| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| Inhibition of PI3K inhibits phosphorylation of Rb , induction of cyclin D 3 , and degradation of p27kip1 . ^^^ |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| Treatment of PI3K inhibitor LY 294002 and the MAP kinase inhibitor PD 098059 , but not p 38 inhibitor SB 203580 , effectively blocks IGF 1 induced upregulation of Pin 1 , cyclin D 1 and RB phosphorylation . ^^^ |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| Despite this oncogenic lesion , Y 1 cells retain tight regulatory mechanisms of cell cycle control typified by the sequential events comprising the mitogenic response triggered by FGF 2 in G0 / G1 arrested Y 1 cells : 1 ) activation of ERK1 / 2 and PI3K , by 5 minutes ; 2 ) induction of c Fos and c Myc proteins by 2 hours ; 3 ) induction of cyclin D 1 protein by 5 hours ; 4 ) phosphorylation of Rb protein between 6 and 8 hours ; 5 ) onset of DNA synthesis by 8 9 hours . ^^^ |
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| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| The CDKN2A / B genes encode various components of the Rb and p 53 pathways , and the PIK3CA gene makes a catalytic subunit of the protein phosphatidylinositol 3 OH kinase ( PI3K ) , which is known to be involved in the PI3K / ATK signaling pathways . ^^^ |
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| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that Ras downregulates RhoB expression by a phosphatidylinositol 3 kinase ( PI3K ) and Akt but not Mek dependent mechanism . ^^^ Furthermore , genetic and pharmacological blockade of PI3K / Akt results in upregulation of RhoB expression . ^^^ We also provide evidence for the importance of the downregulation of RhoB in oncogenesis by demonstrating that RhoB antagonizes Ras / PI3K / Akt malignancy . ^^^ Ectopic expression of RhoB , but not the close relative RhoA , inhibits Ras , PI3K , and Akt induction of transformation , migration , and invasion and induces apoptosis and anoikis . ^^^ These studies identify suppression of RhoB as a mechanism by which the Ras / PI3K / Akt pathway induces tumor survival , transformation , invasion , and metastasis . . ^^^ |
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| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| PI3K activation was mandatory for IL 7 mediated Bcl 2 up regulation , p27kip1 down regulation , Rb hyperphosphorylation , and consequent viability and cell cycle progression of T ALL cells . ^^^ |
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| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| However , the possible interactions between PI3K and Rb pathways remain to be defined . ^^^ It was reported that the unique 24 amino acid N terminal end of the p 55 regulatory subunits of PI3K is an Rb binding domain and affects Rb action or Rb E2F interaction . ^^^ These observations suggest that PI3K can regulate cell cycle progression and cell proliferation in human gastric tumor cells via Rb mediated pathway , and that this effect of PI3K is mediated through a direct association with Rb via the N terminal end of its p 55 kDa regulatory subunits and modulating Rb E2F interactions . ^^^ Strategies targeting PI3K signal transduction or the association of PI3K with Rb , or regulating PI3K Rb interactions could be employed for gene therapy or chemotherapy of gastric cancer and other tumors . . ^^^ |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| The response of tumors to MET stress depends on their mutational status , however , it always involves inhibition of CDK 1 and in most cases the upregulation of p 21 , p 27 , GADDs and 14 3 3sigma in response to upregulation of TGF beta , IRF 1 , TNF alpha , Rb and / or MDA 7 and the downregulation of PI3K , RAS and NF kappaB . ^^^ |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| Enzyme immunoassay ( EIA ) of ginsenoside Rb 1 ( GRb 1 ) , one of the glucosides of protopanaxadiol from Panax ginseng , was explored . ^^^ |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| Ginsenoside Rb 1 ( GRb 1 ) also had an effect in the rat and displayed some influence in the chick . ^^^ |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| In the present study , we investigated the effects of ginsenoside Rb 1 ( GRb 1 ) and malonylginsenoside Rb 1 ( GRb 1 m ) on the induction of long term potentiation ( LTP ) in the dentate gyrus using anesthetized rats . ^^^ |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| Effects of malonylginsenoside Rb 1 ( GRb 1 m ) isolated from dried root of Panax ginseng C . ^^^ Meyer ( Araliaceae ) on neuronal survival and neurite outgrowth were compared with those of ginsenoside Rb 1 ( GRb 1 ) using organ culture of chick embryonic dorsal root ganglia ( DRG ) and cell culture of DRG neurons . ^^^ |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| A high dose of nerve growth factor ( NGF ) mixed with ginsenoside Rb 1 ( GRb 1 ) was encapsulated by collagen and placed in silicone rubber chambers , which were used to repair dissected Sprague Dawley rat sciatic nerves with 15 mm gaps . ^^^ |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| METHODS : Whole embryo culture was used to explore the developmental toxicity of ginsenoside Rb 1 ( GRb 1 ) on mouse embryos . ^^^ |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| Silicone rubber chambers filled with collagen containing ginsenoside Rb 1 ( GRb 1 ) were used to repair lesioned rat sciatic nerves with 15 mm gaps between stumps . ^^^ |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| The most active constituent was ginsenoside Rb 1 ( GRb 1 ) , a protopanaxadiol glycoside , which was investigated for its anti ulcer effect . ^^^ |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|