| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| The ability of IGF IR or chIR / YY to prevent apoptosis is not blocked by addition of the PI3K inhibitor wortmannin . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| DRG neurons express IGF 1 receptors ( IGF IR ) , and IGF 1 activates the phosphatidylinositol 3 kinase ( PI3K ) / Akt pathway . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| In a human breast cancer cell line MCF 7 , which expresses IGF 1 receptor ( IGF IR ) , stimulation with insulin or IGFs resulted in autophosphorylation of the IGF IR in an increased proportion of ras bound to GTP and in the association of phosphatidylinositol 3 ' kinase ( PI3K ) activity and of p 85 PI3K with M ( r ) 185 , 000 phosphotyrosinylated proteins corresponding in size to insulin / IGF IR substrates . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| Thus , the PI3K / Akt / FKHRL1 pathway is essential for inhibition of apoptosis in response to Epo and SCF , while the IGF 1 receptor utilizes a different pathway . . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| They had phosphorylation of the IGF 1 receptor beta subunit , phosphorylation of insulin receptor substrate ( IRS ) 1 , and association of the p 85 subunit ( phosphatidylinositol 3 kinase [ PI3K ] ) with the IGF 1 receptor and IRS 1 in D NOD cells in the basal state . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| Taken together , these data reveal that endogenous FKHRL 1 is a downstream substrate of PI3K / Akt in IGF 1 receptor signaling in hippocampal neurons and suggest that the phosphorylation of this transcription factor may play an important role in the neuronal survival properties of IGF 1 . . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| This response required the IGF 1 receptor , which activates phosphoinositide 3 kinase ( PI3K ) and mitogen activated protein kinase / extracellular signal regulated kinase ( MAPK / ERK ) pathways . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| IGF 1 stimulates the IGF 1 receptor ( IGF1R ) and downstream signaling pathways , including extracellular signal regulated kinase ( ERK ) and phosphoinositol 3 kinase ( PI3K ) . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| The transcript level of upstream signaling molecules , such as IGF binding protein 5 ( IGFBP 5 ) , IGF 1 receptor ( IGF 1R ) , and phosphoinositide 3 kinase ( PI3K ) , was studied using reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| To determine the genetic relationship between S6Ks and the IGF 1 PI3K pathway , S6K transgenic and knockout mice were crossed with cardiac specific transgenic mice overexpressing the IGF 1 receptor ( IGF1R ) or PI3K mutants . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| Results obtained with a function blocking antibody and an siRNA targeting the insulin like growth factor 1 ( IGF 1 ) receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the phosphatidylinositol 3 kinase ( PI3k ) Cdc 42 pathway by the IGF 1 receptor , but not by the TrkA or TrkB receptors . . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| Here we investigate the requirement of MAP ( MAPK ) and phosphatidylinositol 3 ( PI3K ) kinases in the transformation of rat intestinal epithelial ( RIE ) cells by oncogenic forms of insulin receptor ( gag IR ) , insulin like growth factor 1 receptor ( gag IGFR ) , and 5 Src . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| The resistance of cells to apoptosis by IGF 1R signaling was mediated through MAPK and phosphatidylinositol 3 kinase ( PI3K ) pathways and a yet unidentified pathway ( s ) . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation of both receptor forms by antibodies against the alpha subunit and against the carboxy terminus of the beta subunit of the IGF IR suggests that the 75 kDa form could be the beta chain truncated at the amino terminus above the alpha beta disulphide bridges . 3 ) The ATA activated IGF IR forms underwent slow dephosphorylation , compared with a rapid dephosphorylation of the IGF 1 activated receptor . 4 ) The insulin receptor substrate 1 / 2 associated PI3K , Shc proteins , and the kinases Akt and Erk1 / 2 , downstream mediators of the antiapoptotic signaling by IGF IR , were activated to a higher extent and for a longer time period by ATA , compared with IGF 1 . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| IRS 1 and Shc , substrates of the IGF IR , are known to mediate IGF IR signaling pathways such as those of mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3 kinase ( PI3K ) , which are believed to play important roles in some of the IGF IR dependent biological functions . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| IGF IR binding to its ligand , insulin like growth factor ( IGF 1 ) activates phosphoinositide 3 kinase ( PI3K ) , promotes cell proliferation by activating the mitogen activated protein kinase ( MAPK ) cascade , and blocks apoptosis by inducing the phosphorylation and inhibition of proapoptotic proteins such as BAD . ^^^ Signaling through IGF IR rescued cells from ASK 1 induced apoptotic cell death in a manner independent of PI3K activity . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation / Western blot studies revealed that CLA inhibited IGF 1 induced phosphorylation of IGF IR and insulin receptor substrate ( IRS ) 1 , recruitment of the p 85 regulatory subunit of phosphatidylinositol 3 kinase ( PI3K ) to IGF IR , IGF IR associated PI3K activity , and phosphorylated Akt and extracellular signal regulated kinase ( ERK ) 1 / 2 levels . ^^^ In conclusion , the inhibition of cell proliferation and induction of apoptosis by CLA in HT 29 cells may be mediated in part by its ability to decrease IGF 2 synthesis and to downregulate IGF IR signaling and the PI3K / Akt and ERK 1 / 2 pathways . . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| The phosphoinositide 3 kinase ( PI3K ) Akt p70S6K1 pathway was significantly activated in hearts from IGF1R transgenics . ^^^ Cardiac hypertrophy induced by overexpression of IGF1R was completely blocked by a dominant negative PI3K ( p110alpha ) mutant , suggesting IGF1R promotes compensated cardiac hypertrophy in a PI3K ( p110alpha ) dependent manner . ^^^ This study suggests that targeting the cardiac IGF1R PI3K ( p110alpha ) pathway could be a potential therapeutic strategy for the treatment of heart failure . . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| They are consistent with the view that the IGF IR mediated attenuation of trastuzumab induced growth inhibition we recently described is dependent on IGF 1 induced PI3K signaling rather than IGF 1 induced MAPK signaling . . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| Activation of IGF IR by its ligands promotes cell proliferation via mitogen activated protein kinase ( MAPK ) cascade and cell survival via phosphoinositide 3 kinase ( PI3K ) cascade . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| Synergy between PI3K / Akt and Raf / MEK / ERK pathways in IGF 1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells . ^^^ These results demonstrate that the PI3K / Akt and Raf / MEK / ERK pathways are intimately involved in IGF 1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells . . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| Thus , strategies that block IGF 1R signaling and consequently the Akt / PI3K pathway could be a priority in the treatment of patients with multiple myeloma , especially those lacking CD 45 expression that have a very poor clinical outcome . . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| Future SCLC clinical trials incorporating IGF IR inhibitors alone or in combination with other kinase inhibitors should include assessment of PI3K Akt activity as a pharmacodynamic end point . . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| However , IGF IR and its downstream signalling , including the protein levels of PI3K and phosphorylated Akt , known to maintain physiological cardiac hypertrophy and cardiomyocyte survival , were downregulated . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| Radiation and new molecular agents , part 2 : targeting HDAC , HSP 90 , IGF 1R , PI3K , and Ras . ^^^ Agents targeting single pathways , including EGFR , IGF 1R , PI3K , and Ras , have been studied alone and in combination with radiation . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| These results suggest that inhibition of cell proliferation and induction of apoptosis by genistein are mediated , at least in part , by its ability to inhibit IGF IR signaling and the PI3K / Akt pathway . . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| Since EN is known to bind IRS 1 as an adaptor protein , our findings suggest that IGF IR may function to localize EN / IRS 1 complexes to cell membranes , in turn facilitating PI3K Akt activation and suppression of anoikis . . ^^^ |
|
| Interacting proteins: P08069 and P27986 |
Pubmed |
SVM Score :0.0 |
| The contribution of signaling pathways downstream of IGFIR activation to proliferation and apoptosis were determined by pharmacological inhibition of phosphatidylinositol 3 ' kinase ( PI3K ) with LY 294002 , MAP kinase kinase ( MEK ) with UO 126 and mammalian target of rapamycin ( mTOR ) with rapamycin . ^^^ Inhibition of PI3K with LY 294002 or MEK with UO 126 prevented the development of acinar structures from IGFIR expressing but not control cells . ^^^ |
|