| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| HRG was found to potently induce the recruitment of the M ( r ) 85 , 000 regulatory subunit of PI3K by phosphotyrosine proteins in both nonneoplastic H16N 2 mammary epithelial cells ( which express normal c erbB 2 levels ) and in the 21MT 2 and 21MT 1 cell lines , which were all isolated from a single patient with intraductal and invasive ductal carcinoma of the breast and express c erbB 3 but not c erbB 4 in culture . ^^^ These data indicate that PI3K may be an especially important mediator of HRG induced proliferation in mammary epithelial cells and is involved in the autonomous proliferation of growth factor independent breast carcinoma cells with c erbB 2 gene amplification . . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| While investigating the downstream signals involved in HRG beta 1 enhanced cell aggregation , we observed that HRG beta 1 induced tyrosine phosphorylation of erbB 2 and crbB 3 receptor heterodimers and increased the association of the dimerized receptors with the 85 kDa subunit of phosphatidylinositol 3 kinase ( PI3K ) . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| G 1 progression was associated with ErbB 2 transactivation of ErbB 3 and subsequent stimulation of the phosphatidylinositol 3 kinase ( PI3K ) pathway whereas apoptosis was dependent on p 38 MAPK . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| We used this model to identify domains within the large beta ( 4 ) cytoplasmic domain that are involved in the interaction of alpha ( 6 ) beta ( 4 ) with ErbB 2 , invasion , and phosphatidylinositol 3 kinase ( PI3K ) activation . ^^^ These transfectants were examined for their ability to invade Matrigel and their ability to activate PI3K , as well as for the ability of alpha ( 6 ) beta ( 4 ) to co immunoprecipitate with ErbB 2 . ^^^ Finally , we observed strong activation of PI3K with beta ( 4 ) wild type and with those beta ( 4 ) deletion mutants that were able to stimulate invasion upon the expression in NIH3T3 / ErbB 2 cells . ^^^ In conclusion , our results establish that there is cooperation between alpha ( 6 ) beta ( 4 ) and ErbB 2 in promoting PI3K dependent invasion and implicate a specific region of the beta ( 4 ) cytoplasmic domain ( amino acids 854 1183 ) in this event . . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Phosphatidylinositol 3 kinase ( PI3K ) is activated by p 185 ( erbB 2 ) / erbB 3 heterodimers in cells stimulated by HRG , and PI3K is constitutively activated by p 185 ( erbB 2 ) / erbB 3 in breast carcinoma cells that overexpress c erbB 2 . ^^^ Furthermore , erbB 3 principally mediated the direct recruitment of p 85 in cells stimulated by HRG or EGF , indicating that , in addition to the high level activation of PI3K by p 185 ( erbB 2 ) / erbB 3 , EGFR / erbB 3 heterodimer interaction is essential for the weak but significant level of PI3K activated by EGF in cells that express normal EGFR levels . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| The mechanism by which EGFR recruits the PI3K / Akt pathway was in part differentially regulated at the level of Ras but independent of heterodimerization of EGFR with either ErbB 2 or ErbB 3 based upon functional dissection of pathways in esophageal cancer cell lines . . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Phosphatidylinositol 3 kinase ( PI3K ) , which is often activated in ErbB 2 overexpressing breast cancer cells , is known to regulate cell proliferation and cell survival . ^^^ Wortmannin , LY 294002 , and rapamycin at concentrations that did not affect MAPK phosphorylation but substantially inhibited PI3K , Akt , and p 70 ( S6K ) significantly suppressed the soft agar growth of tumor cell lines that overexpress ErbB 2 but not the growth of tumor lines with low ErbB 2 expression . ^^^ A similar growth inhibition of ErbB 2 overexpressing carcinoma lines was observed when a dominant negative p 85 ( PI3K ) mutant was introduced into these cells . ^^^ Furthermore , treatment with LY 294002 resulted in the selective increase of cyclin dependent kinase inhibitors p 21 ( Cip 1 ) or p 27 ( Kip 1 ) and suppression of cyclin E associated Cdk 2 kinase activity in ErbB 2 overexpressing lines , which may account for their hypersensitivity toward inhibitors of the PI3K pathway in anchorage independent growth . ^^^ Our results indicate that the PI3K / Akt / p70 ( S6K ) pathway plays an enhanced role in the anchorage independent growth of ErbB 2 overexpressing breast cancer cells , therefore providing a molecular basis for the selective targeting of this signaling pathway in the treatment of ErbB 2 related human breast malignancies . . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| We have examined whether inhibition of phosphatidylinositol 3 kinase ( PI3K ) and its target , the serine / threonine kinase Akt , play a role in the antitumor effect of the HER 2 antibody Herceptin . ^^^ Treatment of BT 474 cells with Herceptin inhibited the constitutive tyrosine phosphorylation of HER 3 and disrupted the basal association of HER 3 with HER 2 and of HER 3 with p85alpha potentially explaining the inhibition of PI3K . ^^^ These data suggest that ( a ) changes in cell cycle and apoptosis regulatory molecules after HER 2 blockade with Herceptin result , at least in part , from the inhibition of Akt ; and ( b ) disabling PI3K and Akt is required for the antitumor effect of HER 2 inhibitors . . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Oncogenic Ras / Her 2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that HER 2 signaling induced by overexpression in mouse 3T3 cells or heregulin stimulation of human MCF 7 breast cancer cells results in increased HIF 1alpha protein and VEGF mRNA expression that is dependent upon activity of PI3K , AKT ( also known as protein kinase B ) , and the downstream kinase FRAP ( FKBP rapamycin associated protein ) . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Treatment with AG 1478 resulted in rapid ErbB 2 dephosphorylation , reversible G ( 1 ) arrest , and interruption of constitutive mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3 kinase ( PI3K ) / Akt signaling . ^^^ These data imply that : ( a ) modulation of both p 27 and cyclin D 1 are required for the growth arrest that results from blockade of the ErbB 2 kinase ; and ( b ) ErbB 2 overexpressing cells use both MAPK and PI3K / Akt to modulate p 27 and cyclin D 1 and , hence , subvert the G ( 1 ) to S transition . . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Together , these results demonstrate that HRG stimulation of HER 2 overexpressing cells leads to enhanced c Myc protein synthesis through activation of the PI3K / Akt / mTOR pathway and that the P2L of c Myc mRNA is the element responsible for induction of c Myc translation . . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| However , we could also show that downstream of phosphoinositide 3 kinase ( PI3K ) , protein kinase B ( PKB ) acted as a previously unknown , potent inhibitor of integrin function and mediator of the disruptive effects of c erbB 2 on adhesion and morphogenesis . ^^^ In addition , the PI3K dependent mTOR / S6 kinase pathway was shown to mediate c erbB 2 induced inhibition of adhesion ( but not spreading ) independently of PKB . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| To evaluate the role of the phosphatidylinositol 3 kinase ( PI3K ) / Akt pathway in breast cancer cell survival and therapeutic resistance , we analyzed a panel of six breast cancer cell lines that varied in erbB 2 and estrogen receptor status . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Accordingly , T47D cells grown on LAM had the greatest increase in ErbB 2 activation , PI3K activity , and phosphorylation of Akt . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Because phosphatidylinositol 3 ' kinase ( PI3K ) is a major target of erbB 2 activation , we tested the contribution that PI3K and its downstream signaling pathways make to these phenotypes . ^^^ Utilizing a constitutively active form of PI3K , p110CAAX , we show that PI3K can mediate most phenotypes observed in erbB 2 overexpressing cells . ^^^ To identify pathways leading from PI3K to specific phenotypes , we expressed constitutively active AKT or PTEN in erbB 2 overexpressing cells or in HME cells . ^^^ Rottlerin blocked invasion induced by p110CAAX and erbB 2 , suggesting that protein kinase C delta ( PKC delta ) is the downstream effector of PI3K responsible for the invasive capacity of the cells . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to examine the effects of combining flavopiridol with several signal transduction inhibitors : the SC 236 COX 2 inhibitor , a PKC kinase inhibitor and LY 294002 , a phosphatidylinositol 3 kinase ( PI3K ) inhibitor in a control vector transfected MCF 7 human breast cancer cell line ( MCF / neo ) and a HER 2 / neu transfected MCF 7 cell line ( MCF / 18 ) . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Anti ErbB 2 monoclonal antibody 2C4 blocked heregulin stimulated phosphorylation of ErbB 2 and ErbB 3 ; activation of mitogen activated protein kinase ( MAPK ) , phosphatidylinositol 3 ' kinase ( PI3K ) , and Akt ; proliferation ; and anchorage independent growth . 2C4 blocked EGF mediated phosphorylation of ErbB 2 and inhibited PI3K / Akt and anchorage independent growth but did not affect ErbB 1 or MAPK . ^^^ Furthermore , we identify ErbB 2 as a critical component of EGF signaling to the Gab1 / Gab2 PI3K Akt pathway and anchorage independent growth , but EGF stimulation of MAPK and monolayer growth can occur efficiently without the contribution of ErbB2 . . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| This enhancement is due to an increase in cell survival rather than an increase in cell proliferation and is dependent on the activation of erbB 2 and phosphatidylinositol 3 kinase ( PI3K ) . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| In this report we have explored the mechanism linking the loss of expression of ERalpha in breast cancer cells with overexpression of Her 2 / neu , which signals constitutively via a phosphatidylinositol 3 kinase ( PI3K ) / Akt kinase pathway . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| RESULTS : We demonstrated that CM ( Coll ) Listeria / TSB increases the tyrosine phosphorylation level of ErbB 2 and ErbB 3 , members of the epidermal growth factor receptor ( EGFR ) family , and the association between ErbB 3 and the phosphatidylinositol 3 kinase ( PI3K ) regulatory subunit ( p85alpha ) . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Thus , anti HER 2 antibody preferentially affects genes contributing to cell cycle progression and cell growth / maintenance , in part through the PI3K AKT signaling . ^^^ Transcriptional regulation by anti HER 2 antibody through PI3K AKT pathway may potentiate the growth inhibitory activity of docetaxel by affecting cell cycle progression . . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| These data suggest that NRG 1 , binding to the HER2 / HER3 heterodimer receptor complex , induces pulmonary branching morphogenesis through HER 2 activation of the PI3K pathway . . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Moreover , alpha6beta4 associated haptotaxis inhibition was linked to a phosphatidylinositol 3 kinase ( PI3K ) pathway and required erbB 2 activation . erbB 2 , the ligand less member of the epidermal growth factor receptor family , was shown to form a complex with the hemidesmosomal integrin alpha6beta4 . ^^^ These effects were abolished when erbB 2 or PI3K were blocked . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Downregulation of wild type p 53 protein by HER 2 / neu mediated PI3K pathway activation in human breast cancer cells : its effect on cell proliferation and implication for therapy . ^^^ In the present study , we showed that the overexpression of HER 2 / neu could decrease the amount of wild type p 53 protein via activating PI3K pathway , as well as inducing MDM 2 nuclear translocation in MCF 7 human breast cancer cells . ^^^ Our study indicates that blocking PI3K pathway activation mediated by HER 2 / neu overexpression may be useful in the treatment of breast tumors with HER 2 / neu overexpression and wild type p53 . . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| The loss of adhesion was reversed by AG 825 , an inhibitor of erbB 2 receptor signalling and by wortmannin , a PI3K inhibitor , but not by the protein synthesis inhibitor cycloheximide . ^^^ EGF receptor signalling involving the erbB 2 and PI3K pathways plays a role in mediating these events in Capan 1 cells . . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Independent role of phosphoinositol 3 kinase ( PI3K ) and casein kinase 2 ( CK 2 ) in EGFR and Her 2 mediated constitutive NF kappaB activation in prostate cancer cells . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| HER 2 signaling downregulation by trastuzumab and suppression of the PI3K / Akt pathway : an unexpected effect on TRAIL induced apoptosis . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| In many human lung adenocarcinoma cell lines , a pathway involving epidermal growth factor receptor ( EGFR ) , ErbB 2 and ErbB 3 receptors , phosphatidyl inositol 3 kinase ( PI3K ) , Akt , glycogen synthase kinase 3 beta ( GSK 3 beta ) , and cyclin D 1 controls cell growth , survival , and invasiveness . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Taken together , the present studies suggest that amiloride enhances TRAIL induced cytotoxicity by inhibiting phosphorylation of the HER 2 / neu PI3K Akt pathway associated kinases and phosphatase . . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| The human epidermal growth factor receptor 2 ( HER 2 ) protein , a transmembrane growth factor receptor , is frequently overexpressed in malignancies , causing activation of the phosphatidylinositol 3 kinase ( PI3K ) and extracellular signal regulated kinase ( ERK ) signal pathways . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Although Herceptin could down regulate both phosphatidylinositol 3 kinase ( PI3K ) / AKT signal and mitogen activated protein / extracellular signal related kinase ( ERK ) kinase 1 ( MEK 1 ) / ERK signal in HER 2 positive breast cancer cells , PI3K specific inhibitor but not MEK 1 specific inhibitor could decrease the survivin levels . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the association between ERBB 2 overexpression and PIK3CA mutation implies that more than one input activating the PI3K / AKT pathway may be required to overcome intact PTEN . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Transfection of PI3K siRNA in breast cancer cells resulted in a significant decrease in cell viability and induction of apoptosis irrespective of their estrogen receptor alpha ( ERalpha ) or ErbB 2 status . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Transient or stable transfection of ErbB 2 cDNA to HB 2 cells upregulated the transcripts and the activity of the MMP 2 / 9 gene promoter ; the upregulation of MMP 2 / 9 expression was mediated by p 38 mitogen activated protein kinase ( p 38 MAPK ) and phosphatidylinositol 3 kinase ( PI3K ) . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Using such a method , we show that whereas both ErbB 2 homodimers and ErbB 1 ErbB2 heterodimers were equally potent in activating the Ras / mitogen activated protein kinase pathway , the heterodimers were more potent in activating the phosphoinositide 3 ' kinase ( PI3K ) and phospholipase Cgamma 1 pathways than ErbB 2 homodimers . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| The HSP 90 inhibitor 17 allylamino 17 demethoxygeldanamycin ( 17 AAG ) depletes some proteins involved in PI3K / AKT signaling , e . g . , ERBB 2 , epidermal growth factor receptor ( EGFR ) , and phosphorylated AKT ( p AKT ) . 17 AAG and paclitaxel were combined ( at a fixed 1 : 1 ratio of their IC ( 50 ) ) in four ovarian cancer cell lines that differ in expression of p AKT , EGFR , and ERBB 2 . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Binding of the antibody activates an immune response and decreases Her 2 phosphorylation , phosphatidylinositol 3 kinase ( PI3K ) / Akt activity and vascular endothelial growth factor levels . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Co expression studies in insect cells have shown that p 85 alpha and p 85 beta are substrates for the protein tyrosine kinases of epidermal growth factor , colony stimulating factor 1 and c erbB 2 receptors and the src family kinase p59c fyn . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| Following PMA induced tyrosine phosphorylation , ErbB 2 and ErbB 3 were able to associate with the SH 2 domains of several signaling proteins including the p85alpha subunit of phosphatidylinositol 3 kinase , Syp , and Grb 2 . ^^^ |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27986 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|