| Interacting proteins: P30530 and P27986 |
Pubmed |
SVM Score :0.0 |
| Gas 6 is the ligand of Axl receptor tyrosine kinase ; upon binding to its receptor Gas 6 activates the phosphatidylinositol 3 OH kinase ( PI3K ) and its downstream targets S6K and Akt . ^^^ |
|
| Interacting proteins: P30530 and P27986 |
Pubmed |
SVM Score :0.0 |
| Three putative Ufo substrates were identified : phospholipase Cgamma 1 ( PLCgamma ) , as well as p85alpha and p85beta subunits of phosphatidylinositol 3 ' kinase ( PI 3 kinase ) . ^^^ |
|
| Interacting proteins: P30530 and P27986 |
Pubmed |
SVM Score :0.0 |
| Prevention of apoptosis by Gas 6 Axl required activation of phosphatidyl inositol 3 kinase ( PI3K ) as shown by treatment with LY 294002 or transfection of an Axl deletion mutant that does not bind PI3K ( Axl triangle up PI3K ) . ^^^ There was no significant role for ERK1 / 2 in the anti apoptotic effects of Gas 6 Axl since ERK1 / 2 activity was maintained in cells transfected with Axl triangle up PI3K and Axl K567R . ^^^ These findings establish the Gas 6 Axl PI3K Akt pathway as an anti apoptotic mechanism for VSMC that may be important in the response to vascular injury . . ^^^ |
|
| Interacting proteins: P30530 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30530 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30530 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30530 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30530 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30530 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30530 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|