| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| Here we provide evidence that C1q and mannose binding lectin ( MBL ) , a member of the collectin family of proteins , bind to apoptotic cells and stimulate ingestion of these by ligation on the phagocyte surface of the multifunctional protein , calreticulin ( also known as the cC1qR ) , which in turn is bound to the endocytic receptor protein CD 91 , also known as the alpha 2 macroglobulin receptor . ^^^ |
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| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| In addition , two other ER resident proteins , RAP [ low density lipoprotein receptor related protein ( LRP ) receptor associated protein ] and calreticulin , were found to be clustered at IAC , whereas kinesin was not . ^^^ |
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| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| This mediates signaling through a receptor co complex involving calreticulin and low density lipoprotein ( LDL ) receptor related protein ( LRP ) . ^^^ Calreticulin null and LRP null fibroblasts do not migrate in response to TSP1 / hep 1 , nor do endothelial cells treated with the LRP inhibitor receptor associated protein ( RAP ) . ^^^ |
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| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| In RAP / cells , three well known ER chaperones , calnexin , calreticulin , and protein disulfide isomerase ( PDI ) , associate with LRP and likely compensate for the absence of RAP . . ^^^ |
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| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| The N terminus , called the heparin binding domain ( HBD ) , interacts with a variety of macromolecules including heparan sulfate proteoglycans at the membrane and in the matrix , LDL receptor related protein ( LRP ) , sulfated glycolipids , calreticulin , and integrins . ^^^ |
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| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| Cell surface calreticulin initiates clearance of viable or apoptotic cells through trans activation of LRP on the phagocyte . ^^^ We demonstrate here that calreticulin acts as a second general recognition ligand by binding and activating LDL receptor related protein ( LRP ) on the engulfing cell . ^^^ Disruption of interactions between CD 47 ( integrin associated protein ) on the target cell and SIRPalpha ( SHPS 1 ) , a heavily glycosylated transmembrane protein on the engulfing cell , permitted uptake of viable cells in a calreticulin / LRP dependent manner . ^^^ |
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| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| CD 91 is a common receptor for heat shock proteins gp 96 , hsp 90 , hsp 70 , and calreticulin . ^^^ |
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| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| The uptake and removal of necrotic or lysed cells involves inflammation and an immune response , due in part to processes that involve members of the collectin family , surface calreticulin and CD 91 . ^^^ |
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| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| Differential CD 91 dependence for calreticulin and Pseudomonas exotoxin A endocytosis . ^^^ |
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| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| These cell membrane molecules include various Fc receptors , recognizing different isotypes of antibodies and various complement receptors , such as CR 3 , CR 4 and the C1q binding complex of calreticulin and CD 91 . ^^^ |
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| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| These proteins also exhibit both inflammatory and anti inflammatory functions , which occur through interactions with pattern recognition receptors including Toll like receptor and CD 14 , signal inhibitory regulatory protein alpha and a receptor complex of calreticulin and CD 91 . ^^^ |
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| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| Role of surfactant proteins A , D , and C1q in the clearance of apoptotic cells in vivo and in vitro : calreticulin and CD 91 as a common collectin receptor complex . ^^^ Other collectins , such as mannose binding lectin and the collectin like C1q , have been shown to bind to apoptotic cells and drive ingestion through interaction with calreticulin and CD 91 on the phagocyte in vitro . ^^^ We sought to determine the relative importance of SP A , SP D , and C1q in pulmonary clearance of apoptotic cells using knockout and overexpressing mice , and to determine the role of calreticulin and CD 91 in this process . ^^^ Similar to C1q and mannose binding lectin , SP A and SP D bound to apoptotic cells in a localized , patchy pattern and drove apoptotic cell ingestion by phagocytes through a mechanism dependent on calreticulin and CD 91 . ^^^ |
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| Interacting proteins: Q07954 and P27797 |
Pubmed |
SVM Score :0.0 |
| Impaired recognition of apoptotic neutrophils by the C1q / calreticulin and CD 91 pathway in systemic lupus erythematosus . ^^^ The monocyte endocytic receptor CD 91 is implicated in the endocytosis of apoptotic neutrophils via interactions with C1q and calreticulin . ^^^ In this clinical study , we studied the binding of C1q to leukocytes and determined whether C1q bound specifically to calreticulin and CD 91 on cells undergoing apoptosis in SLE . ^^^ RESULTS : C1q appeared to colocalize to apoptotic blebs on the surface of leukocytes in association with both calreticulin and CD 91 , as determined by phage display and transfected cell studies . ^^^ However , C1q did not bind to apoptotic cells isolated from SLE patients , despite the positivity of the cells for both calreticulin and CD 91 . ^^^ |
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