Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
It is known that the two types of IL 1 receptors ( IL 1RI and IL 1RII ) play different roles in the regulation of IL 1 activity , with IL 1RI being solely responsible for cell triggering upon IL 1 binding , whereas IL 1RII acts as a scavenger of IL 1 and can thus be considered as a natural IL 1 inhibitor . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
Since IL 1Ra blocks IL 1 from binding to both the IL 1RI and Il 1RII , monoclonal antibodies directed against each receptor were used to ascertain which IL 1R mediates IL 1 induced HIV 1 expression . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
Plasma interleukin 1 ( IL 1 ) activity is modulated in part through the simultaneous appearance of several inhibitors of IL 1 action , including interleukin 1 receptor antagonist ( IL 1ra ) and the soluble IL 1 type 2 receptor ( IL 1RII ) . ^^^ In the present report , plasma IL 1beta , IL 1ra , and soluble IL 1RI and IL 1RII concentrations were evaluated in 118 patients with sepsis syndrome or after elective operative trauma . ^^^ We conclude that both plasma IL 1ra and soluble IL 1RII concentrations often increase in sepsis and following some operative trauma . ^^^ Less severe operative trauma increases the plasma concentration of only IL 1ra , whereas both IL 1ra and soluble IL 1RII are increased in patients with sepsis syndrome or following thoraco abdominal aneurysm repair . . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
The data suggest the operation of an IL 1 beta feedback system ( IL 1 beta / IL 1RI / IL 1RII / IL 1Ra ) within a brain region . ^^^ The fine regulation of the CNS IL 1 beta system may depend on a balance between the ligand ( IL 1 beta ) action on the IL 1RI and the induction of inhibitory mechanisms ( IL 1RII and IL 1Ra ) . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
To hypothesize the involvement of the IL 1 system in ischemic injury , we examined other IL 1 components , including IL 1ra , IL 1RI , and IL 1RII for their mRNA expression after focal stroke . ^^^ CONCLUSIONS : Differential expression of IL 1 beta , IL 1ra , IL 1RI , and IL 1RII mRNAs after focal stroke may suggest a distinct role ( s ) for each component of the IL 1 system in ischemic injury . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
The combination of endotoxin and dexamethasone induces type 2 interleukin 1 receptor ( IL 1r 2 ) in monocytes : a comparison to interleukin 1 beta ( IL 1 beta ) and interleukin 1 receptor antagonist ( IL 1ra ) . ^^^ Soluble type 2 interleukin 1 receptor ( IL 1r 2 ) and interleukin 1 receptor antagonist ( IL 1ra ) regulate inflammation by competitively inhibiting the binding of IL 1 beta to the signalling IL 1 receptor . ^^^ Interestingly , increased serum levels of soluble IL 1r 2 and IL 1ra have been measured in septic patients , although the mechanism is unclear . ^^^ In this respect , the authors characterize new pathways in which IL 1r 2 and IL 1ra may be regulated in sepsis through combined stimulation with lipopolysaccharide ( LPS ) and dexamethasone of peripheral blood mononuclear cells ( PBMC ) . ^^^ Although IL 1r 2 and IL 1ra may work together to suppress IL 1 beta effects in sepsis , inflammatory cells differentially regulate these cytokines . . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
IL 1 receptor antagonist ( IL 1ra ) and IL 1R type 2 ( IL 1RII ) were both significantly overexpressed in mutually exclusive compartments of PP epidermis , the suprabasal and basal compartment , respectively . ^^^ The mRNA levels of the secreted IL 1ra isoform , but not intracellular IL 1raI and 2 , and IL 1RII were elevated in PP EC and paralleled those of IL 1beta . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
The present study was carried out to test the hypotheses that ( 1 ) cellular secretion of interleukin 1 beta ( IL 1 beta ) , interleukin 1 receptor antagonist ( IL 1Ra ) , and soluble interleukin 1 receptor type 2 ( IL 1sRII ) is abnormal in female CFS patients compared to age and activity matched controls ; ( 2 ) that these abnormalities may be evident only at certain times in the menstrual cycle ; and ( 3 ) that physical exertion ( stepping up and down on a platform for 15 min ) may accentuate differences between these groups . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
IL 1beta increased IL 1beta , IL 1 receptor types 1 and 2 ( IL 1RI and IL 1RII ) , IL 1 receptor accessory protein soluble form ( IL 1R AcP 2 ) , IL 1 receptor antagonist ( IL 1Ra ) , TNF alpha , and TGF beta 1 mRNAs in the hypothalamus from obese and lean rats . ^^^ The data suggest 1 ) the operation of an IL 1beta feedback system ( IL 1beta / IL 1RI / IL 1R Acp II / IL 1RII / IL 1Ra ) and 2 ) potential cytokine cytokine interactions with positive ( IL 1beta < > TNF alpha ) and negative ( TGF beta 1 > IL 1beta / TNF alpha ) feedback . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
The expression of IL 1beta , IL 1 Receptor 1 ( IL 1R1 ) , Il 1R2 , IL 1R antagonist ( IL 1Ra ) , and ICE mRNA within the pancreas was examined by quantitative differential RT PCR . ^^^ There was constitutive expression of pancreatic IL 1R1 , IL 1R2 , IL 1Ra , and ICE but not IL 1beta . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
OBJECTIVE : To compare plasma levels of interleukin 1 receptor antagonist ( IL 1Ra ) , soluble IL 1 receptor type 1 ( sIL 1RI ) , and soluble IL 1 receptor type 2 ( sIL 1RII ) in patients with chronic polyarthritis , and to establish correlations between levels of these naturally occurring IL 1 inhibitors and indices of disease activity and joint destruction . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
Although plasma interleukin 6 ( IL 6 ) was undetectable and soluble interleukin 1 receptor type 2 ( IL 1sRII ) remained unchanged , interleukin 1 receptor antagonist ( IL 1ra ) concentrations were elevated directly after the race with a further increase at 3 h ( P < 0 . 0001 ) . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
Two naturally occurring IL 1 antagonists have been described , namely the IL 1 receptor antagonist ( IL 1Ra ) and the IL 1 receptor type 2 ( IL 1RII ) . ^^^ Shedding of IL 1RII yields the soluble IL 1 receptor type 2 ( IL 1sRII ) which retains the ability of membrane bound IL 1RII to bind IL 1beta avidly , but binds IL 1Ra and IL 1alpha with low affinity . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
In the present study , the levels of soluble IL 1 receptor type 2 ( sIL 1R type 2 ) , IL 1 receptor antagonist ( IL 1ra ) , IL 1beta , IL 6 and TNF alpha were analyzed in cerebrospinal fluid ( CSF ) samples from Alzheimer ' s disease patients and control subjects . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
Specifically , the IL 1 type 1 receptor ( IL 1RI ) , IL 1 type 2 receptor ( IL 1RII ) , IL 1 receptor accessory protein ( IL 1RAcP ) , and IL 1 receptor antagonist ( IL 1Ra ) were analyzed . ^^^ IL 1beta induced chemokine production and release were inhibited by a 10 to 1 , 000 fold molar excess of recombinant IL 1RII or IL 1Ra , whereas IL 1RI was a less effective inhibitor . ^^^ Release of extracellular IL 1 inhibitors , including soluble IL 1Ra and soluble IL 1RII , by other inflammatory cells present in the airway may be critical for regulation of IL 1beta activity in the airway microenvironment . . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
Our present study investigated the expression of IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , and IL 1 receptor ( IL 1RI and IL 1RII ) mRNA in carotid artery after balloon angioplasty using semiquantitative reverse transcription / polymerase chain reaction ( RT / PCR ) and Northern analysis . ^^^ The differential but concomitant expression of IL 1beta , IL 1ra , IL 1RI , and IL 1RII mRNAs after balloon angioplasty suggests that each of these IL 1 system components may play a distinct role in neointima formation . . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
Gene array analysis of human normal and OA affected cartilage showed mRNA expression of IL 1 receptor accessory protein ( IL 1RAcp ) and IL 1 type 1 receptor ( IL 1RI ) , but not IL 1 antagonist ( IL 1ra ) and IL 1 type 2 decoy receptor ( IL 1RII ) . ^^^ In osteoarthritis , deficient expression by chondrocytes of innate regulators or antagonists of IL 1 such as IL 1ra and IL 1RII ( soluble or membrane form ) may allow the catabolic effects of IL 1 to proceed unopposed . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
Gene expression arrays show that human epithelial cells and human arthritis affected cartilage lack detectable amounts of mRNA for IL 1 antagonizing molecules : IL 1Ra and IL 1RII , but constitutively express IL 1 . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
Our data indicate that CGA and IL 1RI are expressed by all seven , IL 1 beta by five , IL 1RII and IL 1RA by six lines . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
The aim of the present work was to investigate the expression of IL 1alpha , IL 1beta , IL 1ra , IL 1R1 , and IL 1R2 genes in equine cumulus cells and oocytes . ^^^ In conclusion , we demonstrated for the first time , in mares , the presence of IL 1beta and IL 1R2 transcripts in oocytes and of IL 1beta , IL 1ra , IL 1R1 , and IL 1R2 in cumulus cells . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
The IL 1 family consists of two agonists , IL 1alpha and IL 1beta , two receptors , biologically active IL 1RI and inert IL 1RII , and a specific receptor antagonist , IL 1Ra . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
Seven genes , including interleukin 1 receptor antagonist ( IL 1ra ) , IL 1receptor type 2 ( IL 1RII ) , insulin like growth factor binding protein 4 ( IGFBP 4 ) , transforming growth factor beta ( TGF beta ) , granulocyte colony stimulating factor receptor ( G CSFR ) , leukemia inhibitory factor receptor ( LIFR ) , and soluble IL 4 receptor ( sIL 4R ) were selected as probable candidate genes for the trabecular bone sparing effect of estrogen , as the mRNA levels of these genes were highly correlated ( r 2 > 0 . 65 ) to the trabecular BMD . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
In addition to IL 1beta , IL 6 , TNF alpha , and their receptors , LEW / N hypothalamic cells also transcribed more anti inflammatory molecules , IL 1RII , IL 1RA , and transforming growth factor ( TGFbeta 1 ) , than F334 / N cells . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
Binding levels are influenced by the IL 1 receptor antagonist ( IL 1Ra ) , IL 1RII ( decoy receptor with no signal transduction ) , soluble IL 1RI , and soluble IL 1RII . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
RESULTS : We demonstrated that interleukin 1beta ( IL 1beta ) , interleukin 1 receptor 2 ( IL 1R2 ) and interleukin 1 receptor antagonist ( IL 1RA ) genes are expressed in equine granulosa cells . ^^^ We observed that the IL 1beta and IL 1RA mRNA content changed in granulosa cells during the terminal follicular maturation whereas IL 1R2 mRNA did not vary . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
Based on our previous studies , we hypothesize that the IL 1 family of cytokines , antagonists ( IL 1ra ) and receptors ( IL 1RI and IL 1RII ) are present within the human breast cancer ( HBC ) tumor microenvironment and that the IL 1 network of cytokines and receptors within the tumor microenvironment can control tumor cell subpopulation expression of other protumorigenic cytokines such as the angiogenic / growth factor , interleukin 8 ( IL 8 ) . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
We have analysed transcripts of IL 1 gene system ( IL 1alpha , IL 1beta , IL 1RI , IL 1RII and IL 1RA ) to evaluate the possible link between the level of gene ( s ) transcription and their function . ^^^ Looking more closely at gene ( s ) differential expression it appears that IL 1alpha can be preferentially down regulated by IL 1RA gene in intratubular fraction while the IL 1beta , through the `` false ' ' IL 1RII receptor in the interstitium . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
The IL 1 gene family includes genes which play important roles in both these processes and consists of IL 1 ? , IL 1ss , IL 18 , the IL 1 receptor antagonist ( IL 1RA ) , two IL 1 receptors ( IL 1RI , IL 1RII ) , the IL 18 receptor ( IL 18R ? ) , and the receptor associated proteins IL 1RAcP and IL 18Rss . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
IL 1RI , IL 1RII , and IL 1Ra were all up regulated , whereas the IL 1beta converting enzyme , caspase 1 , and IRAK M were down regulated . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
VS also inhibited LPS dependent up regulation of IL 1beta and IL 6 mRNA in the brain , while increasing by 50 % the cerebral expression of transcripts of the specific antagonist of IL 1 receptors IL 1RA and IL 1R2 . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
These findings show a high expression of IL 1beta and its functional receptor ( IL 1RI ) in FCD and GNT specimens together with a relative paucity of mechanisms ( IL 1RII and IL 1Ra ) apt to inactivate IL 1beta actions . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
In the following single point analysis , SNPs on IL1RN , IL1R2 , ESR 1 , Factor 5 , and OPRM 1 genes were identified as possible risk factors in PTD . . ^^^
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18510 and P27930	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
The combination of endotoxin and dexamethasone induces type 2 interleukin 1 receptor ( IL 1r 2 ) in monocytes : a comparison to interleukin 1 beta ( IL 1 beta ) and interleukin 1 receptor antagonist ( IL 1ra ) . ^^^ Soluble type 2 interleukin 1 receptor ( IL 1r 2 ) and interleukin 1 receptor antagonist ( IL 1ra ) regulate inflammation by competitively inhibiting the binding of IL 1 beta to the signalling IL 1 receptor . ^^^ Interestingly , increased serum levels of soluble IL 1r 2 and IL 1ra have been measured in septic patients , although the mechanism is unclear . ^^^ In this respect , the authors characterize new pathways in which IL 1r 2 and IL 1ra may be regulated in sepsis through combined stimulation with lipopolysaccharide ( LPS ) and dexamethasone of peripheral blood mononuclear cells ( PBMC ) . ^^^ Although IL 1r 2 and IL 1ra may work together to suppress IL 1 beta effects in sepsis , inflammatory cells differentially regulate these cytokines . . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
The present study was carried out to test the hypotheses that ( 1 ) cellular secretion of interleukin 1 beta ( IL 1 beta ) , interleukin 1 receptor antagonist ( IL 1Ra ) , and soluble interleukin 1 receptor type 2 ( IL 1sRII ) is abnormal in female CFS patients compared to age and activity matched controls ; ( 2 ) that these abnormalities may be evident only at certain times in the menstrual cycle ; and ( 3 ) that physical exertion ( stepping up and down on a platform for 15 min ) may accentuate differences between these groups . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
OBJECTIVE : To compare plasma levels of interleukin 1 receptor antagonist ( IL 1Ra ) , soluble IL 1 receptor type 1 ( sIL 1RI ) , and soluble IL 1 receptor type 2 ( sIL 1RII ) in patients with chronic polyarthritis , and to establish correlations between levels of these naturally occurring IL 1 inhibitors and indices of disease activity and joint destruction . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
Although plasma interleukin 6 ( IL 6 ) was undetectable and soluble interleukin 1 receptor type 2 ( IL 1sRII ) remained unchanged , interleukin 1 receptor antagonist ( IL 1ra ) concentrations were elevated directly after the race with a further increase at 3 h ( P < 0 . 0001 ) . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
Two naturally occurring IL 1 antagonists have been described , namely the IL 1 receptor antagonist ( IL 1Ra ) and the IL 1 receptor type 2 ( IL 1RII ) . ^^^ Shedding of IL 1RII yields the soluble IL 1 receptor type 2 ( IL 1sRII ) which retains the ability of membrane bound IL 1RII to bind IL 1beta avidly , but binds IL 1Ra and IL 1alpha with low affinity . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
In the present study , the levels of soluble IL 1 receptor type 2 ( sIL 1R type 2 ) , IL 1 receptor antagonist ( IL 1ra ) , IL 1beta , IL 6 and TNF alpha were analyzed in cerebrospinal fluid ( CSF ) samples from Alzheimer ' s disease patients and control subjects . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
Since IL 1Ra blocks IL 1 from binding to both the IL 1RI and Il 1RII , monoclonal antibodies directed against each receptor were used to ascertain which IL 1R mediates IL 1 induced HIV 1 expression . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
Plasma interleukin 1 ( IL 1 ) activity is modulated in part through the simultaneous appearance of several inhibitors of IL 1 action , including interleukin 1 receptor antagonist ( IL 1ra ) and the soluble IL 1 type 2 receptor ( IL 1RII ) . ^^^ In the present report , plasma IL 1beta , IL 1ra , and soluble IL 1RI and IL 1RII concentrations were evaluated in 118 patients with sepsis syndrome or after elective operative trauma . ^^^ We conclude that both plasma IL 1ra and soluble IL 1RII concentrations often increase in sepsis and following some operative trauma . ^^^ Less severe operative trauma increases the plasma concentration of only IL 1ra , whereas both IL 1ra and soluble IL 1RII are increased in patients with sepsis syndrome or following thoraco abdominal aneurysm repair . . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
The data suggest the operation of an IL 1 beta feedback system ( IL 1 beta / IL 1RI / IL 1RII / IL 1Ra ) within a brain region . ^^^ The fine regulation of the CNS IL 1 beta system may depend on a balance between the ligand ( IL 1 beta ) action on the IL 1RI and the induction of inhibitory mechanisms ( IL 1RII and IL 1Ra ) . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
To hypothesize the involvement of the IL 1 system in ischemic injury , we examined other IL 1 components , including IL 1ra , IL 1RI , and IL 1RII for their mRNA expression after focal stroke . ^^^ CONCLUSIONS : Differential expression of IL 1 beta , IL 1ra , IL 1RI , and IL 1RII mRNAs after focal stroke may suggest a distinct role ( s ) for each component of the IL 1 system in ischemic injury . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
IL 1 receptor antagonist ( IL 1ra ) and IL 1R type 2 ( IL 1RII ) were both significantly overexpressed in mutually exclusive compartments of PP epidermis , the suprabasal and basal compartment , respectively . ^^^ The mRNA levels of the secreted IL 1ra isoform , but not intracellular IL 1raI and 2 , and IL 1RII were elevated in PP EC and paralleled those of IL 1beta . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
It is known that the two types of IL 1 receptors ( IL 1RI and IL 1RII ) play different roles in the regulation of IL 1 activity , with IL 1RI being solely responsible for cell triggering upon IL 1 binding , whereas IL 1RII acts as a scavenger of IL 1 and can thus be considered as a natural IL 1 inhibitor . ^^^ Conversely , binding of IL 1beta to IL 1RII bearing cells could be inhibited by DoB 0041 much less efficiently than by wild type IL 1ra . ^^^ Thus , the enhanced inhibitory capacity of DoB 0041 as compared with wild type IL 1ra is explained in terms of better binding to the activating receptor IL 1RI and poorer interaction with the inhibitory receptor IL 1RII . . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
IL 1beta increased IL 1beta , IL 1 receptor types 1 and 2 ( IL 1RI and IL 1RII ) , IL 1 receptor accessory protein soluble form ( IL 1R AcP 2 ) , IL 1 receptor antagonist ( IL 1Ra ) , TNF alpha , and TGF beta 1 mRNAs in the hypothalamus from obese and lean rats . ^^^ The data suggest 1 ) the operation of an IL 1beta feedback system ( IL 1beta / IL 1RI / IL 1R Acp II / IL 1RII / IL 1Ra ) and 2 ) potential cytokine cytokine interactions with positive ( IL 1beta < > TNF alpha ) and negative ( TGF beta 1 > IL 1beta / TNF alpha ) feedback . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
The expression of IL 1beta , IL 1 Receptor 1 ( IL 1R1 ) , Il 1R2 , IL 1R antagonist ( IL 1Ra ) , and ICE mRNA within the pancreas was examined by quantitative differential RT PCR . ^^^ There was constitutive expression of pancreatic IL 1R1 , IL 1R2 , IL 1Ra , and ICE but not IL 1beta . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
Specifically , the IL 1 type 1 receptor ( IL 1RI ) , IL 1 type 2 receptor ( IL 1RII ) , IL 1 receptor accessory protein ( IL 1RAcP ) , and IL 1 receptor antagonist ( IL 1Ra ) were analyzed . ^^^ IL 1beta induced chemokine production and release were inhibited by a 10 to 1 , 000 fold molar excess of recombinant IL 1RII or IL 1Ra , whereas IL 1RI was a less effective inhibitor . ^^^ Release of extracellular IL 1 inhibitors , including soluble IL 1Ra and soluble IL 1RII , by other inflammatory cells present in the airway may be critical for regulation of IL 1beta activity in the airway microenvironment . . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
Our present study investigated the expression of IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , and IL 1 receptor ( IL 1RI and IL 1RII ) mRNA in carotid artery after balloon angioplasty using semiquantitative reverse transcription / polymerase chain reaction ( RT / PCR ) and Northern analysis . ^^^ The differential but concomitant expression of IL 1beta , IL 1ra , IL 1RI , and IL 1RII mRNAs after balloon angioplasty suggests that each of these IL 1 system components may play a distinct role in neointima formation . . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
Gene array analysis of human normal and OA affected cartilage showed mRNA expression of IL 1 receptor accessory protein ( IL 1RAcp ) and IL 1 type 1 receptor ( IL 1RI ) , but not IL 1 antagonist ( IL 1ra ) and IL 1 type 2 decoy receptor ( IL 1RII ) . ^^^ In osteoarthritis , deficient expression by chondrocytes of innate regulators or antagonists of IL 1 such as IL 1ra and IL 1RII ( soluble or membrane form ) may allow the catabolic effects of IL 1 to proceed unopposed . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
Gene expression arrays show that human epithelial cells and human arthritis affected cartilage lack detectable amounts of mRNA for IL 1 antagonizing molecules : IL 1Ra and IL 1RII , but constitutively express IL 1 . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
Our data indicate that CGA and IL 1RI are expressed by all seven , IL 1 beta by five , IL 1RII and IL 1RA by six lines . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
The aim of the present work was to investigate the expression of IL 1alpha , IL 1beta , IL 1ra , IL 1R1 , and IL 1R2 genes in equine cumulus cells and oocytes . ^^^ In conclusion , we demonstrated for the first time , in mares , the presence of IL 1beta and IL 1R2 transcripts in oocytes and of IL 1beta , IL 1ra , IL 1R1 , and IL 1R2 in cumulus cells . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
The IL 1 family consists of two agonists , IL 1alpha and IL 1beta , two receptors , biologically active IL 1RI and inert IL 1RII , and a specific receptor antagonist , IL 1Ra . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
Seven genes , including interleukin 1 receptor antagonist ( IL 1ra ) , IL 1receptor type 2 ( IL 1RII ) , insulin like growth factor binding protein 4 ( IGFBP 4 ) , transforming growth factor beta ( TGF beta ) , granulocyte colony stimulating factor receptor ( G CSFR ) , leukemia inhibitory factor receptor ( LIFR ) , and soluble IL 4 receptor ( sIL 4R ) were selected as probable candidate genes for the trabecular bone sparing effect of estrogen , as the mRNA levels of these genes were highly correlated ( r 2 > 0 . 65 ) to the trabecular BMD . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
In addition to IL 1beta , IL 6 , TNF alpha , and their receptors , LEW / N hypothalamic cells also transcribed more anti inflammatory molecules , IL 1RII , IL 1RA , and transforming growth factor ( TGFbeta 1 ) , than F334 / N cells . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
Binding levels are influenced by the IL 1 receptor antagonist ( IL 1Ra ) , IL 1RII ( decoy receptor with no signal transduction ) , soluble IL 1RI , and soluble IL 1RII . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
RESULTS : We demonstrated that interleukin 1beta ( IL 1beta ) , interleukin 1 receptor 2 ( IL 1R2 ) and interleukin 1 receptor antagonist ( IL 1RA ) genes are expressed in equine granulosa cells . ^^^ We observed that the IL 1beta and IL 1RA mRNA content changed in granulosa cells during the terminal follicular maturation whereas IL 1R2 mRNA did not vary . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
Based on our previous studies , we hypothesize that the IL 1 family of cytokines , antagonists ( IL 1ra ) and receptors ( IL 1RI and IL 1RII ) are present within the human breast cancer ( HBC ) tumor microenvironment and that the IL 1 network of cytokines and receptors within the tumor microenvironment can control tumor cell subpopulation expression of other protumorigenic cytokines such as the angiogenic / growth factor , interleukin 8 ( IL 8 ) . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
In the following single point analysis , SNPs on IL1RN , IL1R2 , ESR 1 , Factor 5 , and OPRM 1 genes were identified as possible risk factors in PTD . . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
We have analysed transcripts of IL 1 gene system ( IL 1alpha , IL 1beta , IL 1RI , IL 1RII and IL 1RA ) to evaluate the possible link between the level of gene ( s ) transcription and their function . ^^^ Looking more closely at gene ( s ) differential expression it appears that IL 1alpha can be preferentially down regulated by IL 1RA gene in intratubular fraction while the IL 1beta , through the `` false ' ' IL 1RII receptor in the interstitium . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
The IL 1 gene family includes genes which play important roles in both these processes and consists of IL 1 ? , IL 1ss , IL 18 , the IL 1 receptor antagonist ( IL 1RA ) , two IL 1 receptors ( IL 1RI , IL 1RII ) , the IL 18 receptor ( IL 18R ? ) , and the receptor associated proteins IL 1RAcP and IL 18Rss . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
IL 1RI , IL 1RII , and IL 1Ra were all up regulated , whereas the IL 1beta converting enzyme , caspase 1 , and IRAK M were down regulated . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
VS also inhibited LPS dependent up regulation of IL 1beta and IL 6 mRNA in the brain , while increasing by 50 % the cerebral expression of transcripts of the specific antagonist of IL 1 receptors IL 1RA and IL 1R2 . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
These findings show a high expression of IL 1beta and its functional receptor ( IL 1RI ) in FCD and GNT specimens together with a relative paucity of mechanisms ( IL 1RII and IL 1Ra ) apt to inactivate IL 1beta actions . ^^^
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27930 and P18510	Pubmed	SVM Score :0.0
NA