| Interacting proteins: Q6ZUJ8 and P27986 |
Pubmed |
SVM Score :0.0 |
| Here , we report the identification of a novel B cell adaptor for phosphoinositide 3 kinase ( PI3K ) , termed BCAP . ^^^ Tyrosine phosphorylation of BCAP is mediated by Syk and Btk , thereby providing binding site ( s ) for the p 85 subunit of PI3K . ^^^ Moreover , recruitment of PI3K to glycolipid enriched microdomains ( GEMs ) is significantly attenuated in the absence of BCAP . ^^^ Hence , these data suggest that BCAP bridges BCR associated kinases to the PI3K pathway by regulating PI3K localization . . ^^^ |
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| Interacting proteins: Q6ZUJ8 and P27986 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of BCAP , mediated by Lyn , provides binding site ( s ) for phosphoinositide 3 kinase ( PI3K ) , thereby participating in Akt activation . ^^^ Thus , these results provide evidence that BCAP serves as an adaptor molecule for CD 19 to activate the PI3K pathway in B cells . . ^^^ |
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| Interacting proteins: Q6ZUJ8 and P27986 |
Pubmed |
SVM Score :0.0 |
| BCAP was recently cloned as a binding molecule to phosphoinositide 3 kinase ( PI3K ) . ^^^ |
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| Interacting proteins: Q6ZUJ8 and P27986 |
Pubmed |
SVM Score :0.0 |
| Under our conditions , hydrogen peroxide induced PI3K and Akt activation was independent of Lyn , Syk , Cbl , BCAP , or Ras when each was eliminated individually either by mutation or by a specific inhibitor . ^^^ |
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