| Interacting proteins: O15524 and P27986 |
Pubmed |
SVM Score :0.0 |
| Using two independent approaches , one involving inhibition of specific signaling molecules and the other employing cell lines that express particular EpoR mutants and thereby activate only subsets of signaling cascades , we demonstrate that induction of SOCS 1 , SOCS 2 , SOCS 3 , and cytokine inducible SH 2 containing protein ( CIS ) in response to EPO stimulation appears to depend on Stat 5 but not on mitogen activated protein kinase ( MAPK ) or phosphatidylinositol 3 kinase ( PI3K ) . ^^^ |
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| Interacting proteins: O15524 and P27986 |
Pubmed |
SVM Score :0.0 |
| Unlike IRAK M ( IL 1 receptor associated kinase M ) and SOCS 1 ( suppressor of cytokine signaling 1 ) that are induced by TLR signaling and function during the second or continuous exposure to stimulation , PI3K functions at the early phase of TLR signaling and modulates the magnitude of the primary activation . ^^^ Thus , PI3K , IRAK M and SOCS 1 have unique roles in the gate keeping system , preventing excessive innate immune responses . . ^^^ |
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| Interacting proteins: O15524 and P27986 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that postinfarct remodeling disrupts cellular signaling from the EPO receptor to PI3K , presumably by increased SOCS 1 . ^^^ |
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| Interacting proteins: O15524 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15524 and P27986 |
Pubmed |
SVM Score :0.0 |
| NA |
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