| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| We now demonstrate that GLP 2 , in a cycloheximide insensitive manner , enhanced survival in baby hamster kidney cells stably transfected with the rat GLP 2R ; reduced mitochondrial cytochrome c efflux ; and attenuated the caspase dependent cleavage of Akt , poly ( ADP ribose ) polymerase , and beta catenin following inhibition of phosphatidylinositol 3 kinase ( PI3K ) by LY 294002 . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| Interestingly , a strong association of p85alpha and p110alpha subunits of PI3K with beta catenin is induced in V12Ras expressing keratinocytes , and in vitro binding assays show a direct interaction between beta catenin and p85alpha . ^^^ These results indicate that H Ras activation induces the relocalization and cytoplasmic stabilization of beta catenin by a mechanism involving its interaction with PI3K . . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| Moreover , we show that the repression of AR activity by LY 294002 is mediated through phosphorylation and inactivation of GSK3beta , a downstream substrate of PI3K / Akt , which results in the nuclear accumulation of beta catenin . ^^^ Given the recent evidence that beta catenin acts as a coactivator of AR , our findings suggest a novel mechanism by which PI3K / Akt modulates androgen signaling . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| Therefore , we hypothesized that BCR engagement would induce the accumulation of beta catenin via a PI3K / Akt / GSK 3 pathway . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| PI3K dependent induction of cyclin D 1 was blocked by inhibitors of PI3K / Akt / IkappaB / IKKalpha or beta catenin signaling . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| MDA 7 negatively regulates the beta catenin and PI3K signaling pathways in breast and lung tumor cells . mda 7 is a novel tumor suppressor with cytokine properties . ^^^ Microarray analyses implicated both the beta catenin and the PI3K signaling pathways . ^^^ Ad mda 7 treatment increased protein expression from tumor suppressor genes , including E cadherin , APC , GSK 3beta , and PTEN , and decreased expression of proto oncogenes involved in beta catenin and PI3K signaling . ^^^ Thus , in breast and lung tumor cells MDA 7 protein expression modulates cell cell adhesion and intracellular signaling via coordinate regulation of the beta catenin and PI3K pathways . . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| In androgen deprived LNCaP cells , TNF alpha and TRAIL stimulated the cell growth and activated the mitogenic and antiapoptotic signaling pathways involving NF kappa B , STAT 3 , PI3K , and beta catenin . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| Here we show that EBV LMP2A activates the PI3K and beta catenin signaling pathways in telomerase immortalized human foreskin keratinocytes ( HFK ) . ^^^ The cytoplasmic accumulation of beta catenin downstream of LMP2A was independent of PI3K signaling , whereas its nuclear translocation was dependent on PI3K signaling . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| Activation of PI3K can affect the activity of beta catenin , the target of the wnt signaling pathway . ^^^ Neither the cytoplasmic accumulation of beta catenin nor the nuclear inactivation of GSK3beta was affected by the inhibition of PI3K signaling . ^^^ These data indicate that latent infection with EBV has unique effects on beta catenin signaling that are distinct from activation of wnt and independent of its effects on PI3K . . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| When the phosphatidylinositol 3 kinase ( PI3K ) / Akt pathway was inhibited by wortmannin , DEX no longer inhibited beta catenin levels . ^^^ These results suggest that inhibition of a PI3K / Akt / GSK3beta / beta catenin / LEF axis and stimulation of HDAC 1 cooperate to mediate the inhibitory effect of DEX on Wnt signaling and the osteoblast differentiation related cell cycle . . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| Tumor cell killing correlates with regulation of proteins involved in the Wnt and PI3K pathways : beta catenin , APC , GSK 3 , JNK , and PTEN . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| Inhibition of the PI3K / Akt pathway suppressed the Wnt / beta catenin pathway by activation of glycogen synthase kinase 3beta ( GSK 3beta ) and degradation of beta catenin . ^^^ Suppression of cardiomyocyte differentiation by inhibiting the PI3K / Akt pathway was rescued by forced expression of a nonphosphorylated , constitutively active form of beta catenin . ^^^ These results suggest that the PI3K pathway regulates cardiomyocyte differentiation through suppressing the GSK 3beta activity and maintaining the Wnt / beta catenin activity . . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| Our laboratory has delineated that the phosphatidylinositol 3 ' kinase ( PI3K ) / AKT / I kappa B kinase ( IKK ) pathway positively regulates NF kappa B and beta catenin , both important transcriptional regulators in colorectal cancer ( CRC ) . ^^^ Therefore , we investigated the effect of inhibiting the PI3K / AKT / IKK alpha pathway in regulating the inappropriate constitutive activation of NF kappa B and beta catenin in CRC cell lines . ^^^ The constitutive activation of NF kappa B and beta catenin dependent transcription is inhibited by transiently transfecting either kinase dead ( KD ) IKK alpha , which blocks IKK alpha kinase activity , KD AKT , which blocks AKT activity , or wildtype ( WT ) PTEN , which inhibits PI3K and AKT activity . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| Given the prevalence of beta catenin mutations in many human tumors , especially colon and hepatocellular carcinomas , these data implicate NS5A mediated PI3K activation as a contributory factor in the increasingly common association between HCV infection and the development of hepatocellular carcinoma . . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| Both effects are associated to the formation of beta catenin / p85alpha and inhibition of beta catenin / APC complexes and are independent of GSK 3 and PI3K activities . ^^^ Direct metabolic regulation of beta catenin activity by the p85alpha regulatory subunit of phosphoinositide 3 OH kinase . ^^^ In addition , the regulatory subunit p85alpha directly binds beta catenin , but the role of this interaction in the context of the lipid kinase regulation of beta catenin signaling is unknown . ^^^ Here we report that expression of exogenous p85alpha in mouse keratinocytes increases the metabolic stability and has a strong synergistic effect on the transcriptional activity of beta catenin . ^^^ These findings suggest that p85alpha can act as a direct metabolic regulator of beta catenin activity . . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| In thyroid cancer , alterations are often seen in proteins that regulate beta catenin , including those of the RAS , PI3K / AKT , and peroxisome proliferation activated receptor gamma ( PPARgamma ) pathways , and evidence from the literature suggests that beta catenin may play a direct role in the dedifferentiation commonly observed in late stage disease . ^^^ Activation of AKT by phosphatidylinositide 3 kinase ( PI3K ) , a RAS effector , results in GSK3beta phosphorylation and deactivation and subsequent beta catenin upregulation in thyroid cancer . ^^^ We hypothesize that activation of the RAS , PI3K / AKT , and PPARgamma pathways ultimately impinges upon beta catenin . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| Transfection with a nondegradable mutant of beta catenin blocked the increase in ERalpha transcriptional activity induced by the PI3K inhibitor wortmannin , suggesting a role for beta catenin in estrogen signaling . ^^^ |
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| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|