Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q9Y5K6 and P27986	Pubmed	SVM Score :0.0
We demonstrate that both nephrin and CD2AP interact with the p 85 regulatory subunit of phosphoinositide 3 OH kinase ( PI3K ) in vivo , recruit PI3K to the plasma membrane , and , together with podocin , stimulate PI3K dependent AKT signaling in podocytes . ^^^ Our findings reveal a novel role for the slit diaphragm proteins nephrin , CD2AP , and podocin and demonstrate that these three proteins , in addition to their structural functions , initiate PI3K / AKT dependent signal transduction in glomerular podocytes . . ^^^
Interacting proteins: Q9Y5K6 and P27986	Pubmed	SVM Score :0.0
CD2AP was required for early activation of anti apoptotic phosphatidylinositol 3 kinase ( PI3K ) / AKT and extracellular signal regulated kinase 1 / 2 by TGF beta . ^^^ CD2AP was not required for PI3K / AKT activation by insulin and epidermal growth factor , indicating that CD2AP is a selective mediator of anti apoptotic TGF beta signaling . ^^^