| Interacting proteins: O43184 and P27986 |
Pubmed |
SVM Score :0.0 |
| The PI3K inhibitor LY 294002 and the mitogen activated protein kinase kinase ( MEK ) inhibitor UO 126 prevented ADAM 12 induction by TGF beta , suggesting the involvement of PI3K and MEK activities . ^^^ |
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| Interacting proteins: O43184 and P27986 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The phophatidylinositol 3 kinase ( PI3K ) inhibitor LY 294002 and the mitogen activated protein kinase inhibitor , UO 126 , decreased the TGF beta 1 dependent ADAM 12 expression and prevented the phosphorylation of p70S6K . ^^^ CONCLUSIONS : The data suggest that TGF beta 1 induces ADAM 12 gene expression through both the PI3K / Frap mTOR / p70S6K and MEK / ERK pathways . ^^^ The involvement of PI3K in ADAM 12 expression , similar to that previously observed for collagen 1 and fibronectin , suggests common pathways for gene up regulation in hepatic stellate cells that occur during liver fibrogenesis and contribute to tumor progression . . ^^^ |
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