| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :1.2176363 |
| The association did not appear to correlate with proliferation , since a similar interaction between p 85 alpha and tyrosine phosphorylated proteins was also observed in poorly proliferating resident peritoneal macrophages stimulated with CSF 1 . 1.2176363^^^ |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| We looked for association and / or phosphorylation of phospholipase C gamma ( PLC gamma ) and phosphatidylinositol 3 ' phosphate ( PI3K ) , after stimulation of the FF 4 molecules by CSF 1 . ^^^ |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| In the present studies , we demonstrate that M CSF also induces direct interaction of PI 3 kinase ( p 85 alpha subunit ) with the SH2 / SH3 adaptor protein Grb 2 . ^^^ |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| Both WT ( 100 or 500 nM ) and LY 294002 ( 100 microM ) , a specific PI3K inhibitor structurally unrelated to WT , significantly inhibited osteoclast chemotaxis in response to M CSF . ^^^ |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| M CSF treatment induced M CSF receptor tyrosine phosphorylation and recruitment of the p 85 subunit of phosphatidylinositol 3 kinase ( PI3K ) to these receptors . ^^^ To clarify that PI3K products activate Akt in response to M CSF , NIH 3T3 fibroblasts expressing mutant human M CSF receptors ( 3T3 FMS ( Y809F ) ) that fail to activate Ras in response to M CSF also exhibit increased Akt kinase activity in response to M CSF challenge . ^^^ In normal human monocytes , M CSF increased the levels of tyrosine phosphorylated proteins and induced Akt activation in a PI3K dependent manner . ^^^ The PI3K inhibitor LY 294002 blocked M CSF mediated monocyte survival , an effect that was partially restored by caspase 9 inhibitors . ^^^ |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| Elutriated monocytes were differentiated to macrophages by macrophage colony stimulating factor ( M CSF ) and co cultured with fixed T cells chronically stimulated in a cytokine cocktail of IL 2 / IL 6 / tumour necrosis factor ( TNF ) alpha in the presence or absence of wortmannin and LY 294002 , inhibitors of phosphatidylinositol 3 kinase ( PI3K ) , or of rapamycin , an inhibitor of p 70 S6 kinase ( p70S6K ) . ^^^ IL 10 production in RA SMCs and M CSF primed macrophages , activated by interaction with Tck , is PI3K and p70S6K dependent . . ^^^ |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| M CSF activates its receptor , Fms tyrosine kinase , and Fms sequentially activates a number of signaling molecules , including PI3K or phospholipase Cgamma ( PLCgamma ) . ^^^ |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| PI3K inhibition caused apoptosis of nearly all osteoclasts in purified and co cultured marrow derived osteoclasts and spleen derived osteoclasts maintained with RANKL and M CSF . ^^^ |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| Using bone marrow derived macrophages ( BMMs ) deficient in the expression of p85alpha subunit of class IA phosphatidylinositol 3 ( PI 3 ) kinase , we demonstrate 50 % reduction in proliferation in response to macrophage colony stimulating factor ( M CSF ) as well as granulocyte macrophage colony stimulating factor ( GM CSF ) compared with wild type controls . ^^^ |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| Extracellularly regulated kinase ( ERK ) , Jun N terminal kinase ( JNK ) and phosphatidylinositol 3 kinase ( PI3K ) were found to be negatively involved in M CSF induced FAK phosphorylation , as their inhibition resulted in FAK hyper phosphorylation . ^^^ Following M CSF treatment , FAK and the active forms of M CSFR and Src were redistributed to the cytoskeleton , where active ERK , JNK and PI3K were detectable . ^^^ |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| Rac 1 is critically involved in M CSF receptor signaling and mediates survival signaling primarily through PI3K / Akt pathways . ^^^ CONCLUSIONS : Small guanosine triphosphatase ( GTPase ) Rac 1 is critically involved in M CSF receptor signaling and mediates survival signaling of osteoclasts primarily by modulating PI3K / Akt pathways . ^^^ |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09603 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|