| Interacting proteins: Q99490 and P27986 |
Pubmed |
SVM Score :0.0 |
| Here , we investigated two further Pi3k / Akt pathway genes , namely PIK3CA ( 3q26 . 3 ) and phosphatidylinositol 3 kinase enhancer ( PIKE ) ( CENTG 1 , 12q14 ) , for genetic alteration and aberrant expression in a series of 97 primary glioblastomas . ^^^ |
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| Interacting proteins: Q99490 and P27986 |
Pubmed |
SVM Score :0.0 |
| A novel protein , PIKE ( PI3Kinase Enhancer ) , interacts with nuclear PI3K to stimulate its lipid kinase activity . ^^^ Dominant negative PIKE prevents the NGF enhancement of PI3K and upregulation of cyclin D 1 . ^^^ Overexpression of 4 . 1N abolishes PIKE effects on PI3K . ^^^ Activation of nuclear PI3K by PIKE is inhibited by the NGF stimulated 4 . 1N translocation to the nucleus . ^^^ Thus , PIKE physiologically modulates the activation by NGF of nuclear PI3K . . ^^^ |
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| Interacting proteins: Q99490 and P27986 |
Pubmed |
SVM Score :0.0 |
| Recently published results from Snyder and colleagues describe the ability of PLC gamma to facilitate guanine nucleotide exchange for the recently identified nucleus localized GTPase PIKE , which acts to enhance the enzymatic activity of phosphatidylinositol 3 ' kinase ( PI3K ) . ^^^ |
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| Interacting proteins: Q99490 and P27986 |
Pubmed |
SVM Score :0.0 |
| Here we show that nuclear PI3K and its upstream regulator PIKE mediate the antiapoptotic activity of nerve growth factor ( NGF ) in the isolated nuclei . ^^^ Nuclei from constitutively active PI3K adenovirus infected cells display the same resistance as those treated by NGF , whereas PI3K inhibitors , dominant negative PI3K or PIKE abolishes it . ^^^ Knockdown of either PI3K or PIKE diminishes the antiapoptotic activity of NGF . ^^^ These results demonstrate that PIKE / nuclear PI3K signaling through nuclear PI ( 3 , 4 , 5 ) P 3 and Akt plays an essential role in promoting cell survival . . ^^^ |
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| Interacting proteins: Q99490 and P27986 |
Pubmed |
SVM Score :0.0 |
| Even though PI PLCbeta 1 is present and does not translocate to eukaryotic nuclei , this organelle , even though only in some conditions contains also PI PLCgamma 1 which acts not only as a PI PLC but also as guanine nucleotide exchange factor ( GEF ) for PI 3 kinase enhancer ( PIKE ) and is somehow linked to PI 3 kinase ( PI3K ) activity . ^^^ |
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| Interacting proteins: Q99490 and P27986 |
Pubmed |
SVM Score :0.0 |
| PI 3 kinase enhancer ( PIKE ) is a nuclear GTPase that enhances PI 3 kinase ( PI3K ) activity . ^^^ Surprisingly , nuclei from 30 min NGF treated PC 12 cells are resistant to DNA fragmentation initiated by the activated cell free apoptosome , and both PIKE and nuclear PI3K are sufficient and necessary for this effect . ^^^ Thus , PI ( 3 , 4 , 5 ) P3 / B23 complex and nuclear Akt effectors might coordinately mediate PIKE / nuclear PI3K signaling in promoting cell survival by NGF . . ^^^ |
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| Interacting proteins: Q99490 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q99490 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q99490 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
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