| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :1.151426 |
| Finally , recombinant GHF 1 interacted directly with c Jun but not c Fos proteins . 1.151426^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| Transcription factors containing a different type of TAD ( e . g . , GHF 1 , estrogen receptor , or serum response factor ) fail to inhibit Jun activity , suggesting that these proteins act through a different mechanism . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| However , within this segment we noted the presence of two AP 1 , Sp 1 , and cAMP responsive element ( CRE ) sequences , an interferon consensus sequence ( ICS ) , and three POU proteins ( e . g . , GHF 1 ) binding elements . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| By contrast , the PMA and forskolin dependent activation of the rGH promoter by Pit 1 expression was comparatively insignificant unless 1 ) the sequences deleted from the pUC vector ( including a putative site for the transcription factor AP 1 ) were restored to the plasmid carrying the rGH promoter ; or 2 ) the T3R was coexpressed , which led to a marked synergistic response . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| We show by gel shift and Southwestern experiments that fragment A binds Pit 1 monomer and also a ubiquitous factor that is neither cAMP responsive element binding protein nor activator protein 1 . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| DNase 1 footprinting assays revealed that eight DNA motifs of this distal region bound protein Pit 1 and that two other motifs were recognized by ubiquitous factors , one of which seems to belong to the AP 1 ( jun ) family . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| These include , among others , sites for PEA 3 , AP 1 , and Pit 1 . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| A surprisingly high proportion of other transcription factors tested , AP 1 ( c Fos / c Jun ) , Pit 1 , Oct 1 , CP1a and b , c Myc , ATF / CREB , AP 2 and AP 3 but not Sp 1 , were similarly cleaved by m calpain to produce specific partial digestion products . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| Within the 5 ' flanking region , a number of potential cis acting elements were identified , including 2 Pit 1 binding sites , 15 E box motifs , and near perfect matches for AP 1 and AP 2 sites . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| The 1 . 8 kb 5 ' flanking sequence contains an SF 1 site , an AP 1 site , CCAAT sequences , a Pit 1 binding site , and a potential CRE like sequence . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| The levels of Pit 1 , GH , cJun and cFos mRNAs were examined using the reverse transcription polymerase chain reaction . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| Specific antibodies were used to confirm that the OA induced complex is related to AP 1 and to show that it contains JunD and c fos , but not Pit 1 . ^^^ Transient transfection experiments showed that both AP 1 and Pit 1 are involved in the regulation of basal and OA stimulated promoter activity . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| Three nuclear transcriptional factors , AP 1 , CREB , and Pit 1 , which are targets of protein kinase C and A , appear to play critical roles in both neoplastic growth and hormone secretion in hormone producing adenomas . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| Several regulatory sequences for various hormones and other regulatory factors were identified , including PEA 3 , AP 1 , AP 2 , and Pit 1 sites . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| Growth factors such as epidermal growth factor ( EGF ) and insulin regulate development and metabolism via genes containing both POU homeodomain ( Pit 1 ) and phorbol ester ( AP 1 ) response elements . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| Luciferase reporter gene assays in transiently transfected mouse ATDC 5 chondrocytes and human SaOS 2 osteoblasts indicated that the activity of the mouse Pit 1 promoter depends on several cis acting elements , including ATF / CREB , Sp 1 and AP 1 sites , an E box and a TATA box . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| The promoter region contained several putative binding sites for transcriptional factors including pituitary specific transcription factor ( Pit 1 ) , activator protein 1 ( AP 1 ) , and specificity protein ( Sp 1 ) , but no typical TATA or CAAT box . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| Comparison of the 5 ' flanking region of the ibis TSHbeta gene with those of mammals reveals that several regulatory sequences , such as negative thyroid hormone responsive element ( nTRE ) , Pit 1 responsive element , and AP 1 responsive element , which were characterized in mammalian TSHbeta genes , are also found in the promoter region . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| The binding sites for CREB , Pit 1 , and AP 1 were found upstream of all three Pem CHH genes . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| EGF stimulates Pit 1 independent transcription of the human prolactin pituitary promoter in human breast cancer SK BR 3 cells through its proximal AP 1 response element . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| RCC arising in end stage kidneys was pT 1 and 5 of these cases showed increased c Jun activation . ^^^ |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28069 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|