| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.55943704 |
| The interaction between Cas and p 85 PI3K appears to be driven primarily by Src dependent tyrosine phosphorylation of Cas , and mapping studies indicate that the carboxyl terminus of Cas is necessary and sufficient for binding to p 85 PI3K . 0.55943704^^^ |
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| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| The pro survival effects detected in serum starved GD25beta1A cells were due to direct , PI3K mediated stimulation of PKB / Akt activity by beta 1 integrins and induced p130Cas and paxillin phosphorylation . ^^^ |
|
| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| Additionally , the beta 1 integrin downstream targets p130Cas and paxillin impaired survival regulating PI3K dependent JNK . ^^^ In A 172 glioma cells , beta 1 integrin knockdown and PI3K inhibition confirmed the central role of beta 1 integrins in Akt and p130Cas / paxillin mediated prosurvival signaling . ^^^ |
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| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| Together , these results strongly suggest that PI3K binding is required for FAK to promote cell migration and that the binding of Src and p 130 ( Cas ) to FAK may not be sufficient for this event . . ^^^ |
|
| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| Here we show that gelsolin coprecipitates some of the focal adhesion associated proteins such as c Src , phosphoinositide 3 kinase ( PI3K ) , p 130 ( Cas ) , focal adhesion kinase , integrin alpha ( 5 ) beta ( 3 ) , vinculin , talin , and paxillin . ^^^ |
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| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| While IGF 1 induced activation of IRS 1 , Shc , PI3K , and MAPK pathways was unaffected , IGF 1 inducible beta 1 integrin associated kinase activity and association of Crk with p 130 ( CAS ) were significantly inhibited by RACK 1 overexpression . ^^^ |
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| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| R Ras effector domain mutants and pharmacological inhibition suggest a partial role for phosphatidylinositol 3 kinase ( PI3K ) , but not Raf , in R Ras signaling to FAK and p 130 ( Cas ) . ^^^ |
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| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| Using Sertoli germ cells cocultured in vitro to study the regulation of AJ assembly , it was shown that this event associated with a transient induction of beta 1 integrin , vinculin , p FAK Tyr ( 397 ) , and phosphatidylinositol 3 kinase ( PI3K ) but not the nonphosphorylated form of focal adhesion kinase ( FAK ) , paxillin , and p 130 Cas . ^^^ When rats were treated with 1 ( 2 , 4 dichlorobenzyl ) indazole 3 carbohydrazide ( AF 2364 ) to perturb Sertoli germ cell AJs , an induction of beta 1 integrin , vinculin , p FAK Tyr ( 397 ) , PI3K , and p 130 Cas but not the nonphosphorylated form of FAK and paxillin was also detected in the testis , coinciding with the time spermatids began to deplete from the epithelium , indicating their involvement in AJ disassembly . ^^^ Thereafter , the levels of vinculin , p FAK Tyr ( 397 ) , PI3K , and p 130 Cas in the testis plunged , coinciding with the declining events of AJ disruption when virtually all spermatids were depleted from the epithelium . ^^^ In summary , the events of AJ dynamics in the testis , in particular at the site of ES , are regulated , at least in part , by proteins that are found in the FAC in other epithelia , such as beta 1 integrin , vinculin , and FAK utilizing the integrin / pFAK / PI3K / p130 Cas signaling pathway . . ^^^ |
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| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| CAS phosphorylation , as well as phosphatidylinositol 3 kinase ( PI3K ) activation resulting from its binding to the FAK Tyr 397 site , have been implicated as downstream FAK signaling events that confer a resistance to apoptosis . ^^^ |
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| Interacting proteins: P56945 and P27986 |
Pubmed |
SVM Score :0.0 |
| In some contexts , steroid receptors interact directly with c Src and other cytoplasmic signaling molecules , such as Shc , PI3K , and p 130 Cas . ^^^ |
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