear to have an accessory role in this regard . ^^^ In particular , emerging data suggest that somatodendritic 5 HT1A autoreceptor and nerve terminal 5 HT1B autoreceptor mediated feedback may be relatively more important in the control of 5 HT output in dorsal raphe frontal cortex and median raphe dorsal hippocampus systems , respectively . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Their receptor binding profiles ( 5 HT1A , 5 HT1B , M 1 , M 2 , neuronal nicotinic receptor ) and analgesic activity ( hot plate , acetic acid induced writhing ) have been studied . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
It is hypothesized that the delayed maximal increase in extracellular 5 HT contents after fluoxetine treatment , due to negative feedback regulations induced by the activation of 5 HT1A and 5 HT1B autoreceptors , is not the primary cause for the delayed normalization of corticosteroid receptor numbers that regulates the HPA axis functioning . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Effects of serotonergic 5 HT1A and 5 HT1B ligands on ventral pallidal neuronal activity . ^^^ To clarify the role of the 5 HT system in limbic outputs , the present study compared the effects of the 5 HT1A agonist 8 OH DPAT and the 5 HT1B agonist CP 94253 with the non selective 5 HT agonist TFMPP on the firing rate of ventral pallidal ( VP ) neurons recorded in chloral hydrate anesthetized rats . 8 OH DPAT ( 0 . 25 256 microg / kg i . v . ) dose dependently enhanced ( 9 / 26 neurons ) or suppressed ( 8 / 26 ) activity , and the 5 HT1A antagonist ( + ) WAY 100135 often attenuated these responses . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Basal 5 HT levels , and the effects of challenges with the 5 HT1A receptor agonist 8 OH DPAT and the 5 HT1B antagonist GR 127935 on 5 HT levels were determined using in vivo microdialysis . ^^^ Rats which had undergone chronic rTMS showed reduced responses to both challenges , indicating subsensitivity of both the presynaptic 5 HT1A autoreceptors situated somatodendritically in the raphe nuclei and the 5 HT1B autoreceptors situated on nerve terminals . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
OBJECTIVE : Given reports that ( + / ) pindolol , a beta adrenergic 5 HT1A / 1B receptor antagonist , accelerates the onset of the therapeutic effect of certain antidepressant drugs in major depression , the aim of this study was to assess the effect of sustained ( + / ) pindolol administration on the sensitivity of pre and postsynaptic 5 HT1A receptors , terminal 5 HT1B autoreceptors and on overall 5 HT neurotransmission . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT1A receptor agonist 8 OH DPAT ( 0 . 01 to 1 microM ) and the 5 HT1B receptor agonist CGS 12066A ( 0 . 01 to 1 microM ) inhibited the electrically stimulated [ 3H ] serotonin and [ 3H ] GABA release . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Their receptor binding profiles ( 5 HT1A , 5 HT1B ) and analgesic activity ( hot plate , acetic acid induced writhing ) have been studied . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Results showed that the 5 HT releaser d fenfluramine , the selective serotonin reuptake inhibitor fluoxetine , the 5 HT1A receptor agonist 8 hydroxy 2 [ di n propylamino ] tetralin , the partial 5 HT1A receptor agonist buspirone , and the 5 HT1B / 5 HT2C receptor agonist 1 ( 3 trifluoromethylphenyl ) piperazine , but not the 5 HT2A / 5 HT2C receptor agonist 1 ( 2 , 5 dimethoxy 4 iodophenylaminopropane ) 2 , selectively reduced responding on a lever leading to presentation of an ethanol paired conditioned stimulus . ^^^ Results are consistent with involvement of the dopaminergic and 5 HT systems , in particular activation of 5 HT1A and 5 HT1B receptor subtypes , in mediation of the conditioned or secondary reinforcing properties of ethanol . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In the presence of ketanserin , 5 HT decreased the discharge rate ; a similar effect was observed when the 5 HT1A receptor agonist 8 OH DPAT or the 5 HT1B receptor agonist CGS 12066B was applied . ^^^ The inhibitory effects can be attributed to activation of 5 HT1A and 5 HT1B receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Intrathecal administration of a 5 HT1A receptor agonist , 8 hydroxy 2 ( di n propylamino ) tetraline ( 8 OH DPAT ; 1 , 10 , and 30 microg ) , or a 5 HT1B receptor agonist , 1 , 4 dihydro 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridinyl ) 5H pyrrol ( 3 , 2 b ) pyridin 5 one ( CP 93129 ; 1 and 10 microg ) , produced no significant change in the number of flinches . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Regional changes in density of serotonin transporter in the brain of 5 HT1A and 5 HT1B knockout mice , and of serotonin innervation in the 5 HT1B knockout . 5 HT1A knockout ( KO ) mice display an anxious like phenotype , whereas 5 HT1B KOs are over aggressive . ^^^ To identify serotoninergic correlates of these altered behaviors , autoradiographic measurements of 5 HT1A and 5 HT1B serotonin ( 5 HT ) receptors and transporter ( 5 HTT ) were obtained using the radioligands [ 3H ] 8 OH DPAT , [ 125I ] cyanopindolol and [ 3H ] citalopram , respectively . ^^^ By comparison to wild type , density of 5 HT1B receptors was unchanged throughout brain in 5 HT1A KOs , and that of 5 HT1A receptors in 5 HT1B KOs . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In addition , the 5 HT1A receptor antagonist WAY 100635 ( 0 . 3 , 1 mg / kg ) and the 5 HT1B receptor antagonists GR 127935 ( 1 , 2 mg / kg ) and SB 224289 ( 2 10 mg / kg ) did not affect d fenfluramine induced hypophagia . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Region specific decrease in 5 HT1A and 5 HT1B binding sites after intra hippocampal ibotenic acid injections in the rat . ^^^ The cellular location of 5 HT1A and 5 HT1B binding sites in the hippocampus was investigated using a stereotaxic unilateral lesion of the CA 1 field by ibotenic acid , followed by autoradiography on brain sections with the specific ligands [ 3H ] 8 OH DPAT and S CM G [ 125I ] TNH 2 , respectively . ^^^ As compared to the contralateral side of the lesion , the ipsilateral side exhibited a decrease in the density of 5 HT1A binding sites in the strata oriens and radiatum of CA 1 , and of 5 HT1B binding sites in the dorsal subiculum and stratum oriens of CA 1 . ^^^ The results demonstrate that 5 HT1A binding sites are located on dendrites whereas 5 HT1B binding sites are located on axon terminals of CA 1 pyramidal cells . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effect of CP 93 , 129 was prevented by SB 224289 , but not by WAY 100635 , selective 5 HT1B and 5 HT1A receptor antagonists , respectively . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The results are discussed in the context of an increase in the effectiveness of postsynaptic 5 HT 1A and 5 HT 1B receptors and a decrease in the effectiveness of presynaptic 5 HT 1A ( somatodendritic ) and 5 HT 1B ( terminal ) receptors following adaptation to stress . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Behavioural , electrophysiological and microdialysis studies have shown that serotonin ( 5 HT ) receptors , mainly 5 HT1A , 5 HT1B and 5 HT2C sub types , exert a key role in modulating antidepressant activity . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Recent advances in understanding the role of 5 HT in parkinsonism and the generation of side effects of dopamine replacement therapy ( e . g . wearing off and levodopa induced dyskinesia ) have identified 5 HT1A , 5 HT1B and 5 HT2C receptors as potential therapeutic targets in Parkinson ' s disease . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These changes were associated with marked increases in the levels of mRNAs encoding the serotonin transporter , the 5 HT1A and 5 HT1B receptors and the BDNF receptor tyrosine kinase B ( TrkB ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Coactivation of purinergic ( P 2Y ) receptors reduces agonist efficacy at serotonin 1B ( 5 HT 1B ) , but not 5 HT 1A receptors . ^^^ Herein , we report that pretreatment for 5 min with the P 2Y receptor agonist ATP reduced agonist responsiveness at the 5 HT 1A , but not at the 5 HT 1B , receptor . ^^^ ATP pretreatment blocked the inhibitory effect produced by 5 HT 2C receptor activation on the 5 HT 1A , but not the 5 HT 1B , receptor response , suggesting that the 5 HT 1A receptor itself was the target for PLD / PKC action . ^^^ Moreover , this work underscores the importance of time as a variable in receptor signaling cross talk and serves to further illustrate differences between the 5 HT 1A and 5 HT 1B receptor systems . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The influence of the pre and postweaning maternal environment on the offspring ' s phenotype was examined in 5 HT1A and 5 HT1B receptor knockout mice ( KO1A and KO1B , respectively ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
We have now used autoradiographic receptor binding techniques to determine the location of 5 HT1A and 5 HT1B binding sites in the laminated optic tectum . 5 HT1A binding sites , as labeled with [ 3H ] 8 hydroxy dipropylaminotetralin ( 8 OH DPAT ) , were highest in the superficial , retinorecipient layers of the tectum , intermediate in layers 6 and 7 and low in the remaining layers . ^^^ We conclude that both 5 HT1A and 5 HT1B receptors are present in the adult frog tectum and that changes in their activation levels can produce changes in retinotectal transmission levels that drive visual plasticity in opposite directions . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Central administration of 5 HT agonists specific to 5 HT1A , 5 HT1B , 5 HT2A or 5 HT2C receptors increased CRH mRNA in the PVN by 15 50 % , POMC mRNA in the anterior pituitary by 15 27 % and ACTH secretion three to five fold , whereas a specific 5 HT 3 agonist had no effect . ^^^ It is concluded that 5 HT via activation of 5 HT1A , 5 HT2A , 5 HT2C and possibly also 5 HT1B receptors increases the synthesis of CRH in the PVN and POMC in the anterior pituitary lobe , which results in increased ACTH secretion . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Intracerebroventricular infusion of 5 HT agonists selective for the 5 HT1A , 5 HT1B , 5 HT2A and 5 HT2C receptor increased oxytocin mRNA in the SON and PVN . ^^^ We conclude that stimulation with 5 hydroxytryptophan or 5 HT agonists increases mRNA expression of oxytocin in the PVN and the SON via stimulation of at least 5 HT1A , 5 HT1B , 5 HT2A and 5 HT2C receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
RESULTS : Citalopram induced LA was dose dependently attenuated by the 5 HT1B / 1D receptor antagonists , S 18127 , GR 125 , 743 and GR 127 , 935 , and by the selective 5 HT1B antagonist , SB 224 , 289 , but unaffected by the selective 5 HT1A antagonist , WAY 100 , 635 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Operant learning and differential reinforcement of low rate 36 s responding in 5 HT1A and 5 HT1B receptor knockout mice . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The differential effects of food restriction on 5 HT1A and 5 HT1B receptor mediated control of serotonergic transmission in the hippocampus and hypothalamus of rats . ^^^ We recorded basal 5 HT release in the hypothalamus and hippocampus , and the sensitivity of the somatodendritic 5 HT1A autoreceptors in the raphe nuclei , and the nerve terminal 5 HT1B autoreceptors which together regulate the synthesis and release of 5 HT in these regions . ^^^ Sensitivity of the somatodendritic 5 HT1A autoreceptors was assessed by measuring the reduction in extracellular 5 HT induced by systemic administration of the 5 HT1A receptor agonist 8 hydroxy 2 di n ( propylamino ) tetralin ( 8 OH DPAT ) , while sensitivity of nerve terminal 5 HT1B autoreceptors was measured by observing the increase in 5 HT release after systemic injection of the 5 HT1B receptor antagonist GR 127935 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Systemic administration of the mixed 5 HT1B / 1D receptor antagonist GR 127935 ( 4 mg / kg ) in chronically treated wild type mice potentiated the effect of a paroxetine challenge dose on [ 5 HT ] ext in the ventral hippocampus , whereas systemic administration of the selective 5 HT1A receptor antagonist WAY 100635 did not . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The serotonin activity in the brainstem is primarily under the control of 5 HT1A somatodendritic receptors , although some data also suggest the involvement of 5 HT1B receptors . ^^^ METHODS : The effects of acetaminophen ( 600 mg / kg intraperitoneal ) followed by different doses of antagonists ( WAY 100635 [ 0 . 2 0 . 8 mg / kg subcutaneous ] and SB 216641 [ 0 . 2 0 . 8 mg / kg subcutaneous ] ) or agonists ( 8 OH DPAT [ 0 . 25 1 mg / kg subcutaneous ] and CP 93129 [ 0 . 125 0 . 5 mg / kg subcutaneous ] ) of 5 HT1A and 5 HT1B receptors , respectively , were determined in the hot plate test in mice . ^^^ CONCLUSIONS : These results suggest that the combination of acetaminophen with compounds having 5 HT1A and 5 HT1B antagonist properties could be a new strategy to improve the analgesia of acetaminophen , thanks to its mild serotonergic properties . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
HT 1A / 1B receptor mediated effects of the selective serotonin reuptake inhibitor , citalopram , on sleep : studies in 5 HT 1A and 5 HT 1B knockout mice . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In vivo microdialysis in conscious rats was used to evaluate the effect of 5 HT1A agonist ( + / ) 8 hydroxy 2 ( n dipropylamino ) tetralin ( 8 OH DPAT ) , 5 HT2A / 2C agonist ( + / ) 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane ( DOI ) and 5 HT1B receptor agonist 3 ( 1 , 2 , 5 , 6 tetrahydropyrid 4 yl ) pyrrolo [ 3 , 2 b ] pyrid 5 one ( CP 93129 ) on the veratridine evoked glutamate ( Glu ) and aspartate ( Asp ) release in the rat prefrontal cortex . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In this paper , studies focusing on anxiety using 5 HT1A receptor knockout ( 1AKO ) and 5 HT1B receptor knockout ( 1BKO ) mice are reviewed . 1AKO mice on different genetic background strains have initially been described as more anxious . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
While the A 1 adenosine receptor does not distinguish between Gi1alpha and Gtalpha sequences , the 5 HT1A and 5 HT1B serotonin and M 2 muscarinic receptors can couple with Gi 1 but not Gt . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
These data demonstrate that raphe pallidus inputs to hypoglossal motoneurones are predominantly glutamatergic in nature , with 5 HT decreasing the release of glutamate from these projections as a result of activation of 5 HT1A and / or 5 HT1B receptors located on presynaptic terminals . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Recently , the excessive aggressive and impulsive traits of neuronal NO synthase knockout ( nNOS / ) mice were shown to be caused by reductions in serotonin ( 5 HT ) turnover and deficient 5 HT1A and 5 HT1B receptor function in brain regions regulating emotion . ^^^ The consistently high levels of aggression observed in nNOS / mice could be reversed by 5 HT precursors and by treatment with specific 5 HT1A and 5 HT1B receptor agonists . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Effects of combined administration of 5 HT1A and / or 5 HT1B receptor antagonists and paroxetine or fluoxetine in the forced swimming test in rats . ^^^ Clinical data suggest that coadministration of pindolol , a 5 HT1A / 5 HT1B / beta adrenoceptor antagonist , and selective serotonin reuptake inhibitors ( SSRIs ) may shorten the time of onset of a clinical action and may increase beneficial effects of the therapy of drug resistant depression . ^^^ The aim of the present study was to investigate effects of a 5 HT1A antagonist ( WAY 100635 ) , 5 HT1B antagonists ( SB 216641 and GR 127935 ) or pindolol , given in combination with paroxetine or fluoxetine ( SSRIs ) , in the forced swimming test in rats ( Porsolt test ) . ^^^ The obtained results seem to indicate that blockade of 5 HT1B receptors , but not 5 HT1A ones , can facilitate the antidepressant like effect of paroxetine in the forced swimming test in rats . ^^^ No interaction was observed between fluoxetine and 5 HT1A / 5 HT1B receptor antagonists . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The role of 5 HT1A and 5 HT1B receptors in entrainment function was studied in Otsuka Long Evans Tokushima fatty ( OLETF ) rats and control Long Evans Tokushima Otsuka ( LETO ) rats . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Acceleration of onset of action in schedule induced polydipsia : combinations of SSRI and 5 HT1A and 5 HT1B receptor antagonists . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Serotonin 5 HT1A , 5 HT1B , and 5 HT2A receptor mRNA expression in subjects with major depression , bipolar disorder , and schizophrenia . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Chronic fluoxetine induced desensitization of 5 HT1A and 5 HT1B autoreceptors : regional differences and effects of WAY 100635 . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The 5 HT1A , 5 HT1B , and 5 HT 2 receptor subtypes were chosen for their implication in depression and their location in / or next to these regions . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
We also investigated GR 46611 ( 3 [ 3 ( 2 dimethylaminoethyl ) 1H indol 5 yl ] N ( 4 methoxybenzyl ) acrylamide ) , which has agonist activity predominantly at 5 HT1B and 5 HT1D receptors but also at the 5 HT1A receptor . ^^^ Both 5 HT1A and 5 HT1B / 1D agonists may offer a promising means of reducing bladder hyperactivity and increasing bladder capacity in patients with chronic SCI . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Co infusion of the 5 HT1B receptor antagonist SB 216641 ( 10 microM ) , but not the 5 HT1A receptor antagonist WAY 100635 ( 10 microM ) or the 5 HT1D / 1A receptor antagonist BRL 15572 ( 10 microM ) , antagonized not only the effects of intra tegmental CP 93129 ( 80 microM ) on VTA DA and NAC DA but also on VTA GABA . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In pharmacological bioassays on isolated ring shaped auricle preparations of Sepia officinalis , the action of the specific 5 hydroxytryptamine ( 5 HT ) agonists 8 OH DPAT ( 5 HT1a ) , CP 93129 ( 5 HT1b ) , TFMPP ( 5 HT1b ) and RS 67333 ( 5 HT 4 ) on these autonomously contractile compartments was studied . 8 OH DPAT and CP 93129 induced mainly positive effects on frequency and tone on the isotonically suspended auricles . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In radioligand binding experiments , urgosedin had significant binding affinities on alpha1 / alpha2 , 5 HT1A , 5 HT1B and 5 HT2A receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Expression of the mRNAs of the 5 hydroxytryptamine ( 5 HT ) receptors ( 5 HT1A , 5 HT1B , and 5 HT2C ) , which have been suggested to be involved in the ejaculation process , were examined by semiquantitative reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Effects of triiodothyronine and fluoxetine on 5 HT1A and 5 HT1B autoreceptor activity in rat brain : regional differences . ^^^ Fluoxetine alone induced a trend towards desensitization of 5 HT1A autoreceptors as shown by a reduction in the effect of 8 OH DPAT to lower 5 HT levels in frontal cortex , and desensitized 5 HT1B autoreceptors in frontal cortex . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Thirteen kilobases of DNA including the complete coding regions of 5 HT1A , 5 HT1B , and 5 HT 2 were sequenced in 216 highly inbred lines extracted from two North American populations in California and North Carolina . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The anticonvulsant action of both SKF 99101 ( 15 mg kg ( 1 ) i . p . ) and RU 24969 ( 2 . 5 mg kg ( 1 ) i . p . ) was dose dependently abolished by the selective 5 HT1B receptor antagonist SB 224289 ( 0 . 1 3 mg kg ( 1 ) p . o . , 3 h pretest ) but was unaffected by the selective 5 HT1A receptor antagonist WAY 100635 ( 0 . 01 0 . 3 mg kg ( 1 ) s . c . , 1 h pretest ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Because 5 HT dysregulation is associated with several common psychiatric disorders , the potential for epistasis among genetic variants in the 5 HT transporter ( SERT ) , 5 HT1B terminal autoreceptor and the 5 HT1A somatodendritic autoreceptor should be examined . ^^^ Parameters representing extracellular 5 HT clearance rates ( SERT ) , 5 HT release levels ( 5 HT1B ) and inhibitory thresholds ( the amount of extracellular 5 HT above which cell firing is inhibited , an indication of 5 HT1A autoreceptor sensitivity ) were varied to simulate genetic deletion ( i . e . knockout ) of each component singly , and in combination . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Male Swiss mice were acutely administered HG 1 at active doses in association with GABA antagonists such as flumazenil , bicuculline and picrotoxine , then , with 5 HT1A ( NAN 190 , WAY 100635 ) and 5 HT1B receptor antagonist ( methiothepine ) . ^^^ Finally , we tried to potentiate non active doses of HG 1 with 5 HT1A ( 8 OHDPAT ) and 5 HT1B receptor agonists ( anpirtoline ) in the mouse elevated plus maze . ^^^ HG 1 mechanism of action in the mouse elevated plus maze seems to associate a GABA ergic component exerting a limited regulation of 5 HT neuronal activity and a major serotonergic component , which seems to implicate presynaptic 5 HT1A and 5 HT1B receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Several doses of the 5 HT receptor agonists 8 hydroxy 2 ( di n propylamino ) tetraline ( 8 OH DPAT , 5 HT1A ) , 1 , 4 dihydro 3 ( 1 , 2 , 3 , 6 tetrahydro 4 pyridinyl ) 5H pyrrolo [ 3 , 2 b ] pyridin 5 one dihydrochloride ( CP 93129 , 5 HT1B ) , alpha methyl 5 hydroxytryptamine maleate ( m 5 HT , 5 HT 2 ) , 1 ( 2 , 5 dimethoxy 4 iodophenyl ) 2 aminopropane ( DOI , 5 HT2C ) , and 1 ( m chlorophenyl ) biguanide ( 5 HT 3 ) were subsequently infused via the microdialysis probe . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Role of 5 HT1A and 5 HT1B receptors in the hypophagic effect of 5 HT on the structure of feeding behavior . ^^^ In order to reveal the involvement of 5 HT1A and 5 HT1B receptors in the paraventricular nucleus of the hypothalamus ( PVN ) on serotonin induced hypophagia , we examined the effects of intra PVN injections of serotonin in WAY 100635 or SB 216641 pretreated rats on the structure of feeding behavior . ^^^ Blockade of 5 HT1A or 5 HT1B receptors in the paraventricular nucleus was effected by WAY 100635 ( 2 microg ) or SB 216641 ( 2 microg ) pretreatment ; ten minutes later , 5 HT ( 2 microg ) was applied into the same nucleus , then food intake and meal patterns were measured in a 30 minute period . ^^^ CONCLUSIONS : The hypophagic effect induced by 5 HT requires activation of 5 HT1A and 5 HT1B receptors , and the specific contribution of these subtype receptors is different , since the 5 HT1A subtype showed higher behavioral selectivity . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Wheel running alters serotonin ( 5 HT ) transporter , 5 HT1A , 5 HT1B , and alpha 1b adrenergic receptor mRNA in the rat raphe nuclei . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Role of 5 HT1A and 5 HT1B receptors in the antinociceptive effect of tramadol . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In contrast , MDMA induced generalised anxiety , as measured by the emergence test , seems unlikely to involve the 5 HT 1A , 5 HT 1B or 5 HT 2A , 5 HT 2B or 5 HT 2C receptors . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The template was N substituted to give a series of compounds showing binding to human cloned 5 HT1A , 5 HT1B and 5 HT1D receptors with pKi ' s greater than 9 and selectivities up to 1000 fold against other serotonin , dopamine and adrenergic receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
This is made evident after administration of 5 HT ( 2A / 2C ) , and 5 HT 4 receptor agonists , or 5 HT1A , 5 HT 3 and probably 5 HT1B receptor antagonists . ^^^ A better understanding of the role played in cognition by these and other serotonin receptor subtypes is likely to result from the recent availability of highly specific ligands such as 5 HT1A , 5 HT1B , and 5 HT2A receptor antagonists , and new molecular tools such as gene knock out mice , especially inducible mice for which the genetic alteration can be restricted both temporally and anatomically . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Stimulation of the lateral hypothalamus produces antinociception mediated by 5 HT1A , 5 HT1B and 5 HT 3 receptors in the rat spinal cord dorsal horn . ^^^ Intrathecal injections of the selective 5 HT1A , 5 HT1B , 5 HT 3 receptor antagonists , WAY 100135 , SB 224289 , and tropisetron , respectively , and the non specific antagonist methysergide , were given . ^^^ These results suggest that the lateral hypothalamus modifies nociception in part by activating spinally projecting serotonin neurons that act at 5 HT1A , 5 HT1B , and 5 HT 3 receptors in the dorsal horn . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effects of 5 HT were mimicked by 5 carboxamidotryptamine ( a 5 HT 1 receptor agonist ) and L 694 247 ( a selective 5 HT1D receptor agonist ) , but not by 8 hydroxy 2 dipropylaminotetralin ( a 5 HT1A receptor agonist ) , CGS 12066B ( a 5 HT1B receptor agonist ) , alpha methyl 5 HT ( a 5 HT 2 receptor agonist ) , 1 ( 3 chlorophenyl ) piperazine ( a 5 HT2C receptor agonist ) or 1 phenylbiguanide ( a 5 HT 3 receptor agonist ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
In particular , phenotypic changes in mice bearing inactivation mutations of 5 HT1A and 5 HT1B receptors , 5 HT transporter , 5 HT neuron specific transcription factor Pet 1 , monoamine oxidase A and genes related to 5 HT signalling will be discussed and major findings highlighted . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
For this purpose , we used antibodies for the 5 HT1A , 5 HT1B , 5 HT2A , 5 HT2C and 5 HT 3 receptors , and for the 5 HT transporter , as well as antibodies for cytokeratin 20 ( as a marker of Merkel cells ) and neurofilament H ( a marker of type 1 sensory nerve terminals ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Finally , the results of studies using DRL behavior highlight important roles for central beta 1 adrenergic receptors , as well as 5 HT1A , 5 HT1B , 5 HT2A , and 5 HT2C receptors , in the mediation of antidepressant like behavioral effects . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The ( postsynaptic ) 5 HT1B and to a lesser extent , the 5 HT1A receptor seems to play a prominent role , at least in rodents , in the modulation of ( offensive ) aggression . . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Synthesis and SAR of highly potent dual 5 HT1A and 5 HT1B antagonists as potential antidepressant drugs . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Measurement of 5 HT1A autoreceptors in the median raphe and 5 HT1B receptors in the SCN also showed no effect of LL . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
PROCEDURE : Amounts of mRNA coding for 7 subtypes of 5 HTRs ( 5 HT1A , 5 HT1B , 5 HT1D , 5 HT1F , 5 HT2A , 5 HT2B , and 5 HT 4 ) were measured by quantitative real time reverse transcriptase PCR assay . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
The effects of T 3 , alone and together with the SSRI fluoxetine , on mRNA levels for the 5 HT1A and 5 HT1B autoreceptors , which mediate serotonergic neurotransmission by feedback actions at the levels of cell firing ( somatodendritic 5 HT1A autoreceptors ) and neurotransmitter release ( nerve terminal 5 HT1B autoreceptors ) were also determined . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
At one end of a spectrum is combination therapies that maintain the benefits associated with SSRIs but attempt to either improve efficacy or reduce side effects by adding additional mechanisms ( 5 HT1A , 5 HT1B , 5 HT1D , 5 HT2C , alpha 2A ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Pretreatment with the 5 HT ( 2C / 2B ) antagonist SB 206553 , but not with the 5 HT1A antagonist WAY 100635 , the 5 HT1B antagonist SB 224289 or the 5 HT 3 antagonist Y 25130 inhibited the fluoxetine induced increase in escape behaviour and the associated elevated LC Fos response . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
SB 649915 , a novel , potent 5 HT1A and 5 HT1B autoreceptor antagonist and 5 HT re uptake inhibitor in native tissue . ^^^ It has been proven that selective serotonin re uptake inhibitors are effective antidepressants but the delay to therapeutic onset of these agents is thought to be due to the time required for 5 HT1A , and possibly 5 HT1B , autoreceptor desensitisation . ^^^ Therefore an agent incorporating 5 HT re uptake inhibition coupled with 5 HT1A and / or 5 HT1B autoreceptor antagonism may provide a fast acting clinical agent . ^^^ The current studies describe the in vitro profile of SB 649915 ( 6 [ ( 1 { 2 [ ( 2 methylquinolin 5 yl ) oxy ] ethyl } piperidin 4 yl ) methyl ] 2H 1 , 4 benzoxazin 3 ( 4H ) one ) , a novel compound which has high affinity for human recombinant 5 HT1A , 5 HT1B and 5 HT1D receptors ( pKi values of 8 . 6 , 8 . 0 , 8 . 8 , respectively ) and the human recombinant 5 HT transporter ( pKi value of 9 . 3 ) . ^^^ SB 649915 also displays high affinity for rat , guinea pig , mouse and marmoset native tissue 5 HT1A , 5 HT1B and 5 HT1D receptors and rat native tissue 5 HT transporters ( pKi values > or=7 . 5 ) . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
One tube RT PCR was performed using primers specific for human 5 HT1A , 5 HT1B , 5 HT1E , 5 HT2A , 5 HT2B , 5 HT2C , 5 HT 3 , 5 HT 4 , 5 HT 6 , and 5 HT 7 receptors . ^^^ Both PHA stimulated human and monkey PBMCs express mRNAs for 5 HT1A , 5 HT1B , 5 HT1E , 5 HT2A , 5 HT 3 , 5 HT 4 , 5 HT 6 receptor types / subtypes . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Among 5 HT 1 receptors , the 5 HT1A receptor transcript is expressed densely in E14 . 5 16 . 5 thalamus , in hippocampus , and in a medial to lateral gradient in cortex , whereas the 5 HT1B receptor mRNA is expressed in more lateral parts of the dorsal thalamus and in the striatum at these ages . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Most previous studies of suicide have analyzed polymorphisms of the receptors 5 HT1A , 5 HT1B , 5 HT2A , fewer have examined 5 HT1F . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Quantitative mapping of tryptophan hydroxylase 2 , 5 HT1A , 5 HT1B , and serotonin transporter expression across the anteroposterior axis of the rat dorsal and median raphe nuclei . ^^^ To foster uniform definitions of locations within these nuclei , we have quantitatively mapped gene expression in DRN and MRN for tryptophan hydroxylase 2 ( Tph 2 ) , the serotonin transporter , as well as 5 HT1A and 5 HT1B receptors . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Genes regulating the synthesis ( TPH ) , storage ( VMAT 2 ) , membrane uptake ( HTT ) , and metabolism ( MAOA ) of 5 HT , as well as a number of 5 HT receptors ( HTR1A , HTR1B , HTR2A , HTR2C , and HTR5A ) , have been studied and this initial research is reviewed here . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
Single nucleotide polymorphisms ( SNPs ) in five serotonin receptor genes ( HTR1A , HTR1B , HTR2A , HTR2C and HTR 6 ) and the 5 HT transporter linked polymorphic region ( 5 HTTLPR ) were genotyped . ^^^
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA
Interacting proteins: P28222 and P08908	Pubmed	SVM Score :0.0
NA