| Interacting proteins: Q13191 and P27986 |
Pubmed |
SVM Score :0.0 |
| Proteolysis independent regulation of PI3K by Cbl b mediated ubiquitination in T cells . ^^^ The p 85 regulatory subunit of phosphatidylinositol 3 kinase ( PI3K ) was identified as a substrate for Cbl b . ^^^ The enhanced activation of Cbl b ( / ) T cells was suppressed by the inhibition of PI3K . ^^^ |
|
| Interacting proteins: Q13191 and P27986 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of the regulatory subunit of the phosphatidylinositol 3 kinase ( PI3K ) , p 85 , is apparently normal then , yet this protein fails to partition to the lipid raft fraction , and this is associated with stable expression of its negative regulator Cbl b . ^^^ Thus , by interaction with lipid rafts , MV contact initially targets recruitment of PI3K by preventing stimulated Cbl b degradation and activation of PI3K dependent signaling components . . ^^^ |
|
| Interacting proteins: Q13191 and P27986 |
Pubmed |
SVM Score :0.0 |
| T cell to T cell clustering enhances NF kappaB activity by a PI3K signal mediated by Cbl b and Rho . ^^^ Over expression of a dominant negative form of Cbl b , an endogenous inhibitor of PI3K , in unclustered cells rescued NF kappaB activation to the same levels caused by cell clustering . ^^^ |
|
| Interacting proteins: Q13191 and P27986 |
Pubmed |
SVM Score :0.0 |
| Denervation decreased the amounts of insulin receptor substrate 1 ( IRS 1 ) , phosphatidly inositol 3 phosphate kinase ( PI3K ) , and Akt 1 proteins in femora of Cbl b ( + / + ) mice , whereas the amounts of these IGF 1 signaling molecules in femora of Cbl b ( / ) mice were constant after denervation . ^^^ |
|
| Interacting proteins: Q13191 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|