| Interacting proteins: P46108 and P27986 |
Pubmed |
SVM Score :0.0 |
| It is rapidly tyrosine phosphorylated and associates with Crk ( L ) and p 85 phosphatidylinositol 3 kinase ( PI3K ) upon engagement of numerous receptors linked to tyrosine kinases . ^^^ We demonstrate that 70Z Cbl shows increased basal and activation induced tyrosine phosphorylation and association with Crk ( L ) and p 85 PI3K in Jurkat T cells . 70Z Cbl , however , retains the ability to enhance NFAT and activating protein 1 ( AP 1 ) activity in the absence of Crk ( L ) / p85 PI3K association . ^^^ We conclude that 70Z Cbl induced NFAT / AP1 activation requires the phosphotyrosine binding domain but not Crk ( L ) / p85 PI3K association . ^^^ |
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| Interacting proteins: P46108 and P27986 |
Pubmed |
SVM Score :0.0 |
| While IGF 1 induced activation of IRS 1 , Shc , PI3K , and MAPK pathways was unaffected , IGF 1 inducible beta 1 integrin associated kinase activity and association of Crk with p 130 ( CAS ) were significantly inhibited by RACK 1 overexpression . ^^^ |
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| Interacting proteins: P46108 and P27986 |
Pubmed |
SVM Score :0.0 |
| We have also used these adipocytes to see if IRS 1 and IRS 2 are required for activation of Cbl , which is required for insulin stimulated glucose transport and has been found to function upstream of both PI3K / aPKC and Crk during thiazolidinedione action in 3T3 / L1 adipocytes [ Miura et al . ( 2003 ) Biochemistry 42 , 14335 ] . ^^^ |
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| Interacting proteins: P46108 and P27986 |
Pubmed |
SVM Score :0.0 |
| The designed peptides exhibit a significant increase in the quantum yield of the long wavelength fluorescence emission band ( 596 nm ) upon binding to selected SH 2 domains ( e . g . , Crk SH 2 , Abl SH 2 , and PI3K SH 2 ) . ^^^ |
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| Interacting proteins: P46108 and P27986 |
Pubmed |
SVM Score :0.0 |
| HGF stimulated Gab 1 association with c Met , Grb 2 , SHP 2 , PI3K , Shc , Crk isoforms and CrkL , but not with PLCgamma 1 . ^^^ |
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| Interacting proteins: P46108 and P27986 |
Pubmed |
SVM Score :0.0 |
| It interacts with SH 2 containing proteins such as phosphatidylinositol 3 ' kinase ( PI3K ) , Grb 2 , Crk 2 , and CrkL . ^^^ |
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| Interacting proteins: P46108 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46108 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46108 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46108 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46108 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46108 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|