| Interacting proteins: P62070 and P27986 |
Pubmed |
SVM Score :0.0 |
| In this study , we determined that TC 21 interacts strongly with some ( RalGDS , RGL , RGL2 / Rlf , AF 6 , and the phosphatidylinositol 3 kinase ( PI3K ) catalytic subunit p110delta ) , and weakly with other Ras small middle dotGTP binding proteins . ^^^ We then examined if RalGDS , a RalA guanine nucleotide exchange factor , or PI3K are effectors for TC 21 mediated signaling and cell proliferation in murine fibroblasts . ^^^ In contrast , like Ras , expression of activated TC 21 resulted in membrane translocation and an increase in the PI3K dependent phosphorylation of Akt , and inhibition of PI3K activity interfered with TC 21 focus formation . ^^^ Finally , unlike Ras , TC 21 did not activate the Rac small GTPase , indicating that Ras may not activate Rac by PI3K . ^^^ |
|
| Interacting proteins: P62070 and P27986 |
Pubmed |
SVM Score :0.0 |
| In microcystin transformed cells , PI3K , MAPKAPK 2 , Akt , cyclin D 1 and cyclin D 3 in the Akt pathway ; IQGAP 2 , RabGTPase , Rap1GAP , RasGAP , R Ras , Krev 1 and TC 21 of the Ras GTP / GDP protein family ; and A Raf , B Raf and PAK in the Ras / MAPK pathway were all markedly upregulated . ^^^ |
|
| Interacting proteins: P62070 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P62070 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P62070 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|