| Basal and insulin modulated NET activities were reduced by the tyrosine kinase inhibitor genistein and the PI3K inhibitors wortmannin and LY 294002 , but not by the PKC inhibitor staurosporine . ^^^ Effects of tyrosine kinase and PI3K inhibitors on basal NET uptake appear to arise from a loss of cell surface NET protein , whereas the p 38 MAPK dependent enhancement of NE transport occurs without a detectable enhancement of surface NET . ^^^ |