Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.63209768
Scatchard analysis of equilibrium dialysis studies have revealed that in the presence of 3 . 0 mM MgCl 2 and 150 mM KCl , calregulin has a single binding site for Ca2+ with an apparent dissociation constant ( apparent Kd ) of 0 . 05 microM and 14 binding sites for Zn2+ with apparent Kd ( Zn2+ ) of 310 microM . 0.63209768^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.5492369
A calreticulin like protein co purifies with a ' 60 kD ' component of Ro / SSA , but is not recognized by antibodies in Sjgren ' s syndrome sera . 0.5492369^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.58671532
We observed calcium dependent binding of calreticulin to erythrocyte membranes with a Kd of 2 . 7 10 10 ( 7 ) M and a saturation average of 10 ( 5 ) molecules calreticulin per erythrocyte . 0.58671532^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.55243472
Calreticulin was isolated from either human or pig spleen using a multi step purification method and found to interact preferentially with biotinylated peptides derived from the sequence of the Ro 60 kD 175 184aa ( 10p ) and 216 232aa ( 17p ) . 0.55243472^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Recently a new protein of 46 kD , termed calregulin , was suggested as an additional component of the SSA / Ro antigens . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
A 60 kD protein , stained metachromatically with Stains All was identified as calreticulin with immunoblotting . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The down regulated proteins included calreticulin , cyclophin A , and an isoform of the 27 kD heat shock protein . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The KD for the total specific [ 3H ] Ro 15 4513 binding in the ANT animals was about half of that in the AT animals . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
They were treated according to 5 different schedules , 3 of them combining aromatic retinoid Ro 10 9359 ( AR ) with PUVA therapy . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Small platform stress did not alter the characteristics ( KD and Bmax ) of [ 3H ] Ro 15 4513 binding to cerebellar membranes . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
We have cloned and sequenced a 46 kD Ro / SS A autoantigen gene that is the human homologue of the calcium binding protein , calreticulin . ^^^ The sequence of this 46 kD Ro / SS A protein ( calreticulin ) has significant homology to lambda Ral 1 , a recombinant cDNA clone corresponding to a major antigen of the nematode , Onchocerca volvulus , the infectious agent of onchocerciasis . ^^^ We therefore sought to determine whether antibodies produced by onchocerciasis patients might crossreact with the human 46 kD Ro / SS A autoantigen ( calreticulin ) . 20 of 22 sera from Liberian onchocerciasis patients who had no known evidence of autoimmune disease were found to contain antibodies that reacted with the 46 kD Ro / SS A ( calreticulin ) by immunoblot analysis . ^^^ In addition , a monoclonal antibody raised against O . volvulus organisms reacted to purified human WiL 2 cell 46 kD Ro / SS A antigen ( calreticulin ) by ELISA . ^^^ These results strongly suggest that onchocerciasis patients produce antibodies that crossreact with the 46 kD human Ro / SS A autoantigen ( calreticulin ) and raise the possibility that infectious organisms such as O . volvulus might play a triggering or exacerbating role in the human Ro / SS A autoimmune response . . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
To address this question , we studied the effect of UVB irradiation on the expression of three different polypeptide components of the SSA / Roautoantigen complex ( 60 kD SSA / Ro , 52 kD SSA / Ro , and 46 kD SSA / Ro ( calreticulin ) in A 431 cells , a transformed human epidermal keratinocytes cell line . ^^^ Our results suggest that both total cellular and cell surface calreticulin , but not the 60 and 52 kD SSA / Ro polypeptides , is increased after 100 J / M2 of UVB irradiation , indicating that perturbed calreticulin expression may be primarily responsible for the UVB induced increased binding of anti SSA / Ro to keratinocytes . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Recombinant calreticulin bound vitamin K dependent coagulation factors , 125I Factor 9 , 125I Factor 10 , and 125I prothrombin ( Kd values of approximately 2 . 7 , 3 . 2 , and 8 . 3 nM , respectively ) , via interaction with its C domain , although it did not affect the coagulant properties of these proteins . 125I Calreticulin also bound to endothelial cells in vitro ( Kd approximately 7 . 4 nM ) , and mouse infusion studies showed an initial rapid phase of clearance in which calreticulin could be localized on the vascular endothelium . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
N terminal amino acid analysis of the first 15 amino acids of the 62 kD protein and a protein of 60 kD found in control cells identified both proteins as calreticulin . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Its expression levels are considerable especially in the cerebellum ( 65 % with respect to calreticulin ) . 45Ca binding experiments on 2D blots suggest the protein to be of high capacity ( higher than calreticulin ) and low affinity ( apparent Kd : 3 mM ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Here we show that both the 60K protein ( p 60 ) , purified on a KLGFFKR Sepharose affinity matrix , and recombinant calreticulin can inhibit the binding of androgen receptor to its hormone responsive DNA element in a KXFFKR sequence specific manner . ^^^ Calreticulin can also inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo , as well as retinoic acid induced neuronal differentiation . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The 46 kD antigen is calreticulin ( CR ) , a highly conserved calcium binding protein that resides predominately in the endoplasmic reticulum where it may be involved in protein assembly . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
To investigate the effect of human cytomegalovirus ( CMV ) infection on the expression of Ro autoantigen in human keratinocytes , the binding of anti Ro peptide antibodies ( anti 60 KD / Ro , anti 52 KD / Ro and anti calreticulin ) to cultured human keratinocytes was detected by fixed cell enzyme linked immunoassay ( ELISA ) , immunofluorescence , flow cytometry ( FACS ) analysis and immunoblotting . ^^^ There was a significant increase in the binding of anti 60 KD / Ro antibody but not anti 52 KD / Ro or anti calreticulin antibody to the surface of cultured keratinocytes at 24 h after CMV infection compared with uninfected cells , by ELISA and immunofluorescence . ^^^ The 60 KD / Ro , 52 KD / Ro and calreticulin were all induced on the UVB irradiated cell surface but not significant synergistic effect of UVB and CMV was found . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Calreticulin was detected in several T . cruzi clones , in the Tulahun strain , and in T . rangeli , displaying alternative 43 and 46 kD forms . . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Northern blot and / or RT PCR analysis revealed that ( 1 ) AR , ERalpha and ERbeta mRNA levels were unchanged in DES exposed animals , and ( 2 ) mRNA levels for the AR responsive genes calreticulin , SEC 23B , and ornithine decarboxylase were significantly decreased in DES exposed animals . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Mature 8 wk old female C3H / HeJ mice ( n=43 ) were immunized with 60 kD Ro , 48 kD La , or recombinant calreticulin autoantigens . ^^^ Maternal immunization with 60 kD Ro , 48 kD La , or recombinant calreticulin autoantigens resulted in AVB in a significant percentage of fetuses , however , lesser degrees of AVB were seen at birth . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The complete amino acid sequence of CRP 55 , the major 55 kd calcium binding protein of the ER lumen , was deduced from the murine cDNA nucleotide sequence . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Two classes of binding sites were demonstrated : Type 1 , of low affinity ( Kd approximately 160 nM ) and high capacity ( Ro approximately 1 10 10 ( 5 ) sites per cell ) ; and Type 2 , of high affinity ( Kd approximately 9 nM ) but low capacity ( Ro approximately 1 . 5 10 10 ( 4 ) sites per cell ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
At pH 6 . 0 , binding was maximal ( 30 35 % ) and there was one class of binding sites [ Kd = 6 . 8 10 10 ( 9 ) M ; binding capacity ( Ro ) = 57 pmol / mg of protein ] . ^^^ At pH 7 . 4 , Scatchard plots of binding were nonlinear , indicating either a single class of negatively cooperative sites ( Kd = 3 . 7 10 10 ( 9 ) M ; Ro = 26 pmol / mg of protein ) or , alternatively , independent high ( Kd = 5 . 0 10 10 ( 10 ) M ; Ro = 3 pmol / mg of protein ) and low affinity ( Kd = 1 . 7 10 10 ( 8 ) M ; Ro = 26 pmol / mg of protein ) binding sites . ^^^ The kinetically determined binding constants ( Kd = 1 . 7 10 10 ( 11 ) M ; Ro = 2 pmol / mg of protein ) were more similar to those determined for the high affinity component than to those predicted from the negative cooperativity model . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The results showed that the apparent binding capacity ( Ro ) and the apparent dissociation constant ( Kd ) of GCR were 8468 + / 993 sites per cell and 10 . 2 + / 0 . 6 nM ( n = 6 ) , respectively , under unstressed condition . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The enhancement of [ 3H ] Ro 15 4513 binding was due to an increase in the affinity of the binding sites ( KD ) , without any effect on binding capacity ( Bmax ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The KD ( 40 . 4 + / 2 . 2 nM ) estimated by fluorescence was in good agreement with the Ki ( 77 . 4 + / 13 . 5 nM ) obtained in competition studies with [ 3H ] Ro 5 4864 . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Equilibrium dissociation constants ( Kd ) for the carboxyl terminal ( KdI ) and amino terminal ( KdII ) binding sites of purified ACE , using 125I Ro 31 8472 , were similar for Ro 31 8472 ( lung kdI , 65 + / 7 pM ; KdII , 175 + / 38 pM ) but were clearly different for 351A ( lung KdI , 19 + / 2 pM ; KdII , 2771 + / 489 pM ; p less than 0 . 01 ) . ^^^ Kd in testis was 46 + / 6 pM for Ro 31 8472 and 16 + / 3 pM for 351A , corresponding to estimates at the carboxyl terminal binding site of somatic ACE . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In cultured mesangial cells , AA , but not EPA , decreased Ro of ANP receptors ( 48 . 7 + / 4 . 8 % of control , P less than 0 . 05 ) without affecting KD . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In the liver , treatment reduced the affinity ( Kd ) of [ 3H ] PK 11195 for MBRs ( from 3 . 56 to 15 . 37 nM , P < 0 . 01 ) and the maximum number of binding sites ( Bmax ) ( 55 % decrease , P < 0 . 05 ) ; the affinity ( Ki ) of RO 5 4864 for [ 3H ] PK 11195 binding sites was also reduced ( from 23 . 9 to 72 . 99 nM , P < 0 . 05 ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Ro 24 5913 ( Kd = 3 . 0 + / 2 . 1 nM ) , FPL 55712 ( Kd = 4945 + / 2868 nM ) , LY 171883 ( Kd = 19628 + / 12365 nM ) , SKF 104353 ( Kd = 74 . 2 + / 46 nM ) and its enantiomer SKF 104373 ( Kd = 13627 + / 6813 nM ) were found to interact with a single class of binding sites . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The number of beta 3 adrenergic receptors ( AR ) in plasma membranes from interscapular brown adipose tissue ( IBAT ) was decreased by 62 % in lean Zucker rats treated with the thermogenic beta adrenergic agonist Ro 16 8714 as compared with controls after 72 h of treatment . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Scatchard plot of the specific binding of 3H dexamethasone to the macrophages indicated that the Kd and Ro of glucocorticoid receptor was approximately 3 . 0 nM and 5 , 500 binding sites per cell , respectively . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
KD and Bmax values for 3H Ro 41 1049 in rat cerebral cortex were 10 . 7 nM and 7 . 38 pmol / mg protein , respectively , and for 3H Ro 19 6327 were 18 . 4 nM and 3 . 45 pmol / mg protein , respectively . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Ro 15 4513 binds with the same affinity ( Kd approximately 4 . 5 nM ) to both diazepam sensitive and DZ IS sites in the cerebellum . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Scatchard plots of NPY binding to cerebellar membranes were curvilinear ; the high affinity component had an affinity ( Kd ) of 1 . 1 nM , with a receptor concentration ( Ro ) of 182 fmol / mg membrane protein . ^^^ Scatchard plots of NPY binding to chicken cerebral cortex membranes were linear , with a Kd of 0 . 63 nM and Ro of 90 fmol / mg . ^^^ As previously reported , 125I APP bound to cerebellar membranes with a Kd of 0 . 365 nM and an Ro of 323 fmol / mg , and unlabeled NPY showed about one order of magnitude lower affinity than did unlabeled APP for 125I APP binding sites . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
While [ 3H ] PK 11195 ( 0 . 05 10 nM , final concentration ) bound with high affinity ( KD about 2 nM ) to human cerebral cortex , kidney , and colon membranes , yielding maximal numbers of binding sites of 255 + / 23 , 1908 + / 28 , and 1633 + / 98 fmol / mg protein , respectively , the specific binding of [ 3H ] Ro 5 4864 ( 1 . 25 40 nM , final concentration ) , was barely detectable ( nonspecific binding about 90 % of the total binding ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In saturation experiments , clonazepam and PK 11195 significantly increased KD but not Bmax of the labelled ligand while Ro 5 4864 increased both KD and Bmax . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
A common autoepitope near the carboxyl terminus of the 60 kD Ro ribonucleoprotein : sequence similarity with a viral protein . ^^^ The Ro ribonucleoprotein is composed of hY RNA and a 60 . 7 kD peptide that is antigenic for autoantibodies produced by many patients with systemic lupus erythematosus or Sjgren ' s syndrome and mothers of newborns with complete congenital heart block . ^^^ A major immunoreactive fragment ( 13 kD ) of the 60 kD Ro is bound by 28 of 45 ( 62 % ) of the anti Ro sera tested . ^^^ Amino acid sequence analysis localizes this fragment to the carboxyl end of the 60 kD Ro peptide . ^^^ All possible overlapping octapeptides of this 13 kD peptide of 60 kD Ro have been assessed for antigenicity . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In normal rats ET bound to specific glomerular receptor sites [ equilibrium affinity constant ( Kd ) , 46 . 6 + / 5 . 8 pM ; receptor number ( Ro ) , 1 , 167 + / 160 fmol / mg ( n = 7 ) ] . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
RESULTS : In patients , both total and free plasma cortisol concentrations were higher than in the normal women , as was their urinary free cortisol ; the number of glucocorticoid receptors per cell ( Ro ) and the binding affinity ( Kd ) for dexamethasone were , however , not significantly different ( Ro : 7687 + / 1750 vs 7347 + / 1285 sites / cell ; Kd : 7 . 7 + / 2 . 4 vs 7 . 4 + / 1 . 7 nM at 24 degrees C ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
A single oxytocin binding site was found with an affinity ( Kd ) and receptor concentration ( Ro ) of 3 . 0 + / 0 . 8 nmol / l and 200 + / 60 fmol / mg protein , respectively ( SEM ; n = 5 ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In addition , binding studies with ( 3H ) dexamethasone have been performed to determine the dissociation constant ( Kd ) and receptor numbers ( Ro ) in the monocytes of these two groups of subjects . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Dissociation of immune responses to the SS A ( Ro ) 52 kd and 60 kd polypeptides in systemic lupus erythematosus and Sjgren ' s syndrome . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The KD of 6 . 10 nmol / L for neocortex at 37 degrees C in vitro is of the same order as the KD of 10 nmol / L obtained by positron emission tomography for [ 11C ] Ro 15 1788 binding to benzodiazepine receptors in the human neocortex in vivo . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The carcinoma was induced by implantation of 7 , 12 dimethylbenz [ a ] anthracene ( DMBA ) into the glands . [ 3H ] Ro 5 4864 binding to normal and malignant submandibular glands indicated one population of binding sites with high affinity ( KD of 3 . 4 and 4 . 4 nM for normal and malignant respectively ) and saturability ( Bmax ) of 487 and 321 pmol / g tissue for normal and malignant respectively ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
This allowed us to calculate in vivo ( i . e . , at physiological temperature , neurotransmitters concentrations , and ionic environment ) the apparent density of available benzodiazepine receptors ( B ' max ) and the dissociation constant of Ro 15 1788 ( Kd ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
An homogeneous population of high affinity binding sites for [ 3H ] Ro 41 1049 was found in membrane preparations from human frontal cortex and placenta ( Kd = 16 . 5 + / 1 . 4 and 64 . 4 + / 19 . 2 nM , respectively ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Rabbit antibodies raised against this protein ' s recently described amino terminal epitope react with a previously identified 52 kD human Ro protein and immunoprecipitate the human cytoplasmic RNAs . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Ro 5 4864 and PK 11195 inhibited and potentiated respectively the binding of [ 3H ] nitrendipine to synaptosomes by effects on the KD value . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The KD value of Ro 18 3981 ( 1 . 0 nM ) was similar to the IC 50 value for blockade of ICa at a Vh of 20 mV ( 2 . 3 nM ) , i . e . at a level of near maximal depolarization . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In contrast a prolonged treatment with maprotiline ( 20 mg / kg i . p . ) increased the apparent Kd value of [ 3H ] CGP 12177 by 43 % and the apparent maximal binding value of [ 3H ] RO 15 1788 by 20 % as compared to control . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Scatchard analysis of 125I EGF binding suggested the presence of both high affinity binding with a dissociation constant ( Kd ) of 5 10 10 ( 10 ) M and maximal binding sites ( Ro ) of 2 . 7 10 10 ( 3 ) binding sites / cell and low affinity binding , with Kd of 8 . 3 10 10 ( 9 ) M and Ro of 1 . 8 10 10 ( 4 ) binding sites / cell . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In control rats the high affinity binding dissociation constant ( Kd ) was 0 . 59 + / 0 . 15 nM ( n = 26 ; mean + / SD ) and receptor number ( Ro ) was 732 + / 195 fmol / mg glomerular protein . ^^^ At 3 weeks , the diabetic glomerular AII receptor Kd was 0 . 38 + / 0 . 07 nM ( n = 6 ; P less than 0 . 02 vs . control ) and Ro was 784 + / 97 fmol / mg protein ( P = NS vs . control ) ; diabetic high E Kd was 0 . 39 + / 0 . 06 nM ( n = 6 ; P less than 0 . 02 vs . control ) , and Ro was 873 + / 105 fmol / mg protein ( P = NS vs . diabetes without E ) . ^^^ By 10 weeks , a Kd of 0 . 49 + / 0 . 12 nM ( n = 32 ; P less than 0 . 01 vs . control ) and a Ro of 780 + / 174 fmol / mg protein ( P = NS vs . control ) were observed when all of the diabetic group data were pooled . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
On the other hand , the respective Bmax and KD values for [ 3H ] Ro 5 4864 ( 1 . 25 to 40 nM ) were 2 , 688 + / 275 , 14 , 182 + / 1 , 134 , 144 + / 23 and 205 + / 17 fmol / mg protein ( about 75 , 55 , 11 , and 8 % , respectively , of that of [ 3H ] PK 11195 ) and 13 . 8 + / 1 . 5 , 14 . 6 + / 1 . 1 , 10 . 6 + / 1 . 7 , and 19 . 9 + / 1 . 2 nM . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Scatchard analysis of specific binding data reveals a single , homogeneous class of whole cell binding sites with a Kd of 3 . 94 + / 0 . 22 nM and a Bmax value of 155 + / 11 fmol ( Ro 5 4864 bound ) / 2 10 10 ( 6 ) cells . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The maximal binding capacity ( Ro ) and dissociation constant ( Kd ) of glucocorticoid receptor ( GCR ) in peripheral leukocytes were estimated by radioligand binding method and the plasma cortisol levels measured in 25 stroke patients ( hemorrhagic 15 , ischemic 10 ) , compared with 12 healthy controls , the plasma cortisol level in stroke patients were significantly higher . ^^^ Ro of GCR in 15 hemorrhagic stroke , 10 ischemic stroke patients and 12 controls were 3496 + / 424 , 5678 + / 1101 and 5940 + / 763 sites / cell respectively kd of GCR were 10 . 47 + / 4 . 17 , 7 . 01 + / 3 . 24 and 5 . 81 + / 1 . 05 nmol / L respectively . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Equilibrium binding experiments showed that Ro 19 3704 increased the apparent KD of [ 3H ] yohimbine binding from 2 . 02 + / 0 . 15 to 7 . 3 + / 0 . 4 nM . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The first type of sites ( receptor content [ Ro ] , 10 . 8 + / 1 . 6 fmoles / 10 ( 6 ) cells [ mean + / SD of 4 experiments ] ; equilibrium dissociation constant ( Kd ) , 0 . 3 + / 0 . 1 nM ) have a capacity similar to that of the dexamethasone binding site ( Ro , 11 . 2 fmoles / 10 ( 6 ) cells ; Kd , 1 . 2 nM ) . ^^^ The second type of sites ( Ro , 56 + / 27 fmoles / 10 ( 6 ) cells : Kd , 19 + / 5 nM ) have a higher capacity and lower affinity for RU 486 than the first type of sites and do not interact with dexamethasone . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In contrast , thirty and sixty minutes after convulsions induced by Ro 5 4864 , strychnine , or pentylenetetrazol , neither the Bmax nor Kd of [ 3H ] Ro 5 4864 binding to mouse cerebral cortical membranes was altered . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The glucocorticoid receptor capacity Ro and the dissociation constant Kd were determined in the liver of Xenopus laevis by Scatchard analysis . ^^^ In 5 year old female toads Ro was about three times higher than that in males ( 153 . 9 , 54 . 3 fmol / mg protein ) and Kd was similar in both sexes ( 4 . 0 , 4 . 1 nM ) . ^^^ Some of the animals used had abnormal enlarged thyroid glands , atrophic ovaries , or both defects in connection with different levels of Ro , but not of Kd , compared to those of normal animals . ^^^ Ro and Kd were determined on the following day . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Binding was saturable and a Scatchard plot gave a maximal binding capacity ( Ro ) = 5 . 5 + / 0 . 7 micrograms / mgp ( 79 + / 10 pmol / mgp ) , and a half saturation constant ( KD ) = 55 + / 8 micrograms / ml ( 0 . 8 + / 0 . 1 microM ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Receptor binding studies showed that the B cells had a lower binding affinity but much higher receptor density per cell ( KD = 2 . 1 nM , Ro = 7709 ) than the T cells ( KD = 0 . 4 nM , Ro = 241 ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
One dimensional analysis identified the Ro protein as a 57 kilodalton ( kd ) protein , although many anti Ro sera also react with a 50 kd protein . ^^^ Ro and La were acidic , and La showed a unique set of acidic charge isomers at 50 and 43 kd . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Scatchard analyses of [ 3H ] Ro 5 4864 binding to renal membranes demonstrated that this session of tailshock reduced the density ( Bmax ) of `` peripheral type ' ' benzodiazepine receptors without effecting the apparent affinity ( Kd ) of the radioligand for these sites . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
However , if non specific binding was defined using Ro 15 1788 ( a selective CBR ligand ) , the Bmax and Kd of [ 3H ] flunitrazepam decreased 51 and 58 % , respectively . ^^^ These observations are in sharp contrast to the rat pineal gland , in which both [ 3H ] Ro 5 4864 and [ 3H ] PK 11195 bind to a large number of PBR with high affinity ( Kd approximately equal to 1 . 9 nM , Bmax approximately equal to 26 pmol / mg protein ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
This decrease in peripheral benzodiazepine receptor density was manifest as a decrease in the maximum binding of two ligands , [ 3H ] Ro 5 4864 and [ 3H ] PK 11195 , without accompanying changes in their Kd for this site . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
No change was observed in the Kd values for [ 3H ] Ro 5 4864 and [ 3H ] PK 11195 binding to renal membranes preserved under any condition tested . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Using the immunoblotting technique , sera from 433 patients with rheumatic diseases were screened for the presence of antibodies against several nuclear and cytoplasmic antigens , such as RNP , Sm , Ro ( SSA ) , La ( SSB ) , CR 19 ( centromeric antigen ) , Topo 1 ( Scl 70 ) , Jo 1 , histone and 56 kD . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
However , judging from the micromolar concentrations required for the enhancement of [ 3H ] phenytoin binding , they appear unlikely to be the same ' peripheral ' type binding sites as measured by [ 3H ] Ro 5 4864 binding ( Kd approx . 1 nM ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Alkaline phosphatase staining MCT cells also express epithelial growth factor receptors with a Kd of 0 . 87 nM and an epithelial growth factor receptor constant ( Ro ) of 2 . 1 10 10 ( 4 ) receptors / cell . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The dissociation constant , Kd , decreased from 7 . 4 + / 0 . 2 pM after one hour to 2 . 5 + / 0 . 4 pM after three hours of incubation while the receptor density , RO , decreased from 970 + / 170 to 713 + / 58 sites / cell . ^^^ Analysis of computer simulated binding curves confirmed the decrease in Kd and RO at prolonged incubations . ^^^ This leads to an overestimation of Kd and to a lesser extent of RO values . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The apparent dissociation constant ( KD ) ranged from 3 . 3 to 17 . 1 ( mean , 7 . 0 + / 4 . 3 ) nmol / liter , and the receptor concentration ( Ro ) from 17 to 65 ( mean , 42 + 15 ) fmol / mg protein . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Hence , EGF receptors ( Ro = 48 , 000 , Kd = 3 . 5 10 10 ( 10 ) M ) are found only on the basal surface of the MDCK cells and neither surface expresses insulin receptors . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The glucocorticoid receptors in the tumor cells had similar binding capacity ( Ro ) and equilibrium dissociation constant ( Kd ) as in control rat fibroblasts . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The benzodiazepine [ 3H ] Ro 5 4864 bound specifically and saturably to an apparently homogenous , univalent species of binding site on the calmodulin molecule with an associated equilibrium dissociation rate constant ( Kd ) of 644 + / 121 nM . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The determination of apparent binding parameters of insulin specific receptors using Scatchard plots showed that insulin exposure caused a decrease in receptor concentration ( Ro ) , dexamethasone exposure caused an increase in affinity ( Kd ) , and , compared to insulin alone , treatment with insulin plus dexamethasone increased receptor concentration with no change in apparent affinity . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Androgen receptor content ( Ro ) and binding affinity ( Kd ) in cultured pubic skin fibroblasts were measured using a dispersed , whole cell assay . ^^^ Androgen receptor content ( Ro ) and binding affinity ( Kd ) in cultured pubic skin fibroblasts were measured using a dispersed , whole cell assay . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Fingernail growth was studied in 28 patients who were receiving systemic treatment with the aromatic retinoid , Ro 10 9359 known as Tigason ( etretinate ; AR ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The [ 3H ] Ro 5 4864 bound with a high affinity ( Kd approximately equal to 3 nM ) to a single , saturable population of binding sites ( Bmax = 27 pmol / g tissue wet weight ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The binding of ( ) 3H QNB was of high affinity ( KD = ( 1 . 2 + / 0 . 1 ) 10 10 ( 10 ) M ) , saturable ( Ro = 160 + / 15 fmol . / mg . protein ) and possessed the pharmacological specificity expected of an interaction with muscarinic receptors . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Receptor affinity ( Kd = 45 nM ) in MDCK cells is 30 50 fold lower than in rat kidney , but its pharmacological specificity is identical to that of peripheral type BZD receptors in the rat kidney ( PK 11195 greater than RO 5 4864 greater than diazepam = flunitrazepam greater than clonazepam ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The binding of the novel ligand [ 3H ] Ro 5 4864 to membrane preparations of rat kidney and brain was studied . [ 3H ] Ro 5 4864 binds with high affinity ( Kd = 0 . 6 nM ) to a single saturable population of benzodiazepine recognition sites on renal membranes . ^^^ Specific high affinity ( Kd = 1 . 1 nM ) [ 3H ] Ro 5 4864 binding to the peripheral type benzodiazepine binding site can also be demonstrated using rat brain membranes . [ 3H ] Ro 5 4864 lacks stereospecificity with regard to chiral activity in position 3 . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Scatchard analysis of data revealed high capacity of ( Ro 0 . 44 mol / micrograms 10 10 ( 12 ) but low affinity ( Kd 1 . 8 M 10 10 ( 7 ) binding sites similar to that reported in other tissues . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Both [ 3H ] Ro 15 1788 and [ 3H ] flunitrazepam bound to benzodiazepine receptors with apparent dissociation constants ( KD ) in the nanomolar range and Hill coefficients near unity . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Ro 15 1788 reduced [ 3H ] flunitrazepam binding in the brain in vivo with a potency similar to that of diazepam and effectively inhibited [ 3H ] diazepam binding in vitro ( IC 50 = 2 . 3 + / 0 . 6 nmol / liter ) . [ 3H ] Ro 15 1788 bound to tissue fractions of rat cerebral cortex with an apparent dissociation ( KD ) of 1 . 0 + / 0 . 1 nmol / liter . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The dissociation constant , KD , for the soluble receptor is 0 . 56 + / 0 . 07 nM ( mean + / SEM ) and the number of sites , Ro , is 85 + / 17 fmols / mg protein . ^^^ For the membrane bound receptor the KD is 0 . 50 + / 0 . 04 nM and Ro is 300 + / 18 fmols / mg protein . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The receptors in the major peak bound 125I IGF 2 with a KD of 0 . 6 nM ; the total binding capacity , Ro , was 21 . 6 pmol mg of protein 1 compared to 1 . 6 pmol mg of protein 1 for the membrane associated receptor . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Binding studies conducted with [ 3H ] Ro 5 4864 , a specific ligand for peripheral type benzodiazepine receptors , on circulating lymphocytes from 5 normal volunteers provided evidence for a single , saturable ( Bmax 12 . 2 + / 3 . 6 fmol / 10 ( 6 ) cells ) , and high affinity ( KD 7 . 1 + / 2 . 0 nM ) specific binding site . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Binding of insulin to Golgi fraction ( per cent per 0 . 1 mg protein ) was 5 . 5 + / 0 . 4 % with straight line Scatchard plot ; Kd = 5 . 6 nM , Ro = 3 . 06 pmol / mg ; it was only half of that found in rats . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In the medullary collecting tubule , the association and dissociation rate constants at 4 degrees C were k 1 = 3 . 0 10 10 ( 6 ) M 1 10 min 1 and k 1 = 0 . 021 min 1 ; the ratio k 1 / k1 = 7 . 0 nM was in agreement with the estimated equilibrium dissociation constant ( Kd = 2 . 4 nM ) . [ 3H ] PK 11195 binding sites from medullary ascending limb and medullary collecting tubule revealed the following sequence of specificity : PK 11195 = Ro 5 4864 much greater than clonazepam , indicating that tubule binding sites might be the peripheral benzodiazepine receptors of the rat kidney . . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Scatchard analysis of saturation isotherms suggested that both 3H labeled ligands bind to single binding sites ( [ 3H ] Ro 5 4864 Kd = 2 nM , [ 3H ] methylclonazepam Kd = 3 . 5 nM ) , although [ 3H ] Ro 5 4864 bound to 3 times the number of sites labeled by [ 3H ] methylclonazepam ( respective Bmax values were 15 vs 5 . 3 pmol / g tissue ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
These binding sites for estrogen were high affinity , low capacity with an affinity constant ( Kd ) of 1 . 9 10 10 ( 10 ) M ( binding capacity , Ro = 80 pM ) for nuclear sites and a Kd = 3 . 5 10 10 ( 10 ) M ( Ro = 45 pM ) for cytosol sites . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Ro determinants were identified on polypeptides of 50 and / or 57 kd . ^^^ Antigenic activity was also detected in the void volume of spleen extract fractionated by Sephadex G 200 and in 8 to 9S and greater than 19S regions of sucrose gradients , suggesting either aggregation of the Ro protein or participation in protein protein complexes . pI values of 4 . 3 to 5 . 5 were obtained for the Ro antigen , and two dimensional maps revealed that the 57 kd polypeptide had a similar charge heterogeneity to the La protein , whereas the 50 kd polypeptide had a different fingerprint . ^^^ Immunoblotting of extracts from bovine , rabbit , and dog extracts showed that antibodies to Ro and La reacted with a limited number of polypeptides ( m . w . 50 and / or 57 kd for anti Ro and 43 or 50 kd for anti La ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
A method is described for the determination of binding capacity ( Ro ) and dissociation constant ( Kd ) of androgen receptors in dispersed , whole , cultured human skin fibroblasts . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In a phase 1 study of safety and immunogenicity , two recombinant proteins ( Ro 46 2717 , a circumsporozoite [ CS ] protein ) construct with a molecular mass of 35 kD , and Ro 46 2924 , a merozoite surface antigen [ MSA 2 ] construct with a molecular mass of 25 kD ) adsorbed onto alum were injected in two low ( 20 micrograms ) or two high ( 100 micrograms ) doses in the right and left deltoid muscles of 33 healthy Swiss volunteers ; six other volunteers received a placebo ( alum alone ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The binding of hemin to the transfected receptors exhibited a relatively high affinity with a Kd of 12 nM , and was inhibited by several benzodiazepine ligands , including PK 11195 , Ro 5 4864 , diazepam and protoporphyrin 9 . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Detection of autoantibodies to SS A / Ro by indirect immunofluorescence using a transfected and overexpressed human 60 kD Ro autoantigen in HEp 2 cells . ^^^ Seventy three sera having SS A / Ro autoantibodies as determined by double immunodiffusion ( ID ) and immunoblotting ( IB ) were tested by IIF on a HEp 2 cell substrate that had been transfected with a full length cDNA encoding a human 60 kD SS A / Ro autoantigen . ^^^ Prototype human and rabbit sera directed against the 60 kD SS A / Ro antigen produced intense speckled nuclear and nucleolar staining of transfected cells . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The Bmax values for [ 125I ] ET 1 and [ 125I ] IRL 1620 ( an agonist for the ETB receptors ) bindings were greater in the hyperplastic artery , without changes in Kd values . [ 125I ] ET 1 binding was completely inhibited by unlabeled ET 1 and Ro 46 2005 , a mixed type antagonist for the ETA and ETB receptors , but partially by BQ 123 , a selective antagonist for ETA receptors , and IRL 1620 . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Immunization with vesicular stomatitis virus nucleocapsid protein induces autoantibodies to the 60 kD Ro ribonucleoprotein particle . ^^^ The epitopes of SLE associated 60 kd Ro ( or SSA ) autoantigen share sequence with vesicular stomatitis virus ( VSV ) nucleocapsid ( N ) protein and SLE patients with anti Ro are more likely to bind the N protein than anti Ro negative patients . ^^^ The IgG fraction of the rabbit immune serum precipitates 60 kd Ro protein as well as its associated Y RNAs . ^^^ Antibodies elicited by 10 immunizations of VSV N protein bind to at least 20 linear epitope groups on VSV N protein and over 25 linear epitope groups on 60 kd Ro protein . ^^^ These antibodies also bound 5 of the 6 shared sequences between 60 kd Ro protein and VSV N protein . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Regarding the fine specificity of anti SSA / Ro , a prevalent response to the 52 kD protein of the Ro antigen was found . ^^^ We conclude that patients with SLE developing deformities of the hands belong to a subset of patients with circulating antibodies to SSA / Ro , particularly to the 52 kD component , and to SSB / La . . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
We show here that most of the current inferences about the actions of endothelin assume that the peptide acts in the vessel wall under conditions known as non stoichiometric binding conditions , that is , under conditions in which the receptor concentration in tissues ( [ Ro ] ) is smaller than the equilibrium dissociation constant of endothelin receptor complexes ( Kd ) . ^^^ Under stoichiometric binding conditions ( defined by the condition [ Ro ] > Kd ) , most ligand molecules are bound to receptors and can not be present in a free form . ^^^ Estimates of [ Ro ] and Kd from the literature suggests that in vivo endothelin probably binds stoichiometrically to its receptors . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
METHODS : Forty PBC patients and thirty patients with other types of liver cirrhosis were tested for SS and associated autoantibodies ( ANA , AMA 2 , anti Ro , anti La , anti U1RNP A , C , 68 kD , and rheumatoid factors ) . ^^^ Anti 52 kD Ro antibodies were positive in seven PBC / SS cases ( p < 0 . 025 ) . ^^^ Three patients with PBC / SS with anti 52 kD Ro and anti smooth muscle antibodies developed lung fibrosis . ^^^ Anti 52 kD Ro antibodies seem to be a characteristic serologic finding for SS in PBC , suggesting their pathogenic role in autoimmune sialadenitis . . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Authors were grouped by status of their manuscripts : AR ( accept with revision ) , RR ( reject but may resubmit ) , and RO ( reject outright ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Receptors immunoprecipitated by anti gamma 2 or anti gamma 3 antibodies were labeled with [ 3H ] Ro 15 1788 with similar affinities ( Kd for anti gamma 2 immunoprecipitated receptors , 1 . 9 nM ; Kd for anti gamma 3 immunoprecipitated receptors , 1 . 7 nM ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In human , the peripheral type benzodiazepine receptor density ( Bmax = 13 , 575 + / 1 , 929 fmols / mg ) is double that in rat ( Bmax = 6 , 345 + / 314 fmols / mg ) . [ 3H ] Ro 5 4864 , an agonist , showed a low affinity ( KD = 188 . 38 + / 16 . 46 nM ) for human peripheral type benzodiazepine receptor subtype . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Sera of fifty three infants with different heart rhythm disorders and eight unaffected children born to SLE mothers were tested for antibodies to Ro ( SS A ) , La ( SS B ) and U1RNP ( including recombinant A , C , 68 kD proteins ) using enzyme immunoassays and immunoblot . 21 sera from affected and 8 sera from healthy children reacted in counter immunoelectrophoresis with Ro ( SS A ) . 8 / 8 infants with third degree atrioventricular ( AV ) block , 4 / 8 with first degree AV block , one with sinusbradyarrhythmia ( SB ) and another with SB / first degree AV block were anti 52 kD Ro ( SS A ) positive compared to 7 / 8 healthy infants . ^^^ Infants with third degree AV block had significantly higher anti 52 kD Ro ( SS A ) levels than those with the milder heart rhythm disorders ( P < 0 . 01 ) and the healthy group ( P < 0 . 002 ) . ^^^ It was concluded that the influence of antibody levels to the 52 kD Ro ( SS A ) and La ( SS B ) components and the association of anti 52 kD Ro ( SS A ) , La ( SS B ) and 60 kD Ro ( SS A ) antibodies , as well as the sex , on the severity of congenital AV conduction defects suggests involvement of these factors in the pathogenesis of these disorders . . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In addition , maternal as well as fetal sera were evaluated for the presence of anti SSA ( Ro ) , anti SSB ( La ) and anti 70 kd RNP autoantibodies . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Kinetic methods were used to obtain regional estimates of benzodiazepine receptor concentration ( Bmax ) and equilibrium dissociation constant ( Kd ) from high and low specific activity ( SA ) [ 11C ] flumazenil ( [ 11C ] Ro 15 1788 ) positron emission tomography studies of five normal volunteers . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In both tissues , saturation isotherms of [ 3H ] PK 11195 binding indicated that the presence of RO 5 4864 caused changes in Kd without any effect on Bmax . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Presence of anti La ( SS B ) is associated with binding to the 13 kD carboxyl terminus of 60 kD Ro ( SS A ) in systemic lupus erythematosus . ^^^ We undertook this study to determine whether the fine specificity of the autoimmune response to 60 kD Ro ( SS A ) was related to the presence of other autoantibodies . ^^^ We screened 74 patients with SLE for antibodies to the carboxyl 13 kD terminal of 60 kD Ro ( SS A ) ( 13 kD ) . ^^^ All nine sera with Ro ( SS A ) and La ( SS B ) Ouchterlony immunodiffusion precipitins bound 13 kD ( p = 0 . 01 ) , whereas 10 of 11 sera with both anti Ro ( SS A ) and anti La ( SS B ) as determined by immunosorbent assay bound 13 kD ( p = 0 . 002 ) . ^^^ Inhibition studies demonstrated that antibodies binding the 13 kD fragment bound the 60 kD Ro ( SS A ) protein but did not bind the La ( SS B ) protein . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Phosphorylation profiles of 60 kD Ro antigen in synchronized HEp 2 cells . ^^^ The purpose of this study was to determine whether phosphorylation has an effect on the characteristics of the 60 kD Ro antigen throughout the cell cycle . ^^^ The presence of the Ro protein was detected with a molecular weight of 60 kD during all phases of the cell cycle , except at the M phase , where it was increased to 65 kD . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Significantly increased maternal and fetal IgG autoantibody levels to 52 kD Ro ( SS A ) and La ( SS B ) in complete congenital heart block . ^^^ The current study investigated quantitative and qualitative differences of anti 52 , 60 kD Ro ( SS A ) , 0La ( SS B ) and U1RNP ( C , A , 68 kD ) autoantibodies ( either IgG or IgM ) in sera derived from 16 infants with CHB and their mothers compared to eight healthy anti Ro ( SS A ) positive infants ( controls ) born to SLE mothers . ^^^ Anti 60 , 52 kD Ro ( SS A ) and La ( SS B ) IgG antibodies coincided in 9 / 16 CHB cases , exclusively ( P < 0 . 05 ) . ^^^ Associated anti 52 kD Ro ( SS A ) and La ( SS B ) IgG antibodies were detected in 14 / 16 CHB and in 3 / 8 control cases ( P < 0 . 05 ) . ^^^ The fetal CHB sera contained significantly higher IgG levels of anti 52 kD Ro ( SS A ) ( P < 0 . 005 ) and La ( S B ) ( P < 0 . 015 ) compared to control samples . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
There were no significant differences in affinity constants ( KD ) values for ET 1 , ET 3 , Sarafotoxin S6c ( SRTX S6c ) , BQ 123 , and bosentan ( Ro 47 0203 ) between tissues . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In her second pregnancy plasma hyperviscosity and high antibody reactivities to 52 / 60 kD Ro ( SS A ) and La ( SS B ) represented elevated risk factors for abortion and fetal congenital heart block . ^^^ The combined therapy led to a decrease in both the autoantibody reactivities to 52 kD Ro ( SS A ) and La ( SS B ) and the plasmaviscosity . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
When binding was performed using very low ligand concentrations a benzodiazepine site with an exceptionally high affinity for Ro 15 4513 ( Kd approximately 0 . 1 nM ) was evident in all major regions of the CNS except the cerebellum . ^^^ GABA at 100 microM had little effect on the Kd value for the very high affinity site ( GABA shift : approximately 0 . 8 to 1 . 0 ) , suggesting that Ro 15 4513 is a partial inverse agonist or an antagonist at this site . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Dissociation constant ( Kd ) and number of binding sites ( Ro ) were estimated by Scatchard analysis . ^^^ Kd and Ro of the type 1 receptor for the SLE patients were 12 . 2 + / 6 . 5 ( nM ) and 69 . 0 + / 42 . 4 ( 10 1000 / cell ) , respectively , while those of the normals were 14 . 5 + / 3 . 7 and 86 . 8 + / 23 . 4 , respectively . ^^^ Three patients displayed relatively low Kd or Ro values . ^^^ Although further studies of a larger number of samples are needed to conclude , these results suggest that peripheral blood monocytes of SLE patients express the estrogen receptor whose Kd and Ro are similar to those of normals . . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Minor differences were detected when the frequencies of the Ro 60 kD , Ro 52 kD and La autoantibody specificities to full length proteins in the pSS and sSS groups were compared . ^^^ However , when reactivity to different parts of the Ro 60 kD antigen was analysed , including recombinant fragments encompassing amino acid ( aa ) 1 134 , aa 181 320 and aa 397 525 , only two sera , both from pSS patients , reacted to the aminoterminal fragment aa 1 134 , and 3 / 4 sera that reacted with the carboxyterminal aa 397 525 fragment derived from sSS patients . ^^^ Of all the anti Ro 60 kD positive sera , 80 % reacted with the middle fragment encompassing aa residues 181 320 . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Peripheral blood in Sjgren ' s syndrome does not contain increased levels of T lymphocytes reactive with the recombinant Ro / SS A 52 kD and La / SS B 48 kD autoantigens . ^^^ The enzyme linked immunospot ( ELISPOT ) assay was performed after 48 hours cultivation of PBL in the presence of recombinant Ro 52 kD protein or recombinant La 48 kD protein . ^^^ Thus , T cells reactive with the recombinant Ro 52 kD and La 48 kD proteins do not occur with any increased frequency in peripheral blood of SS patients . . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Accessibility of epitopes on the 52 kD Ro / SSA protein ( Ro 52 ) and on the RoRNP associated Ro 52 protein as determined by anti peptide antibodies . ^^^ Among several Ro proteins , a protein of 52 kD ( Ro 52 ) has been identified , but its association with RoRNPs remains questionable . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
All sera were examined by Western blot using recombinant antigens , encoding the Ro 60 kD and the La proteins . ^^^ Thirteen patients reacted only with the Ro 52 kD antigen and all had severe skin eruptions caused by gold therapy . ^^^ Another ten patients who reacted only with the Ro 60 kD antigen had other side effects to gold ( six had proteinuria and four leucopenia ) . ^^^ Six patients who reacted to all three antigens ( Ro 52 kD , Ro 60 kD and La ) had secondary Sjgren ' s syndrome . ^^^ Our data indicated that antibodies to the Ro 52 kD antigen are associated with skin eruptions in RA patients treated with gold . . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Specific binding of [ 3H ] Ro 63 0563 ( nonspecific binding defined in the presence of 10 microM methiothepin ) to recombinant rat and human 5 HT 6 receptors was saturable , rapid , and reversible with equilibrium dissociation constants ( Kd ) of 6 . 8 nM and 4 . 96 nM , respectively . ^^^ In equilibrium binding studies with rat striatal membranes , [ 3H ] Ro 63 0563 labeled a single binding site with Kd and Bmax values of 11 . 7 nM and 175 fmol / mg protein , respectively . ^^^ In porcine striatal membranes , [ 3H ] Ro 63 0563 also labeled a single binding site with Kd and Bmax values of 8 . 0 nM and 130 fmol / mg protein , respectively . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
This is the same exon configuration associated with the 180 kd CD 45 isoform expressed by memory T cells and monocytes / macrophages ; however , these cell types are RO+ whereas normal Langerhans cells are RO . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The Ro ribonucleoproteins ( RoRNP ) consist of at least one major protein of 60 kD , Ro 60 , and one small associated RNA , designated Y RNA . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The Ro / SSA autoantigen consists of a 52 kD and a 60 kD protein , complexed with one of four small RNA molecules . ^^^ To study the intracellular sorting and targeting of Ro 52 kD we have constructed expression plasmids encoding fusion proteins between the full length Ro 52 kD protein as well as Ro 52 kD fragments and the green fluorescent protein ( GFP ) from the jelly fish , Aequorea Victoria . ^^^ The subcellular distribution of the GFP Ro 52 kD fusion proteins was investigated in transient expression experiments using transfected HeLa cells . ^^^ The GFP full length Ro 52 kD fusion protein was accumulated in the cytoplasm and excluded from the nucleus . ^^^ Clones coding for Ro 52 kD fragments containing the hydrophilic central part of the Ro 52 kD protein gave the same intracellular location and type of cytoplasmic speckles as the full length Ro 52 kD protein . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The bovine Ro 60 kD protein was used as target antigen . ^^^ Six of six primary SS patients had LSG B cells producing anti bovine Ro 60 kD of the IgG isotype , and two of two primary SS patients had in addition PB lymphocytes producing anti bovine Ro 60 kD of the IgG isotype . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The anti Ro antibody ( anti Ro 60 kD , anti Ro 52 kD ) specificity did not change in any of the patients during the follow up period . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Inotropic responses to isoproterenol ( non selective beta AR agonist ) and RO 363 ( selective beta 1 AR agonist ) , in left atria and left papillary muscle , were reduced by up to 65 % , while chronotropic responses in right atria were unaffected . beta 1 and beta 2 AR density did not change after MI , suggesting that changes in beta AR responsiveness are due to changes occurring downstream of the receptor . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Our data showed that 60 kD Ro and La colocalize in the nucleus of the cell . ^^^ Previous data have indicated that 60 kD Ro and La co exist via interactions with the hYRNAs . ^^^ We were interested to see whether 60 kD Ro and La interact with each other through protein protein interactions . ^^^ MAPs were produced with sequences derived from the autoepitopes of 60 kD Ro . ^^^ Using SPR , kinetic analyses gave an apparent affinity constant of about 1 10 10 ( 7 ) M ( 1 ) for Ro MAP 60 kD Ro interactions . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In this study an ELISA assay was used to quantify the levels of antibodies against the recombinant Ro 52 kD , Ro 60 kD , and La 48 kD proteins in plasma and saliva of 17 Sjgren ' s syndrome patients . ^^^ About one third of the patients had salivary enrichment of IgA and IgM against the Ro 52 kD , Ro 60 kD , and La 48 kD antigens and IgG against La 48 kD , while no enrichment of IgG against Ro 52 kD and Ro 60 kD was found . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Alpha 2 AR antagonist properties were revealed in vivo by blockade of UK 14 , 304 induced antinociception , while antagonist actions at 5 HT2C receptors were demonstrated by blockade of Ro 60 0175 induced penile erections and discriminative stimulus properties . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Several centers , using different techniques , have investigated the B cell epitopes on the protein components Ro 60 kD , Ro 52kD , and La 48 kD . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Characterization and genomic sequence of the murine 60 kD Ro gene . ^^^ Autoantibodies binding 60 kD Ro ( or SS A ) are commonly found in patients with systemic lupus erythematosus and Sjgren ' s syndrome . ^^^ As part of a broad effort to better understand animal models of anti Ro autoimmunity we have characterized the murine 60 kD Ro gene . ^^^ Southern blot analysis of mouse genomic DNA suggests that the 60 kD Ro gene is a single copy gene . ^^^ The murine 60 kD Ro gene spans approximately 23 kb and consists of 8 or 9 exons . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The estimated Ro values were 70 + / 8 . 9 Vs 91 + / 8 . 9 pmoles / mg protein ( p < 0 . 05 N=4 ) and the estimated Kd values were 0 . 37 + / 0 . 03 and 0 . 28 + / 0 . 05 microM ( p : NS ) in ethanol and control experiments respectively . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Saturation studies showed that [ 3H ] Ro 15 1788 bound saturatably , reversibly and with a high affinity to a single class of binding sites ( Kd value of 1 . 18 1 . 5 nM and Bmax values of 124 1671 fmol / mg of protein , depending on brain regions ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
This procedure enabled us to identify a cross reactive D 1 antigen on the neutrophil surface that bound antibodies that targeted 60 kD Ro autoantigen in systemic lupus erythematosus , an autoimmune disorder . . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Antibodies against recombinant Ro 60 Kd , Ro 52 and La 48 Kd proteins in primary Sjogren ' s Syndrome . ^^^ AIM : To determine the immune reactivity of sera from patients with Sjgren ' s syndrome , against fusion recombinant proteins ( prf ) Ro 60 Kd , Ro 52 Kd and La 48 Kd expressed in E coli and recombinant protein Ro 52 Kd , expressed in baculovirus ( prb ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The protein kinase C ( PKC ) inhibitor calphostin C or RO 31 8220 abolished the NA induced downregulation of alpha 1D AR mRNA . ^^^ However , calphostin C , RO 31 8220 or PMA had no effect on the induction of alpha 1B AR mRNA by NA . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The values obtained for the dissociation constant Kd = ( 9 . 9 + / 1 . 9 ) nm and the rate constant for ligand receptor dissociation kdisS = ( 1 . 28 + / 0 . 08 ) 10 10 ( 3 ) s ( 1 ) show that there is a specific and high affinity interaction between the dye labeled ligand ( Ro Alexa ) and the receptor site . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Autoantibodies directed against 52 kD and 60 kD Ro / SS A are frequently found in the sera of patients with lupus erythematosus and Sjgren ' s syndrome related disorders . ^^^ It has been postulated that 52 kD Ro ( 52 Ro ) co localizes with the 60 kD Ro autoantigen in the nucleus , while others demonstrated that 52 Ro is primarily cytoplasmic . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
The frequency of maternal low titer autoantibodies to 52 kD Ro detected by ELISA was significantly greater than in the NC group ( 31 % vs . 5 % , P = 0 . 014 ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
We present a case of acute AIH in a 55 year old woman who tested positive for anti Ro 60 kD antibodies . ^^^ A review of the literature revealed frequencies of 21 34 % for anti Ro 52 kD and of 9 13 6 % for anti Ro 60 kD in AIH . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
OBJECTIVE : To describe the preclinical pharmacology of Ro 115 1240 , a peripherally acting selective alpha1A / 1L adrenoceptor ( AR ) partial agonist , compared with the alpha1A / 1L AR full agonist amidephrine , as AR agonists have some utility in the treatment of stress urinary incontinence ( SUI ) but are limited by undesirable cardiovascular and central nervous system side effects . ^^^ The potency and intrinsic activity of amidephrine and Ro 115 1240 relative to noradrenaline were determined in native and cell based assays using human recombinant alpha 1 ARs ; they acted as selective alpha1A / 1L AR full and partial agonists , respectively . ^^^ CONCLUSION : These results show that by combining selectivity for the alpha1A / 1L AR subtype with a reduction in intrinsic agonist efficacy , Ro 115 1240 has reduced haemodynamic effects while retaining to some degree the contractile effects on urethral smooth muscle . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
All of the women were positive to 52 kd and 60 kd Ro autoantibodies . ^^^ CHB mothers had higher titer antibodies to 52 kd Ro protein than did the mothers with healthy infants ( P = 0 . 026 ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Isolated amyloid fibrils from three cases of systemic senile amyloidosis ( SSA ) contained subunit proteins with molecular masses of 14 ( 10 20 % ) , 10 12 ( 60 80 % ) , and 5 6 kD ( 5 10 % ) when fractionated under reducing and dissociating conditions . ^^^ Anti SKO 4 reacted with SSA in tissue at equivalent dilutions to anti Pa ( TTr ) and with the 10 12 kD fraction of SSA on Western blots ; reactivity was blocked by SKO 4 , but not by Pa ( TTr ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
In any individual asthmatic having sustained SSA , AR was strikingly stable . ^^^ Asthmatics who have had SSA do not demonstrate particularly AR , which is not related to the severity of their asthma . 2 . ^^^ A marked increase in AR can be observed before SSA . . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
To determine if an association exists between streptococcal superantigens and KD , we examined serum antibody responses to superantigens in sera from 50 paired acute and convalescent KD patients using purified recombinant streptococcal superantigens , such as SPEA , SPEC , SSA and MF . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
These methods consisted of a chemical deproteinization of blood samples with sulfosalicylic acid ( 1 . 6 M , 0 . 1 ml for 1 ml of sample ) or perchloric acid ( 1 M , 1 ml for 1 ml of sample ) followed by ultrafiltration through a 3 , 000 Da cut off filter ( SSA + UF 3 kD ) or gel filtration through a Sephadex G 15 column ( 1 , 500 Da cut off filter ; PCA + G 15 ) , respectively , prior to PAA analysis . ^^^ Peptide concentrations as determined by amino acid concentrations before and after hydrolysis of samples were slightly greater with the SSA + UF 3 kD ( 991 microM ) than with the PCA + G 15 ( 605 microM ) methodology . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
To assess functional roles of Ssa proteins in the Hst 5 antifungal mechanism in vivo , both binding and fungicidal assays were carried out using S . cerevisiae isogenic SSA1 / SSA2 mutants . 125I Hst 5 binding assays showed saturable binding ( Kd = 2 . 57 10 10 ( 6 ) m ) with the wild type SSA1 / SSA2 strain ; however , Hst 5 binding with the Deltassa1ssa2 double mutant was reduced ( Kd = 1 . 25 10 10 ( 6 ) m ) . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
Affinity assays using a resonant biosensor showed that both the mutant and monomeric wild type SSA have affinity for human Vbeta5 . 2 and Vbeta 1 with Kd of 9 11 microm with a fast kass and a moderately fast kdiss . ^^^
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
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Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27797 and P10275	Pubmed	SVM Score :0.0
NA