| Interacting proteins: P17181 and P27986 |
Pubmed |
SVM Score :0.0 |
| AVP stimulated mesangial cell growth by activating both the Ras mitogen activated protein kinase ( MAPK ) and the phosphatidylinositol 3 kinase ( PI3K ) cell signaling pathways . ^^^ Both the selective PI3K inhibitor LY 294002 and the MAPK kinase ( MEK ) inhibitor PD 98059 inhibited AVP stimulated mesangial cell proliferation . ^^^ However , LY 294002 was more potent , indicating an important role for PI3K activation in AVP stimulated mesangial cell proliferation . ^^^ AVP appeared to exert its effect on MAPK and PI3K activation , as well as on cell proliferation , by activating the epidermal growth factor receptor ( EGF R ) . ^^^ Treatment with rapamycin , an inhibitor of the p70S6 kinase activator mTOR , also resulted in growth inhibition , further suggesting the importance of the PI3K signaling pathway in AVP induced proliferation . ^^^ |
|
| Interacting proteins: P17181 and P27986 |
Pubmed |
SVM Score :0.0 |
| PKC inhibitor Go 6983 and PI3K inhibitors wortmannin and LY 294002 all inhibit ERK1 / 2 activation by AVP , but not by FGF 2 . ^^^ |
|
| Interacting proteins: P17181 and P27986 |
Pubmed |
SVM Score :0.0 |
| In contrast , p85 / 110 beta PI3K activity was not altered by either PDGF or AVP , whereas both agents caused a delayed activation of Class IB p101 / 110 gamma PI3K . ^^^ |
|
| Interacting proteins: P17181 and P27986 |
Pubmed |
SVM Score :0.0 |
| AVP time dependently induced the phosphorylation of PI3K and Akt . ^^^ The AVP induced HSP 27 phosphorylation was attenuated by LY 294002 , a PI3K inhibitor . ^^^ Furthermore , LY 294002 or Akt inhibitor did not affect the AVP induced phosphorylation of p 38 MAP kinase and SB 203580 did not affect the phosphorylation of PI3K or Akt . ^^^ These results suggest that PI3K / Akt plays a part in the AVP induced phosphorylation of HSP 27 , maybe independently of p 38 MAP kinase , in aortic smooth muscle A 10 cells . . ^^^ |
|
| Interacting proteins: P17181 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17181 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|