Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
P . gingivalis LPS selectively activates the PI3K Akt pathway via Toll like receptor 2 , and inhibition of this pathway results in an abrogation of extracellular signal regulated kinase 1 / 2 phosphorylation , whereas the activation of p 38 and c Jun N terminal kinase 1 / 2 kinases were unaffected . ^^^
Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
S . aureus stimulation causes the recruitment of active Rac 1 and phosphatidylinositol 3 kinase ( PI3K ) to the TLR 2 cytosolic domain . ^^^
Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
In contrast to previous studies , identifying Rac 1 PI3K as an upstream element in TLR 2 initiated response to NF kappaB , PI3K signaling was not required for RhoA or PKCzeta activity . ^^^
Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
Phagocytosis by CD 14 positive THP 1 cells was attenuated by phosphatidylinositol 3 inhibitors LY 294002 and wortmannin and experiments using transfected CHO cells showed substantial accumulation of phosphatidylinositol 3 , 4 , 5 trisphosphate at the BCG attachment site in CHO cells expressing CD 14 and TLR 2 suggesting that bacteria bind to CD 14 and use TLR 2 to initiate a PI3K signaling pathway . ^^^ These findings reveal that mycobacteria promote their uptake through a process of `` inside out ' ' signaling involving CD 14 , TLR 2 , PI3K , and cytohesin 1 . ^^^
Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
Furthermore , NF kappaB activation by LTA required the integrity of two putative PI3K binding domains within TLR 2 and was inhibited by wortmannin , indicating an essential role for PI3K in cellular activation by LTA . ^^^
Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
TLR 2 transmodulates monocyte adhesion and transmigration via Rac 1 and PI3K mediated inside out signaling in response to Porphyromonas gingivalis fimbriae . ^^^ Fimbriae induced CD11b / CD18 dependent adhesion of human monocytes or mouse macrophages to endothelial receptor ICAM 1 ; these activities were inhibited by TLR 2 blockade or deficiency or by pharmacological inhibitors of PI3K . ^^^ Thus , P . gingivalis fimbriae activate a novel proadhesive pathway in human monocytes , involving TLR 2 , Rac 1 , PI3K , and CD11b / CD18 , which may constitute a mechanistic basis linking P . gingivalis to inflammatory atherosclerotic processes . . ^^^
Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
The enhancing effects of HSP 60 costimulation on Tregs involved innate signaling via TLR 2 , led to activation of PKC , PI3K , and p 38 , and were further enhanced by inhibition of ERK . ^^^
Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
Using biochemical and genetic approaches , we demonstrate that TLR 2 ligands stimulate release of Ca ( 2+ ) from intracellular stores by activating TLR 2 phosphorylation by c Src , and recruiting PI3K and phospholipase Cgamma to affect Ca ( 2+ ) release through inositol ( 1 , 4 , 5 ) trisphosphate receptors . ^^^
Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
Collectively , these findings provide new insight into the homeostatic mechanism controlling type 1 immune responses during mycobacterial infection involving the intracellular network of PI3K , S6K1 , ERK 1 / 2 and p 38 MAPK pathways in a TLR 2 dependent manner . . ^^^
Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
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Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
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Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
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Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
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Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
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Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
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Interacting proteins: O60603 and P27986	Pubmed	SVM Score :0.0
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