| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| Inhibition of dystroglycan binding to laminin disrupts the PI3K / AKT pathway and survival signaling in muscle cells . ^^^ |
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| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| These results suggest that alpha ( 1 ) adrenoceptor mediated activation of MAPK involves a PTX sensitive G protein , PLC , PI3K , and 1 , 2 diacyl glycerol ( DAG ) dependent PKC isozyme . ^^^ |
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| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| In these cells TNFalpha triggered phosphoinositide 3 kinase ( PI3K ) dependent PC hydrolysis within 4 8 min with concomitant production of both diacylglycerol ( DAG ) and phosphocholine ( P chol ) . ^^^ PC PLC stimulation was followed by PI3K independent PLD activation with concomitant phosphatidic acid ( PA ) production followed by PA derived DAG accumulation and sustained nuclear factor kappaB ( NF kappaB ) activation . ^^^ |
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| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| These changes include : ( 1 ) activation of phosphatidylinositol 3 kinase ( PI3K ) and production of PIP 3 ; ( 2 ) PIP 3 dependent activation of atypical protein kinase Cs ( PKCs ) ; ( 3 ) PIP 3 dependent activation of PKB ; ( 4 ) PI3K dependent activation of phospholipase D and hydrolysis of phosphatidylcholine with subsequent increases in phosphatidic acid ( PA ) and diacylglycerol ( DAG ) ; ( 5 ) PI3K independent activation of glycerol 3 phosphate acylytansferase and increases in de novo synthesis of PA and DAG ; and ( 6 ) activation of DAG sensitive PKCs . ^^^ Recent findings suggest that atypical PKCs and PKB serve as important positive regulators of insulin stimulated glucose metabolism , whereas mechanisms that result in the activation of DAG sensitive PKCs serve mainly as negative regulators of insulin signaling through PI3K . ^^^ |
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| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| Moreover , the xanthogenate compound D 609 that inhibits DNR induced phosphatidylcholine ( PC ) hydrolysis and subsequent diacylglycerol ( DAG ) production , as well as wortmannin that blocks phosphoinositide 3 kinase ( PI3K ) stimulation , only partially inhibited Raf 1 and ERK 1 stimulation . ^^^ Altogether , these results demonstrate that DNR activates the classical Raf 1 / MEK / ERK pathway and that Raf 1 activation is mediated through complex signaling pathways that involve at least 2 contributors : PC derived DAG and PI3K products that converge toward PKCzeta . ^^^ |
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| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| The early DAG production seems to be due to PI breakdown , probably through phosphatidyl inositol 3 kinase ( PI3K ) involvement , whereas the delayed DAG increase is derived directly from the PC PLC activity . ^^^ |
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| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| Non PKC DAG / phorbol ester receptor ( s ) inhibit complement receptor 3 and nPKC inhibit scavenger receptor AI / II mediated myelin phagocytosis but cPKC , PI3k , and PLCgamma activate myelin phagocytosis by both . ^^^ |
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| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14118 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|