| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.5098321 |
| We demonstrate here that phosphorylated c cbl complexes with CD 19 and with PI3Kp85 via its C terminal SH 2 domain , and that both c cbl and CD 19 are associated with active PI3K in anti Ig stimulated cells . 0.5098321^^^ |
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| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| This process has been proposed to be mediated by an interaction between the Src family kinase LYN and the p 85 subunit of PI3K and / or through p 85 membrane recruitment mediated by CBL and / or CD 19 . ^^^ Whereas CD 19 does not appear to be involved in this SYK dependent pathway , the SYK substrate CBL is likely involved as the dominant negative SYK markedly attenuates CBL tyrosine phosphorylation and completely blocks the BCR dependent association of CBL with p 85 PI3K . . ^^^ |
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| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| Loss of Lyn , PTEN ( phosphatase and tensin homolog ) , or SH 2 containing inositol phosphatase suppressed the Btk ( lo ) phenotype in vitro but not in vivo , whereas CD 19 and the p85alpha form of phosphoinositide 3 kinase behaved as Btk ( lo ) enhancers in vivo but not in vitro . ^^^ |
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| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| In analyses of signaling intermediates , the phosphatidylinositol 3 kinase ( PI3K ) inhibitor wortmannin partially suppressed the release of Ca2+ induced by coligation of CD 19 and mIgM but the selective PKC inhibitor bisindolylmaleimide 1 ( BIM 1 ) did not . ^^^ Thus , in normal human B cells , PI3K is upstream of the Ca2+ response while PI3K , Ca2+ release and protein kinase C are all required for ERK 2 activation , and CD 19 enhances the MAPK cascade at multiple levels , depending on the state of differentiation . . ^^^ |
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| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| A prominent feature of CD 19 signaling is the binding and activation of phosphoinositide 3 kinase ( P13K ) , which accounts for the majority of PI3K activity induced by BCR ligation . ^^^ |
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| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| The docking proteins that the BCR uses to recruit PI3K include CD 19 , Cbl , Gab 1 , and perhaps Gab 2 . ^^^ |
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| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| Thus , these results provide evidence that BCAP serves as an adaptor molecule for CD 19 to activate the PI3K pathway in B cells . . ^^^ |
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| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| Inactivation of PTEN rescued germinal center , MZ B and B 1 cell formation in CD 19 / mice , arguing that recruitment and activation of PI3K are the dominant roles for CD 19 in these B cell subpopulations . ^^^ |
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| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| This may reflect the recruitment of additional PI3K subunits , as we found that p110alpha becomes associated with CD 19 upon B cell activation . ^^^ |
|
| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|