| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| L 59 neurite promoting activity was decreased in the presence of inhibitors of Src , Trk , PLCgamma , PKC , PI3K and MAPK . ^^^ |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| These findings suggested that NGF initiated chemotactic movement of PMCs through both MAPK and PI3K signaling pathways following TrkA activation . ^^^ |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| The inhibitory pathway from TrkA to RhoA involves phosphatidylinositol 3 kinase ( PI3K ) , because the inhibitors LY 294002 or wortmannin prevented NGF induced RhoA translocation and increased RhoA association with ROK . ^^^ Taken together , these data indicate that NGF mediated activation of TrkA receptor stimulates PI3K , which in turn increases Rac 1 activity to induce transient RhoA inactivation during the initial phase of neurite outgrowth . . ^^^ |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| These results demonstrate that TrkA kinase initiates differentiation , and p 75 enhances differentiation by rescuing differentiating cells from apoptosis via the PI3K pathway . ^^^ |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| The pharmacological inhibition of phosphatidylinositol 3 kinase ( PI3K ) by wortmannin significantly suppressed the survival supporting activity of MC 14 , whereas the NGF receptor ( tyrosine kinase A or TrkA ) inhibitor K252a showed no detectable effect on MC 14 activity . ^^^ |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| We show here that T . cruzi , via its neuraminidase , binds TrkA in a NGF inhibitable manner , induces TrkA autophosphorylation , and , through TrkA dependent mechanisms , triggers phosphatidylinositol 3 kinase ( PI3K ) / Akt kinase signaling , cell survival , and neurite outgrowth . ^^^ |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| TrkA can utilise a number of intracellular signalling pathways , including the mitogen activated protein kinase ( MAPK ) pathway and the phosphatidylinositol 3 kinase ( PI3K ) pathway . ^^^ We now show , using pharmacological inhibitor studies of PC 12 cells and sympathetic neurons in culture and in vitro kinase and activation assays , that the MAPK pathway , and not the PI3K pathway , links NGF engagement with the TrkA receptor to GSK3beta activation in PC 12 cells and sympathetic neurons . ^^^ |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| PMGS induces axon specification by enhancing TrkA activity locally , which triggers phosphatidylinositol 3 kinase ( PI3K ) and Rac 1 dependent inhibition of RhoA signaling and the consequent actin depolymerization in one neurite only . ^^^ |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| Inhibitors of the three major pathways for TrkA receptor signalling , extracellular signal related kinase ( ERK ) / mitogen activated protein kinase kinase ( MEK ) ( ERK / MEK ) , phosphatidylinositol 3 kinase ( PI3K ) , and phospholipase Cgamma ( PLCgamma ) all attenuate NGF induced hyperalgesia . ^^^ |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| NGF mediated nuclear translocation of PIPSLS was blocked by K252a , a TrkA inhibitor , or wortmannin , a PI3K inhibitor . ^^^ These findings suggest that nuclear translocation of PIPS is involved in NGF mediated neuronal survival via TrkA , PI3K , and Gab 1 signaling pathway . . ^^^ |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| K252a , an inhibitor of TrkA receptor , and LY 294002 , an inhibitor of phosphatidylinositol 3 kinase ( PI3K ) , reduced the toxin induced production of O 2 ( ) and phosphorylation of PDK 1 , but not the formation of DG . ^^^ |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| Results obtained with a function blocking antibody and an siRNA targeting the insulin like growth factor 1 ( IGF 1 ) receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the phosphatidylinositol 3 kinase ( PI3k ) Cdc 42 pathway by the IGF 1 receptor , but not by the TrkA or TrkB receptors . . ^^^ |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| Although the mechanism of retrograde neurotrophin signaling is not fully elucidated , considerable evidence supports a model in which the vesicular transport of neurotrophin Trk complexes transmits a survival signal that involves PI3K and Erk 5 . ^^^ |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| The ability of BDNF to rescue the cells from chemotherapeutic agent induced cell death was inhibited by treatment with the Trk tyrosine kinase inhibitor K252a or the phosphatidylinositol 3 ' kinase ( PI3K ) inhibitor LY 294002 , but not by the mitogen activated protein kinase kinase inhibitor PD 98059 or the peritoneal lymphocyte gamma inhibitor U 73122 , indicating that both TrkB and PI3K activities are required for the survival promoting effects of BDNF . ^^^ |
|
| Interacting proteins: P04629 and P27986 |
Pubmed |
SVM Score :0.0 |
| However , activation of PI3K ( phosphatidylinositol 3 kinase ) / Akt and MEK ( mitogen activated protein kinase kinase ) / Erk pathways prevented pro NGF induced apoptosis , revealing a novel critical checkpoint in survival versus apoptotic signaling downstream of Trk activation , and suggesting that pro NGF blocks survival signaling by preventing Akt and Erk activation . ^^^ |
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