| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| However , Nef mutants that cause internalized CD 4 to be recycled do not associate with PI3K activity ; thus Nef associated PI3K activity might be involved in the latter process of targeting CD 4 to a degradative pathway . ^^^ We conclude that HIV 1 Nef plays a critical role in multiple processes in CD 4 down regulation : ( 1 ) disrupting the CD 4 p56 ( lck ) complex on the cell surface to allow CD 4 internalization and ( 2 ) diverting the internalized CD 4 to a lysosomal pathway for its degradation , likely through a PI3K activity . . ^^^ |
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| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| SDF 1 was shown to promote CD 4 ( + ) T cell survival through the phosphatidylinositol 3 kinase ( PI3K ) and mitogen activated protein kinase ( MAPK ) cascades without cell cycle progression . ^^^ |
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| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that CD 4 ( + ) T cells from CD 28 deficient mice show increased susceptibility to Fas mediated apoptosis via a phosphatidylinositol 3 kinase ( PI3K ) dependent pathway . ^^^ |
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| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrated that IL 12 activates phosphatidylinositol 3 kinase ( PI3K ) / Akt pathway in murine CD 4 ( + ) T cells , and that this signaling pathway is required for IL 12 induced T cell proliferation and antiapoptotic function , but not for IFN gamma induction . ^^^ These results suggest that PI3K / Akt pathway is critical for mediating IL 12 induced CD 4 ( + ) T cell responses such as T cell proliferation and survival . . ^^^ |
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| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| Genetic alteration of both PI3K isoforms also affects positive selection ; p110gamma deletion decreased and p 65 ( PI3K ) expression augmented the CD 4 ( + ) / CD8 ( + ) differentiation ratio . ^^^ These observations underscore the contribution of PI3K in T cell development , as well as its implication in determining the CD 4 ( + ) / CD8 ( + ) T cell differentiation ratio in vivo . . ^^^ |
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| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01730 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|