| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| It interacts with SH 2 containing proteins such as phosphatidylinositol 3 ' kinase ( PI3K ) , Grb 2 , Crk 2 , and CrkL . ^^^ |
|
| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| HGF stimulated Gab 1 association with c Met , Grb 2 , SHP 2 , PI3K , Shc , Crk isoforms and CrkL , but not with PLCgamma 1 . ^^^ |
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| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| These data suggest that BCR / ABL may induce the formation of multimeric complexes of signaling proteins which include p120CBL , PI3K , c CRK or CRKL , c ABL and BCR / ABL itself . . ^^^ |
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| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| Because p 85 ( PI3K ) is known to bind to the activated c Kit receptor , the possibility that CRKL interacted with c Kit indirectly through p 85 ( PI3K ) was investigated . ^^^ Far Western blotting with a CRKL SH 3 glutathione S transferase fusion protein showed that CRKL binds directly to p 85 ( PI3K ) in vitro . ^^^ However , although a small amount of CRKL was preassociated with p 85 ( PI3K ) , the interaction was increased after SF stimulation , suggesting that the interactions of these three proteins are complex . ^^^ We conclude that SF induces the formation of a signaling complex potentially containing CRKL and p 120 ( CBL ) , both of which bind to c Kit through p 85 ( PI3K ) . ^^^ These data suggest that one function of CRKL in normal cells might be to recruit signaling molecules such as CBL into a complex with PI3K . ^^^ |
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| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| Upon treatment with CGP 57148 , CRKL , a specific substrate for BCR ABL that propagates signals via phosphatidylinositol 3 ' kinase ( PI3K ) , was dephosphorylated , indicating inhibition of BCR ABL tyrosine kinase at the cellular level . ^^^ |
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| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| SHIP 1 was found to form a novel signaling complex with BCR / ABL that includes DOK 1 ( p 62 ( DOK ) ) , phosphatidylinositol 3 kinase ( PI3K ) , and CRKL , each of which has been previously shown to regulate migration in diverse cell types . ^^^ PI3K was likely linked to this complex by CRKL . ^^^ |
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| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| Gab 2 becomes tyrosine phosphorylated in response to a variety of growth factors and forms multimolecular complexes with SH 2 domain containing signaling molecules such as the p 85 regulatory subunit of the phosphoinositide 3 kinase ( p 85 PI3K ) , the tyrosine phosphatase SHP 2 and the adapter protein CrkL . ^^^ Using this assay , we demonstrated that p97 / Gab2 specifically interacts with the SH 2 domains of PI3K , SHP 2 and CrkL . ^^^ |
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| Interacting proteins: P46109 and P27986 |
Pubmed |
SVM Score :0.0 |
| Furthermore , cross linking of alpha4beta1 induced activation of the Rho family small GTPase Rac , which was enhanced by induced overexpression of CrkL and was inhibited by the phosphatidylinositol 3 ( ' ) kinase ( PI3K ) inhibitor LY 294002 . ^^^ These results implicate CrkL in PI3K dependent activation of Rac by outside in signaling from alpha4beta1 and suggest that adhesion through alpha4beta1 further activates cytokine receptor associated Jak 2 to induce phosphorylation of these receptors . . ^^^ |
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