| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| One mechanism involves PI3K / PKB dependent phosphorylation of 4E BP 1 , which dissociates from eIF4E , allowing initiation of translation from the 7 methylGTP cap of mRNAs . ^^^ |
|
| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| Moreover , CAP Delta SH 3 has no effect on the PI3K dependent activation of protein phosphatase 1 or phosphorylation of glycogen synthase kinase 3 . ^^^ |
|
| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| Given the high percentage of CaP patients with mutations in the PTEN tumor suppressor gene , we sought to determine the involvement of the phosphatidylinositol 3 ' kinase ( PI3K ) cascade in the development of CaP drug resistance . ^^^ Furthermore , modulation of PI3K activity with the use of constitutively active and dominant negative inhibitors was found to affect the ability to CaP cells to respond to chemotoxic treatments . ^^^ Additionally , inhibition of PI3K with a small molecular weight inhibitor ( LY 294002 ) was able to potentiate the antineoplastic activity of both doxorubicin and paclitaxel in CaP cells . ^^^ |
|
| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| The APS adapter protein is recruited to the autophosphorylated kinase domain of the insulin receptor and initiates the phosphatidylinositol 3 kinase ( PI3K ) independent pathway of insulin stimulated glucose transport by recruiting CAP and c Cbl . ^^^ |
|
| Interacting proteins: O60885 and P27986 |
Pubmed |
SVM Score :0.0 |
| Together , our results suggest that beta cat / Tcf 4 signaling transcriptionally activates ET 1 in CaP cells ; meanwhile , ET 1 enhances beta cat / Tcf 4 signaling and in turn further increases ET 1 expression in a PI3K dependent manner . ^^^ |
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