| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.6437136 |
| We show that association of c Met with PI3K and GAB 2 is diminished by inhibiting c Met . 0.6437136^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression of c jun was likely to undergo a negative regulation through a mechanism involving PI3K , while that of c met seemed to be almost independent from various protein kinases ( PI3K , pp 60 ( c src ) , and PKC ) . . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| The blebbing response was dependent on autocrine HGF ( hepatocyte growth factor ) activation of c Met and prevented by inhibition of RhoA , ROCK and p 38 MAPK ( p 38 mitogen activated protein kinase ) , but not ERK ( extracellular signal regulated kinase ) or PI3K ( phosphoinositide 3 kinase ) . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| Single strand conformational polymorphism and heteroduplex analysis of the coding region of the regulatory p85alpha subunit in cDNA isolated from human muscle tissue from 70 insulin resistant NIDDM patients and 12 control subjects revealed three silent polymorphisms and a missense mutation at nucleotide position 1020 ( G > A ) , changing a Met to Ile at codon 326 . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| Prevalence of a polymorphism of the phosphatidylinositol 3 kinase p 85 alpha regulatory subunit ( codon 326 Met > Ile ) in Japanese NIDDM patients . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| HGF stimulated DNA synthesis in 184B5 and 32D / c Met cells , while HGF / NK2 was mitogenically inactive , despite the ability of HGF / NK2 to stimulate c Met autophosphorylation , mitogen activated protein kinase ( MAPK ) , and phosphatidylinositol 3 kinase ( PI3K ) in both cell systems . ^^^ These data suggest that ( 1 ) alternative HGF isoforms signaling through c Met generate both common and distinct biological responses , ( 2 ) the extent and duration of ligand stimulated c Met and MAPK activities are dependent on the cellular context and are not predictive of mitogenic signaling , and ( 3 ) in at least some HGF target cells , the activation of both MAPK and PI3K signaling pathways is insufficient for mitogenesis elicited through c Met . . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| All melanocytic cells expressed the HGF receptor c Met , and autocrine HGF caused constitutive activation of c Met , MAPK and PI3K . ^^^ MAPK inhibitor PD 98059 and PI3K inhibitor wortmannin partially blocked the downregulation , suggesting that both pathways are involved in this process . c Met was coimmunoprecipitated with E cadherin , Desmoglein 1 and Plakoglobin , suggesting that they form a complex ( es ) that acts to regulate intercellular adhesion . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| In support of this divergent effect of ERK on Gab1 / PI3K association following HGF and EGF stimulation , U 0126 decreased the HGF stimulated association of p 85 and the Gab 1 c Met binding domain but did not alter the EGF stimulated association of p 85 and the c Met binding domain . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| Rat hepatoma CBRH 7919 cells transfected with pemt 2 cDNA showed that : ( 1 ) signaling proteins including c Met , PDGF receptor , PI3K , Akt and Bcl 2 all had reduced expression as shown by Western blotting studies ; ( 2 ) flow cytometric and DNA ladder assays showed that 22 . 9 % of the pemt 2 transfected cells were undergoing apoptosis ; ( 3 ) the activity of Akt was decreased as shown by Western blotting using antibody directed against p Akt ( Thr 308 ) ; ( 4 ) wortmannin and PD 98059 , inhibitors of PI3K and MEK , respectively , both inhibited Akt activity , indicating that PI3K and MAPK pathways were merging at Akt in CBRH 7919 cells . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| HGF stimulated Gab 1 association with c Met , Grb 2 , SHP 2 , PI3K , Shc , Crk isoforms and CrkL , but not with PLCgamma 1 . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| Met 5 enkephalin induced cardioprotection occurs via transactivation of EGFR and activation of PI3K . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| In this context , we show that short term exposure of mesenchymal stem cells ( MSCs ) to HGF can induce the activation of its cognate Met receptor and the downstream effectors ERK1 / 2 , p38MAPK , and PI3K / Akt , while long term exposure to HGF resulted in cytoskeletal rearrangement , cell migration , and marked inhibition of proliferation through the arrest in the G 1 S checkpoint . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| Following Met activation , alpha6beta4 is tyrosine phosphorylated and combines with Shc and PI3K , generating an additional signaling platform that potentiates HGF triggered activation of Ras and PI3K dependent pathways . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| Two amino acid substitutions have been identified in the gene for the regulatory subunit of human p85alpha , Met 326Ile , and Asn 330Asp , and the former has been associated with alterations in glucose / insulin homeostasis . ^^^ When the four human p85alpha proteins were expressed in yeast , a 27 % decrease occurred in the level of protein expression of p85alpha ( Ile / Asp ) ( P = 0 . 03 ) and a 43 % decrease in p85alpha ( Ile / Asn ) ( P = 0 . 08 ) as compared with p85alpha ( Met / Asp ) . ^^^ Both p85alpha ( Ile / Asp ) and p85alpha ( Ile / Asn ) also exhibited increased binding to phospho insulin receptor substrate 1 by 41 % and 83 % , respectively ( P < 0 . 001 ) , as compared with p85alpha ( Met / Asp ) . ^^^ Both p85alpha ( Met ) and p85alpha ( Ile ) had similar effects on AKT activity and were able to reconstitute differentiation of the preadipocytes , although the triglyceride concentration in fully differentiated adipocytes and insulin stimulated 2 deoxyglucose uptake were slightly lower than in adipocytes expressing p85alpha ( Met ) . ^^^ Thus , the Met 326Ile variant of p85alpha is functional for intracellular signaling and adipocyte differentiation but has small alterations in protein expression and activity that could play a role in modifying insulin action . . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| In this study , we define the role of these effectors in response to HGF by utilizing Met mutants , designed to obtain preferential coupling of Met to either Grb 2 or PI3K or both . ^^^ This inhibition occurs only when PI3K signaling downstream of Met is low . ^^^ Imposing an efficient coupling of PI3K to Met would lead to upregulation of muscle regulatory factors and subsequent cell differentiation . . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| THC and MET induced translocation of Raf 1 to the membrane and phosphorylation of p44 / 42 Erk kinase , which was reversed by cannabinoid receptor antagonists and PI3K inhibitor . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| The effect exerted by MET was blocked by the cannabinoid receptor antagonists SR 141716 ( SR 1 ) and SR 144528 ( SR 2 ) as well as by the phosphoinositide 3 kinase ( PI3K ) inhibitor LY 294002 , suggesting an involvement of cannabinoid receptors and the PI3K pathway in the mechanism of MET action . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| Combined signaling through ERK , PI3K / AKT , and RAC1 / p38 is required for met triggered cortical neuron migration . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| The response of tumors to MET stress depends on their mutational status , however , it always involves inhibition of CDK 1 and in most cases the upregulation of p 21 , p 27 , GADDs and 14 3 3sigma in response to upregulation of TGF beta , IRF 1 , TNF alpha , Rb and / or MDA 7 and the downregulation of PI3K , RAS and NF kappaB . ^^^ |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|