| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :1.3288987 |
| Terminal differentiation of lactotroph cells and direct regulation of the prolactin gene both require interactions between Pit 1 and cell type specific partners , including panpituitary transcriptional regulators such as Pitx 1 and Pitx 2 . 1.3288987^^^ |
|
| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :0.0 |
| P OTX : a PIT 1 interacting homeodomain factor expressed during anterior pituitary gland development . ^^^ P OTX is able to independently activate and to synergize with Pit 1 on pituitary specific target gene promoters . ^^^ |
|
| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :0.0 |
| The pan pituitary activator of transcription , Ptx 1 ( pituitary homeobox 1 ) , acts in synergy with SF 1 and Pit 1 and is an upstream regulator of the Lim homeodomain gene Lim3 / Lhx3 . ^^^ Indeed , in the somatolactotrope lineage , synergism between Ptx 1 and Pit 1 is observed on the PRL promoter , and strong synergism between Ptx 1 and SF 1 is observed in gonadotrope cells on the betaLH promoter but not on the alphaGSU ( glycoprotein hormone alpha subunit gene ) and betaFSH promoters . ^^^ |
|
| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :0.0 |
| A number of transcription factors evidenced in the pituitary may play a part in the development of this gland , namely Pit 1 , Prop 1 , P Lim , Ptx 1 , Rpx , Dax 1 , SF 1 . ^^^ |
|
| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :0.0 |
| In particular , Ptx 1 contributes to promoter and lineage specific transcription by interaction with cell restricted factors such as SF 1 , Egr 1 , Pit 1 , and the basic helix loop helix heterodimer NeuroD1 / Pan1 . ^^^ Also like Ptx 1 , the Ptx1b , Ptx2a , and Ptx2b transcription factors synergize with the structurally unrelated factors SF 1 , Egr 1 , Pit 1 , and NeuroD1 / Pan1 to activate promoter specific transcription . ^^^ |
|
| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :0.0 |
| There is no typical TATA or CAAT but a GC box and putative binding sites for several transcription factors including Pit 1 and pituitary homeobox 1 ( Ptx 1 ) . ^^^ |
|
| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :0.0 |
| Pitx 1 mutants have a mild pituitary phenotype , but Pitx 2 is necessary for the development of Rathke ' s pouch , expression of essential transcription factors in gonadotropes , and expansion of the Pit 1 lineage . ^^^ |
|
| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :0.0 |
| The 5 ' flanking region of the POC gene contains two TATA boxes , a CCAAT box , eight E boxes , STAT , RAIE , and one binding site each for Ptx 1 , Pit 1 , and Tpit . ^^^ |
|
| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :0.0 |
| The HESX 1 , PITX 1 , PITX 2 , PROP 1 and POU1F1 genes are of particular interest because of their recognized or potential associations with human disease . ^^^ |
|
| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28069 and P78337 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :1.3288987 |
| Terminal differentiation of lactotroph cells and direct regulation of the prolactin gene both require interactions between Pit 1 and cell type specific partners , including panpituitary transcriptional regulators such as Pitx 1 and Pitx 2 . 1.3288987^^^ |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :0.0 |
| The pan pituitary activator of transcription , Ptx 1 ( pituitary homeobox 1 ) , acts in synergy with SF 1 and Pit 1 and is an upstream regulator of the Lim homeodomain gene Lim3 / Lhx3 . ^^^ |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :0.0 |
| There is no typical TATA or CAAT but a GC box and putative binding sites for several transcription factors including Pit 1 and pituitary homeobox 1 ( Ptx 1 ) . ^^^ |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :0.0 |
| P OTX : a PIT 1 interacting homeodomain factor expressed during anterior pituitary gland development . ^^^ P OTX is able to independently activate and to synergize with Pit 1 on pituitary specific target gene promoters . ^^^ |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :0.0 |
| A number of transcription factors evidenced in the pituitary may play a part in the development of this gland , namely Pit 1 , Prop 1 , P Lim , Ptx 1 , Rpx , Dax 1 , SF 1 . ^^^ |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :0.0 |
| The HESX 1 , PITX 1 , PITX 2 , PROP 1 and POU1F1 genes are of particular interest because of their recognized or potential associations with human disease . ^^^ |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :0.0 |
| In particular , Ptx 1 contributes to promoter and lineage specific transcription by interaction with cell restricted factors such as SF 1 , Egr 1 , Pit 1 , and the basic helix loop helix heterodimer NeuroD1 / Pan1 . ^^^ Also like Ptx 1 , the Ptx1b , Ptx2a , and Ptx2b transcription factors synergize with the structurally unrelated factors SF 1 , Egr 1 , Pit 1 , and NeuroD1 / Pan1 to activate promoter specific transcription . ^^^ |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :0.0 |
| Pitx 1 mutants have a mild pituitary phenotype , but Pitx 2 is necessary for the development of Rathke ' s pouch , expression of essential transcription factors in gonadotropes , and expansion of the Pit 1 lineage . ^^^ |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :0.0 |
| The 5 ' flanking region of the POC gene contains two TATA boxes , a CCAAT box , eight E boxes , STAT , RAIE , and one binding site each for Ptx 1 , Pit 1 , and Tpit . ^^^ |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78337 and P28069 |
Pubmed |
SVM Score :0.0 |
| NA |
|